Affiliation: University of North Carolina
Takada M, Zhang W, Suzuki A, Kuroda T, Yu Z, Inuzuka H, et al
. FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Cancer Res. 2017;77:4881-4893 pubmed publisher
..Overall, our results revealed a pathway that cyclin E1/CDK2 activation coupled with FBW7 loss promotes CIN and tumor progression via CENP-A-mediated centromere dysfunction. Cancer Res; 77(18); 4881-93. ©2017 AACR. ..
Zhang J, Zhang Q. Using Seahorse Machine to Measure OCR and ECAR in Cancer Cells. Methods Mol Biol. 2019;1928:353-363 pubmed publisher
..This protocol is provided for researchers who are unfamiliar with the method and to aid them in carrying out the technique successfully. ..
Durand J, Zhang Q, Baldwin A. Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer. Cells. 2018;7: pubmed publisher
..Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy. ..
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, et al
. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018;361:290-295 pubmed publisher
..Mechanistically, integrated chromatin immunoprecipitation sequencing and microarray analysis showed that ZHX2 promoted nuclear factor κB activation. These studies reveal ZHX2 as a potential therapeutic target for ccRCC. ..
Zhang J, Zhang Q. VHL and Hypoxia Signaling: Beyond HIF in Cancer. Biomedicines. 2018;6: pubmed publisher
..and their physiological roles in hypoxia signaling and cancer. We will also discuss the crosstalk between VHL and NF-ÎºB signaling. Lastly, we will review the latest findings on targeting VHL signaling in cancer. ..
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, et al
. EglN2 associates with the NRF1-PGC1Î± complex and controls mitochondrial function in breast cancer. EMBO J. 2015;34:2953-70 pubmed publisher
..In addition, FDXR, as one of effectors for EglN2, contributes to breast tumorigenesis in vitro and in vivo. Our findings suggest that EglN2 regulates mitochondrial function in ERÎ±-positive breast cancer. ..
Zurlo G, Guo J, Takada M, Wei W, Zhang Q. New Insights into Protein Hydroxylation and Its Important Role in Human Diseases. Biochim Biophys Acta. 2016;1866:208-220 pubmed publisher
..Better understanding of protein hydroxylation will help identify novel therapeutic targets and their regulation mechanisms to foster development of more effective treatment strategies for various human cancers. ..