Jiyong Zhao

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    J Zhao
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:2283-97. 2000
  2. pmc Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
    J Zhao
    Laboratory of Molecular Oncology, Massachusetts General Hospital MGH Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 12:456-61. 1998
  3. pmc Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit
    David A Barbie
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Mol Cell Biol 24:595-607. 2004
  4. ncbi request reprint Coordination of DNA synthesis and histone gene expression during normal cell cycle progression and after DNA damage
    Jiyong Zhao
    Department of Biomedical Genetics, University of Rochester Medicial Center, New York 14642, USA
    Cell Cycle 3:695-7. 2004
  5. pmc Assessing G1-to-S-phase progression after genotoxic stress
    Michael DeRan
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, New York 14642, USA
    Methods Mol Biol 782:221-30. 2011
  6. pmc DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
    Chuan Su
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    EMBO J 23:1133-43. 2004
  7. pmc NPAT expression is regulated by E2F and is essential for cell cycle progression
    Guang Gao
    Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 23:2821-33. 2003
  8. ncbi request reprint Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway
    Xiao Feng Le
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cell Cycle 5:1654-61. 2006
  9. pmc Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition
    Michael DeRan
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 28:435-47. 2008
  10. ncbi request reprint Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells
    Sang Woo Kim
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:1644-53. 2008

Collaborators

  • Brian K Kennedy
  • A G Matera
  • Nicholas Dyson
  • Mong Hong Lee
  • Takashi Imai
  • Marie K Classon
  • Michael DeRan
  • Chuan Su
  • Guang Gao
  • Mary Pulvino
  • Sang Woo Kim
  • Xiao Feng Le
  • David A Barbie
  • Eriko Greene
  • Craig T Jordan
  • Randall M Rossi
  • David W Oleksyn
  • Ignacio Sanz
  • Luojing Chen
  • Khandan Keyomarsi
  • Weiqun Mao
  • Mollianne Murray
  • Zhen Lu
  • Robert C Bast
  • Isabelle Bedrosian
  • MICHAEL A O'REILLY
  • Brett R Johnson
  • Richard Frock
  • Brian A Kudlow
  • Carsten Weiss
  • Ed Harlow
  • Dirk Bohmann
  • Sandra Schneider
  • Christopher Helt
  • Masashi Sagara
  • Kristian Helin
  • Adrian P Bracken
  • Diego Pasini
  • Claire Attwooll
  • Karina Burkard

Detail Information

Publications10

  1. pmc NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    J Zhao
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 14:2283-97. 2000
    ..Thus, our results both show that NPAT is involved in a key S phase event and provide a link between the cell cycle machinery and activation of histone gene transcription...
  2. pmc Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
    J Zhao
    Laboratory of Molecular Oncology, Massachusetts General Hospital MGH Cancer Center, Charlestown, Massachusetts 02129, USA
    Genes Dev 12:456-61. 1998
    ..Overexpression of NPAT accelerates S-phase entry, and this effect is enhanced by coexpression of cyclin E-CDK2. These results suggest that NPAT is a substrate of cyclin E-CDK2 and plays a role in S-phase entry...
  3. pmc Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit
    David A Barbie
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Mol Cell Biol 24:595-607. 2004
    ..These results suggest that mammalian cells undergo a large-scale reorganization of chromatin during the rounds of DNA replication that precede cell cycle exit...
  4. ncbi request reprint Coordination of DNA synthesis and histone gene expression during normal cell cycle progression and after DNA damage
    Jiyong Zhao
    Department of Biomedical Genetics, University of Rochester Medicial Center, New York 14642, USA
    Cell Cycle 3:695-7. 2004
    ..Regulation of the cyclin E-Cdk2 substrate NPAT, which is essential for both histone gene expression and S phase entry, provides a mechanism coordinating histone and DNA synthesis in mammalian cells...
  5. pmc Assessing G1-to-S-phase progression after genotoxic stress
    Michael DeRan
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, New York 14642, USA
    Methods Mol Biol 782:221-30. 2011
    ..In this chapter we present methods for the induction of genotoxic stress. Additionally, we describe methods for studying the progression of cells from G(1) to S phase after genotoxic stress...
  6. pmc DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
    Chuan Su
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    EMBO J 23:1133-43. 2004
    ..Our results thus suggest that inhibition of Cdk2 activity following DNA damage results in the downregulation of histone gene transcription through dissociation of NPAT from histone gene clusters...
  7. pmc NPAT expression is regulated by E2F and is essential for cell cycle progression
    Guang Gao
    Department of Biomedical Genetics, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 23:2821-33. 2003
    ..As NPAT is involved in the regulation of S-phase-specific histone gene transcription, our findings indicate that NPAT links E2F to the activation of S-phase-specific histone gene transcription...
  8. ncbi request reprint Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway
    Xiao Feng Le
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cell Cycle 5:1654-61. 2006
    ....
  9. pmc Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition
    Michael DeRan
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Cell Biol 28:435-47. 2008
    ..Thus, our data support a model in which NPAT recruits the TRRAP-Tip60 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition...
  10. ncbi request reprint Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells
    Sang Woo Kim
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:1644-53. 2008
    ..Together, these results indicate that PKK plays a pivotal role in the survival of human DLBCL cells and represents a potential target for DLBCL therapy...

Research Grants8

  1. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2003
    ..It is not unreasonable to expect that this research may lead to identification of novel targets for cancer diagnosis or therapy. ..
  2. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2004
    ..It is not unreasonable to expect that this research may lead to identification of novel targets for cancer diagnosis or therapy. ..
  3. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2005
    ..It is not unreasonable to expect that this research may lead to identification of novel targets for cancer diagnosis or therapy. ..
  4. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2006
    ..It is not unreasonable to expect that this research may lead to identification of novel targets for cancer diagnosis or therapy. ..
  5. Function and regulation of cyclin E-Cdk2 substrate NPAT
    Jiyong Zhao; Fiscal Year: 2007
    ..It is not unreasonable to expect that this research may lead to identification of novel targets for cancer diagnosis or therapy. ..
  6. The role of protein kinase PKK in BAFF signaling and B-cell malignancies
    Jiyong Zhao; Fiscal Year: 2009
    ..The proposed research seeks to identify and characterize the potential therapeutic targets for B-cell lymphoma treatment. Thus, this research may lead to the development of better therapeutic strategies for B-cell lymphoma treatment. ..
  7. The role of protein kinase PKK in BAFF signaling and B-cell malignancies
    Jiyong Zhao; Fiscal Year: 2010
    ..The proposed research seeks to identify and characterize the potential therapeutic targets for B-cell lymphoma treatment. Thus, this research may lead to the development of better therapeutic strategies for B-cell lymphoma treatment. ..