Affiliation: University of California
Kwak J, Zhang Y, Park J, Chen E, Shen J, Chawan C, et al
. Pharmacokinetics and osteogenic potential of PEGylated NELL-1 in vivo after systemic administration. Biomaterials. 2015;57:73-83 pubmed publisher
..Our findings suggest that the PEGylation technique presents a viable and promising approach to further develop NELL-1 into an effective systemic therapeutic for the treatment of osteoporosis. ..
Zhang X, Zara J, Siu R, Ting K, Soo C. The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration. J Dent Res. 2010;89:865-78 pubmed publisher
..Note: NELL-1 and NELL-1 indicate the human gene and protein, respectively; Nell-1 and Nell-1 indicate the mouse gene and protein, respectively.] ..
Li C, Jiang J, Zheng Z, Lee K, Zhou Y, Chen E, et al
. Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation. Am J Pathol. 2017;187:963-972 pubmed publisher
..Nell-1 is a key functional mediator of chondrogenesis, thus opening up new possibilities for the application of Nell-1 in cartilage regeneration. ..
Pan H, Lee S, Ting K, Shen J, Wang C, Nguyen A, et al
. Cyst-Like Osteolytic Formations in Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) Augmented Sheep Spinal Fusion. Am J Pathol. 2017;187:1485-1495 pubmed publisher
..Despite promoting successful fusion, rhBMP-2 use in clinical applications may result in local adverse structural alterations and compromised biomechanical changes to the bone. ..