Dawen Zhao

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi Liposomal encapsulation enhances in vivo near infrared imaging of exposed phosphatidylserine in a mouse glioma model
    Liang Zhang
    Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Molecules 18:14613-28. 2013
  2. pmc In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Int J Radiat Oncol Biol Phys 80:574-81. 2011
  3. pmc Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    Chang Hyuk Kwon
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Cancer Res 68:3286-94. 2008
  4. pmc Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor
    Vincent A Bourke
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 9058, USA
    Int J Radiat Oncol Biol Phys 67:1179-86. 2007
  5. ncbi Tumor physiologic response to combretastatin A4 phosphate assessed by MRI
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9058, USA
    Int J Radiat Oncol Biol Phys 62:872-80. 2005
  6. pmc Tumor oxygen dynamics: correlation of in vivo MRI with histological findings
    Dawen Zhao
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 5:308-18. 2003
  7. pmc Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance
    Kimmo J Hatanpaa
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 12:675-84. 2010
  8. doi Comparison of 1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Magn Reson Med 62:357-64. 2009
  9. pmc The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma
    Seongmi Park
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    Cancer Res 69:2809-16. 2009
  10. ncbi Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor
    Dawen Zhao
    Departments of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 159:621-31. 2003

Collaborators

Detail Information

Publications23

  1. doi Liposomal encapsulation enhances in vivo near infrared imaging of exposed phosphatidylserine in a mouse glioma model
    Liang Zhang
    Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Molecules 18:14613-28. 2013
    ..Our data further suggest the usefulness of PS-targeted imaging probes for sensitive tumor detection and the potential of utilizing liposomal platform for glioma theranostics. ..
  2. pmc In vivo near-infrared spectroscopy and magnetic resonance imaging monitoring of tumor response to combretastatin A-4-phosphate correlated with therapeutic outcome
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Int J Radiat Oncol Biol Phys 80:574-81. 2011
    ..To develop a combination treatment consisting of combretastatin A-4-phosphate (CA4P) with radiation based on tumor oxygenation status...
  3. pmc Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    Chang Hyuk Kwon
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Cancer Res 68:3286-94. 2008
    ..The presence of ectopically migrating neural stem/progenitor lineage cells in presymptomatic Pten-deficient mutant brains supports the notion that these tumors may arise from stem/progenitor cells...
  4. pmc Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor
    Vincent A Bourke
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 9058, USA
    Int J Radiat Oncol Biol Phys 67:1179-86. 2007
    ..To investigate the application of pretreatment oxygenation to the AT1 subline of the Dunning R3327 prostate tumor, which is more hypoxic and faster growing than the H1 subline previously studied...
  5. ncbi Tumor physiologic response to combretastatin A4 phosphate assessed by MRI
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9058, USA
    Int J Radiat Oncol Biol Phys 62:872-80. 2005
    ..To evaluate the effect of the vascular targeting agent, combretastatin A4 phosphate, on tumor oxygenation compared with vascular perfusion/permeability...
  6. pmc Tumor oxygen dynamics: correlation of in vivo MRI with histological findings
    Dawen Zhao
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 5:308-18. 2003
    ..These results further validate the utilization of FREDOM to monitor tumor oxygenation and concur with the hypothesis that the level of hypoxia is related to tumor growth rate and poor vascularity...
  7. pmc Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance
    Kimmo J Hatanpaa
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 12:675-84. 2010
    ..In this review, we discuss recent progress in key aspects of EGFR signaling in GBM, focusing on neuropathology, signal transduction, imaging of the EGFR, and the role of the EGFR in mediating resistance to radiation therapy in GBM...
  8. doi Comparison of 1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Magn Reson Med 62:357-64. 2009
    ..Significantly, the magnitude of the BOLD response appears to be predictive for residual tumor HFs...
  9. pmc The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma
    Seongmi Park
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    Cancer Res 69:2809-16. 2009
    ..Importantly, RIP1 levels correlate strongly with mdm2 levels in glioblastoma. Our results show a key interaction between the NF-kappaB and p53 pathways that may have implications for the targeted treatment of glioblastoma...
  10. ncbi Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor
    Dawen Zhao
    Departments of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 159:621-31. 2003
    ....
  11. pmc Continuous low-dose (metronomic) chemotherapy on rat prostate tumors evaluated using MRI in vivo and comparison with histology
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9058, USA
    Neoplasia 7:678-87. 2005
    ..These results show the efficacy of the metronomic CTX +/- Tha for delaying tumor growth and indicate that MRI provides insights into the mode of action and early indication of efficacy...
  12. pmc Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice
    Heling Zhou
    Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e8051. 2009
    ..We have applied in vivo optical imaging to study dynamic uptake of a near-infrared dye-labeled glucose analogue, 2-deoxyglucose (2-DG) by orthotopic glioma in a mouse model...
  13. doi Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, 5523 Harry Hines, Dallas, TX 75390 9058, USA
    FASEB J 22:2445-51. 2008
    ..We believe this finding provides an important novel application for BLI that could have widespread application in screening novel therapeutics expected to cause acute vascular changes in tumors...
  14. ncbi Tumor oxygen dynamics: comparison of 19F MR EPI and frequency domain NIR spectroscopy
    Yulin Song
    Joint Graduate Program in Biomedical Engineering, Department of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Exp Med Biol 530:225-36. 2003
    ..Generally, changes in vascular sO2 preceded tissue pO2, particularly for smaller tumors...
  15. ncbi Tumor oximetry: comparison of 19F MR EPI and electrodes
    Ralph P Mason
    U T Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Exp Med Biol 530:19-27. 2003
    ..We also compare MR and electrode approaches to monitoring dynamic changes with respect to interventions and demonstrate extension of the MR technique to rat breast tumors...
  16. ncbi Comparison of BOLD contrast and Gd-DTPA dynamic contrast-enhanced imaging in rat prostate tumor
    Lan Jiang
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Magn Reson Med 51:953-60. 2004
    ..This suggests that the BOLD technique may be a useful tool for investigating interventions (such as drugs) that cause vascular disruption...
  17. pmc A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment
    Ralph P Mason
    Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, USA
    Integr Biol (Camb) 3:375-87. 2011
    ..This review focuses on an integration of the appropriate biochemical and biological tools necessary to assess (preclinically) new small-molecule, tubulin active VDAs for their potential to be clinically effective anticancer agents...
  18. pmc Longitudinal MRI evaluation of intracranial development and vascular characteristics of breast cancer brain metastases in a mouse model
    Heling Zhou
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e62238. 2013
    ..The characteristic rCBV of brain metastases may have a diagnostic value...
  19. doi Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy
    Vasu Tumati
    Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int J Oncol 42:1613-9. 2013
    ..This model recapitulates radiation-resistant prostate cancers which can be used to demonstrate and quantify therapeutic response to combined modality treatments...
  20. ncbi Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge
    Dawen Zhao
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9058, USA
    Int J Radiat Oncol Biol Phys 53:744-56. 2002
    ..Since hypoxia may influence tumor response to therapy and prognosis, we have compared oxygenation of tumors known to exhibit differential growth rate and tissue differentiation...
  21. pmc Near-infrared Optical Imaging of Exposed Phosphatidylserine in a Mouse Glioma Model
    Dawen Zhao
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
    Transl Oncol 4:355-64. 2011
    ..800CW-PGN635 may be a useful new imaging probe for detection of exposed PS in tumors responding to therapy...
  22. pmc Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    Yuan Zhu
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cancer Cell 8:119-30. 2005
    ....
  23. pmc RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB-mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and down-regulation of PTEN
    Seongmi Park
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8813, USA
    Cancer Res 69:4107-11. 2009
    ..Our data suggest that the RIP1-NF-kappaB status of tumors may influence response to treatments targeting the PTEN-PI3K-mTOR signaling axis...