Xinping Zhang

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Tissue Eng 13:435-45. 2007
  2. pmc A perspective: engineering periosteum for structural bone graft healing
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Orthop Relat Res 466:1777-87. 2008
  3. ncbi request reprint Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering
    Xinping Zhang
    Department of Orthopaedics, University of Rochester Medical Center, New York, USA
    J Bone Miner Res 20:2124-37. 2005
  4. pmc Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    Amish A Naik
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 24:251-64. 2009
  5. ncbi request reprint Biological effects of rAAV-caAlk2 coating on structural allograft healing
    Mette Koefoed
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Ther 12:212-8. 2005
  6. pmc Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4
    Chao Xie
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Pathol 175:772-85. 2009
  7. pmc Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation
    Christine A Clark
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Orthop Res 27:785-92. 2009
  8. pmc Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing
    Qun Wang
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Bone 48:524-32. 2011
  9. pmc Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur
    Cemal Yazici
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    Mol Ther 19:1416-25. 2011
  10. ncbi request reprint PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling
    Tian Fang Li
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 300:159-69. 2004

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Tissue Eng 13:435-45. 2007
    ..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering...
  2. pmc A perspective: engineering periosteum for structural bone graft healing
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Orthop Relat Res 466:1777-87. 2008
    ....
  3. ncbi request reprint Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering
    Xinping Zhang
    Department of Orthopaedics, University of Rochester Medical Center, New York, USA
    J Bone Miner Res 20:2124-37. 2005
    ....
  4. pmc Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    Amish A Naik
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 24:251-64. 2009
    ..The findings suggest that COX-2/EP4 agonists may compensate for deficient molecular signals that result in the reduced fracture healing associated with aging...
  5. ncbi request reprint Biological effects of rAAV-caAlk2 coating on structural allograft healing
    Mette Koefoed
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Ther 12:212-8. 2005
    ..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation...
  6. pmc Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4
    Chao Xie
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Pathol 175:772-85. 2009
    ..Taken together, our studies demonstrate that EP2 and EP4 have differential functions during endochondral bone repair. Activation of EP4, but not EP2 rescued impaired bone fracture healing in COX-2(-/-) mice...
  7. pmc Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation
    Christine A Clark
    Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Orthop Res 27:785-92. 2009
    ..18 cells and in primary murine sternal chondrocytes. Altogether, the findings show that PGE2 regulates chondrocyte maturation in part by targeting BMP/Smad signaling and suggest an important role for PGE2 in endochondral bone formation...
  8. pmc Expression of endogenous BMP-2 in periosteal progenitor cells is essential for bone healing
    Qun Wang
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Bone 48:524-32. 2011
    ..Future studies are necessary to determine the mechanisms by which the BMP-2 pathway is activated in periosteal progenitor cells at the onset of cortical bone repair...
  9. pmc Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur
    Cemal Yazici
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    Mol Ther 19:1416-25. 2011
    ..Collectively, these results demonstrate that scAAV2.5-BMP2 coating overcomes the major limitations of structural allografts, which can be used to heal critical defects of any size...
  10. ncbi request reprint PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling
    Tian Fang Li
    Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Exp Cell Res 300:159-69. 2004
    ..These observations demonstrate potent prostaglandin regulatory effects on chondrocyte maturation and show a role for both PKA and PKC signaling in PGE2 regulatory events...
  11. ncbi request reprint Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation
    Christine A Clark
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 328:764-76. 2005
    ....
  12. ncbi request reprint Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles
    Xiaochao Wei
    Center for Musculoskeletal Research University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    J Bone Miner Res 20:1136-48. 2005
    ..Fibroblasts pretreated with titanium or PGE2 stimulated osteoclast formation, showing the functional importance of RANKL induction. Synovial fibroblasts and their activation pathways are potential targets to prevent osteolysis...
  13. pmc Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
    Hiromu Ito
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    Nat Med 11:291-7. 2005
    ..In conclusion, we find that RANKL and VEGF are necessary and sufficient for efficient autograft remodeling and can be transferred using rAAV to revitalize structural allografts...
  14. pmc Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency
    Jonathan J Carmouche
    Center for Musculoskeletal Research, University of Rochester Medical Center, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 113:749-55. 2005
    ..We conclude that Pb delays fracture healing at environmentally relevant doses and induces fibrous nonunions at higher doses by inhibiting the progression of endochondral ossification...
  15. pmc COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Bone 43:1075-83. 2008
    ..Elimination of COX-2 at the early stage of healing could lead to detrimental effects on periosteal progenitor cell-initiated cortical bone repair...
  16. pmc PGE2 signaling through the EP4 receptor on fibroblasts upregulates RANKL and stimulates osteolysis
    Ryosuke Tsutsumi
    Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Bone Miner Res 24:1753-62. 2009
    ..These results show that periprosthetic fibroblasts are important mediators of osteolysis through the expression of RANKL, which is induced after PGE2 signaling through the EP4 receptor...
  17. pmc Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway
    Xiaochao Wei
    Center for Musculoskeletal Research, Univ of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 297:C310-20. 2009
    ..These findings define important targets for osteolysis but may also have importance in other diseases where fibroblasts respond to environmental particles, including pulmonary diseases...
  18. doi request reprint Electrospun fibers as a scaffolding platform for bone tissue repair
    Seungyoun Lyu
    Department of Chemical Engineering, University of Rochester, Rochester, New York, USA
    J Orthop Res 31:1382-9. 2013
    ..4 μm. Taken together, our data support the use of submicron-sized electrospun fibers for engineering of oriented fibrous tissue mimetic, such as periosteum, for guided bone repair and reconstruction...
  19. ncbi request reprint Recent advances in gene delivery for structural bone allografts
    Hani A Awad
    Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
    Tissue Eng 13:1973-85. 2007
    ..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications...
  20. ncbi request reprint COX-2 has a critical role during incorporation of structural bone allografts
    REGIS J O'KEEFE
    Department of Orthopedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Ann N Y Acad Sci 1068:532-42. 2006
    ..Furthermore, our data support the notion that COX-2-dependent PGE2 produced at the early stage of bone healing is prerequisite for efficient skeletal repair...
  21. pmc Activation of the Hh pathway in periosteum-derived mesenchymal stem cells induces bone formation in vivo: implication for postnatal bone repair
    Qun Wang
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Pathol 177:3100-11. 2010
    ....
  22. pmc Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
    J Clin Invest 109:1405-15. 2002
    ..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair...
  23. ncbi request reprint Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation
    Xinping Zhang
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
    Bone 34:809-17. 2004
    ....
  24. pmc Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation
    Chao Xie
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Bone Joint Surg Am 90:9-13. 2008
    ..Our current approach overcomes this encumbrance and enables examination of gene function in a time-dependent and repair-tissue-specific manner...
  25. pmc Regulation of chondrogenesis and chondrocyte differentiation by stress
    Michael J Zuscik
    Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Clin Invest 118:429-38. 2008
    ..A summary of the influence of the most well-understood normal and pathologic stressors on the differentiation program is also presented...
  26. ncbi request reprint Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts
    David G Reynolds
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620, USA
    J Biomech 40:3178-86. 2007
    ..The statistical correlations approach used in this mouse study could be useful in guiding future development of non-invasive predictors of the biomechanical properties of allografts using clinical CT...
  27. pmc Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase
    Mo Chen
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Genesis 45:44-50. 2007
    ..These results demonstrate that Col2a1-CreER(T2) transgenic mice can be used as a valuable tool for an inducible and chondrocyte-specific gene deletion approach...
  28. ncbi request reprint A novel murine segmental femoral graft model
    Prarop Tiyapatanaputi
    Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, NY 14642, USA
    J Orthop Res 22:1254-60. 2004
    ..This small animal model of structural bone grafting can be used to evaluate tissue-engineered allografts and novel bone graft substitutes using quantitative and molecularly defined outcome measures...
  29. ncbi request reprint PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway
    Susan V Bukata
    The Department of Orthopaedics, University of Rochester Medical Center, Center for Musculoskeletal Research, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Orthop Res 22:6-12. 2004
    ....
  30. pmc The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings
    Cemal Yazici
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biomaterials 29:3882-7. 2008
    ..Thus, surface demineralization of human cortical bone allograft increases its absorbance for uniform rAAV coating, without affecting vector transduction efficiency...
  31. ncbi request reprint Smad6 is induced by BMP-2 and modulates chondrocyte differentiation
    Xeufeng Li
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    J Orthop Res 21:908-13. 2003
    ..Additional studies are required to determine the extent to which this pathway participates in pathologic processes involving cartilage...
  32. ncbi request reprint Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healing
    Lisa M Flick
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Orthop Res 21:676-84. 2003
    ..Together, these data imply that osteoclast depletion via inhibition of RANK signaling is a viable option for the treatment of pathological bone loss since no adverse effects on fracture healing are observed when therapy is discontinued...
  33. ncbi request reprint COX-1 and COX-2 expression in osteoid osteomas
    David V Mungo
    Department of Orthopaedics, Medical Center, University of Rochester, NY 14642, USA
    J Orthop Res 20:159-62. 2002
    ..These findings suggest that the newly selective COX-2 inhibitors could be used to more safely treat osteoid osteomas...
  34. ncbi request reprint Overexpressing Sonic Hedgehog Peptide Restores Periosteal Bone Formation in a Murine Bone Allograft Transplantation Model
    Chunlan Huang
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
    Mol Ther . 2013
    ..Hh agonist-based therapy, therefore, merits further investigation in tissue engineering-based applications aimed at enhancing bone defect repair and reconstruction.Molecular Therapy (2013); doi:10.1038/mt.2013.222...
  35. pmc The effect of mesenchymal stem cells delivered via hydrogel-based tissue engineered periosteum on bone allograft healing
    Michael D Hoffman
    University of Rochester, Department of Biomedical Engineering, Rochester, NY, USA
    Biomaterials 34:8887-98. 2013
    ..However, this bottom-up biomaterials approach, the engineered periosteum, can be augmented with alternative cell types, matrix cues, growth factors, and/or other small molecule drugs to expedite the process of ossification. ..
  36. pmc Alteration of femoral bone morphology and density in COX-2-/- mice
    Galen Robertson
    Parker H Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Bone 39:767-72. 2006
    ..In conclusion, our study suggests that genetic ablation of COX-2 may have a sex-related effect on cortical bone homeostasis and COX-2 plays a role in maintaining normal bone micro-architecture and density in mice...

Research Grants4

  1. Angiogenesis & Osteogenesis in Structural Graft Healing
    Xinping Zhang; Fiscal Year: 2007
    ..abstract_text> ..