Su Chun Zhang

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Neural subtype specification from embryonic stem cells
    Su Chun Zhang
    Department of Anatomy, School of Medicine and Public Health, Waisman Center, Wisconsin Stem Cell Research Program, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Brain Pathol 16:132-42. 2006
  2. ncbi request reprint Embryonic stem cells for neural replacement therapy: prospects and challenges
    Su Chun Zhang
    Department of Anatomy, School of Medicine, Waisman Center, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    J Hematother Stem Cell Res 12:625-34. 2003
  3. pmc Human embryonic stem cells for brain repair?
    Su Chun Zhang
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Centre, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Philos Trans R Soc Lond B Biol Sci 363:87-99. 2008
  4. ncbi request reprint In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    S C Zhang
    Department of Anatomy, University of Wisconsin 1500 Highland Avenue, Madison, WI 53705, USA
    Nat Biotechnol 19:1129-33. 2001
  5. pmc Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells
    Yiping Yan
    Department of Anatomy, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Stem Cells 23:781-90. 2005
  6. ncbi request reprint Induced expression of Olig2 is sufficient for oligodendrocyte specification but not for motoneuron specification and astrocyte repression
    Zhong Wei Du
    Department of Anatomy, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Mol Cell Neurosci 33:371-80. 2006
  7. pmc Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway
    Young Dong Yoo
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 29:1975-82. 2011
  8. pmc Differentiation of human oligodendrocytes from pluripotent stem cells
    Bao Yang Hu
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Protoc 4:1614-22. 2009
  9. pmc Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain
    Daniel J Guillaume
    Departments of Anatomy and Neurology, School of Medicine, The Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurosci Res 84:1165-76. 2006
  10. ncbi request reprint Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors
    Su Chun Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Glia 41:191-8. 2003

Research Grants

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Neural subtype specification from embryonic stem cells
    Su Chun Zhang
    Department of Anatomy, School of Medicine and Public Health, Waisman Center, Wisconsin Stem Cell Research Program, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Brain Pathol 16:132-42. 2006
    ..This is also a rational and realistic way of producing enriched populations of functional neurons and glia for pathological analyses as well as possible therapeutic applications...
  2. ncbi request reprint Embryonic stem cells for neural replacement therapy: prospects and challenges
    Su Chun Zhang
    Department of Anatomy, School of Medicine, Waisman Center, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    J Hematother Stem Cell Res 12:625-34. 2003
    ..Here I will concentrate on the donor side and discuss how recent advancement in stem cell technology offers hope for transplant therapy, with a focus on the potentials and hurdles of human embryonic stem cells as a sustainable source...
  3. pmc Human embryonic stem cells for brain repair?
    Su Chun Zhang
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Centre, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Philos Trans R Soc Lond B Biol Sci 363:87-99. 2008
    ..We propose that careful studies on neural differentiation from human ES cells may provide more immediate answers to clinically relevant problems, such as drug discovery, mechanisms of disease and stimulation of endogenous stem cells...
  4. ncbi request reprint In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    S C Zhang
    Department of Anatomy, University of Wisconsin 1500 Highland Avenue, Madison, WI 53705, USA
    Nat Biotechnol 19:1129-33. 2001
    ..No teratoma formation was observed in the transplant recipients. These results depict human ES cells as a source of transplantable neural precursors for possible nervous system repair...
  5. pmc Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells
    Yiping Yan
    Department of Anatomy, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Stem Cells 23:781-90. 2005
    ..They may thus provide a renewable source of functional human DA neurons for drug screening and development of sustainable therapeutics for disorders affecting the DA system...
  6. ncbi request reprint Induced expression of Olig2 is sufficient for oligodendrocyte specification but not for motoneuron specification and astrocyte repression
    Zhong Wei Du
    Department of Anatomy, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Mol Cell Neurosci 33:371-80. 2006
    ....
  7. pmc Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway
    Young Dong Yoo
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 29:1975-82. 2011
    ..Furthermore, FGF-ERK1/2-PARP-1 cascade regulated the expression of PAX6, a transcription determinant of human neuroectoderm. Together, we propose that FGF regulates hESC neural specification through the ERK1/2-PARP-1 signaling pathway...
  8. pmc Differentiation of human oligodendrocytes from pluripotent stem cells
    Bao Yang Hu
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Protoc 4:1614-22. 2009
    ..This 3-month differentiation protocol consistently yields OPCs of high purity capable of producing myelin sheaths in vivo...
  9. pmc Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain
    Daniel J Guillaume
    Departments of Anatomy and Neurology, School of Medicine, The Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurosci Res 84:1165-76. 2006
    ....
  10. ncbi request reprint Suppression of activated microglia promotes survival and function of transplanted oligodendroglial progenitors
    Su Chun Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA
    Glia 41:191-8. 2003
    ..Hence, minocycline likely modulates the function of reactive glia in vivo to promote the survival and myelination of transplanted oligodendroglial progenitors...
  11. ncbi request reprint In vitro differentiation of neural precursors from human embryonic stem cells
    Xue Jun Li
    Department of Anatomy, School of Medicine, Stem Cell Research Program, Waisman Center, Madison, WI, USA
    Methods Mol Biol 331:169-77. 2006
    ..Thus, our system not only provides a source of synchronized neuroectodermal cells, but also offers a paradigm to dissect mechanisms of neural induction and cell lineage specification during early human development...
  12. pmc Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects
    Bao Yang Hu
    Department of Anatomy and Neurology, University of Wisconsin Madison, Madison, WI 53705, USA
    Development 136:1443-52. 2009
    ..2. Thus, despite the conservation of a similar transcriptional network across vertebrates, human stem/progenitor cells may respond differently to those of other vertebrates to certain extrinsic factors...
  13. pmc Intracerebral transplantation of differentiated human embryonic stem cells to hemiparkinsonian monkeys
    Marina E Emborg
    Preclinical Parkinson s Research Program, Wisconsin National Primate Research Center, Madison, WI 53715, USA
    Cell Transplant 22:831-8. 2013
    ....
  14. pmc Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain
    Marina E Emborg
    Preclinical Parkinson s Research Program, Wisconsin National Primate Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Cell Rep 3:646-50. 2013
    ..This finding represents a significant step toward personalized regenerative therapies...
  15. pmc Pax6 is a human neuroectoderm cell fate determinant
    Xiaoqing Zhang
    Waisman Center and the WiCell Institute, Madison, WI 53705, USA
    Cell Stem Cell 7:90-100. 2010
    ....
  16. pmc Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits
    Yan Liu
    Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Nat Biotechnol 31:440-7. 2013
    ..Our findings support the prospect of using human stem cell-derived MGE-like progenitors in developing therapies for neurological disorders of learning and memory...
  17. pmc miR-200 and miR-96 families repress neural induction from human embryonic stem cells
    Zhong Wei Du
    Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA
    Development 140:2611-8. 2013
    ..Given the essential roles of ZEBs and PAX6 in neural induction, we propose a model by which miR-200 and miR-96 families coordinate to regulate neural induction...
  18. pmc Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    Bao Yang Hu
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin, Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 107:4335-40. 2010
    ..These findings, which show a need for improving differentiation potency of iPSCs, suggest the possibility of employing human iPSCs in pathological studies, therapeutic screening, and autologous cell transplantation...
  19. pmc Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs
    Bao Yang Hu
    Department of Anatomy, Waisman Center, School of Medicine and Public Health, The WiCell Institute, University of Wisconsin Madison, Madison, WI, USA
    Methods Mol Biol 636:123-37. 2010
    ..This protocol has been shown equally effective in generating motor neurons from human induced pluropotent stem (iPS) cells...
  20. pmc Genetic modification of human embryonic stem cells
    Xiaofeng Xia
    WiCell Research Institute, University of Wisconsin Madison, Madison, WI 53705, USA
    Biotechnol Genet Eng Rev 24:297-309. 2007
  21. pmc Specification of transplantable astroglial subtypes from human pluripotent stem cells
    Robert Krencik
    Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Biotechnol 29:528-34. 2011
    ....
  22. pmc Generation of integration-free and region-specific neural progenitors from primate fibroblasts
    Jianfeng Lu
    Department of Neuroscience, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, Madison, WI 53705, USA
    Cell Rep 3:1580-91. 2013
    ..The ability to generate defined, integration-free iNPs from adult primate fibroblasts under a defined condition with predictable fate choices will facilitate disease modeling and therapeutic development...
  23. pmc Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage
    Matthew T Pankratz
    Waisman Center, Rm T613, University of Wisconsin, 1500 Highland Ave, Madison, Wisconsin 53705, USA
    Stem Cells 25:1511-20. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  24. ncbi request reprint Neural differentiation from embryonic stem cells: which way?
    Zhong Wei Du
    Department of Anatomy, School of Medicine, Waisman Center, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Stem Cells Dev 13:372-81. 2004
    ..This synthesis has led to our suggestions on issues for future design of neural differentiation protocols...
  25. pmc Directed differentiation of functional astroglial subtypes from human pluripotent stem cells
    Robert Krencik
    Neuroscience Training Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Protoc 6:1710-7. 2011
    ..This method generates robust populations of functionally diversified astrocytes with high efficiency...
  26. pmc Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells
    Xiao Qing Zhang
    Departments of Anatomy and Neurology, School of Medicine, The Stem Cell Research Program, Waisman Center, and the WiCell Institute, University of Wisconsin Madison, Madison, WI, USA
    Methods Mol Biol 584:355-66. 2010
    ..Identification of the primitive neuroepithelial cells permits efficient patterning of region-specific progenitors and neuronal subtypes such as midbrain dopaminergic neurons...
  27. pmc Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
    Xue Jun Li
    Department of Anatomy and the Stem Cell Research Program, Madison, Wisconsin 53705, USA
    Stem Cells 26:886-93. 2008
    ..Thus, the directed neural differentiation system with small molecules, even without further purification, will facilitate basic and translational studies using human motoneurons at a minimal cost...
  28. pmc Deficits in human trisomy 21 iPSCs and neurons
    Jason P Weick
    Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 110:9962-7. 2013
    ..Thus, Ts21 iPSCs and neurons display unique developmental defects that are consistent with cognitive deficits in individuals with Down syndrome and may enable discovery of the underlying causes of and treatments for this disorder...
  29. pmc Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner
    Xiaofeng Xia
    WiCell Research Institute, University of Wisconsin Madison, Madison, WI 53705, USA
    Stem Cells Dev 16:167-76. 2007
    ..Cautions should be taken to choose the optimal promoter when lentiviruses are used for genetic modification of human ES cells...
  30. pmc In vitro- and in vivo-induced transgene expression in human embryonic stem cells and derivatives
    Xiaofeng Xia
    WiCell Research Institute, Madison, Wisconsin, USA
    Stem Cells 26:525-33. 2008
    ..These results provide a technical basis for regulation of gene expression in hESCs and derivatives in vitro and in vivo...
  31. doi request reprint Lentiviral vector-mediated transgenesis in human embryonic stem cells
    Zhong Wei Du
    Departments of Anatomy and Neurology, School of Medicine and Public Health, WiCell Institute, University of Wisconsin, Madison, WI, USA
    Methods Mol Biol 614:127-34. 2010
    ..Here, we describe an efficient lentiviral vector mediated method to establish stable transgenic hESCs...
  32. pmc Specification of neuronal and glial subtypes from human pluripotent stem cells
    Huisheng Liu
    Waisman Center, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705, USA
    Cell Mol Life Sci 68:3995-4008. 2011
    ..Such information will be instrumental in translating biological findings to therapeutic development...
  33. pmc Survival and differentiation of transplanted neural stem cells derived from human induced pluripotent stem cells in a rat stroke model
    Matthew B Jensen
    Department of Neurology, University of Wisconsin, Madison, Wisconsin 53705 2281, USA
    J Stroke Cerebrovasc Dis 22:304-8. 2013
    ..We studied whether these cells could survive, differentiate, and improve stroke recovery in an ischemic stroke model...
  34. pmc Human embryonic stem cell-derived dopaminergic neurons reverse functional deficit in parkinsonian rats
    Dali Yang
    Department of Anatomy, School of Medicine and Public Health, Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 26:55-63. 2008
    ..Furthermore, progenies of grafted cells were neurons and glia with greatly diminished mitotic activity by 5 months. Thus, the in vitro-produced human dopamine neurons can functionally engraft in the brain...
  35. ncbi request reprint Stem cell neural differentiation: A model for chemical biology
    Robert Krencik
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, Wisconsin Stem Cell Research Program, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Curr Opin Chem Biol 10:592-7. 2006
    ..Thus, stem cells find their most powerful use in chemical biology, which may ultimately lead to applications in regenerative medicine...
  36. ncbi request reprint Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation
    Bernard L Schneider
    Waisman Center and Department of Anatomy, University of Wisconsin, Madison, WI 53705, USA
    Hum Mol Genet 16:651-66. 2007
    ..Thus, neural cells derived from hESC provide a useful model system to understand the development of alpha-synuclein-related pathologies and allow therapeutic drug screening...
  37. pmc Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network
    Jason P Weick
    Waisman Center, University of Wisconsin Madison, 647 Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 108:20189-94. 2011
    ..Thus, hESC-derived neurons can participate in and modulate neural network activity through functional synaptic integration, suggesting they are capable of contributing to neural network information processing both in vitro and in vivo...
  38. pmc Differentiation of neuroepithelia from human embryonic stem cells
    Xiaofeng Xia
    Department of Anatomy, School of Medicine and Public Health, Waisman Center, University of Wisconsin Madison, Madison, WI, USA
    Methods Mol Biol 549:51-8. 2009
    ..In particular, the primitive neuroepithelial cells generated by this protocol can be further induced into neuronal and glial cells with forebrain, mid/hind brain, and spinal cord identities and targeted transmitter phenotypes...
  39. pmc Developmental regulation of human embryonic stem cell-derived neurons by calcium entry via transient receptor potential channels
    Jason P Weick
    Waisman Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Stem Cells 27:2906-16. 2009
    ....
  40. pmc Modeling early retinal development with human embryonic and induced pluripotent stem cells
    Jason S Meyer
    Stem Cell Research Program, Waisman Center, Departments of Anatomy and Neurology, University of Wisconsin Madison, 1500 Highland Avenue, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 106:16698-703. 2009
    ..These findings should aid in the investigation of the molecular events governing retinal specification from human pluripotent stem cells...
  41. pmc Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1
    Nityanand Maddodi
    Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 285:242-54. 2010
    ..Our data suggest that BRAF oncogene levels can regulate melanoma neuronal differentiation and tumor progression...
  42. pmc Regulation of neural specification from human embryonic stem cells by BMP and FGF
    Timothy M LaVaute
    Neuroscience Training Program, School of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 27:1741-9. 2009
    ..Blocking FGF signaling inhibited neural induction, but did not alter the phosphorylation of the linker region of Smad1, suggesting that FGF enhances human neural specification independently of BMP signaling...
  43. pmc Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity
    S C Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 96:4089-94. 1999
    ..The ability to generate such cells from the adult brain therefore opens an avenue to explore the potential of these cells for repairing myelin disorders in adulthood...
  44. ncbi request reprint Tracing human oligodendroglial development in vitro
    S C Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Neurosci Res 59:421-9. 2000
    ..Thus the survival, proliferation and maturation of oligodendroglia are influenced by other cell types...
  45. ncbi request reprint Reactive microglia in dysmyelination and demyelination
    S C Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706 1102, USA
    Glia 34:101-9. 2001
    ..Thus, this study indicates that microglial reaction is graded in chronic neurological disorders and suggests that MHC II expression marks a functional change of activated microglia...
  46. ncbi request reprint Self-renewing canine oligodendroglial progenitor expanded as oligospheres
    S C Zhang
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
    J Neurosci Res 54:181-90. 1998
    ..Transplantation studies indicated that the extensively expanded oligosphere cells retained myelination capacity. The oligospheres thus provide a valuable source for experimental cell therapy studies...
  47. ncbi request reprint Inhibition of autoimmune encephalomyelitis by a tetracycline
    Natalija Popovic
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Ann Neurol 51:215-23. 2002
    ..As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis...
  48. pmc Functional control of transplantable human ESC-derived neurons via optogenetic targeting
    Jason P Weick
    Waisman Center, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Stem Cells 28:2008-16. 2010
    ..This pluripotent cell line will allow both in vitro and in vivo analysis of functional development as well as the integration capacity of neuronal populations for cell-replacement strategies...
  49. pmc Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells
    Sabine Pellett
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    Biochem Biophys Res Commun 404:388-92. 2011
    ..The data presented indicate that this assay can reliably detect BoNT/A with a similar sensitivity as the MBA...
  50. pmc Cre recombination-mediated cassette exchange for building versatile transgenic human embryonic stem cells lines
    Zhong Wei Du
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA
    Stem Cells 27:1032-41. 2009
    ..This strategy and the master cell lines allow for rapid production of transgenic hESC lines in ordinary laboratories...
  51. pmc Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture
    M Austin Johnson
    Neuroscience Training Program, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurosci 27:3069-77. 2007
    ..These results lay the foundation for future studies examining the functional development of human neurons and provide support for the potential application of human cells in restorative neuronal therapies...
  52. doi request reprint Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
    Yan Liu
    Waisman Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Nat Protoc 8:1670-9. 2013
    ..This simple and efficient protocol does not require transgenic modification or cell sorting, and it has been replicated with multiple human ESC and iPSC lines. ..
  53. pmc The myelin mutants as models to study myelin repair in the leukodystrophies
    Ian D Duncan
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Neurotherapeutics 8:607-24. 2011
    ..We discuss how grafts are identified and functional outcomes are measured. Finally, we briefly discuss the cells that have been successfully transplanted, which may be used in future clinical trials...
  54. pmc Differentiation of spinal motor neurons from pluripotent human stem cells
    Bao Yang Hu
    Department of Anatomy and Department of Neurology, School of Medicine and Public Health, Waisman Center, The WiCell Institute, University of Wisconsin Madison, Madison, WI, USA
    Nat Protoc 4:1295-304. 2009
    ..In comparison with other methods, our protocol does not use feeder cells, has a minimum dependence on proteins (purmorphamine replacing SHH), has controllable adherent selection and is adaptable for scalable suspension culture...
  55. pmc Human embryonic stem cells: a potential source of transplantable neural progenitor cells
    Daniel J Guillaume
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Neurosurg Focus 24:E3. 2008
    ..This review will focus on the potential of ESCs as a source of transplantable cells for use in cell replacement therapy...
  56. ncbi request reprint Monitoring stem cell therapy in vivo using magnetodendrimers as a new class of cellular MR contrast agents
    Jeff W M Bulte
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA
    Acad Radiol 9:S332-5. 2002
  57. ncbi request reprint Specification of motoneurons from human embryonic stem cells
    Xue Jun Li
    Nat Biotechnol 23:215-21. 2005
    ....
  58. ncbi request reprint Magnetically labeled glial cells as cellular MR contrast agents
    Jeff W M Bulte
    Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA
    Acad Radiol 9:S148-50. 2002

Research Grants15

  1. Neural Specification of Embryonic Stem Cells
    Su Chun Zhang; Fiscal Year: 2010
    ..Understanding the molecular regulators in directing the fate of neural stem cells will significantly expand our ability to instigate regeneration of our aging and/or diseased brain. ..
  2. Neural Specification of Embryonic Stem Cells
    Su Chun Zhang; Fiscal Year: 2009
    ..Understanding the molecular regulators in directing the fate of neural stem cells will significantly expand our ability to instigate regeneration of our aging and/or diseased brain. ..
  3. Common Human Stem Cell Lines for Inducible Gene Expression and Knockdown
    Su Chun Zhang; Fiscal Year: 2007
    ..It will ultimately speed up the potential use of hESCs in regenerative medicine.. ..
  4. Neural Specification of Embryonic Stem Cells
    Su Chun Zhang; Fiscal Year: 2007
    ..This study will lead to an optimized procedure for generating enriched or purified neural precursor cells, which will lay the groundwork for potential future use of human ES cells in the treatment of neurological injuries and diseases. ..
  5. Stem Cell Therapy For Parkinson's Disease
    Su Chun Zhang; Fiscal Year: 2005
    ..abstract_text> ..
  6. Induction of Dopamine Neurons from Monkey Stem Cells
    Su Chun Zhang; Fiscal Year: 2003
    ..Information gained from these studies will be crucial in ultimately utilizing human ES cells to treat neurological illnesses including Parkinson?s disease. ..
  7. Neural Specification of Embryonic Stem Cells
    Su Chun Zhang; Fiscal Year: 2010
    ..Understanding the molecular regulators in directing the fate of neural stem cells will significantly expand our ability to instigate regeneration of our aging and/or diseased brain. ..