Yuexing Zhang

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer
    Yuexing Zhang
    Greenebaum Cancer Center and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:240-8. 2010
  2. pmc Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice
    Yuexing Zhang
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Cell Biol 9:69. 2008
  3. ncbi request reprint Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:26126-33. 2004
  4. pmc The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, BRB 9 029, 655 W Baltimore Street, Baltimore, MD 21201, USA
    Nucleic Acids Res 33:6024-33. 2005
  5. ncbi request reprint Ebp1-mediated inhibition of cell growth requires serine 363 phosphorylation
    Damilola Akinmade
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Int J Oncol 31:851-8. 2007
  6. pmc EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Mol Cancer Ther 7:3176-86. 2008
  7. pmc The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells
    Yuexing Zhang
    Greenebaum Cancer Center and Departments of Pathology and Pharmacology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:9890-5. 2005
  8. pmc Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Nucleic Acids Res 31:2168-77. 2003
  9. pmc Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1
    Yuexing Zhang
    Department of Pathology, University of Maryland, Baltimore, MD, United States
    Cancer Lett 265:298-306. 2008
  10. pmc Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer
    Hua Zhou
    Greenebaum Cancer Center, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nucleic Acids Res 38:3619-31. 2010

Collaborators

Detail Information

Publications13

  1. pmc ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer
    Yuexing Zhang
    Greenebaum Cancer Center and Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:240-8. 2010
    ..Collectively, our results reveal an EBP1-Foxa-AGR2 signaling circuit with functional significance in metastatic prostate cancer...
  2. pmc Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice
    Yuexing Zhang
    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA
    BMC Cell Biol 9:69. 2008
    ..However, the physiological role of Ebp1 in the whole organism is not known. Therefore, we generated Ebp1-deficient mice carrying a gene trap insertion in intron 2 of the Ebp1 (pa2g4) gene...
  3. ncbi request reprint Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:26126-33. 2004
    ..Our findings suggest that Ebp1, by linking HRG activation of membrane receptors to E2F gene activity, may be a downstream modulator of the effects of HRG on cell cycle progression...
  4. pmc The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, BRB 9 029, 655 W Baltimore Street, Baltimore, MD 21201, USA
    Nucleic Acids Res 33:6024-33. 2005
    ..These results demonstrate that Ebp1 participates in transcriptional regulation via its interaction with the Sin3-HDAC...
  5. ncbi request reprint Ebp1-mediated inhibition of cell growth requires serine 363 phosphorylation
    Damilola Akinmade
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Int J Oncol 31:851-8. 2007
    ..Although Ebp1 S363A interacted with an E2F1 promoter element, it did not bind HDAC2 and mSin3a. These results indicate the importance of S363 phosphorylation in the function of Ebp1...
  6. pmc EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Mol Cancer Ther 7:3176-86. 2008
    ..Our data support a role for EBP1 in the development of hormone-refractory prostate cancer via inhibition of both AR- and HRG-stimulated growth and present a novel strategy for treating androgen-refractory prostate cancer...
  7. pmc The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells
    Yuexing Zhang
    Greenebaum Cancer Center and Departments of Pathology and Pharmacology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 102:9890-5. 2005
    ..These findings suggest that Ebp1 is a previously unrecognized therapeutic target for treatment of hormone refractory prostate cancer...
  8. pmc Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Nucleic Acids Res 31:2168-77. 2003
    ..Our results suggest that Ebp1 can repress transcription of some E2F-regulated promoters and that one mechanism of Ebp1- mediated transcriptional repression is via its ability to recruit HDAC activity...
  9. pmc Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1
    Yuexing Zhang
    Department of Pathology, University of Maryland, Baltimore, MD, United States
    Cancer Lett 265:298-306. 2008
    ..These results suggest that EBP1, by down-regulating ErbB signal transduction, attentuates HRG-mediated growth of breast cancer cells...
  10. pmc Post-transcriptional regulation of androgen receptor mRNA by an ErbB3 binding protein 1 in prostate cancer
    Hua Zhou
    Greenebaum Cancer Center, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Nucleic Acids Res 38:3619-31. 2010
    ..Thus, decreases of EBP1 in prostate cancer could be important for the post-transcriptional up-regulation of AR contributing to aberrant AR expression and disease progression...
  11. pmc EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells
    Hua Zhou
    Greenebaum Cancer Center, University of Maryland School of Medicine, 655 West Baltimore Street, BRB 9 029, Baltimore, MD 21201, U S A
    Anticancer Res 31:3129-35. 2011
    ..Although EBP1 regulates AR in hormone-sensitive prostate cancer cells, by both destabilizing AR mRNA and inhibiting protein translation, the mechanism of EBP1 down regulation of AR in CRPC is unknown...
  12. pmc The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells
    Yan Lu
    Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Breast Cancer Res Treat 126:27-36. 2011
    ..These results suggest that EBP1 inhibits expression of ErbB2 protein levels by multiple mechanisms and that EBP1's effects on tamoxifen sensitivity are mediated in part by its ability to modulate ErbB2 levels...
  13. ncbi request reprint Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1
    Yuexing Zhang
    Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, MD 21201, USA
    Oncogene 21:5609-18. 2002
    ..These studies suggest that Ebp1 may play a role in the function of the AR and provide a link between ErbB receptors and the AR...