Research Topics
| Xue Qiao ZhaoSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Intracoronary thrombus and platelet glycoprotein IIb/IIIa receptor blockade with tirofiban in unstable angina or non-Q-wave myocardial infarction. Angiographic results from the PRISM-PLUS trial (Platelet receptor inhibition for ischemic syndrome managemenX Q Zhao
University of Washington School of Medicine, Seattle, Washington, USA
Circulation 100:1609-15. 1999....- Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control studyX Q Zhao
Division of Cardiology, Department of Medicine, the Diagnostic Imaging Sciences Center, University of Washington, Seattle, USA
Arterioscler Thromb Vasc Biol 21:1623-9. 2001..In this case-control study, prolonged intensive lipid-lowering therapy is associated with a markedly decreased lipid content, a characteristic of clinically stable plaques... 
MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time courseXue Qiao Zhao
Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
JACC Cardiovasc Imaging 4:977-86. 2011..The purpose of this study was to test the lipid depletion hypothesis and to establish the time course of change in carotid plaque morphology and composition during lipid therapy using high-resolution magnetic resonance imaging (MRI)...- Quantitative evaluation of carotid atherosclerotic plaques by magnetic resonance imagingChun Yuan
Division of Cardiology, University of Washington, Box 358771, 1914 North 34th Street, Suite 105, Seattle, WA 98103, USA
Curr Atheroscler Rep 4:351-7. 2002..MRI allows direct visualization of the diseased vessel wall and is capable of characterizing the morphology of individual atherosclerotic carotid plaques... 
Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-AtheroscleroXue Qiao Zhao
Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA
Am J Cardiol 104:1457-64. 2009..Greater stenosis progression rate is associated with a higher event rate. LDL cholesterol-lowering and HDL cholesterol-increasing therapies independently and significantly decrease coronary stenosis progression and decrease CV events...- Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition StudyXue Qiao Zhao
Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98103, USA
Am Heart J 154:239-46. 2007..In vivo testing of the lipid depletion hypothesis in human beings during lipid-modifying therapy has not been possible until recent developments in magnetic resonance imaging (MRI)... - Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study)Xue Qiao Zhao
Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington 98103, USA
Am J Cardiol 93:307-12. 2004..Thus, the simvastatin plus niacin regimen is effective, safe, and well tolerated in patients with or without diabetes mellitus... - Angiotensin-converting enzyme inhibitors and change in aortic valve calciumKevin D O'Brien
Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
Arch Intern Med 165:858-62. 2005.... - Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imagingBinh An P Phan
Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103 8771, USA
Int J Cardiovasc Imaging 23:337-42. 2007..81 +/- 19 mm(3), P = 0.05) compared with patients with HDL levels > 35 mg/dL. Among CAD patients, low HDL-C levels were significantly associated with increased carotid atherosclerotic plaque burden and lipid content by MRI... - Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imagingLi Dong
Department of Radiology, University of Washington School of Medicine, 815 Mercer St, Seattle, WA 98109, USA
Radiology 260:224-31. 2011..To investigate whether short-term, intensive lipid therapy leads to changes in microvascular characteristics, as measured by using dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging... - Effects of Niacin on Glucose Levels, Coronary Stenosis Progression, and Clinical Events in Subjects With Normal Baseline Glucose Levels (<100 mg/dl): A Combined Analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis TreatmBinh An P Phan
Division of Cardiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois Electronic address
Am J Cardiol 111:352-5. 2013.... - Determination of carotid artery atherosclerotic lesion type and distribution in hypercholesterolemic patients with moderate carotid stenosis using noninvasive magnetic resonance imagingBaocheng Chu
Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Stroke 35:2444-8. 2004.... - Usefulness of aortic valve calcium scores by electron beam computed tomography as a marker for aortic stenosisDavid M Shavelle
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Am J Cardiol 92:349-53. 2003..Results of this study suggest that AVC scores should be calculated routinely for coronary calcium screening EBT scans, and that patients with Agatston AVC scores above a certain level (e.g., >150) should be referred for echocardiography... - Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trialHunter R Underhill
Department of Radiology, University of Washington, Seattle, WA 98109, USA
Am Heart J 155:584.e1-8. 2008..Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition... - Antioxidant vitamins and lipid therapy: end of a long romance?B Greg Brown
Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, USA
Arterioscler Thromb Vasc Biol 22:1535-46. 2002..We conclude that they should rarely, if ever, be recommended for cardiovascular protection... - Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRIBinh An P Phan
Department of Medicine, University of Washington, Seattle, Washington 98103 8771, USA
J Magn Reson Imaging 23:481-5. 2006..To investigate whether gadolinium (Gd)-based contrast enhancement (CE) affects high-resolution magnetic resonance imaging (MRI) measurements of carotid arterial wall volume... - MRI of carotid atherosclerosisWilliam S Kerwin
Department of Radiology, University of Washington, Seattle, WA
AJR Am J Roentgenol 200:W304-13. 2013..CONCLUSION: MRI of carotid atherosclerosis has a proven role in pharmaceutical trials and may improve patient management once large-scale clinical trials have been completed... - Reproducibility of carotid atherosclerotic lesion type characterization using high resolution multicontrast weighted cardiovascular magnetic resonanceBaocheng Chu
Department of Radiology, University of Washington Medical Center, Seattle, Washington 98195, USA
J Cardiovasc Magn Reson 8:793-9. 2006..Cardiovascular magnetic resonance (CMR) can characterize carotid atherosclerosis. The purpose of this study is to evaluate reader agreement of carotid atherosclerotic lesion types by CMR... - Is intravascular ultrasound the gold standard surrogate for clinically relevant atherosclerosis progression?B Greg Brown
Cardiology Division, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8855, USA
J Am Coll Cardiol 49:933-8. 2007..Here, we review the evidence to date, discuss some of the concerns, and compare IVUS results with those of quantitative arteriography... - HDL in humans with cardiovascular disease exhibits a proteomic signatureTomas Vaisar
Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
Clin Chim Acta 411:972-9. 2010..We tested whether relative levels of proteins in HDL(2) could be used as biomarkers for coronary artery disease (CAD)... - Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studiesBaocheng Chu
Department of Radiology, University of Washington, Seattle, Washington 98195, USA
J Magn Reson Imaging 21:809-17. 2005..To test the image quality (ImQ) and interscan coverage of MRI for measuring carotid atherosclerosis across multiple centers... - Combined statin and niacin therapy remodels the high-density lipoprotein proteomePattie S Green
Department of Medicine, University of Washington, Seattle, WA, USA
Circulation 118:1259-67. 2008..We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes... - Simultaneous low-density lipoprotein-C lowering and high-density lipoprotein-C elevation for optimum cardiovascular disease prevention with various drug classes, and their combinations: a meta-analysis of 23 randomized lipid trialsB Greg Brown
Cardiology Division, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Curr Opin Lipidol 17:631-6. 2006..Our analysis presents an alternative hypothesis to the prevailing view that low-density lipoprotein-C is the only important target of lipid therapy... - Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDLTomas Vaisar
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Clin Invest 117:746-56. 2007.... - Nicotinic acid, alone and in combinations, for reduction of cardiovascular riskB Greg Brown
Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8019, USA
Am J Cardiol 101:58B-62B. 2008..The widespread adoption of this strategy awaits the results of large, ongoing controlled clinical trials of HDL cholesterol raising... - Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosisTobias Saam
Department of Radiology, University of Washington, Seattle, Washington 98195, USA
J Cardiovasc Magn Reson 7:799-808. 2005..This study provides the basis for sample size calculation of future MRI trials... - Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular functionKevin D O'Brien
Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
J Investig Med 52:185-91. 2004..We determined the hemodynamic effects of ACE inhibitors in patients with mild to moderate aortic stenosis (AS) and preserved left ventricular function... - Ultrasonic Doppler vibrometry: novel method for detection of left ventricular wall vibrations caused by poststenotic coronary flowSiddhartha Sikdar
Department of Bioengineering, University of Washington, Seattle, Washington 98195 5061, USA
J Am Soc Echocardiogr 20:1386-92. 2007..We correlated the vibration characteristics measured using vibrometry with the angiographic severity of coronary artery stenosis... - Effects of adding extended-release niacin and colesevelam to statin therapy on lipid levels in subjects with atherosclerotic diseaseAndrew Moore
Division of Cardiology, Department of Medicine, University of Washington, Box 358771, 1914 North 34th Street, Suite 204, Seattle, WA 98103, USA
J Clin Lipidol 1:620-5. 2007..We conducted a study to assess the efficacy and safety of combination therapy with statin plus extended-release (ER) niacin and colesevelam, aimed at lowering LDL-C and raising HDL-C, in subjects with atherosclerotic disease... - Should both HDL-C and LDL-C be targets for lipid therapy? A review of current evidenceB Greg Brown
Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Box 358855, 146 N Canal Street, Suite 200, Seattle, WA 98195 8855, USA
J Clin Lipidol 1:88-94. 2007..Adoption of this strategy into guidelines probably awaits results of at least one large controlled HDL-C-raising clinical trial, of which two are ongoing and one other is planned... - HMG CoA reductase inhibitor (statin) and aortic valve calciumDavid M Shavelle
Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195-6422, USA
Lancet 359:1125-6. 2002..006) and 44-49% fewer statin patients had definite AVC progression (p=0.043). These findings suggest that statins may decrease AVC accumulation... - Statin use and risks of death or fatal rejection in the Heart Transplant Lipid RegistryAudrey H Wu
Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Cardiol 95:367-72. 2005..Statin therapy was significantly associated with lower risk of death and fatal rejection, benefits that were independent of lipid values... - Prediction of native coronary artery disease progression following PTCA or CABG in the Emory Angioplasty Versus Surgery TrialXue-Qiao Zhao
Department of Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, WA 98103, USA
Med Sci Monit 9:CR48-54. 2003..Patients with metabolic atherogenic risk profiles were more likely to have disease progression. These findings indicate the importance of more aggressive risk factor modification following revascularization... - Reproducibility of electron-beam CT measures of aortic valve calcificationMatthew J Budoff
Harbor-UCLA Research and Education Institute, Torrance, Calif, USA
Acad Radiol 9:1122-7. 2002.... - ApoA-I(Milano)/phospholipid complex: clinical implications of dose-response studies in rabbit atherosclerosis with intravascular ultrasound and magnetic resonance imagingXue-Qiao Zhao
J Am Coll Cardiol 51:1110-1. 2008 - Correlation between the TIMI risk score and high-risk angiographic findings in non-ST-elevation acute coronary syndromes: observations from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and SymptomsJessica L Mega
TIMI Study Group, Brigham and Women's Hospital, Boston, Mass 02115, USA
Am Heart J 149:846-50. 2005..These findings likely explain in part the particular benefit of potent antithrombin and antiplatelet agents among patients with higher risk scores...
Research Grants
- CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERINGXue Qiao Zhao; Fiscal Year: 2010....
- Carotid plaque characteristics by MRI in AIM-HIGHXue Qiao Zhao; Fiscal Year: 2010....
- CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERINGXue Qiao Zhao; Fiscal Year: 2009....
- Carotid plaque characteristics by MRI in AIM-HIGHXue Qiao Zhao; Fiscal Year: 2009....
- CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERINGXue Qiao Zhao; Fiscal Year: 2007....
- CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERINGXue Qiao Zhao; Fiscal Year: 2003..abstract_text> ..
- Carotid plaque characteristics by MRI in AIM-HIGHXue Qiao Zhao; Fiscal Year: 2010....