Rui Xin Zhang

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Serotonin Receptor 2A/C Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Evid Based Complement Alternat Med 2011:619650. 2011
  2. pmc DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia
    R X Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA Electronic address
    Neuroscience 252:359-66. 2013
  3. pmc Osteoarthritis pain mechanisms: basic studies in animal models
    R X Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Osteoarthritis Cartilage 21:1308-15. 2013
  4. doi request reprint A new rat model of bone cancer pain
    Ruixin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    Methods Mol Biol 851:261-73. 2012
  5. pmc Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 8:20. 2008
  6. pmc Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation
    R X Zhang
    Center for Integrative Medicine, School of Medicine, 3rd Floor, James Kernan Hospital Mansion, University of Maryland, Baltimore, MD 21201, USA
    Neuroscience 154:1533-8. 2008
  7. pmc Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, HSF 2, Room S209, 20 Penn Street, Baltimore, MD 21201, USA
    Eur J Pain 12:870-8. 2008
  8. ncbi request reprint Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Anesth Analg 105:1482-8, table of contents. 2007
  9. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
  10. ncbi request reprint Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Pain 118:125-36. 2005

Research Grants

Collaborators

Detail Information

Publications35

  1. pmc Serotonin Receptor 2A/C Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Evid Based Complement Alternat Med 2011:619650. 2011
    ..EA also activated serotonergic NRM neurons that project to the spinal cord. These data show that EA inhibits osteoarthritis-induced pain by enhancing spinal 5-HT2A/2C receptor activity...
  2. pmc DAMGO in the central amygdala alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia
    R X Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA Electronic address
    Neuroscience 252:359-66. 2013
    ..The data demonstrate that morphine attenuates the affective component more powerfully than it does the sensory and suggests that the sensory and the emotional-affective dimensions are underpinned by different mechanisms...
  3. pmc Osteoarthritis pain mechanisms: basic studies in animal models
    R X Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Osteoarthritis Cartilage 21:1308-15. 2013
    ..At present there are no satisfying agents for treating OA. To promote OA research and improved treatment, this review summarizes current preclinical evidence on the development of OA...
  4. doi request reprint A new rat model of bone cancer pain
    Ruixin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    Methods Mol Biol 851:261-73. 2012
    ..The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders...
  5. pmc Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 8:20. 2008
    ..This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia...
  6. pmc Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylation
    R X Zhang
    Center for Integrative Medicine, School of Medicine, 3rd Floor, James Kernan Hospital Mansion, University of Maryland, Baltimore, MD 21201, USA
    Neuroscience 154:1533-8. 2008
    ..The results suggest that spinal IL-1beta enhances NR1 phosphorylation to facilitate bone cancer pain...
  7. pmc Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, HSF 2, Room S209, 20 Penn Street, Baltimore, MD 21201, USA
    Eur J Pain 12:870-8. 2008
    ..These results suggest that EA alleviates bone cancer pain at least in part by suppressing dynorphin expression, and they support the clinical use of EA in the treatment of cancer pain...
  8. ncbi request reprint Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Anesth Analg 105:1482-8, table of contents. 2007
    ....
  9. pmc IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pain 135:232-9. 2008
    ..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain...
  10. ncbi request reprint Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Pain 118:125-36. 2005
    ..Further, bone cancer activates spinal glial cells, which may release IL-1beta and other cytokines and contribute to hyperalgesia...
  11. ncbi request reprint Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Neurosci Lett 384:339-43. 2005
    ..This suggests that EA-induced suppression of hyperalgesia is involved, at least partly, in the suppression of the spinal NK-1 receptors induced by sustained peripheral nociceptive input...
  12. ncbi request reprint Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Neurosci Lett 353:213-6. 2003
    ..These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception...
  13. ncbi request reprint Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
    Brain Res 999:135-41. 2004
    ..These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain...
  14. ncbi request reprint Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Neurosci Lett 359:85-8. 2004
    ..The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia...
  15. ncbi request reprint Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1048:235-40. 2005
    ..These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia...
  16. ncbi request reprint Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Complementary Medicine Program, Center for Integrative Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1020:12-7. 2004
    ..These results suggest selective involvement of mu and delta, but not kappa, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain...
  17. ncbi request reprint Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation
    Arthur Yin Fan
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
    J Altern Complement Med 11:323-31. 2005
    ..The present study is an investigation of the effects of a BC extract on persistent hyperalgesia and edema in rats with peripheral inflammation...
  18. ncbi request reprint Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, Department of Family Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, 3rd Floor, Baltimore, MD 21207, USA
    Am J Chin Med 34:833-44. 2006
    ..The data suggest that HLXL dosage-dependently attenuates CFA-induced inflammation and hyperalgesia, at least in part by inhibiting noxious transmission at the dorsal horn of the spinal cord...
  19. ncbi request reprint A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats
    Lixing Lao
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21201, USA
    Brain Res 1020:18-29. 2004
    ..The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain...
  20. ncbi request reprint Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats
    Bing Liu
    Center for Integrative Medicine, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
    Brain Res 1044:87-92. 2005
    ..The data suggest that EA-produced anti-hyperalgesia is mediated by PTX-sensitive Gi/o proteins and the relevant signaling pathways...
  21. pmc The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy
    Xianze Meng
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Brain Res 1414:58-65. 2011
    ..Thus, EA significantly inhibits paclitaxel-induced allodynia/hyperalgesia through spinal opioid receptors, and EA may be a useful complementary treatment for neuropathic pain patients...
  22. pmc Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesia
    Yu Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 685 W Baltimore Street, MSTF Rm 8 22, Baltimore, MD 21201, USA
    Neurochem Res 36:2104-10. 2011
    ..These data demonstrate that EA activates opioid receptors in the rACC to inhibit the affective dimension of pain...
  23. pmc Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model
    Yu Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 685 W Baltimore Street, MSTF Rm 8 22, Baltimore, MD 21201, USA
    Neurochem Res 36:1785-92. 2011
    ..These results show a correlation between EA anti-hyperalgesia and receptor expression. Collectively, the data show that EA activates supraspinal serotonin neurons to release 5-HT, which acts on spinal 5-HT1AR to inhibit hyperalgesia...
  24. ncbi request reprint Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Brain Res 1038:238-42. 2005
    ..These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations...
  25. pmc Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammation
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    BMC Complement Altern Med 7:27. 2007
    ..However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model...
  26. pmc Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system
    Aihui Li
    Center for Integrative Medicine, School of Medicine, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
    Brain Res 1186:171-9. 2007
    ..The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord...
  27. ncbi request reprint Electroacupuncture attenuates inflammation in a rat model
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    J Altern Complement Med 11:135-42. 2005
    ..However, clinical trials investigating the effectiveness of the anti-inflammatory effects of acupuncture have yielded inconsistent results, and the underlying mechanisms of acupuncture-produced anti-inflammation are unclear...
  28. ncbi request reprint Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammation
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 81:146-51. 2005
    ..These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management...
  29. pmc Rostral ventromedial medulla μ, but not κ, opioid receptors are involved in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model
    Yu Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Brain Res 1395:38-45. 2011
    ..This removes the tonic inhibition of GABA on serotonergic neurons in the RVM, and activation of these serotonergic neurons inhibits pain. EA may be used as complementary treatment for inflammatory pain...
  30. ncbi request reprint Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 78:793-7. 2004
    ..The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain...
  31. pmc Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat model
    Xianze Meng
    Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200001, PR China
    Pain 154:294-305. 2013
    ..05) and decreased p-NR1 and IL-17RA compared to control in CFA- and IL-17-injected rats. The results suggest that spinal IL-17 is produced by astrocytes and enhances p-NR1 to facilitate pain...
  32. pmc Preclinical safety evaluation of the aqueous acetone extract of Chinese herbal formula Modified Huo Luo Xiao Ling Dan
    Arthur Yin Fan
    Center for Integrative Medicine, University of Maryland, Baltimore, MD 21201, USA
    Zhong Xi Yi Jie He Xue Bao 8:438-47. 2010
    ..To investigate the safety of oral administration of Modified Huo Luo Xiao Ling Dan (HLXLD), a compound traditional Chinese herbal medicine...
  33. pmc Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats
    Rui Xin Zhang
    Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Man, 2200 Kernan Drive, Baltimore, MD 21207, USA
    J Ethnopharmacol 121:366-71. 2009
    ..The herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation...
  34. ncbi request reprint Is protein kinase C (PKC) involved in nociception?
    Hong Nie
    Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi, P R China
    Int J Neurosci 116:1115-24. 2006
    ....
  35. ncbi request reprint Protein kinase C is partly involved in c-fos protein expression of nocuously-activated neurons but may not in concomitant modulatory action through opioid receptors at the spinal level in rats
    Hong Nie
    Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China
    Sheng Li Xue Bao 56:455-60. 2004
    ....

Research Grants1

  1. Effects of Acupuncture on Bone Cancer Pain in Mice
    Ruixin Zhang; Fiscal Year: 2004
    ..These studies will set a stage for further studying the mechanisms of EA in the control and management of cancer pain. ..