Yuesheng Zhang

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Selected isothiocyanates rapidly induce growth inhibition of cancer cells
    Yuesheng Zhang
    Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA
    Mol Cancer Ther 2:1045-52. 2003
  2. pmc High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
    Yuesheng Zhang
    Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, P O Box 245024, Tucson, AZ 85724, U S A
    Biochem J 364:301-7. 2002
  3. ncbi request reprint Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells
    Yuesheng Zhang
    Department of Medicine, College of Medicine, Arizona Cancer Center, University of Arizona, Room 4985A, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    J Dermatol Sci 30:205-14. 2002
  4. ncbi request reprint Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates
    Eileen C Callaway
    Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Cancer Lett 204:23-31. 2004
  5. ncbi request reprint Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism
    Ming Zhu
    Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724 5024, USA
    Mol Carcinog 41:179-86. 2004
  6. pmc Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates
    Rex Munday
    Ruakura Agricultural Research Centre, AgResearch, Private Bag 3123, Hamilton, New Zealand
    Pharm Res 25:2164-70. 2008
  7. ncbi request reprint The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Anticancer Drugs 17:297-305. 2006
  8. ncbi request reprint c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent
    Song Yao
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Carcinog 45:605-12. 2006
  9. ncbi request reprint Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay
    Rex Munday
    AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand
    Nutr Cancer 54:223-31. 2006
  10. doi request reprint Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    Rex Munday
    AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
    Cancer Res 68:1593-600. 2008

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Selected isothiocyanates rapidly induce growth inhibition of cancer cells
    Yuesheng Zhang
    Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA
    Mol Cancer Ther 2:1045-52. 2003
    ....
  2. pmc High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate
    Yuesheng Zhang
    Arizona Cancer Center, University of Arizona, 1515 N Campbell Avenue, P O Box 245024, Tucson, AZ 85724, U S A
    Biochem J 364:301-7. 2002
    ....
  3. ncbi request reprint Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells
    Yuesheng Zhang
    Department of Medicine, College of Medicine, Arizona Cancer Center, University of Arizona, Room 4985A, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
    J Dermatol Sci 30:205-14. 2002
    ..Moreover, although ras has been shown to stimulate the expression of human GSTP1-1, the effect of c-Ha-ras on GSTP1-1 expression in HaCaT cells appears limited...
  4. ncbi request reprint Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates
    Eileen C Callaway
    Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Cancer Lett 204:23-31. 2004
    ..These findings are consistent with our previous results regarding cellular export of another anticarcinogenic ITC, sulforaphane, and suggest a common cellular response to ITCs...
  5. ncbi request reprint Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism
    Ming Zhu
    Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724 5024, USA
    Mol Carcinog 41:179-86. 2004
    ..This direct effect of SF on AP-1 DNA binding is a novel mechanism for the action of a drug inhibitor of AP-1 activation...
  6. pmc Structure-activity relationships and organ specificity in the induction of GST and NQO1 by alkyl-aryl isothiocyanates
    Rex Munday
    Ruakura Agricultural Research Centre, AgResearch, Private Bag 3123, Hamilton, New Zealand
    Pharm Res 25:2164-70. 2008
    ....
  7. ncbi request reprint The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Anticancer Drugs 17:297-305. 2006
    ..These data show that the NAC-ITCs are biologically similar to their parent compounds and are highly effective against human bladder cancer cells...
  8. ncbi request reprint c-jun/AP-1 activation does not affect the antiproliferative activity of phenethyl isothiocyanate, a cruciferous vegetable-derived cancer chemopreventive agent
    Song Yao
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Carcinog 45:605-12. 2006
    ....
  9. ncbi request reprint Evaluation of isothiocyanates as potent inducers of carcinogen-detoxifying enzymes in the urinary bladder: critical nature of in vivo bioassay
    Rex Munday
    AgResearch, Ruakura Agricultural Centre, Hamilton, New Zealand
    Nutr Cancer 54:223-31. 2006
    ....
  10. doi request reprint Inhibition of urinary bladder carcinogenesis by broccoli sprouts
    Rex Munday
    AgResearch Limited, Ruakura Agricultural Research Center, Hamilton, New Zealand
    Cancer Res 68:1593-600. 2008
    ..In conclusion, broccoli sprout extract is a highly promising substance for bladder cancer prevention and the isothiocyanates in the extract are selectively delivered to the bladder epithelium through urinary excretion...
  11. ncbi request reprint Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Proc Nutr Soc 65:68-75. 2006
    ..Taken together, dietary ITC are highly-promising anti-cancer agents, capable of targetting multiple cellular components that are important for tumour cell survival and proliferation...
  12. ncbi request reprint Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:1250-9. 2005
    ....
  13. ncbi request reprint Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Free Radic Biol Med 38:70-7. 2005
    ..Ironically, although ITC-induced stress may lead to oxidative damage, it has become increasingly clear that much of the chemoprotective activity of ITCs stems from the response of cells to the stress induced by these compounds...
  14. ncbi request reprint Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Nutr 134:2004-10. 2004
    ..However, further increases in ITC concentrations abolished their activities, described above. These findings show that urinary ITC concentrations may need to be maintained at low micromolar concentrations for bladder cancer prevention...
  15. ncbi request reprint Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Basic Science 711, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mutat Res 555:173-90. 2004
    ..These mechanisms, which are discussed in detail in this review, illustrate the remarkable ability of ITCs to inhibit cancer development-effective against both developing and developed cancer cells...
  16. ncbi request reprint Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats
    Rex Munday
    AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand
    Chem Biol Interact 160:115-22. 2006
    ..In view of the evidence that Phase II enzyme induction plays a major role in the chemoprotective action of dithiolethiones, evaluation of the anti-cancer activity of the more potent inducers identified in this study would be of interest...
  17. ncbi request reprint Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 27:1876-82. 2006
    ..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers...
  18. ncbi request reprint Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Science 711, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:935-44. 2006
    ..These data show that broccoli sprout isothiocyanate extract is a highly promising substance for cancer prevention/treatment and that its antiproliferative activity is exclusively derived from isothiocyanates...
  19. ncbi request reprint Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes
    Ming Zhu
    Translational Genomics Research Institute, Phoenix, AZ, USA
    Cancer Lett 244:220-8. 2006
    ..This suggests that the suppressive effect of UVB on ARE activation by tBHQ is mediated by a JNK pathway(s). These findings provide useful information for developing novel strategies for skin cancer chemoprotection through ARE activation...
  20. ncbi request reprint A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cancer Ther 3:885-93. 2004
    ..Moreover, many ARE-mediated inducers have been identified, and several of them have shown promising cancer preventive activity...
  21. ncbi request reprint Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts
    Yuesheng Zhang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 54:9370-6. 2006
    ..In conclusion, broccoli sprout ITC extract is a potent inducer of GST and NQO1 in the bladder and is a promising agent for prevention of bladder cancer...
  22. ncbi request reprint Isothiocyanates in the chemoprevention of bladder cancer
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Curr Drug Metab 5:193-201. 2004
    ..As a result, potential systemic adverse effects of ITCs may be minimized when using ITCs for chemoprevention of bladder carcinogenesis. Taken together, ITCs may be especially useful for the prevention of bladder cancer...
  23. doi request reprint Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:938-44. 2008
    ..93, respectively). These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer...
  24. ncbi request reprint Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
    Lingxiang Ye
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Clin Chim Acta 316:43-53. 2002
    ....