Yu Zhang

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs San Francisco VA, Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Int J Alzheimers Dis 2011:546871. 2011
  2. pmc MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, California, United States of America
    PLoS ONE 8:e66367. 2013
  3. pmc MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes
    Yu Zhang
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA 94121, USA
    J Alzheimers Dis 33:431-44. 2013
  4. pmc White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 132:2579-92. 2009
  5. pmc Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, VA Medical Center, San Francisco, CA, United States
    Neurobiol Aging 31:1991-2001. 2010
  6. pmc Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
  7. pmc Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA, USA
    Amyotroph Lateral Scler 12:421-9. 2011
  8. pmc Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA
    Neuroimage 54:S62-8. 2011
  9. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
  10. doi request reprint Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI
    Susan C Woolley
    Forbes Norris ALS Research Center, Department of Neurology, California Pacific Medical Center, San Francisco, CA 94115, USA
    Amyotroph Lateral Scler 12:52-8. 2011

Detail Information

Publications79

  1. pmc Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs San Francisco VA, Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Int J Alzheimers Dis 2011:546871. 2011
    ..Joint assessments of multimodal MRI have potential value to provide new imaging markers for improved differential diagnoses between FTD and AD...
  2. pmc MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, San Francisco, California, United States of America
    PLoS ONE 8:e66367. 2013
    ..Furthermore, a combination of DTI and structural MRI measurements improves classification accuracy...
  3. pmc MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes
    Yu Zhang
    Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA 94121, USA
    J Alzheimers Dis 33:431-44. 2013
    ..The findings suggest that DTI in general and radial diffusivity in particular are more powerful measures for the classification of FTLD patients from controls than brain atrophy...
  4. pmc White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 132:2579-92. 2009
    ..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease...
  5. pmc Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, VA Medical Center, San Francisco, CA, United States
    Neurobiol Aging 31:1991-2001. 2010
    ..In conclusion, concordant/discordant changes of DTI indices provide additional characterization of white matter alterations that accompany normal aging...
  6. pmc Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease
    Y Zhang
    MR Unit 114M, VA Medical Center, 4150, Clement Street, San Francisco, CA 94121, USA
    Neurology 68:13-9. 2007
    ..However, it is unclear whether these abnormalities also impact the cingulum fibers, which connect the medial temporal lobe and the posterior cingulate regions...
  7. pmc Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA, USA
    Amyotroph Lateral Scler 12:421-9. 2011
    ..In conclusion, longitudinal DTI study captures progression of upper motor fiber degeneration in ALS. DTI can be useful for monitoring ALS progression and efficacy of treatment interventions...
  8. pmc Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study
    Norbert Schuff
    Center for Imaging of Neurodegenerative Diseases, DVA Medical Center San Francisco, CA 94121, USA
    Neuroimage 54:S62-8. 2011
    ..Structural, perfusion, and diffusion MRI together may provide a signature for a PTSD marker...
  9. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
    ..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
  10. doi request reprint Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI
    Susan C Woolley
    Forbes Norris ALS Research Center, Department of Neurology, California Pacific Medical Center, San Francisco, CA 94115, USA
    Amyotroph Lateral Scler 12:52-8. 2011
    ..In conclusion, our findings point towards a biological basis for apathy in the anterior cingulum, consistent with research on apathy in other neurological populations...
  11. doi request reprint In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imaging
    Marzieh Nezamzadeh
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Eur J Radiol 75:e29-36. 2010
    ..This optimized DSI setting should be useful for detecting alterations along the cingulum bundle in Alzheimer disease and related neurodegenerative disorders...
  12. pmc Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI
    Linda L Chao
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America linda chao ucsf edu
    PLoS ONE 8:e65175. 2013
    ....
  13. ncbi request reprint Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging
    Wang Zhan
    Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA
    Mov Disord 27:90-7. 2012
    ..Our data suggest that microstructural alterations detected with diffusion tensor might serve as a potential biomarker for PD...
  14. pmc Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation
    Wang Zhan
    University of California San Francisco, VA Medical Center, Department of Radiology, Center of Imaging for Neurodegenerative Diseases, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Neuroimage 47:T58-65. 2009
    ..These results suggest that the different stages of WM degeneration in elderly subjects can be better characterized by regional DTI-FLAIR correlations than single modality alone...
  15. ncbi request reprint A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects
    G M Dolganov
    Genelabs Technologies, Inc, Redwood City, California 94063, USA
    Genome Res 11:1473-83. 2001
    ..Potential applications for this method include transcriptional profiling in limited numbers of laser captured cells and validation of DNA microarray data in clinical specimens...
  16. ncbi request reprint The effect of LRAP on enamel organ epithelial cell differentiation
    T Q Le
    Department of Orofacial Sciences, University of California at San Francisco, 513 Parnassus Avenue, PO Box 0422 San Francisco, CA 94143 0422, USA
    J Dent Res 86:1095-9. 2007
    ..LAMP-1, a membrane receptor for LRAP in mesenchymal cells, was identified and was up-regulated in the presence of rH58. These results suggest that rH58 promotes differentiation of human enamel organ epithelial cells...
  17. pmc High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study
    M C Nevitt
    University of California, San Francisco, Department of Epidemiology and Biostatistics, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107 1762, USA
    Ann Rheum Dis 69:163-8. 2010
    ..The association of BMD with incident and progressive tibiofemoral OA was tested in a large prospective study of men and women aged 50-79 years with or at risk for knee OA...
  18. ncbi request reprint RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
    J L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, and UCSF Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Leukemia 19:415-9. 2005
    ....
  19. ncbi request reprint Use of reperfusion therapy for acute myocardial infarction in the United States: data from the National Registry of Myocardial Infarction 2
    H V Barron
    Department of Medicine, University of California, San Francisco, USA
    Circulation 97:1150-6. 1998
    ..However, several studies have suggested that many patients with an acute myocardial infarction do not receive this therapy. Whether this underutilization occurs in patients appropriate for such therapy remains unclear...
  20. ncbi request reprint Deficiency of the cysteine protease cathepsin S impairs microvessel growth
    G P Shi
    Department of Medicine, University of California, San Francisco, USA
    Circ Res 92:493-500. 2003
    ..These results demonstrate a novel function of endothelium-derived Cat S in angiogenesis...
  21. ncbi request reprint Characterization of human primary enamel organ epithelial cells in vitro
    P K DenBesten
    University of California at San Francisco, 94143 0640, USA
    Arch Oral Biol 50:689-94. 2005
    ..Tooth enamel is formed by ameloblasts, which are derived from the epithelial cells of the enamel organ...
  22. ncbi request reprint Micromolar fluoride alters ameloblast lineage cells in vitro
    Q Yan
    Department of Orofacial Sciences, University of California at San Francisco, 513 Parnassus Ave S 704, San Francisco, CA 94143 0422, USA
    J Dent Res 86:336-40. 2007
    ..There was no general effect of fluoride on gene expression. These results indicate multiple effects of micromolar fluoride on ameloblast-lineage cells...
  23. ncbi request reprint Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression
    C L Ordoñez
    Department of Pediatrics and Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA
    Am J Respir Crit Care Med 163:517-23. 2001
    ....
  24. ncbi request reprint The roles of terminal sugar residues of surface glycans in the metastatic potential of human hepatocarcinoma
    Y Zhang
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, School of Medicine, Fu Dan University, Shanghai, 200032, China
    J Cancer Res Clin Oncol 128:617-20. 2002
    ..The roles of terminal sialyl and fucosyl residues in cell surface glycans in the metastatic potential of H7721 cells, a human hepatocarcinoma cell line, were studied...
  25. ncbi request reprint Effects of Matrine on proliferation and differentiation in K-562 cells
    L P Zhang
    Chongqing University of Medical Science, 400046, Chongqing, People's Republic of China
    Leuk Res 25:793-800. 2001
    ..Our study confirmed that Matrine plays a significant effect on the inhibition of proliferation cells and inducing differentiation in K-562 cells...
  26. ncbi request reprint Transfection of the nm23-H1 gene into human hepatocarcinoma cell line inhibits the expression of sialyl Lewis X, alpha1,3 fucosyltransferase VII, and metastatic potential
    F Liu
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Fu Dan University Medical Center, Shanghai 200032, China
    J Cancer Res Clin Oncol 128:189-96. 2002
    ....
  27. pmc Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis
    Y Zhang
    Department of Molecular Oral Medicine and Maxillofacial Surgery 1, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
    Proc Natl Acad Sci U S A 98:11336-40. 2001
    ..Our results provided significant insight into the mechanism of KGFR tumor suppression and suggest that KGFR gene therapy might be a viable method of inhibiting human salivary adenocarcinoma growth...
  28. ncbi request reprint Mutations in the human homologue of the Drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines
    E Michimukai
    Department of Molecular Oral Medicine and Maxillofacial Surgery 1, Hiroshima University Faculty of Dentistry, Japan
    In Vitro Cell Dev Biol Anim 37:459-64. 2001
    ..These results strongly suggest that an Shh-patched signaling is involved in the cell growth of oral epithelial cells and in the tumorigenesis of OSCCs...
  29. ncbi request reprint Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development
    T Nikaido
    Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Histochem Cell Biol 116:141-8. 2001
    ....
  30. pmc The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation
    C A Cuff
    The Wistar Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 108:1031-40. 2001
    ..We conclude that CD44 plays a critical role in the progression of atherosclerosis through multiple mechanisms...
  31. ncbi request reprint In vitro osteoblastic response to 30 vol% hydroxyapatite-polyethylene composite
    Y Zhang
    Department of Materials, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biomed Mater Res A 81:409-17. 2007
    ..Although osteoblastic cells derived from skull showed an overall slower response compared with those from femoral heads, these in vitro results show that HA-HDPE composite potentially could be used as a skull implant...
  32. pmc Interferon gamma stabilizes the T helper cell type 1 phenotype
    Y Zhang
    The Department of Cell Biology, Neurobiology, and Anatomy, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    J Exp Med 194:165-72. 2001
    ..Thus, IFN-gamma is not required for the development of IFN-gamma-producing capacity, but it plays a critical role in suppressing the IL-4-producing potential of Th1 cells...
  33. ncbi request reprint Transfection of the c-erbB2/neu gene upregulates the expression of sialyl Lewis X, alpha1,3-fucosyltransferase VII, and metastatic potential in a human hepatocarcinoma cell line
    F Liu
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Fu-Dan University Medical Center, Shanghai, China
    Eur J Biochem 268:3501-12. 2001
    ..Therefore, the c-erbB2/neu gene is proposed to be a metastasis-promoting gene, and its effects are at least partially mediated by the increased expression of alpha1,3-fucosyltransferase VII and SLe(x)...
  34. ncbi request reprint Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family
    B L Black
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 271:26659-63. 1996
    ..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins...
  35. ncbi request reprint Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage
    T R St Amand
    Department of Cell Biology, Tulane University, New Orleans, Louisiana, 70118, USA
    Dev Biol 217:323-32. 2000
    ..These results indicate that the epithelial-derived signaling molecules are responsible not only for restricting specific gene expression in the dental mesenchyme, but also for defining gene expression in the dental epithelium...
  36. pmc Membrane redistribution of the Escherichia coli MinD protein induced by MinE
    S L Rowland
    Department of Microbiology, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Bacteriol 182:613-9. 2000
    ..Studies with the isolated N-terminal and C-terminal MinE domains indicated different roles for the two MinE domains in the redistribution of membrane-associated MinD...
  37. ncbi request reprint Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling
    Y Zhang
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Development 127:2165-76. 2000
    ..Loss of protein kinase A activity restores the proliferation of somatic cells in the absence of Hh activity and allows the formation of normally patterned ovarioles. Hence, localized Hh is not essential to direct egg chamber patterning...
  38. ncbi request reprint Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ
    X Zhao
    Department of Cell and Molecular Biology and Center for Bioenvironmental Research, Tulane University, New Orleans, LA 70118, USA
    Mech Dev 99:29-38. 2000
    ..Expression of Shh and Bmp2 in the enamel knot may not represent critical signals for tooth patterning...
  39. ncbi request reprint Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
    X Zhen
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 276:4879-85. 2001
    ..Taken together, these data suggest a major role for p38 MAPK in transmitting PTH signals to regulate chondrocyte differentiation...
  40. ncbi request reprint Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, California, 90033, USA
    Dev Biol 232:204-18. 2001
    ....
  41. ncbi request reprint Identification of the motif in versican G3 domain that plays a dominant-negative effect on astrocytoma cell proliferation through inhibiting versican secretion and binding
    Y Wu
    Sunnybrook and Women's College Health Sciences Centre and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada
    J Biol Chem 276:14178-86. 2001
    ..The effect seems to depend on the expression efficiency of G3DeltaEGF, and it occurred via the carbohydrate recognition domain...
  42. ncbi request reprint Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vi
    Y Zhang
    Department of Pharmacology, School of Medicine, Kanazawa University, Japan
    Blood 86:2930-7. 1995
    ..These data suggest that TNF may be an important physiologic regulator of hematopoiesis and that TNF-R55 may be essentially involved in TNF-mediated inhibition of the growth of both primitive stem and more committed progenitor cells...
  43. ncbi request reprint Expression profiling of the solute carrier gene family in chicken intestine from the late embryonic to early post-hatch stages
    H Li
    Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061 0306, USA
    Anim Genet 39:407-24. 2008
    ..These results represent a comprehensive characterization of the expression profiles of the SLC family of genes at different stages of development in the chicken intestine and lay the ground work for future nutritional studies...
  44. pmc Model of maltose-binding protein/chemoreceptor complex supports intrasubunit signaling mechanism
    Y Zhang
    Department of Biology, Texas A and M University, College Station, TX 77843, USA
    Proc Natl Acad Sci U S A 96:939-44. 1999
    ....
  45. ncbi request reprint Expression and regulation of the chicken Nkx-6.2 homeobox gene suggest its possible involvement in the ventral neural patterning and cell fate specification
    J Cai
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Dev Dyn 216:459-68. 1999
    ..2 transcription factor: participating in the Shh-initiated ventral patterning during early CNS development and controlling cell fate specification and differentiation during late development...
  46. ncbi request reprint High-yield expression, purification and characterization of tumor-targeted IFN-alpha2a
    J Meng
    Biotechnology Center of The Fourth Military Medical University, Xi an, People s Republic of China
    Cytotherapy 9:60-8. 2007
    ..IFN-alpha has been shown to be effective against hematologic malignancies. However, it is ineffective against most solid tumors and has not been satisfactory because of its toxicity...
  47. ncbi request reprint Insulin-like growth factors, angiopoietin-2, and pigment epithelium-derived growth factor in the hypoxic retina
    V Sivakumar
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurosci Res 86:702-11. 2008
    ..This was supported by the increased density of rat endothelial cell antigen-1 (RECA-1) protein quantification and RECA-1-stained blood vessels in the inner retina...
  48. ncbi request reprint ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2
    D L F Chang
    Graduate Program in Molecular Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Oncogene 26:4627-34. 2007
    ..Thus, this study demonstrates that ARF plays a direct role in regulation of Rb and suggests that inactivation of ARF may lead to defects in both p53 and Rb pathways in human cancer development...
  49. ncbi request reprint Gamma-aminobutyric acid up- and downregulates insulin secretion from beta cells in concert with changes in glucose concentration
    H Dong
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Diabetologia 49:697-705. 2006
    ..However, the reported effects of GABA(A)R activation on insulin secretion from islet beta cells have been controversial...
  50. ncbi request reprint Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum
    C Kaur
    Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Glia 54:826-39. 2006
    ..To this end, melatonin may be beneficial in reducing edema as it reduced VEGF concentration and, hence, vascular permeability...
  51. pmc A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease
    A Hayes
    Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford M6 8HD, UK
    J Neurol Neurosurg Psychiatry 75:1475-7. 2004
    ....
  52. ncbi request reprint Estrogen treatment increases the levels of regulator of G protein signaling-Z1 in the hypothalamic paraventricular nucleus: possible role in desensitization of 5-hydroxytryptamine1A receptors
    G A Carrasco
    Center for Serotonin Disorder Research and Department of Pharmacology Loyola University of Chicago, Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Neuroscience 127:261-7. 2004
    ..These findings may provide insight into the adaptation of 5-HT1A receptor signaling during pharmacotherapies of mood disorders in women and the well-established gender differences in the vulnerability to depression...
  53. ncbi request reprint Insights into a plasma membrane signature
    S Harvey
    Program on Cell Adhesion, Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    Physiol Genomics 5:129-36. 2001
    ..These proteins have functions ranging from cell adhesion to the regulation of translation and the control of oxidant stress...
  54. ncbi request reprint Hedgehog acts as a somatic stem cell factor in the Drosophila ovary
    Y Zhang
    Nature 410:599-604. 2001
    ..We deduce that Hh is a stem-cell factor and suggest that human cancers due to excessive Hh signalling might result from aberrant expansion of stem cell pools...
  55. pmc Ultraweak sugar-sugar interactions for transient cell adhesion
    F Pincet
    , , 75231 Paris Cedex 05, France
    Biophys J 80:1354-8. 2001
    ..This adhesion is ultralow and therefore difficult to measure. Such small interactions explain why the concept of specific interactions between carbohydrates is often neglected...
  56. ncbi request reprint Selective upregulation of endothelin converting enzyme-1a in the human failing heart
    A Ergul
    Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, USA
    J Card Fail 6:314-20. 2000
    ..Accordingly, endothelin converting enzyme-1 (ECE-1) activity and expression in normal and failing heart were examined...
  57. ncbi request reprint Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells
    K K Hiatt
    Herman B Wells Center for Pediatric Research, Departments of Microbiology/Immunology and Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 276:7240-5. 2001
    ..Thus, the GRDs of neurofibromin and p120GAP specify nonoverlapping functions in multiple primary cell types...
  58. ncbi request reprint Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast
    Y Zhang
    Department of Pharmacology, Kobe University School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 275:35600-6. 2000
    ..These data suggest that fission yeast PI(4)P5K Its3 functions coordinately with calcineurin and plays a key role in cytokinesis, and that the plasma membrane localization of Its3 is the crucial event in cytokinesis...
  59. ncbi request reprint Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin
    S S Fakharzadeh
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Blood 95:2799-805. 2000
    ..Thus, expression of factor VIII from the epidermis can correct hemophilia A mice, thereby supporting the feasibility of cutaneous gene therapy for systemic disease. (Blood. 2000;95:2799-2805)..
  60. pmc Immunodominant major outer membrane proteins of Ehrlichia chaffeensis are encoded by a polymorphic multigene family
    N Ohashi
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1093, USA
    Infect Immun 66:132-9. 1998
    ..chaffeensis. These findings suggest that the 30-kDa-range proteins of E. chaffeensis represent a family of antigenically related homologous proteins encoded by a single gene family...
  61. ncbi request reprint Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin43
    C C Naus
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Canada
    J Neurosci Res 49:528-40. 1997
    ..These results suggest that gap junctional intercellular communication mediated by Cx43 is not critical for astrocyte differentiation but is likely involved in the regulation of intercellular calcium signaling and cell growth...
  62. ncbi request reprint Cloning, expression, and regulation of rabbit cyclooxygenase-2 in renal medullary interstitial cells
    Y Guan
    Division of Nephrology, Veterans Affairs Medical Center, Nashville, Tennessee, USA
    Am J Physiol 273:F18-26. 1997
    ..Phorbol ester also upregulated immunoreactive COX2. Constitutive COX2 in these tissues has important implications for side effects of COX2-selective inhibitors...
  63. ncbi request reprint Deregulated expression of c-myc in megakaryocytes of transgenic mice increases megakaryopoiesis and decreases polyploidization
    A Thompson
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02139, USA
    J Biol Chem 271:22976-82. 1996
    ..These transgenic mice represent a novel in vivo model for a Myc-induced myeloproliferative disorder which can be controlled...
  64. ncbi request reprint Ectopic expression of either the Drosophila gooseberry-distal or proximal gene causes alterations of cell fate in the epidermis and central nervous system
    Y Zhang
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208
    Development 120:1151-61. 1994
    ..The gooseberry-proximal protein is also found in the same neuroblasts as gooseberry-distal and in the descendants of these cells...
  65. pmc A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
    Y Tu
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Cell Biol 153:585-98. 2001
    ..These findings reveal a novel CH-ILKBP-ILK-PINCH complex and provide important evidence for a crucial role of this complex in the regulation of cell adhesion and cytoskeleton organization...
  66. ncbi request reprint T cells enhance production of IL-18 by monocytes in response to an intracellular pathogen
    R Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708, USA
    J Immunol 166:6749-53. 2001
    ..These findings suggest that activated T cells can contribute to the initial immune response by augmenting IL-18 production by monocytes in response to an intracellular pathogen...
  67. ncbi request reprint Investigation of the role of ANKH in ankylosing spondylitis
    A E Timms
    Wellcome Trust Centre for Human Genetics, Headington, UK
    Arthritis Rheum 48:2898-902. 2003
    ..This study was undertaken to investigate the role of ANKH in susceptibility to and clinical manifestations of AS...
  68. ncbi request reprint Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss
    J Zou
    Scottish Fish Immunology Research Centre, School of Biological Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    Dev Comp Immunol 27:813-22. 2003
    ..Western blot analysis revealed the presence of multiple forms of rTNF structures including monomeric, dimeric and trimeric forms, suggesting that formation of a homotrimeric structure may be essential for the TNF bioactivities...
  69. ncbi request reprint Thyroid-beta2 and the retinoid RAR-alpha, RXR-gamma and ROR-beta2 receptor mRNAs; expression profiles in mouse retina, retinal explants and neocortex
    S Azadi
    Department of Ophthalmology, Biomedical Center, University of Lund, Klinikgatan 26, S 221 84 Lund, Sweden
    Neuroreport 13:745-50. 2002
    ..Furthermore, divergent diurnal peaks of RR mRNAs are present in young as well as aged mouse retina and neocortex. This data might be relevant in the context of human ageing disorders...
  70. ncbi request reprint Remodeling of vimentin cytoskeleton correlates with enhanced motility of promyelocytic leukemia cells during differentiation induced by retinoic acid
    A Bruel
    Institute of Hematology, Hospital St Louis, Paris, France
    Anticancer Res 21:3973-80. 2001
    ..These results indicate that both vimentin expression and network architecture are tightly controlled during neutrophil differentiation to regulate the mechanical properties of these cells...
  71. pmc Acholeplasma laidlawii up-regulates granulysin gene expression via transcription factor activator protein-1 in a human monocytic cell line, THP-1
    Y Kida
    Department of Bacteriology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    Immunology 104:324-32. 2001
    ..Therefore, the finding of inducible granulysin gene expression by A. laidlawii suggests that inducible granulysin in macrophages may function as a protective weapon when microbial invasion occurs...
  72. ncbi request reprint The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length
    C Benard
    Department of Biology, McGill University, 1205 Avenue Dr Penfield, H3A 1B1, Montreal, Quebec, Canada
    Development 128:4045-55. 2001
    ..However, we find that a functional CLK-2::GFP fusion protein is cytoplasmic in worms. We discuss how the phenotype of clk-2 mutants could be the result of altered patterns of gene expression...
  73. ncbi request reprint Vitamin E inhibits proliferation of primary cultured human mesangial and endothelial cells
    Y Zhang
    Second Department of Internal Medicine, Medical Faculty, Kagoshima University, Kagoshima, Japan
    Nephron 89:291-6. 2001
    ..CONCLUSION: VE at low concentrations had no effect on the proliferation of both MC and EC, but at high concentrations, it showed an inhibitory effect on both cells...
  74. pmc Quantitative effects of Nf1 inactivation on in vivo hematopoiesis
    Y Zhang
    Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Clin Invest 108:709-15. 2001
    ....
  75. ncbi request reprint Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation
    Q Wu
    Musculoskeletal Research Laboratory, Department of Orthopaedics and Rehabilitation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 276:35290-6. 2001
    ..This suggests BMP lies downstream of Ihh in mechanotransduction pathway. Our data suggest that Ihh may transduce mechanical signals during cartilage growth and repair processes...
  76. ncbi request reprint Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
    H P Harding
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 10016, New York, NY, USA
    Mol Cell 7:1153-63. 2001
    ..These findings suggest a special role for translational control in protecting secretory cells from ER stress...
  77. pmc Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity
    W Han
    Laboratory of Medical Immunology, School of Basic Medical Science, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Biochem J 357:127-35. 2001
    ..These results suggest that CKLF1 might have important roles in inflammation and in the regeneration of skeletal muscle...
  78. ncbi request reprint Activin A induces expression of rat Sel-1l mRNA, a negative regulator of notch signaling, in rat salivary gland-derived epithelial cells
    M Furue
    Department of Biochemistry and Molecular Biology, Kanagawa Dental College, Yokosuka, 238 8580, Japan
    Biochem Biophys Res Commun 282:745-9. 2001
    ..These results suggest that activin A regulates the differentiation of RSMG-1 cells to acinar cells...
  79. ncbi request reprint Subunits coupling H+ transport and ATP synthesis in the Escherichia coli ATP synthase. Cys-Cys cross-linking of F1 subunit epsilon to the polar loop of F0 subunit c
    Y Zhang
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison 53706, USA
    J Biol Chem 270:24609-14. 1995
    ....