Xiao Dong Zhang
Affiliation: University of California
Yamoah M, Moshref M, Sharma J, Chen W, Ledford H, Lee J, et al
. Highly efficient transfection of human induced pluripotent stem cells using magnetic nanoparticles. Int J Nanomedicine. 2018;13:6073-6078 pubmed publisher
..The difficult-to-transfect hiPSCs and hiPSC-CMs were efficiently transfected using magnetic NPs. Our study offers a novel approach for transfection of hiPSCs and hiPSC-CMs without the need for viral vector generation. ..
Zhang X, Lieu D, Chiamvimonvat N. Small-conductance Ca2+ -activated K+ channels and cardiac arrhythmias. Heart Rhythm. 2015;12:1845-51 pubmed publisher
..At the translational level, development of SK channel blockers as a new therapeutic strategy in the treatment of atrial fibrillation and the possible proarrhythmic effects merit further considerations and investigations. ..
Zhang X, Coulibaly Z, Chen W, Ledford H, Lee J, Sirish P, et al
. Coupling of SK channels, L-type Ca2+ channels, and ryanodine receptors in cardiomyocytes. Sci Rep. 2018;8:4670 pubmed publisher
Sirish P, Ledford H, Timofeyev V, Thai P, Ren L, Kim H, et al
. Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6. Circ Arrhythm Electrophysiol. 2017;10: pubmed publisher
..pHi is a critical regulator of other membrane and contractile proteins. Future studies are needed to investigate possible changes in these proteins in Slc26a6-/- mice. ..