Yanping Zhang

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc The RP-Mdm2-p53 pathway and tumorigenesis
    Paula L Miliani de Marval
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Oncotarget 2:234-8. 2011
  2. pmc The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression
    Wenqi Pan
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e21625. 2011
  3. pmc Regulation of p53: a collaboration between Mdm2 and Mdmx
    Dongsheng Pei
    Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China
    Oncotarget 3:228-35. 2012
  4. ncbi request reprint Reactivation of p53 by inhibiting Mdm2 E3 ligase: a novel antitumor approach
    J Di
    Provincil Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu, 221002, China
    Curr Cancer Drug Targets 11:987-94. 2011
  5. ncbi request reprint Signaling to p53: ribosomal proteins find their way
    Yanping Zhang
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 16:369-77. 2009
  6. pmc Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
    Mikael S Lindström
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Mol Cell Biol 27:1056-68. 2007
  7. pmc Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53
    Chad Deisenroth
    University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, NC, USA
    Mol Cell Biol 30:3981-93. 2010
  8. ncbi request reprint An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction
    Everardo Macias
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 18:231-43. 2010
  9. ncbi request reprint Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    Koji Itahana
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 12:355-66. 2007
  10. pmc Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
    Mikael S Lindström
    Department of Radiation Oncology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    J Biol Chem 283:15568-76. 2008

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc The RP-Mdm2-p53 pathway and tumorigenesis
    Paula L Miliani de Marval
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Oncotarget 2:234-8. 2011
    ..Here we review some recent studies about RP-Mdm2-p53 signaling and speculate on the relevance of this pathway to human cancer...
  2. pmc The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression
    Wenqi Pan
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e21625. 2011
    ..Thus, unlike the p19Arf-Mdm2-p53 pathway, which is considered a general oncogenic response pathway, the RP-Mdm2-p53 pathway appears to specifically suppress tumorigenesis induced by oncogenic c-Myc...
  3. pmc Regulation of p53: a collaboration between Mdm2 and Mdmx
    Dongsheng Pei
    Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, China
    Oncotarget 3:228-35. 2012
    ....
  4. ncbi request reprint Reactivation of p53 by inhibiting Mdm2 E3 ligase: a novel antitumor approach
    J Di
    Provincil Key Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu, 221002, China
    Curr Cancer Drug Targets 11:987-94. 2011
    ..The potential of inhibitors of Mdm2 E3 ligase as a new novel class of anticancer drugs will also be discussed...
  5. ncbi request reprint Signaling to p53: ribosomal proteins find their way
    Yanping Zhang
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 16:369-77. 2009
    ..The ribosomal protein-MDM2-p53 signaling pathway provides a molecular switch that may constitute a surveillance network monitoring the integrity of ribosomal biogenesis...
  6. pmc Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
    Mikael S Lindström
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Mol Cell Biol 27:1056-68. 2007
    ..Hence, the MDM2 central zinc finger plays a critical role in mediating MDM2's interaction with ribosomal proteins and its ability to degrade p53, and these roles are disrupted by human cancer-associated MDM2 mutations...
  7. pmc Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53
    Chad Deisenroth
    University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, School of Medicine, Chapel Hill, NC, USA
    Mol Cell Biol 30:3981-93. 2010
    ..Our data demonstrate a unique c-Myb-Hep27-Mdm2-p53 mitochondria-to-nucleus signaling pathway that may have functional significance for ER-positive breast cancers...
  8. ncbi request reprint An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction
    Everardo Macias
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 18:231-43. 2010
    ..Collectively, our findings establish RP-Mdm2 interaction as a genuine p53 stress-signaling pathway activated by aberrant ribosome biogenesis and essential for safeguarding against oncogenic c-MYC-induced tumorigenesis...
  9. ncbi request reprint Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    Koji Itahana
    Department of Radiation Oncology, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 12:355-66. 2007
    ....
  10. pmc Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
    Mikael S Lindström
    Department of Radiation Oncology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    J Biol Chem 283:15568-76. 2008
    ..Our results suggest that B23 selectively stores, and protects ribosomal protein S9 in nucleoli and therefore could facilitate ribosome biogenesis...
  11. doi request reprint Mitochondrial p32 is a critical mediator of ARF-induced apoptosis
    Koji Itahana
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cancer Cell 13:542-53. 2008
    ..These findings provide a potential explanation for the frequent human cancer mutations targeting the ARF C terminus...
  12. ncbi request reprint Putting a finger on growth surveillance: insight into MDM2 zinc finger-ribosomal protein interactions
    Mikael S Lindström
    Department of Radiation Oncology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, USA
    Cell Cycle 6:434-7. 2007
    ..Here we further discuss these findings and propose the existence of a ribosomal protein-MDM2-p53 surveillance network responsible for monitoring the stability of the transition between cell growth and division...
  13. pmc p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation
    Chad Deisenroth
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:28343-56. 2011
    ..As a p53 target gene, the observations of Dhrs3 location and potential function provide novel insight into an unexpected role for p53 in lipid droplet dynamics with implications in cancer cell metabolism and obesity...
  14. pmc Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction
    Hilary V Clegg
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e38212. 2012
    ....
  15. ncbi request reprint ARF in the mitochondria: the last frontier?
    Koji Itahana
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    Cell Cycle 7:3641-6. 2008
    ..Here, we discuss the implications of these studies and their potential relevance to human cancer...
  16. pmc p53 Oligomerization is essential for its C-terminal lysine acetylation
    Yoko Itahana
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    J Biol Chem 284:5158-64. 2009
    ..These results, combined with a computer-aided crystal structure analysis, suggest a model in which p53 oligomerization precedes its acetylation by providing docking sites for acetyltransferases...
  17. ncbi request reprint Unlocking the Mdm2-p53 loop: ubiquitin is the key
    Hilary V Clegg
    Lineberger Comprehensive Cancer Center and Curriculum in Genetics and Molecular Biology, School of Medicine, The University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Cell Cycle 7:287-92. 2008
    ..We will also discuss additional research questions that may be addressed using our mouse model...
  18. ncbi request reprint Regulation of the p53 tumor suppressor pathway: the problems and promises of studying Mdm2's E3 ligase function
    Hilary V Clegg
    Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
    Crit Rev Eukaryot Gene Expr 20:77-86. 2010
    ..Here, we discuss potential reasons for the discrepancies concerning Mdm2s functions and how they might be resolved, taking into account new research in the field...
  19. ncbi request reprint B23 and ARF: friends or foes?
    Mikael S Lindström
    Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7512, USA
    Cell Biochem Biophys 46:79-90. 2006
    ..Finally, the functional significance of the ARF-B23 interaction for tumor development and the prospects for novel cancer therapies are evaluated...
  20. ncbi request reprint Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability
    Takeharu Enomoto
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599 7512, USA
    J Biol Chem 281:18463-72. 2006
    ..B23 core mutants displayed increased ubiquitination and proteasomal degradation. We conclude that the functional integrity of the B23 core motif is required for stability, efficient nucleolar localization as well as ARF binding...
  21. pmc Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
    Yoko Itahana
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Box 7512, 101 Manning Dr, Chapel Hill, NC 27514, USA
    Mol Cell Biol 26:4675-89. 2006
    ..Thus, the function of SENP2 is regulated by both nucleocytoplasmic shuttling and polyubiquitin-mediated degradation...
  22. pmc Nuclear import of the stem-loop binding protein and localization during the cell cycle
    Judith A Erkmann
    Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Biol Cell 16:2960-71. 2005
    ..In contrast, we were unable to identify an in vivo role for Transportin-SR2 in SLBP nuclear localization. Thus, only the Impalpha/Impbeta pathway contributes to SLBP nuclear import in HeLa cells...
  23. pmc The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine
    Chad Deisenroth
    Department of Radiation Oncology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Genes Cancer 2:392-403. 2011
    ..Here the authors integrate the known functions of p53 to postulate how changes in nutrient availability may induce the ribosomal protein-Mdm2-p53 signaling pathway to modulate p53-dependent metabolic regulation...

Research Grants12

  1. Regulation of MDM2 by the ribosomal protein L11
    Yanping Zhang; Fiscal Year: 2003
    ..Aim 2. To investigate the in vivo function of the MDM2-L11 interaction using a MDM2 (C305F) knockin. Aim 3. To investigate the mechanism of ARF in the regulation of L11, MDM2, and p53. ..
  2. In vivo function and mechanism of the r-protein-Mdm2-p53 pathway
    Yanping Zhang; Fiscal Year: 2010
    ..Detailed knowledge of the molecular mechanisms and regulation of the Mdm2 and p53 is critically important for the design of future p53-based anticancer strategies. ..
  3. In vivo function of Mdm2 E3 ubiquitin ligase
    Yanping Zhang; Fiscal Year: 2009
    ..Detailed knowledge of the molecular mechanisms and regulation of the Mdm2 E3 ubiqutin ligase is critically important for the design of future p53-based anticancer strategies. ..
  4. In vivo function and mechanism of the r-protein-Mdm2-p53 pathway
    Yanping Zhang; Fiscal Year: 2009
    ..Detailed knowledge of the molecular mechanisms and regulation of the Mdm2 and p53 is critically important for the design of future p53-based anticancer strategies. ..
  5. Regulation of MDM2 by the ribosomal protein L11
    Yanping Zhang; Fiscal Year: 2007
    ..Aim 2. To investigate the in vivo function of the MDM2-L11 interaction using a MDM2 (C305F) knockin. Aim 3. To investigate the mechanism of ARF in the regulation of L11, MDM2, and p53. ..
  6. Regulation of MDM2 by the ribosomal protein L11
    Yanping Zhang; Fiscal Year: 2006
    ..Aim 2. To investigate the in vivo function of the MDM2-L11 interaction using a MDM2 (C305F) knockin. Aim 3. To investigate the mechanism of ARF in the regulation of L11, MDM2, and p53. ..
  7. ARF MDM2 P53 TUMOR SUPPRESSION PATHWAY
    Yanping Zhang; Fiscal Year: 2004
    ..Together these experiments should advance understanding of the regulation of the ARF-MDM2-p53 pathway and the functional consequences of its alterations in human cancer. ..
  8. Regulation of MDM2 by the ribosomal protein L11
    Yanping Zhang; Fiscal Year: 2004
    ..Aim 2. To investigate the in vivo function of the MDM2-L11 interaction using a MDM2 (C305F) knockin. Aim 3. To investigate the mechanism of ARF in the regulation of L11, MDM2, and p53. ..
  9. Regulation of MDM2 by the ribosomal protein L11
    Yanping Zhang; Fiscal Year: 2005
    ..Aim 2. To investigate the in vivo function of the MDM2-L11 interaction using a MDM2 (C305F) knockin. Aim 3. To investigate the mechanism of ARF in the regulation of L11, MDM2, and p53. ..
  10. Regulation of MDM2 by the ribosomal protein L11
    Yanping Zhang; Fiscal Year: 2004
    ..Aim 2. To investigate the in vivo function of the MDM2-L11 interaction using a MDM2 (C305F) knockin. Aim 3. To investigate the mechanism of ARF in the regulation of L11, MDM2, and p53. ..
  11. In vivo function of Mdm2 E3 ubiquitin ligase
    Yanping Zhang; Fiscal Year: 2010
    ..Detailed knowledge of the molecular mechanisms and regulation of the Mdm2 E3 ubiqutin ligase is critically important for the design of future p53-based anticancer strategies. ..