Research Topics
Genomes and Genes
| Qian ZhangSummaryAffiliation: University of Rochester Country: USA Publications
| Collaborators
|
Detail Information
Publications
Increased lymphangiogenesis in joints of mice with inflammatory arthritisQian Zhang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arthritis Res Ther 9:R118. 2007..The lymphatic system may play an important role in the pathogenesis of inflammatory arthritis...
NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1Teruhito Yamashita
Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 282:18245-53. 2007..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption...- Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosisQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 106:15843-8. 2009..These findings provide additional rationale for the therapeutic inhibition of DNA methyltransferases in ALK+ TCL. They also suggest that treatment with TNFalpha may be highly effective in this type of lymphoma... - TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral bloodQian Zhang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
Arthritis Res Ther 10:R37. 2008..The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors (OCPs) from bone marrow... - IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALKQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 108:11977-82. 2011..These results demonstrate that the oncogenic tyrosine kinase NPM-ALK induces epigenetic silencing of the IL-2Rγ gene and that IL-2Rγ acts as a tumor suppressor by reciprocally inhibiting expression of NPM-ALK... - Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)Michal Marzec
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 105:20852-7. 2008..Finally, they suggest that future immunotherapeutic protocols for this type of lymphoma may need to include the inhibition of NPM/ALK and STAT3 to achieve optimal clinical efficacy... - Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expressionZhenqiang Yao
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 281:11846-55. 2006..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease... - Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOSQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
Blood 118:3062-71. 2011..These data also show that the DNA methylation status of the intronic CpG island affects transcriptional activity of the ICOS gene and, consequently, modulates the concentration of the expressed ICOS protein... - VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanismQian Zhang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 283:13491-9. 2008.... - Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteinsRuolin Guo
Department of Pathology and Laboratory Medicine, and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 283:23084-92. 2008..Inhibition of ubiquitin-mediated Smad1 and Runx2 degradation in osteoblasts could help to treat inflammation-induced osteoporosis... - STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expressionQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104 4283, USA
Nat Med 13:1341-8. 2007..These results show that NPM1-ALK induces epigenetic silencing of STAT5A gene and that STAT5A protein can act as a key tumor suppressor by reciprocally inhibiting expression of NPM1-ALK... - TNF-alpha and pathologic bone resorptionBrendan F Boyce
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Keio J Med 54:127-31. 2005..Here we review our current understanding of the mechanisms whereby TNFa increases osteoclastogenesis in vitro and in vivo... - Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytesMonika Kasprzycka
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 181:2506-12. 2008.... 
Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approachesMariusz A Wasik
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA
Semin Oncol 36:S27-35. 2009..They also suggest that immunotherapeutic approaches to ALK(+)TCL and, possibly, other ALK-driven malignancies may require inhibition of ALK and STAT3 to achieve the optimal clinical efficacy...- STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytesQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 7 103 Founders, Philadelphia, 19104, USA
Blood 108:1058-64. 2006..Finally, these data provide further rationale for therapeutically targeting STAT3 in T-cell lymphomas and, possibly, other malignancies... - New roles for osteoclasts in boneBrendan F Boyce
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Ann N Y Acad Sci 1116:245-54. 2007..In this article, we review these findings, which support new roles for osteoclasts and OCPs in the growing field of osteoimmunology and in common pathologic conditions affecting bones and joints... - Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4+ cutaneous T-cell lymphoma cellsMichal Marzec
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Cancer Res 68:1083-91. 2008.... - PU.1 activates transcription of SHP-1 gene in hematopoietic cellsPawel Wlodarski
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 282:6316-23. 2007..1. These findings provide an insight into the structure of the hematopoietic cell-specific P2 promoter of the SHP-1 gene and identify PU.1 as the transcriptional activator of the P2 promoter... - Roles for NF-kappaB and c-Fos in osteoclastsBrendan F Boyce
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
J Bone Miner Metab 23:11-5. 2005.... - Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3Monika Kasprzycka
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
Proc Natl Acad Sci U S A 103:9964-9. 2006..These results also provide an additional rationale to therapeutically target the chimeric kinase and/or STAT3 in ALK+TCL... - Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytesMonika Kasprzycka
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
Am J Pathol 168:1631-41. 2006..Furthermore, our results indicate that Brk may play a key role in lymphomagenesis, hence identifying the kinase as a potential therapeutic target in lymphomas... - Detection of protein tyrosine-kinase (PTK) gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresisZhi-Yong Wang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Mol Diagn 5:113-20. 2003.... - STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytesQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 102:6948-53. 2005..Reversal of such gene silencing represents an attractive aim for novel anticancer therapies... - Diminished expression of the type II receptor for TGFbeta (TGFbetaRII) in T lymphocytes from patients with Sezary syndrome is not due to mutations in the receptor's poly-A tract: limitations of the standard RT-PCR in cDNA sequence analysis of homopolymeriQian Zhang
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Arch Immunol Ther Exp (Warsz) 50:421-9. 2002.... - Comparison between gene expression of conidia and germinating phase in Trichophyton rubrumLi Yang
College of Life Sciences, Wuhan University, Wuhan, 430072, China
Sci China C Life Sci 50:377-84. 2007..rubrum conidial germination, and possess significant meaning to the study of other superficial dermatophytes... - Functional roles of Cav1.3(alpha1D) calcium channels in atria: insights gained from gene-targeted null mutant miceZhao Zhang
Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA
Circulation 112:1936-44. 2005..3 Ca2+ channel-deficient mice (Cav1.3(-/-)) demonstrate sinus bradycardia with a prolonged PR interval. In the present study, we extended our study to examine the role of the Cav1.3(alpha1D) Ca2+ channel in the atria of Cav1.3(-/-) mice... - Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammationAzhar bin Ali
National University Medical Institutes, The National University of Singapore, Singapore, Singapore
Free Radic Biol Med 34:824-9. 2003..Therefore, antioxidant PON-1 is regulated at the mRNA level in a gender-specific manner by proinflammatory LPS and anti-inflammatory dexamethasone... - The use of global transcriptional analysis to reveal the biological and cellular events involved in distinct development phases of Trichophyton rubrum conidial germinationTao Liu
State Key Lab for Molecular Virology and Genetic Engineering, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PR China
BMC Genomics 8:100. 2007..Conidia are considered to be the primary cause of infections by Trichophyton rubrum... - Interactions between effects of estrogen receptor gene polymorphisms on BMD and experiences of the first spermorrhea in Chinese Han boysJing Yin
National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100050, China
Biomed Environ Sci 21:129-36. 2008..To study the interaction between polymorphisms of estrogen receptor (ER) gene and puberty on bone mineral density (BMD)... - Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidaseQian Zhang
Department of Pharmacology, Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
Arterioscler Thromb Vasc Biol 28:1627-33. 2008..However, the specific contribution of ROS to endothelial function is not well understood... - Effects of school milk intervention on cortical bone accretion and indicators relevant to bone metabolism in Chinese girls aged 10-12 y in BeijingKun Zhu
Faculty of Veterinary Science and the School of Public Health, University of Sydney, Sydney, NSW, Australia
Am J Clin Nutr 81:1168-75. 2005..We previously reported that increased milk consumption enhances growth and bone mineral accretion in Chinese girls aged 10-12 y... - Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthmaQiang Du
Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China
Can J Physiol Pharmacol 86:449-57. 2008..These data indicate that astragaloside IV may mitigate the development of characteristic features in chronic experimental asthma... - Cloning and functional study of porcine parotid hormone, a novel proline-rich proteinQian Zhang
Department of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
J Biol Chem 280:22233-44. 2005..In addition, the 30-amino acid parotid hormone was synthesized. Both the expressed and the synthetic proteins were biologically active in that they enhanced intradentinal fluid movement as measured by intradentinal dye penetration... - Differentially expressed genes in hypertensive rats developing cerebral ischemiaZhiming Zhu
Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China
Life Sci 74:1899-909. 2004..For example, the T3 receptor alpha was predominantly expressed in stroke-tissue, indicating that regeneration of nerves in stroke tissue may be facilitated by increased T3 receptor alpha expression... - Healing of maxillary alveolus in transport distraction osteogenesis for partial maxillectomyLim K Cheung
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, People s Republic of China
J Oral Maxillofac Surg 62:66-72. 2004..This study aims to evaluate histologic healing of the new bone and soft tissue in the distraction gap of maxillary alveolus after transport distraction at different consolidation intervals... - Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific mannerE Shyong Tai
Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608
FEBS Lett 546:237-40. 2003..It was restored to baseline within 24 h in females but remained below baseline for >72 h in male mice. In gonadectomized mice of both sexes, PPARalpha mRNA level was restored to baseline within 48 h after the initial decrease... - The subcellular localization of syntaxin 17 varies among different cell types and is altered in some malignant cellsQian Zhang
Department of Gastrointestinal Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
J Histochem Cytochem 53:1371-82. 2005.... - Bone mass in Chinese premenarcheal girls: the roles of body composition, calcium intake and physical activityKun Zhu
Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia
Br J Nutr 92:985-93. 2004..7%). The results indicate that premenarcheal girls should be encouraged to optimise nutrition and Ca intake and exercise regularly to achieve maximum peak bone mass... - Importance of uterine cell death, renewal, and their hormonal regulation in hamsters that show progesterone-dependent implantationQian Zhang
Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2678, USA
Endocrinology 147:2215-27. 2006..The overall results indicate that uterine cell apoptosis and proliferation patterns are highly ordered cell-specific phenomena that play an important role in maintaining the sexual cycle and pregnancy-associated uterine changes... - Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2Ling Lu
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, One Shields Avenue, GBSF 6315, Davis, CA 95616, USA
Circ Res 100:112-20. 2007.... - [Juvenile psoriatic arthritis]Shan Lu
Department of Pediatrics, Peking University Third Hospital, Beijing 100083, China
Zhongguo Dang Dai Er Ke Za Zhi 9:339-42. 2007..A treatment with nonsteroidal anti-inflammatory drugs and sulfasalazine produced no effect. Leflunomide in conjunction with anti-TNF biologic agents (Etanercept) was administered, followed by symptomatic improvement 2 weeks later... - Plus- and minus-stranded foot-and-mouth disease virus RNA quantified simultaneously using a novel real-time RT-PCRChaojiang Gu
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
Virus Genes 34:289-98. 2007..This value ranged from 83/1 to 93/1 in enriched FMDV virions, indicating that FMDV encapsidation is highly specific for plus-stranded RNAs. In addition, the method was applied to surveille the FMDV replication at animal level... - Identification of a crystal cell-specific enhancer of the black cells prophenoloxidase gene in DrosophilaKathleen M Gajewski
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genesis 45:200-7. 2007..Thus, Srp and Lz do not just specify the crystal cell lineage, but also regulate the later differentiation of these cells. Additionally, we now have a sensitive tool for marking crystal cells in live animals... - Indian hedgehog, but not histidine decarboxylase or amphiregulin, is a progesterone-regulated uterine gene in hamstersAtanu Khatua
Division of Reproductive and Developmental Biology, D4124 Medical Center North, 1161 21st Avenue South, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2678, USA
Endocrinology 147:4079-92. 2006..We conclude that similarities and dissimilarities exist in uterine expression pattern of implantation-related genes, including hormonal regulation and their event-specific importance... - Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissuesCarrie E Johnson
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 104:20820-5. 2007..Moreover, they raise the possibility that this phenomenon could be exploited therapeutically to selectively kill brain cancer cells while sparing the surrounding brain parenchyma... - Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83David Fulton
Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, Augusta, GA 30912 2500, USA
Circ Res 102:497-504. 2008..Moreover, our results demonstrate an important role for Src-mediated phosphorylation of eNOS at Tyr83 in agonist stimulation of eNOS activation and vascular relaxation... - Functional roles of a Ca2+-activated K+ channel in atrioventricular nodesQian Zhang
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, One Shields Ave, GBSF 6315, Davis, California 95616, USA
Circ Res 102:465-71. 2008..The new insights may have important implications in providing novel drug targets for the modification of AVN conduction in the treatment of atrial arrhythmias... - Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathyValeriy Timofeyev
Division of Cardiovascular Medicine, University of California, Davis, Davis, CA 95616, and Department of Veterans Affairs, Northern California Health Care System, Mather 95616, USA
J Mol Cell Cardiol 41:170-81. 2006..In summary, our data provide evidence that increased cardiac ACVI content has a salutary effect in cardiomyopathy and cardiac electrical remodeling... - Effects of two years' milk supplementation on size-corrected bone mineral density of Chinese girlsKun Zhu
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia
Asia Pac J Clin Nutr 17:147-50. 2008..0-5.9%, p < 0.05) than did the control group. Milk supplementation showed positive effects on bone mineral accretion when accounting for the changing skeletal size during growth. The effects were mainly on the lower limbs...