Genomes and Genes
Affiliation: University of Maryland
- HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasomeGe Li
Department of Pathology, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e11371. 2010..These findings suggest that Vpr-proteasome interaction might counteract certain host restriction factor(s) to stimulate viral replication in non-dividing cells...
- Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapyHailiu Yang
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
Cell Biosci 2:32. 2012....
- APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replicationLin Li
Department of Pathology, University of Maryland, 10 South Pine Street, MSTF700A, Baltimore, MD 21201, USA
Retrovirology 5:72. 2008..In this pilot study, we tested whether APOBEC3G, when it is fused with UBA2, can resist Vif-mediated proteasomal degradation and further inhibit HIV-1 infection...
- Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein RGe Li
Department of Pathology, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA
Retrovirology 7:59. 2010..Even though Vpr-induced G2 arrest has been studied extensively, how Vpr triggers G2 arrest remains elusive...
- Vpr-host interactions during HIV-1 viral life cycleRichard Y Zhao
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Neuroimmune Pharmacol 6:216-29. 2011....
- Anti-cancer effect of HIV-1 viral protein R on doxorubicin resistant neuroblastomaRichard Y Zhao
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 5:e11466. 2010..Therefore, Vpr could possibly be used as a supplemental viral therapeutic agent for selective inhibition of tumor growth in anti-cancer therapy especially when other therapies stop working...
- [Enhanced protein production of Vif and APOBEC3G by HIV-1 Vpr]Lin Li
Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 22:39-41. 2008..Goal of this study was to test the potential regulatory effects of Vpr on Vif and Vif-mediated degradation of APOBEC3G...
- From single cell gene-based diagnostics to diagnostic genomics: current applications and future perspectivesRichard Zhao
Division Head of Molecular Pathology, Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201 1192, USA
Clin Lab Sci 18:254-62. 2005..New technologies that could potentially be used in future gene-based diagnosis are introduced...
- Viral infections and cell cycle G2/M regulationRichard Y Zhao
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 2120, USA
Cell Res 15:143-9. 2005....
- Molecular-based laboratory testing and monitoring for human immunodeficiency virus infectionsNiel Constantine
Clinical Immunology Laboratory, University of Maryland Medical Center, Baltimore, MD 21201 1192, USA
Clin Lab Sci 18:263-70. 2005..Newer approaches that could be used in future HIV testing are also introduced...
- HIV-1 viral protein R (Vpr) & host cellular responsesRichard Yuqi Zhao
Department of Pathology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 600, Baltimore, MD 21201, USA
Indian J Med Res 121:270-86. 2005..Strategies with potential application for future antiviral therapies directed at suppressing Vpr activities are described...
- Anti-Vpr activity of a yeast chaperone proteinZsigmond Benko
Children s Memorial Institute for Education and Research, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 2430 N Halsted St 218, Chicago, IL 60614, USA
J Virol 78:11016-29. 2004..This finding could potentially provide a new approach to studying the contribution of Vpr to viral pathogenesis and to reducing Vpr-mediated detrimental effects in HIV-infected patients...
- Fission yeast homologue of Tip41-like proteins regulates type 2A phosphatases and responses to nitrogen sourcesCsaba Fenyvuesvolgyi
Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Biochim Biophys Acta 1746:155-62. 2005..These results suggest that fission yeast Tip41 plays a role in cellular responses to nitrogen nutrient conditions at least partly through regulation of type 2A phosphatase activity...
- Cell Cycle G2/M Pathway Modulated by Viral Protein RRichard Zhao; Fiscal Year: 2006..These proposed studies will provide a comprehensive framework for this new cell cycle control pathway and provide insights into fundamental aspects of this new G2/M surveillance system of eukaryotic cells. ..
- Effect of HIV-1 Vpr on Basic Cellular Functions (II)Richard Zhao; Fiscal Year: 2007..abstract_text> ..