Liqin Zhao

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Brain Res 1010:22-34. 2004
  2. pmc Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 7:e31267. 2012
  3. doi request reprint Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 18:1131-42. 2011
  4. pmc 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neurobiol Aging 32:1949-63. 2011
  5. doi request reprint A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 150:770-83. 2009
  6. ncbi request reprint FK506-binding protein ligands: structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates
    Liqin Zhao
    Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China
    J Med Chem 49:4059-71. 2006
  7. ncbi request reprint Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties
    Liqin Zhao
    Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, China
    Bioorg Med Chem Lett 16:4385-90. 2006
  8. pmc Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    BMC Neurosci 7:24. 2006
  9. ncbi request reprint WHI and WHIMS follow-up and human studies of soy isoflavones on cognition
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Expert Rev Neurother 7:1549-64. 2007
  10. pmc Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's
    Fan Ding
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e59825. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
    Brain Res 1010:22-34. 2004
    ....
  2. pmc Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 7:e31267. 2012
    ....
  3. doi request reprint Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Menopause 18:1131-42. 2011
    ....
  4. pmc 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA
    Neurobiol Aging 32:1949-63. 2011
    ....
  5. doi request reprint A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Endocrinology 150:770-83. 2009
    ....
  6. ncbi request reprint FK506-binding protein ligands: structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4-thiazolidine)carboxylates
    Liqin Zhao
    Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China
    J Med Chem 49:4059-71. 2006
    ..This study further suggests the clinical potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson's disease...
  7. ncbi request reprint Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties
    Liqin Zhao
    Laboratory of Computer Aided Drug Design and Discovery, Beijing Institute of Pharmacology and Toxicology, Beijing, China
    Bioorg Med Chem Lett 16:4385-90. 2006
    ..However, in the absence of exogenously added NGF, all test compounds, including GPI-1046, failed to afford any positive effect on DRGs. This study suggests the intriguing potential of these compounds for further investigation...
  8. pmc Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    BMC Neurosci 7:24. 2006
    ..Further, we sought, through computer-aided modeling analyses, to investigate the potential correlation of the molecular mechanisms that conferred estrogen neuroprotection with estrogen interactions with the estrogen receptor (ER)...
  9. ncbi request reprint WHI and WHIMS follow-up and human studies of soy isoflavones on cognition
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Expert Rev Neurother 7:1549-64. 2007
    ..Development of an effective phytoestrogen formulation would benefit both women and men to prevent or treat hormone-dependent conditions and, most of all, to improve neurological health and reduce the risk of Alzheimer's disease...
  10. pmc Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's
    Fan Ding
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 8:e59825. 2013
    ..These findings also indicate that estrogen plays a critical role in sustaining brain bioenergetic capacity through preservation of glucose metabolism...
  11. pmc Potentiation of brain mitochondrial function by S-equol and R/S-equol estrogen receptor β-selective phytoSERM treatments
    Jia Yao
    University of Southern California, Pharmacology and Pharmaceutical Sciences, School of Pharmacy, 1985 Zonal Avenue, PSC 502, Los Angeles, CA 90033, United States
    Brain Res 1514:128-41. 2013
    ..This article is part of a Special Issue entitled Hormone Therapy...
  12. ncbi request reprint Design, synthesis, and estrogenic activity of a novel estrogen receptor modulator--a hybrid structure of 17beta-estradiol and vitamin E in hippocampal neurons
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Med Chem 50:4471-81. 2007
    ..These results provide support for the development of a brain-selective ER modulator, with potential as an efficacious and safe estrogen alternative to prevent Alzheimer's disease and cognitive decline in postmenopausal women...
  13. ncbi request reprint Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile
    Liqin Zhao
    Molecular Pharmacology and Toxicology, Neuroscience, and Biomedical Engineering, University of Southern California, 1985 Zonal Avenue, PSC 503, Los Angeles, CA 90089, USA
    J Pharmacol Exp Ther 319:1124-32. 2006
    ....
  14. pmc Hippocampal responsiveness to 17β-estradiol and equol after long-term ovariectomy: implication for a therapeutic window of opportunity
    Ryan T Hamilton
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1379:11-22. 2011
    ..By extension, the data are consistent with a primary tenet of the critical window hypothesis, i.e., that the brains of post-menopausal women ultimately lose their ability to respond positively to estrogenic stimulation...
  15. ncbi request reprint Estrogen receptor alpha and beta differentially regulate intracellular Ca(2+) dynamics leading to ERK phosphorylation and estrogen neuroprotection in hippocampal neurons
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, Norris Foundation Laboratory for Neuroscience Research, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1172:48-59. 2007
    ..Further, the present analyses suggest that separate from a classical nuclear ER-mediated response, estrogen promotes neuronal survival likely through a non-nuclear cytoplasm or membrane-associated ER-mediated rapid signaling cascade...
  16. ncbi request reprint Early intervention with an estrogen receptor β-selective phytoestrogenic formulation prolongs survival, improves spatial recognition memory, and slows progression of amyloid pathology in a female mouse model of Alzheimer's disease
    Liqin Zhao
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA, USA
    J Alzheimers Dis 37:403-19. 2013
    ..Taken together, these results support the therapeutic potential of the phyto-β-SERM formulation for prevention and/or early intervention of AD, and warrants further investigations in human studies. ..
  17. pmc 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain
    Anusha Jayaraman
    Neuroscience Graduate Program, University of Southern California, Los Angeles, California 90089, USA
    Endocrinology 153:5467-79. 2012
    ..These findings further define sex steroid hormone actions involved in regulation of Aβ, a relationship potentially important to therapeutic approaches aimed at reducing risk of Alzheimer's disease...
  18. pmc The effect of dietary soy isoflavones before and after ovariectomy on hippocampal protein markers of mitochondrial bioenergetics and antioxidant activity in female monkeys
    Jamaica R Rettberg
    Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    Brain Res 1379:23-33. 2011
    ....
  19. pmc Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17β-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis
    Namrata Bali
    University of Southern California Dornsife College of Letters, Arts and Sciences, Los Angeles, California 90089 0191, USA
    Endocrinology 153:759-69. 2012
    ..The differential regulation of hippocampal Pgrmc1 and Pgr by E2 and P4 may guide drug development in hormonal therapy for support of neurogenesis and synaptic regeneration...
  20. pmc Clinically relevant progestins regulate neurogenic and neuroprotective responses in vitro and in vivo
    Lifei Liu
    Program in Neuroscience, University of Southern California, School of Pharmacy Pharmaceutical Sciences Center, Los Angeles, California 90033, USA
    Endocrinology 151:5782-94. 2010
    ..Progestin impact on the regenerative capacity of the brain has clinical implications for contraceptive and hormone therapy formulations prescribed for pre- and postmenopausal women...
  21. ncbi request reprint Structure-based virtual screening for plant-based ERbeta-selective ligands as potential preventative therapy against age-related neurodegenerative diseases
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Med Chem 48:3463-6. 2005
    ..Twelve representative hits derived from database screening were assessed for their binding profiles to both ERs, three of which displayed over 100-fold binding selectivity to ERbeta over ERalpha...
  22. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..Mitochondrial dysfunction provides a plausible mechanistic rationale for the hypometabolism in brain that precedes AD diagnosis and suggests therapeutic targets for prevention of AD...
  23. doi request reprint Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs
    Amit R Agarwal
    Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Univ of Southern California, Los Angeles, CA 90089 9121, USA
    Am J Physiol Lung Cell Mol Physiol 303:L889-98. 2012
    ..These changes occurred independently of inflammatory responses. These findings have implications for the early onset of alterations in energy and redox metabolism upon acute lung exposure to CS...
  24. pmc Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via extracellularly regulated kinase and progesterone receptor membrane components 1 and 2
    Lifei Liu
    Program in Neuroscience, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, California 90089, USA
    Endocrinology 150:3186-96. 2009
    ..Progesterone mediated NPC proliferation and concomitant regulation of mitotic cell cycle genes via a PGRMC/ERK pathway mechanism is a potential novel therapeutic target for promoting neurogenesis in the mammalian brain...
  25. ncbi request reprint Selective estrogen receptor modulators (SERMs) for the brain: current status and remaining challenges for developing NeuroSERMs
    Liqin Zhao
    Department of Molecular Pharmacology and Toxicology and the Program in Neuroscience, School of Pharmacy, University of Southern California, Pharmaceutical Sciences Center, Los Angeles, CA 90089, USA
    Brain Res Brain Res Rev 49:472-93. 2005
    ..Results of these endeavors have yielded insights into strategies for developing novel molecules with NeuroSERM potential in order to prevent brain related climacteric symptoms and neurodegenerative diseases...