Research Topics
Species | Rui Xin ZhangSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
A new rat model of bone cancer painRuixin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
Methods Mol Biol 851:261-73. 2012..The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders...
Electroacupuncture activates corticotrophin-releasing hormone-containing neurons in the paraventricular nucleus of the hypothalammus to alleviate edema in a rat model of inflammationAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
BMC Complement Altern Med 8:20. 2008..This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia...
Strain differences in pain sensitivity and expression of preprodynorphin mRNA in rats following peripheral inflammationRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Neurosci Lett 353:213-6. 2003..These results indicate that genetic factors that determine the spinal PPD mRNA and dynorphin production underlie strain-dependent differences in pain perception...- Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibiaRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Pain 118:125-36. 2005..Further, bone cancer activates spinal glial cells, which may release IL-1beta and other cytokines and contribute to hyperalgesia... - IL-1ra alleviates inflammatory hyperalgesia through preventing phosphorylation of NMDA receptor NR-1 subunit in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pain 135:232-9. 2008..05) and inhibited NR1 phosphorylation compared to saline control. The results suggest that spinal IL-1beta is produced by astrocytes and enhances NR1 phosphorylation to facilitate inflammatory pain... - Electroacupuncture attenuates bone cancer pain and inhibits spinal interleukin-1 beta expression in a rat modelRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
Anesth Analg 105:1482-8, table of contents. 2007.... - Electroacupuncture attenuates bone-cancer-induced hyperalgesia and inhibits spinal preprodynorphin expression in a rat modelRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, HSF 2, Room S209, 20 Penn Street, Baltimore, MD 21201, USA
Eur J Pain 12:870-8. 2008..These results suggest that EA alleviates bone cancer pain at least in part by suppressing dynorphin expression, and they support the clinical use of EA in the treatment of cancer pain... - Interleukin 1beta facilitates bone cancer pain in rats by enhancing NMDA receptor NR-1 subunit phosphorylationR X Zhang
Center for Integrative Medicine, School of Medicine, 3rd Floor, James Kernan Hospital Mansion, University of Maryland, Baltimore, MD 21201, USA
Neuroscience 154:1533-8. 2008..The results suggest that spinal IL-1beta enhances NR1 phosphorylation to facilitate bone cancer pain... - Endogenous and exogenous glucocorticoid suppresses up-regulation of preprodynorphin mRNA and hyperalgesia in rats with peripheral inflammationRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Neurosci Lett 359:85-8. 2004..The results also suggest that spinal PPD mRNA suppression may partially underlie the inhibition of behavioral hyperalgesia... - Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammationRui Xin Zhang
Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
Brain Res 999:135-41. 2004..These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain... - Electroacupuncture suppresses spinal expression of neurokinin-1 receptors induced by persistent inflammation in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital, 2200 Kernan Drive, Baltimore, MD 21207, USA
Neurosci Lett 384:339-43. 2005..This suggests that EA-induced suppression of hyperalgesia is involved, at least partly, in the suppression of the spinal NK-1 receptors induced by sustained peripheral nociceptive input... - Anti-hyperalgesic and anti-inflammatory effects of the modified Chinese herbal formula Huo Luo Xiao Ling Dan (HLXL) in ratsLixing Lao
Center for Integrative Medicine, School of Medicine, Department of Family Medicine, University of Maryland School of Medicine, 2200 Kernan Drive, 3rd Floor, Baltimore, MD 21207, USA
Am J Chin Med 34:833-44. 2006..The data suggest that HLXL dosage-dependently attenuates CFA-induced inflammation and hyperalgesia, at least in part by inhibiting noxious transmission at the dorsal horn of the spinal cord... - A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in ratsLixing Lao
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21201, USA
Brain Res 1020:18-29. 2004..The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain... - Spinal preprodynorphin mRNA expression in neonatal rats following peripheral inflammationRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Brain Res 1038:238-42. 2005..These data suggest that the central nervous systems of neonates and adults respond differently to peripheral noxious inputs, a fact that should be considered when selecting pain treatment strategies for neonate populations... - Acupuncture alleviates the affective dimension of pain in a rat model of inflammatory hyperalgesiaYu Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 685 W Baltimore Street, MSTF Rm 8 22, Baltimore, MD 21201, USA
Neurochem Res 36:2104-10. 2011..These data demonstrate that EA activates opioid receptors in the rACC to inhibit the affective dimension of pain... - Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat modelYu Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 685 W Baltimore Street, MSTF Rm 8 22, Baltimore, MD 21201, USA
Neurochem Res 36:1785-92. 2011..These results show a correlation between EA anti-hyperalgesia and receptor expression. Collectively, the data show that EA activates supraspinal serotonin neurons to release 5-HT, which acts on spinal 5-HT1AR to inhibit hyperalgesia... - The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathyXianze Meng
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Brain Res 1414:58-65. 2011..Thus, EA significantly inhibits paclitaxel-induced allodynia/hyperalgesia through spinal opioid receptors, and EA may be a useful complementary treatment for neuropathic pain patients... - Corticosterone mediates electroacupuncture-produced anti-edema in a rat model of inflammationAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
BMC Complement Altern Med 7:27. 2007..However, the mechanisms are not clear. The present study investigated the biochemical mechanisms of EA anti-inflammation in a rat model... - Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory systemAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, 20 Penn Street, Baltimore, MD 21201, USA
Brain Res 1186:171-9. 2007..The results demonstrate that EA inhibits transmission of noxious messages and hyperalgesia by activating supraspinal neurons that project to the spinal cord... - Rostral ventromedial medulla μ, but not κ, opioid receptors are involved in electroacupuncture anti-hyperalgesia in an inflammatory pain rat modelYu Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Brain Res 1395:38-45. 2011..This removes the tonic inhibition of GABA on serotonergic neurons in the RVM, and activation of these serotonergic neurons inhibits pain. EA may be used as complementary treatment for inflammatory pain... - Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammationRui-Xin Zhang
Complementary Medicine Program, Center for Integrative Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Brain Res 1020:12-7. 2004..These results suggest selective involvement of mu and delta, but not kappa, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain... - Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat modelXianze Meng
Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200001, PR China Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
Pain 154:294-305. 2013..05) and decreased p-NR1 and IL-17RA compared to control in CFA- and IL-17-injected rats. The results suggest that spinal IL-17 is produced by astrocytes and enhances p-NR1 to facilitate pain... - Serotonin Receptor 2A/C Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat ModelAihui Li
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Evid Based Complement Alternat Med 2011:619650. 2011..EA also activated serotonergic NRM neurons that project to the spinal cord. These data show that EA inhibits osteoarthritis-induced pain by enhancing spinal 5-HT2A/2C receptor activity... - Preclinical safety evaluation of the aqueous acetone extract of Chinese herbal formula Modified Huo Luo Xiao Ling DanArthur Yin Fan
Center for Integrative Medicine, University of Maryland, Baltimore, MD 21201, USA
Zhong Xi Yi Jie He Xue Bao 8:438-47. 2010..To investigate the safety of oral administration of Modified Huo Luo Xiao Ling Dan (HLXLD), a compound traditional Chinese herbal medicine... - Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed ratsBing Liu
Center for Integrative Medicine, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Brain Res 1044:87-92. 2005..The data suggest that EA-produced anti-hyperalgesia is mediated by PTX-sensitive Gi/o proteins and the relevant signaling pathways... - Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammationArthur Yin Fan
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21207, USA
J Altern Complement Med 11:323-31. 2005..CONCLUSIONS: The data suggest that BC produces significant antihyperalgesia and anti-inflammation effects and that the antihyperalgesia may be mediated by suppressed inflammation-induced Fos expression in the spinal dorsal horn neurons... - Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammationRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, Baltimore, MD 21207, USA
Brain Res 1048:235-40. 2005..These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia... - Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory ratsRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 78:793-7. 2004..The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain... - Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in ratsRui Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, 3rd Floor, James Kernan Hospital Man, 2200 Kernan Drive, Baltimore, MD 21207, USA
J Ethnopharmacol 121:366-71. 2009..The herbal formula Huo Luo Xiao Ling Dan (HLXL) and its modifications have been used in traditional Chinese medicine for about one hundred years to alleviate pain and inflammation... - Electroacupuncture combined with MK-801 prolongs anti-hyperalgesia in rats with peripheral inflammationRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 81:146-51. 2005..These results demonstrate that EA combined with a sub-effective dose of this NMDA receptor antagonist enhances anti-hyperalgesia, and this combination may provide an effective strategy for pain management... - Electroacupuncture attenuates inflammation in a rat modelRui-Xin Zhang
Center for Integrative Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
J Altern Complement Med 11:135-42. 2005..CONCLUSION: At 10 Hz but not 100 Hz, EA suppresses inflammation by activating the hypothalamus-pituitary-adrenal axis (HPA) and the nervous system... - Is protein kinase C (PKC) involved in nociception?Hong Nie
Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi, P R China
Int J Neurosci 116:1115-24. 2006.... - Protein kinase C is partly involved in c-fos protein expression of nocuously-activated neurons but may not in concomitant modulatory action through opioid receptors at the spinal level in ratsHong Nie
Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi 030001, China
Sheng Li Xue Bao 56:455-60. 2004....
Research Grants
- Effects of Acupuncture on Bone Cancer Pain in MiceRuixin Zhang; Fiscal Year: 2004..These studies will set a stage for further studying the mechanisms of EA in the control and management of cancer pain. ..