Si Ming Zhang

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. ncbi Characterization of immune genes from the schistosome host snail Biomphalaria glabrata that encode peptidoglycan recognition proteins and gram-negative bacteria binding protein
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, MSC03 2020, University of New Mexico, Albuquerque, NM 87131, USA
    Immunogenetics 59:883-98. 2007
  2. ncbi Identification and characterization of five transcription factors that are associated with evolutionarily conserved immune signaling pathways in the schistosome-transmitting snail Biomphalaria glabrata
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, MSC03 2020, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Immunol 48:1868-81. 2011
  3. ncbi Schistosomin from the snail Biomphalaria glabrata: expression studies suggest no involvement in trematode-mediated castration
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Biochem Parasitol 165:79-86. 2009
  4. ncbi Expression profiling and binding properties of fibrinogen-related proteins (FREPs), plasma proteins from the schistosome snail host Biomphalaria glabrata
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, New Mexico 97131, USA
    Innate Immun 14:175-89. 2008
  5. ncbi Fibrinogen-bearing protein genes in the snail Biomphalaria glabrata: characterization of two novel genes and expression studies during ontogenesis and trematode infection
    Si Ming Zhang
    Department of Biology, University of New Mexico, MSC03 2020, Albuquerque, NM 87131, USA
    Dev Comp Immunol 32:1119-30. 2008
  6. ncbi Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 107:21087-92. 2010
  7. ncbi Representation of an immune responsive gene family encoding fibrinogen-related proteins in the freshwater mollusc Biomphalaria glabrata, an intermediate host for Schistosoma mansoni
    Si-Ming Zhang
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Gene 341:255-66. 2004
  8. ncbi A bacterial artificial chromosome library for Biomphalaria glabrata, intermediate snail host of Schistosoma mansoni
    Coen M Adema
    Department of Biology, University of New Mexico, Albuquerque, NM, USA
    Mem Inst Oswaldo Cruz 101:167-77. 2006
  9. ncbi In vitro cercariae transformation: comparison of mechanical and nonmechanical methods and observation of morphological changes of detached cercariae tails
    Kristen A Coultas
    Center for Evolutionary and Theoretical Immunology, Department of Biology, MSC03 2020, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Parasitol 98:1257-61. 2012
  10. ncbi The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Innate Immun 3:17-27. 2011

Research Grants

  1. DIVERSE RECOGNITION CAPABILITY: AN INVERTEBRATE MODEL
    Si Ming Zhang; Fiscal Year: 2003
  2. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2007
  3. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2009
  4. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2010
  5. UNM COBRE: DIVERSE RECOGNITION CAPABILITY: INVERTEBRATE MODEL
    Si Ming Zhang; Fiscal Year: 2009

Collaborators

Detail Information

Publications15

  1. ncbi Characterization of immune genes from the schistosome host snail Biomphalaria glabrata that encode peptidoglycan recognition proteins and gram-negative bacteria binding protein
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, MSC03 2020, University of New Mexico, Albuquerque, NM 87131, USA
    Immunogenetics 59:883-98. 2007
    ....
  2. ncbi Identification and characterization of five transcription factors that are associated with evolutionarily conserved immune signaling pathways in the schistosome-transmitting snail Biomphalaria glabrata
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, MSC03 2020, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Immunol 48:1868-81. 2011
    ..This study not only advances our understanding of the snail's defenses, but also provides new perspectives about the evolution of animal immunity...
  3. ncbi Schistosomin from the snail Biomphalaria glabrata: expression studies suggest no involvement in trematode-mediated castration
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mol Biochem Parasitol 165:79-86. 2009
    ..In conclusion, our data suggest that a role of schistosomin in parasitic castration cannot be established in B. glabrata infected with either of two trematode species...
  4. ncbi Expression profiling and binding properties of fibrinogen-related proteins (FREPs), plasma proteins from the schistosome snail host Biomphalaria glabrata
    Si Ming Zhang
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, New Mexico 97131, USA
    Innate Immun 14:175-89. 2008
    ..Our results suggest that FREPs can recognize a wide range of pathogens, from prokaryotes to eukaryotes, and different categories of FREPs seem to exhibit functional specialization with respect to the pathogen encountered...
  5. ncbi Fibrinogen-bearing protein genes in the snail Biomphalaria glabrata: characterization of two novel genes and expression studies during ontogenesis and trematode infection
    Si Ming Zhang
    Department of Biology, University of New Mexico, MSC03 2020, Albuquerque, NM 87131, USA
    Dev Comp Immunol 32:1119-30. 2008
    ..Our findings further broaden our understanding of the diversity and function of the FBG-bearing protein encoded genes in B. glabrata...
  6. ncbi Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 107:21087-92. 2010
    ..FREP3 up-regulation is also associated with heightened responsiveness following priming with attenuated digenetic trematodes (acquired resistance) in this model invertebrate immune system...
  7. ncbi Representation of an immune responsive gene family encoding fibrinogen-related proteins in the freshwater mollusc Biomphalaria glabrata, an intermediate host for Schistosoma mansoni
    Si-Ming Zhang
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Gene 341:255-66. 2004
    ..glabrata and B. pfeifferi, both important intermediate hosts of the human pathogen, Schistosoma mansoni...
  8. ncbi A bacterial artificial chromosome library for Biomphalaria glabrata, intermediate snail host of Schistosoma mansoni
    Coen M Adema
    Department of Biology, University of New Mexico, Albuquerque, NM, USA
    Mem Inst Oswaldo Cruz 101:167-77. 2006
    ..This BG_BBa BAC library, available from AGI at cost to the research community, gains in relevance because BB02 strain B. glabrata is targeted whole genome sequencing by NHGRI...
  9. ncbi In vitro cercariae transformation: comparison of mechanical and nonmechanical methods and observation of morphological changes of detached cercariae tails
    Kristen A Coultas
    Center for Evolutionary and Theoretical Immunology, Department of Biology, MSC03 2020, University of New Mexico, Albuquerque, New Mexico 87131, USA
    J Parasitol 98:1257-61. 2012
    ..Interestingly, the tails are able to regenerate head-like organs/tissues and survive for at least 4 days. This intriguing change suggests unique biological features of the cells in the tails...
  10. ncbi The primary role of fibrinogen-related proteins in invertebrates is defense, not coagulation
    Patrick C Hanington
    Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Innate Immun 3:17-27. 2011
    ..Herein, we outline the range of invertebrate organisms FREPs can be found in, and detail the roles these molecules play in defense and protection against infection...
  11. ncbi Invertebrate immune systems--not homogeneous, not simple, not well understood
    Eric S Loker
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Immunol Rev 198:10-24. 2004
    ....
  12. ncbi The FREP gene family in the snail Biomphalaria glabrata: additional members, and evidence consistent with alternative splicing and FREP retrosequences. Fibrinogen-related proteins
    Si-Ming Zhang
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Dev Comp Immunol 27:175-87. 2003
    ..1 and its two truncated forms were also recovered. Although these could be the source of the truncated cDNAs, they are believed to be retrosequences...
  13. ncbi In vivo and in vitro knockdown of FREP2 gene expression in the snail Biomphalaria glabrata using RNA interference
    Yiguo Jiang
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Dev Comp Immunol 30:855-66. 2006
    ..glabrata provides an important tool for clarifying the function of genes believed to play a role in host-parasite interactions, specifically between B. glabrata and its trematode parasites, including S. mansoni...
  14. ncbi Manganese superoxide dismutase from Biomphalaria glabrata
    Younghun Jung
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    J Invertebr Pathol 90:59-63. 2005
    ..glabrata and S. mansoni). Thus, MnSOD did not determine resistance or susceptibility for these parasites, but expression of MnSOD is consistent with its involvement in a stress response of B. glabrata...
  15. ncbi Diversification of Ig superfamily genes in an invertebrate
    Si-Ming Zhang
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Science 305:251-4. 2004
    ..Diverse FREP3 transcripts are also produced. We hypothesize a mechanism present in snails that is capable of diversifying molecules involved in internal defense...

Research Grants7

  1. DIVERSE RECOGNITION CAPABILITY: AN INVERTEBRATE MODEL
    Si Ming Zhang; Fiscal Year: 2003
    ..Mechanism and Site of FREP3 Diversification; Specific Aim 2. Diversity of FREPs at the Expression Level; Specific Aim 3. Development of RNAi Techniques to Probe FREP Functions. ..
  2. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2007
    ..mansoni and its snail host. ..
  3. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2009
    ..mansoni and its snail host. ..
  4. Molecular Studies of Immunoparasitology in Snails
    Si Ming Zhang; Fiscal Year: 2010
    ..This may lead to new methods for blocking the transmission of Schistosomiasis, a snail-borne disease that affects 200 million people worldwide. ..
  5. UNM COBRE: DIVERSE RECOGNITION CAPABILITY: INVERTEBRATE MODEL
    Si Ming Zhang; Fiscal Year: 2009
    ..Ultimately, the study will have benefits for the control of schistosomiasis, a snail-borne disease that affects 200 million people world wide. ..