Yingze Zhang

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells
    Yingze Zhang
    Division of Pulmonary, Allergy and Critical Care Medicine, Richard P and Dorothy P Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e20319. 2011
  2. pmc The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease
    Jessica M Bon
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e6865. 2009
  3. pmc Cross talk between Id1 and its interactive protein Dril1 mediate fibroblast responses to transforming growth factor-beta in pulmonary fibrosis
    Ling Lin
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USA
    Am J Pathol 173:337-46. 2008
  4. pmc Autoantibodies in patients with chronic obstructive pulmonary disease
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:156-63. 2008
  5. pmc Plasma inflammatory mediators associated with bone metabolism in COPD
    Jessica M Bon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 7:186-91. 2010
  6. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
  7. pmc Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in Chronic Obstructive Pulmonary Disease (COPD)
    Sowmya P Lakshmi
    From the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 and
    J Biol Chem 289:6383-93. 2014
  8. pmc Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis
    Kazuhisa Konishi
    Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 180:167-75. 2009
  9. pmc Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo
    William S Szczepaniak
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Transl Res 152:213-24. 2008
  10. ncbi request reprint Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease
    Meghan E Fitzpatrick
    Department of Medicine, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, Pennsylvania, 15213, USA
    Microbiol Immunol 58:202-11. 2014

Collaborators

Detail Information

Publications26

  1. pmc High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells
    Yingze Zhang
    Division of Pulmonary, Allergy and Critical Care Medicine, Richard P and Dorothy P Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e20319. 2011
    ..The objective of this study is to identify genome-wide scale map of SMAD3 binding targets and the molecular pathways and networks affected by the TGFβ1/SMAD3 signaling in lung epithelial cells...
  2. pmc The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease
    Jessica M Bon
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 4:e6865. 2009
    ..A cross-sectional study was performed to examine the association of serum biomarkers with radiographic airway and parenchymal phenotypes of COPD...
  3. pmc Cross talk between Id1 and its interactive protein Dril1 mediate fibroblast responses to transforming growth factor-beta in pulmonary fibrosis
    Ling Lin
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USA
    Am J Pathol 173:337-46. 2008
    ..Id1 inhibited DNA binding by Dril1, and the two proteins co-localized in vitro and in vivo, providing a potential mechanism for suppression of fibrosis by Id1 through inhibition of the profibrotic function of Dril1...
  4. pmc Autoantibodies in patients with chronic obstructive pulmonary disease
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:156-63. 2008
    ..Adaptive immune responses are present in patients with chronic obstructive pulmonary disease (COPD), and it has been postulated that these processes could be autoreactive...
  5. pmc Plasma inflammatory mediators associated with bone metabolism in COPD
    Jessica M Bon
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    COPD 7:186-91. 2010
    ..Furthermore, they may be useful in monitoring disease activity, and serve as targets for biological therapy...
  6. pmc Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease
    Zhi Hua Chen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS ONE 3:e3316. 2008
    ..Autophagy is a degradative process involving lysosomal turnover of cellular components, though its role in human diseases remains unclear...
  7. pmc Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in Chronic Obstructive Pulmonary Disease (COPD)
    Sowmya P Lakshmi
    From the Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 and
    J Biol Chem 289:6383-93. 2014
    ....
  8. pmc Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis
    Kazuhisa Konishi
    Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 180:167-75. 2009
    ..The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF...
  9. pmc Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo
    William S Szczepaniak
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Transl Res 152:213-24. 2008
    ..This improvement is observed in the absence of changes in local pulmonary inflammatory cytokine production and an augmentation of systemic inflammation...
  10. ncbi request reprint Pneumocystis jirovecii colonization is associated with enhanced Th1 inflammatory gene expression in lungs of humans with chronic obstructive pulmonary disease
    Meghan E Fitzpatrick
    Department of Medicine, University of Pittsburgh, 3459 Fifth Avenue, Pittsburgh, Pennsylvania, 15213, USA
    Microbiol Immunol 58:202-11. 2014
    ..The finding of upregulation of these inflammatory genes in the setting of Pneumocystis colonization sheds light on infectious-immune relationships in COPD. ..
  11. pmc MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis
    Ivan O Rosas
    Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School ofMedicine, Pittsburgh, Pennsylvania, United States of America
    PLoS Med 5:e93. 2008
    ..The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression...
  12. pmc Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis
    Thomas J Richards
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 302:L746-54. 2012
    ..These results suggest that increased sensitivity of the polymorphic MMP7 promoter to FOXA2 provides one of the genetic bases for the upregulation of MMP7 in IPF...
  13. pmc The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis
    Jianmin Xue
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e14715. 2011
    ..We hypothesized that perturbations of human leukocyte antigen (HLA) allele frequencies, which are often seen among patients with immunologic diseases, may also be present in IPF patients...
  14. pmc A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
    Bill B Chen
    Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Immunol 14:470-9. 2013
    ..These studies identified a pathway of innate immunity that may be useful to detect subjects with altered immune responses during critical illness or provide a basis for therapeutic intervention targeting TRAF protein abundance...
  15. pmc Elevated N-terminal pro-brain natriuretic peptide is associated with mortality in tobacco smokers independent of airflow obstruction
    Jason A Stamm
    Division of Pulmonary and Critical Care Medicine, Geisinger Medical Center, Danville, Pennsylvania, United States of America
    PLoS ONE 6:e27416. 2011
    ..We hypothesized that NT-proBNP would be an independent prognostic marker in a cohort of well-characterized tobacco smokers without known cardiovascular disease...
  16. pmc Distribution of Pneumocystis jirovecii in lungs from colonized COPD patients
    Sheila Sivam
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Diagn Microbiol Infect Dis 71:24-8. 2011
    ....
  17. pmc Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1
    Alexander Hoetzel
    Department of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:1223-32. 2008
    ..Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option...
  18. pmc Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study
    Janet S Lee
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Respir Res 8:64. 2007
    ..A secondary goal was to assess whether unique markers associate with diffusion impairment, based on diffusion capacity of carbon monoxide (DLCO), independent of the forced expiratory volume in 1 second (FEV1)...
  19. ncbi request reprint Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Immunol 179:2592-9. 2007
    ..Recognition that an autoreactive immune process is present in IPF can productively focus efforts toward identifying the responsible Ag, and implementing more effective therapies...
  20. doi request reprint Biomarkers in idiopathic pulmonary fibrosis
    Yingze Zhang
    Division of Pulmonary, Allergy and Critical Care Medicine, Dorothy P and Richard P Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Curr Opin Pulm Med 18:441-6. 2012
    ..Specific attention is dedicated to the recent studies that identified the genes associated with IPF and the peripheral blood biomarkers that predict outcome in IPF...
  21. pmc Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates
    Enrico M Novelli
    Division of Hematology Oncology, University of Pittsburgh Medical Center UPMC, Vascular Medicine Institute VMI, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Hematol 87:326-30. 2012
    ..Our results suggest that TSP1 levels are associated with more VOE, hydroxyurea use and lower rates of hemolysis. High TSP1 concentrations may indicate higher risk of the viscosity/vaso-occlusion phenotype of SCD...
  22. pmc Functional and association analysis of frizzled 1 (FZD1) promoter haplotypes with femoral neck geometry
    Yingze Zhang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Bone 46:1131-7. 2010
    ..05). These results suggest that FZD1 expression is regulated in a haplotype-dependent manner in osteoblasts and that these same haplotypes may be associated with biomechanical indices of bone strength...
  23. pmc Cartilage oligomeric matrix protein in idiopathic pulmonary fibrosis
    Louis J Vuga
    Dorothy P and Richard P Simmons Center for Interstitial Lung Diseases, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e83120. 2013
    ..Hence, studies that explore modalities that affect COMP expression, alleviate extracellular matrix rigidity and lung restriction in IPF and interfere with the amplification of TGF-β1 signaling should be persuaded. ..
  24. pmc Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
    Xiao Mei Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 203:2895-906. 2006
    ..This study indicates a pivotal role for cav-1 in ECM regulation and suggests a novel therapeutic target for patients with pulmonary fibrosis...
  25. pmc A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression
    Bo Hu
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Biomedical Science Tower South Wing, 7th Floor, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:10008-13. 2003
    ....
  26. pmc Asthma diagnosis and airway bronchodilator response in HIV-infected patients
    Matthew R Gingo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 129:708-714.e8. 2012
    ....