Xue Qiao Zhao

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Intracoronary thrombus and platelet glycoprotein IIb/IIIa receptor blockade with tirofiban in unstable angina or non-Q-wave myocardial infarction. Angiographic results from the PRISM-PLUS trial (Platelet receptor inhibition for ischemic syndrome managemen
    X Q Zhao
    University of Washington School of Medicine, Seattle, Washington, USA
    Circulation 100:1609-15. 1999
  2. ncbi request reprint Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition Study
    Xue Qiao Zhao
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98103, USA
    Am Heart J 154:239-46. 2007
  3. pmc Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclero
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Cardiol 104:1457-64. 2009
  4. ncbi request reprint Quantitative evaluation of carotid atherosclerotic plaques by magnetic resonance imaging
    Chun Yuan
    Division of Cardiology, University of Washington, Box 358771, 1914 North 34th Street, Suite 105, Seattle, WA 98103, USA
    Curr Atheroscler Rep 4:351-7. 2002
  5. pmc MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    JACC Cardiovasc Imaging 4:977-86. 2011
  6. ncbi request reprint Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study
    X Q Zhao
    Division of Cardiology, Department of Medicine, the Diagnostic Imaging Sciences Center, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 21:1623-9. 2001
  7. ncbi request reprint Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study)
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington 98103, USA
    Am J Cardiol 93:307-12. 2004
  8. ncbi request reprint Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Cardiovasc Magn Reson 7:799-808. 2005
  9. ncbi request reprint Angiotensin-converting enzyme inhibitors and change in aortic valve calcium
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Arch Intern Med 165:858-62. 2005
  10. ncbi request reprint Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging
    Binh An P Phan
    Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103 8771, USA
    Int J Cardiovasc Imaging 23:337-42. 2007

Detail Information

Publications40

  1. ncbi request reprint Intracoronary thrombus and platelet glycoprotein IIb/IIIa receptor blockade with tirofiban in unstable angina or non-Q-wave myocardial infarction. Angiographic results from the PRISM-PLUS trial (Platelet receptor inhibition for ischemic syndrome managemen
    X Q Zhao
    University of Washington School of Medicine, Seattle, Washington, USA
    Circulation 100:1609-15. 1999
    ....
  2. ncbi request reprint Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition Study
    Xue Qiao Zhao
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98103, USA
    Am Heart J 154:239-46. 2007
    ..In vivo testing of the lipid depletion hypothesis in human beings during lipid-modifying therapy has not been possible until recent developments in magnetic resonance imaging (MRI)...
  3. pmc Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclero
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Cardiol 104:1457-64. 2009
    ..Greater stenosis progression rate is associated with a higher event rate. LDL cholesterol-lowering and HDL cholesterol-increasing therapies independently and significantly decrease coronary stenosis progression and decrease CV events...
  4. ncbi request reprint Quantitative evaluation of carotid atherosclerotic plaques by magnetic resonance imaging
    Chun Yuan
    Division of Cardiology, University of Washington, Box 358771, 1914 North 34th Street, Suite 105, Seattle, WA 98103, USA
    Curr Atheroscler Rep 4:351-7. 2002
    ..MRI allows direct visualization of the diseased vessel wall and is capable of characterizing the morphology of individual atherosclerotic carotid plaques...
  5. pmc MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington, USA
    JACC Cardiovasc Imaging 4:977-86. 2011
    ..The purpose of this study was to test the lipid depletion hypothesis and to establish the time course of change in carotid plaque morphology and composition during lipid therapy using high-resolution magnetic resonance imaging (MRI)...
  6. ncbi request reprint Effects of prolonged intensive lipid-lowering therapy on the characteristics of carotid atherosclerotic plaques in vivo by MRI: a case-control study
    X Q Zhao
    Division of Cardiology, Department of Medicine, the Diagnostic Imaging Sciences Center, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 21:1623-9. 2001
    ..In this case-control study, prolonged intensive lipid-lowering therapy is associated with a markedly decreased lipid content, a characteristic of clinically stable plaques...
  7. ncbi request reprint Safety and tolerability of simvastatin plus niacin in patients with coronary artery disease and low high-density lipoprotein cholesterol (The HDL Atherosclerosis Treatment Study)
    Xue Qiao Zhao
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, Washington 98103, USA
    Am J Cardiol 93:307-12. 2004
    ..Thus, the simvastatin plus niacin regimen is effective, safe, and well tolerated in patients with or without diabetes mellitus...
  8. ncbi request reprint Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Cardiovasc Magn Reson 7:799-808. 2005
    ..The percent lipid-rich/necrotic core (%LR/NC) and calcification (%Ca) were measured as a proportion of the vessel wall. For %LR/NC and %Ca, only those subjects that exhibited LR/NC or Ca components were used in the analysis...
  9. ncbi request reprint Angiotensin-converting enzyme inhibitors and change in aortic valve calcium
    Kevin D O'Brien
    Division of Cardiology, Box 356422, Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Arch Intern Med 165:858-62. 2005
    ....
  10. ncbi request reprint Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging
    Binh An P Phan
    Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103 8771, USA
    Int J Cardiovasc Imaging 23:337-42. 2007
    ..81 +/- 19 mm(3), P = 0.05) compared with patients with HDL levels > 35 mg/dL. Among CAD patients, low HDL-C levels were significantly associated with increased carotid atherosclerotic plaque burden and lipid content by MRI...
  11. pmc Carotid artery atherosclerosis: effect of intensive lipid therapy on the vasa vasorum--evaluation by using dynamic contrast-enhanced MR imaging
    Li Dong
    Department of Radiology, University of Washington School of Medicine, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 260:224-31. 2011
    ..To investigate whether short-term, intensive lipid therapy leads to changes in microvascular characteristics, as measured by using dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging...
  12. ncbi request reprint Usefulness of aortic valve calcium scores by electron beam computed tomography as a marker for aortic stenosis
    David M Shavelle
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Am J Cardiol 92:349-53. 2003
    ..Results of this study suggest that AVC scores should be calculated routinely for coronary calcium screening EBT scans, and that patients with Agatston AVC scores above a certain level (e.g., >150) should be referred for echocardiography...
  13. pmc Effects of niacin on glucose levels, coronary stenosis progression, and clinical events in subjects with normal baseline glucose levels (<100 mg/dl): a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), HDL-Atherosclerosis Treatm
    Binh An P Phan
    Division of Cardiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA
    Am J Cardiol 111:352-5. 2013
    ....
  14. ncbi request reprint Determination of carotid artery atherosclerotic lesion type and distribution in hypercholesterolemic patients with moderate carotid stenosis using noninvasive magnetic resonance imaging
    Baocheng Chu
    Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Stroke 35:2444-8. 2004
    ....
  15. ncbi request reprint Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial
    Hunter R Underhill
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Am Heart J 155:584.e1-8. 2008
    ..Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition...
  16. ncbi request reprint Antioxidant vitamins and lipid therapy: end of a long romance?
    B Greg Brown
    Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle, USA
    Arterioscler Thromb Vasc Biol 22:1535-46. 2002
    ..We conclude that they should rarely, if ever, be recommended for cardiovascular protection...
  17. ncbi request reprint Predictors of hospital outcomes after percutaneous coronary intervention in the community
    Audrey H Wu
    Division of Cardiology, Department of Internal Medicine, University of Washington, Seattle, WA 98103, USA
    J Interv Cardiol 17:151-8. 2004
    ....
  18. ncbi request reprint Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRI
    Binh An P Phan
    Department of Medicine, University of Washington, Seattle, Washington 98103 8771, USA
    J Magn Reson Imaging 23:481-5. 2006
    ..To investigate whether gadolinium (Gd)-based contrast enhancement (CE) affects high-resolution magnetic resonance imaging (MRI) measurements of carotid arterial wall volume...
  19. ncbi request reprint MRI of carotid atherosclerosis
    William S Kerwin
    Department of Radiology, University of Washington, Seattle, WA
    AJR Am J Roentgenol 200:W304-13. 2013
    ..This article summarizes the state of evidence for a clinical role for MRI of carotid atherosclerosis...
  20. pmc HDL in humans with cardiovascular disease exhibits a proteomic signature
    Tomas Vaisar
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Chim Acta 411:972-9. 2010
    ..We tested whether relative levels of proteins in HDL(2) could be used as biomarkers for coronary artery disease (CAD)...
  21. pmc Combined statin and niacin therapy remodels the high-density lipoprotein proteome
    Pattie S Green
    Department of Medicine, University of Washington, Seattle, WA, USA
    Circulation 118:1259-67. 2008
    ..We hypothesized that an intervention that increases HDL levels-combined statin and niacin therapy-might reverse these changes...
  22. ncbi request reprint Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studies
    Baocheng Chu
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 21:809-17. 2005
    ..To test the image quality (ImQ) and interscan coverage of MRI for measuring carotid atherosclerosis across multiple centers...
  23. ncbi request reprint Is intravascular ultrasound the gold standard surrogate for clinically relevant atherosclerosis progression?
    B Greg Brown
    Cardiology Division, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8855, USA
    J Am Coll Cardiol 49:933-8. 2007
    ..Here, we review the evidence to date, discuss some of the concerns, and compare IVUS results with those of quantitative arteriography...
  24. ncbi request reprint Reproducibility of carotid atherosclerotic lesion type characterization using high resolution multicontrast weighted cardiovascular magnetic resonance
    Baocheng Chu
    Department of Radiology, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Cardiovasc Magn Reson 8:793-9. 2006
    ..Cardiovascular magnetic resonance (CMR) can characterize carotid atherosclerosis. The purpose of this study is to evaluate reader agreement of carotid atherosclerotic lesion types by CMR...
  25. pmc Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL
    Tomas Vaisar
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Clin Invest 117:746-56. 2007
    ....
  26. ncbi request reprint Simultaneous low-density lipoprotein-C lowering and high-density lipoprotein-C elevation for optimum cardiovascular disease prevention with various drug classes, and their combinations: a meta-analysis of 23 randomized lipid trials
    B Greg Brown
    Cardiology Division, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Curr Opin Lipidol 17:631-6. 2006
    ..Our analysis presents an alternative hypothesis to the prevailing view that low-density lipoprotein-C is the only important target of lipid therapy...
  27. doi request reprint Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk
    B Greg Brown
    Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8019, USA
    Am J Cardiol 101:58B-62B. 2008
    ..The widespread adoption of this strategy awaits the results of large, ongoing controlled clinical trials of HDL cholesterol raising...
  28. ncbi request reprint Hemodynamic effects of the angiotensin-converting enzyme inhibitor, ramipril, in patients with mild to moderate aortic stenosis and preserved left ventricular function
    Kevin D O'Brien
    Division of Cardiology, University of Washington, Seattle, WA 98195 6422, USA
    J Investig Med 52:185-91. 2004
    ..We determined the hemodynamic effects of ACE inhibitors in patients with mild to moderate aortic stenosis (AS) and preserved left ventricular function...
  29. ncbi request reprint Statin use and risks of death or fatal rejection in the Heart Transplant Lipid Registry
    Audrey H Wu
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 95:367-72. 2005
    ..Statin therapy was significantly associated with lower risk of death and fatal rejection, benefits that were independent of lipid values...
  30. ncbi request reprint Effects of adding extended-release niacin and colesevelam to statin therapy on lipid levels in subjects with atherosclerotic disease
    Andrew Moore
    Division of Cardiology, Department of Medicine, University of Washington, Box 358771, 1914 North 34th Street, Suite 204, Seattle, WA 98103, USA
    J Clin Lipidol 1:620-5. 2007
    ..We conducted a study to assess the efficacy and safety of combination therapy with statin plus extended-release (ER) niacin and colesevelam, aimed at lowering LDL-C and raising HDL-C, in subjects with atherosclerotic disease...
  31. pmc Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase
    Baohai Shao
    From the Department of Medicine, University of Washington, Seattle B S, C T, A s, P S M, G D D, X Q Z, J W H Diabetes and Obesity Center of Excellence, University of Washington, Seattle B S, C T, P S M, J W H Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY N B Center for Molecular Biology and Biotechnology, Florida Atlantic University, Jupiter N B and Children s Hospital Oakland Research Institute, CA M N O
    Circ Res 114:1733-42. 2014
    ..However, the mechanisms that contribute to impaired sterol efflux capacity remain poorly understood...
  32. ncbi request reprint Prediction of native coronary artery disease progression following PTCA or CABG in the Emory Angioplasty Versus Surgery Trial
    Xue Qiao Zhao
    Department of Medicine, Cardiology Division, University of Washington School of Medicine, Seattle, WA 98103, USA
    Med Sci Monit 9:CR48-54. 2003
    ..The natural history of atherosclerosis progression following revascularization procedures (PTCA or CABG) limits the long-term benefits of these procedures and requires continuation of risk management...
  33. ncbi request reprint Predictors of repeat revascularization after nonemergent, first percutaneous coronary intervention in the community
    Audrey H Wu
    Division of Cardiology, Department of Internal Medicine, University of Washington, Seattle, Wash, USA
    Am Heart J 147:146-50. 2004
    ..We sought to determine the incidence of and risk factors for repeat revascularization after nonemergent, first percutaneous coronary intervention (PCI) performed in contemporary community practice...
  34. ncbi request reprint Ultrasonic Doppler vibrometry: novel method for detection of left ventricular wall vibrations caused by poststenotic coronary flow
    Siddhartha Sikdar
    Department of Bioengineering, University of Washington, Seattle, Washington 98195 5061, USA
    J Am Soc Echocardiogr 20:1386-92. 2007
    ..We correlated the vibration characteristics measured using vibrometry with the angiographic severity of coronary artery stenosis...
  35. pmc Should both HDL-C and LDL-C be targets for lipid therapy? A review of current evidence
    B Greg Brown
    Division of Cardiology, Department of Medicine, University of Washington School of Medicine, Box 358855, 146 N Canal Street, Suite 200, Seattle, WA 98195 8855, USA
    J Clin Lipidol 1:88-94. 2007
    ..Adoption of this strategy into guidelines probably awaits results of at least one large controlled HDL-C-raising clinical trial, of which two are ongoing and one other is planned...
  36. ncbi request reprint HMG CoA reductase inhibitor (statin) and aortic valve calcium
    David M Shavelle
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98195 6422, USA
    Lancet 359:1125-6. 2002
    ..006) and 44-49% fewer statin patients had definite AVC progression (p=0.043). These findings suggest that statins may decrease AVC accumulation...
  37. doi request reprint ApoA-I(Milano)/phospholipid complex: clinical implications of dose-response studies in rabbit atherosclerosis with intravascular ultrasound and magnetic resonance imaging
    Xue Qiao Zhao
    J Am Coll Cardiol 51:1110-1. 2008
  38. ncbi request reprint Reproducibility of electron-beam CT measures of aortic valve calcification
    Matthew J Budoff
    Harbor UCLA Research and Education Institute, Torrance, Calif, USA
    Acad Radiol 9:1122-7. 2002
    ..The authors performed this study to establish the interscan, interobserver, and intraobserver reproducibility of aortic valve calcification (AVC) measurements obtained with electron-beam computed tomography (CT)...
  39. ncbi request reprint Correlation between the TIMI risk score and high-risk angiographic findings in non-ST-elevation acute coronary syndromes: observations from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms
    Jessica L Mega
    TIMI Study Group, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am Heart J 149:846-50. 2005
    ....

Research Grants14

  1. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2000
    ..abstract_text> ..
  2. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2010
    ....
  3. Carotid plaque characteristics by MRI in AIM-HIGH
    Xue Qiao Zhao; Fiscal Year: 2010
    ....
  4. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2009
    ....
  5. Carotid plaque characteristics by MRI in AIM-HIGH
    Xue Qiao Zhao; Fiscal Year: 2009
    ....
  6. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2007
    ....
  7. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2006
    ....
  8. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2003
    ..abstract_text> ..
  9. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2002
    ..abstract_text> ..
  10. CAROTID PLAQUE COMPOSITION BY MRI DURING LIPID-LOWERING
    Xue Qiao Zhao; Fiscal Year: 2001
    ..abstract_text> ..
  11. Carotid plaque characteristics by MRI in AIM-HIGH
    Xue Qiao Zhao; Fiscal Year: 2010
    ....