Research Topics
Genomes and Genes | Xinping ZhangSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineeringChao Xie
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Tissue Eng 13:435-45. 2007..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering...
A perspective: engineering periosteum for structural bone graft healingXinping Zhang
The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin Orthop Relat Res 466:1777-87. 2008....- Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineeringXinping Zhang
Department of Orthopaedics, University of Rochester Medical Center, New York, USA
J Bone Miner Res 20:2124-37. 2005.... - Reduced COX-2 expression in aged mice is associated with impaired fracture healingAmish A Naik
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
J Bone Miner Res 24:251-64. 2009..The findings suggest that COX-2/EP4 agonists may compensate for deficient molecular signals that result in the reduced fracture healing associated with aging... - Biological effects of rAAV-caAlk2 coating on structural allograft healingMette Koefoed
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Mol Ther 12:212-8. 2005..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation... - Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4Chao Xie
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Am J Pathol 175:772-85. 2009..Taken together, our studies demonstrate that EP2 and EP4 have differential functions during endochondral bone repair. Activation of EP4, but not EP2 rescued impaired bone fracture healing in COX-2(-/-) mice... - Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturationChristine A Clark
Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Orthop Res 27:785-92. 2009..18 cells and in primary murine sternal chondrocytes. Altogether, the findings show that PGE2 regulates chondrocyte maturation in part by targeting BMP/Smad signaling and suggest an important role for PGE2 in endochondral bone formation... - Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healingQun Wang
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
Bone 48:524-32. 2011..Future studies are necessary to determine the mechanisms by which the BMP-2 pathway is activated in periosteal progenitor cells at the onset of cortical bone repair... - Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femurCemal Yazici
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
Mol Ther 19:1416-25. 2011..Collectively, these results demonstrate that scAAV2.5-BMP2 coating overcomes the major limitations of structural allografts, which can be used to heal critical defects of any size... - Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapyHiromu Ito
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
Nat Med 11:291-7. 2005..In conclusion, we find that RANKL and VEGF are necessary and sufficient for efficient autograft remodeling and can be transferred using rAAV to revitalize structural allografts... - PGE2 inhibits chondrocyte differentiation through PKA and PKC signalingTian-Fang Li
Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Exp Cell Res 300:159-69. 2004..These observations demonstrate potent prostaglandin regulatory effects on chondrocyte maturation and show a role for both PKA and PKC signaling in PGE2 regulatory events... - PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysisRyosuke Tsutsumi
Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
J Bone Miner Res 24:1753-62. 2009..These results show that periprosthetic fibroblasts are important mediators of osteolysis through the expression of RANKL, which is induced after PGE2 signaling through the EP4 receptor... - COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healingChao Xie
Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Bone 43:1075-83. 2008..Elimination of COX-2 at the early stage of healing could lead to detrimental effects on periosteal progenitor cell-initiated cortical bone repair... - Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particlesXiaochao Wei
Center for Musculoskeletal Research University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
J Bone Miner Res 20:1136-48. 2005..Thus, the synovial fibroblast is important mediator of osteolysis and target for therapeutic strategies... - Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequencyJonathan J Carmouche
Center for Musculoskeletal Research, University of Rochester Medical Center, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Environ Health Perspect 113:749-55. 2005..We conclude that Pb delays fracture healing at environmentally relevant doses and induces fibrous nonunions at higher doses by inhibiting the progression of endochondral ossification... - Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturationChristine A Clark
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
Biochem Biophys Res Commun 328:764-76. 2005.... - Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathwayXiaochao Wei
Center for Musculoskeletal Research, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Physiol Cell Physiol 297:C310-20. 2009..These findings define important targets for osteolysis but may also have importance in other diseases where fibroblasts respond to environmental particles, including pulmonary diseases... - Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiationXinping Zhang
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
Bone 34:809-17. 2004.... - Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repairQun Wang
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Am J Pathol 177:3100-11. 2010.... - Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repairXinping Zhang
The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
J Clin Invest 109:1405-15. 2002..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair... - Regulation of chondrogenesis and chondrocyte differentiation by stressMichael J Zuscik
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Clin Invest 118:429-38. 2008..A summary of the influence of the most well-understood normal and pathologic stressors on the differentiation program is also presented... - Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantationChao Xie
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Bone Joint Surg Am 90:9-13. 2008..Our current approach overcomes this encumbrance and enables examination of gene function in a time-dependent and repair-tissue-specific manner... - Micro-computed tomography prediction of biomechanical strength in murine structural bone graftsDavid G Reynolds
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620, USA
J Biomech 40:3178-86. 2007..The statistical correlations approach used in this mouse study could be useful in guiding future development of non-invasive predictors of the biomechanical properties of allografts using clinical CT... - Recent advances in gene delivery for structural bone allograftsHani A Awad
Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
Tissue Eng 13:1973-85. 2007..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications... - Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinaseMo Chen
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642, USA
Genesis 45:44-50. 2007..These results demonstrate that Col2a1-CreER(T2) transgenic mice can be used as a valuable tool for an inducible and chondrocyte-specific gene deletion approach... - COX-2 has a critical role during incorporation of structural bone allograftsREGIS J O'KEEFE
Department of Orthopedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Ann N Y Acad Sci 1068:532-42. 2006..Furthermore, our data support the notion that COX-2-dependent PGE2 produced at the early stage of bone healing is prerequisite for efficient skeletal repair... - The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatingsCemal Yazici
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Biomaterials 29:3882-7. 2008..Thus, surface demineralization of human cortical bone allograft increases its absorbance for uniform rAAV coating, without affecting vector transduction efficiency... - Smad6 is induced by BMP-2 and modulates chondrocyte differentiationXeufeng Li
Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
J Orthop Res 21:908-13. 2003..Additional studies are required to determine the extent to which this pathway participates in pathologic processes involving cartilage... - Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healingLisa M Flick
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Orthop Res 21:676-84. 2003..Together, these data imply that osteoclast depletion via inhibition of RANK signaling is a viable option for the treatment of pathological bone loss since no adverse effects on fracture healing are observed when therapy is discontinued... - A novel murine segmental femoral graft modelPrarop Tiyapatanaputi
Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, NY 14642, USA
J Orthop Res 22:1254-60. 2004..This small animal model of structural bone grafting can be used to evaluate tissue-engineered allografts and novel bone graft substitutes using quantitative and molecularly defined outcome measures... - PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathwaySusan V Bukata
The Department of Orthopaedics, University of Rochester Medical Center, Center for Musculoskeletal Research, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
J Orthop Res 22:6-12. 2004.... - COX-1 and COX-2 expression in osteoid osteomasDavid V Mungo
Department of Orthopaedics, Medical Center, University of Rochester, NY 14642, USA
J Orthop Res 20:159-62. 2002..These findings suggest that the newly selective COX-2 inhibitors could be used to more safely treat osteoid osteomas... - Alteration of femoral bone morphology and density in COX-2-/- miceGalen Robertson
Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
Bone 39:767-72. 2006..In conclusion, our study suggests that genetic ablation of COX-2 may have a sex-related effect on cortical bone homeostasis and COX-2 plays a role in maintaining normal bone micro-architecture and density in mice...
Research Grants
- Angiogenesis & Osteogenesis in Structural Graft HealingXinping Zhang; Fiscal Year: 2007..abstract_text> ..