P J Zhang

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Adult urinary bladder tumors with rhabdomyosarcomatous differentiation: clinical, pathological and immunohistochemical studies
    Zhanyong Bing
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Diagn Pathol 6:66. 2011
  2. ncbi request reprint The role of calretinin, inhibin, melan-A, BCL-2, and C-kit in differentiating adrenal cortical and medullary tumors: an immunohistochemical study
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19147, USA
    Mod Pathol 16:591-7. 2003
  3. ncbi request reprint PDGF-A, PDGF-Rbeta, TGFbeta3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmoplasia: an immunohistochemical study
    Paul J Zhang
    University of Pennsylvania Medical Center, Philadelphia, PA 19147, USA
    Mod Pathol 18:382-7. 2005
  4. ncbi request reprint Cytokeratin 7 immunoreactivity in rectal adenocarcinomas
    Paul J Zhang
    Departments of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York, U S A
    Appl Immunohistochem Mol Morphol 11:306-10. 2003
  5. ncbi request reprint Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps: an immunohistochemical study
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA
    Arch Pathol Lab Med 127:1480-4. 2003
  6. doi request reprint TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int J Gynecol Pathol 28:10-8. 2009
  7. ncbi request reprint Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product
    Paul J Zhang
    Anatomic Pathology, 6 Founders Pavilion, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19147, USA
    Mod Pathol 16:229-35. 2003
  8. ncbi request reprint Immunoreactivity of MIC2 (CD99) in acute myelogenous leukemia and related diseases
    P J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Mod Pathol 13:452-8. 2000
  9. ncbi request reprint Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Surg Pathol 26:82-7. 2002
  10. ncbi request reprint Can Melan-A replace S-100 and HMB-45 in the evaluation of sentinel lymph nodes from patients with malignant melanoma?
    Cynthia Kucher
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Appl Immunohistochem Mol Morphol 14:324-7. 2006

Detail Information

Publications63

  1. pmc Adult urinary bladder tumors with rhabdomyosarcomatous differentiation: clinical, pathological and immunohistochemical studies
    Zhanyong Bing
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Diagn Pathol 6:66. 2011
    ..Both rhabdomyosarcoma and small cell carcinoma could be positive for synaptophysin, a potential pitfall to avoid. In addition, all of the tumors with rhabdomyosarcomatous differentiation were negative for FKHR rearrangement...
  2. ncbi request reprint The role of calretinin, inhibin, melan-A, BCL-2, and C-kit in differentiating adrenal cortical and medullary tumors: an immunohistochemical study
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19147, USA
    Mod Pathol 16:591-7. 2003
    ..C-kit is not useful in the diagnosis of adrenal tumors, and kit kinase inhibitor might have a limited role in the treatment of adrenal tumors and paraganglioma because of the low frequency of c-kit expression in these tumors...
  3. ncbi request reprint PDGF-A, PDGF-Rbeta, TGFbeta3 and bone morphogenic protein-4 in desmoplastic small round cell tumors with EWS-WT1 gene fusion product and their role in stromal desmoplasia: an immunohistochemical study
    Paul J Zhang
    University of Pennsylvania Medical Center, Philadelphia, PA 19147, USA
    Mod Pathol 18:382-7. 2005
    ..Other targets of the EWS-WT1 transcription factor other than PDGF-A may be directly responsible for the prominent tumor-associated desmoplasia seen in desmoplastic small round cell tumor...
  4. ncbi request reprint Cytokeratin 7 immunoreactivity in rectal adenocarcinomas
    Paul J Zhang
    Departments of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York, U S A
    Appl Immunohistochem Mol Morphol 11:306-10. 2003
    ....
  5. ncbi request reprint Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps: an immunohistochemical study
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA
    Arch Pathol Lab Med 127:1480-4. 2003
    ....
  6. doi request reprint TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int J Gynecol Pathol 28:10-8. 2009
    ..TTF 1 immunostaining has the potential to misguide a pathologist to conclude an ovarian or endometrial tumor being a lung metastasis. However, the role of TTF-1 in female genital tract and its tumors is unknown...
  7. ncbi request reprint Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product
    Paul J Zhang
    Anatomic Pathology, 6 Founders Pavilion, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19147, USA
    Mod Pathol 16:229-35. 2003
    ..Detection of EWS-WT1 fusion becomes critical for the diagnosis when the characteristic divergent phenotype cannot be detected immunohistochemically...
  8. ncbi request reprint Immunoreactivity of MIC2 (CD99) in acute myelogenous leukemia and related diseases
    P J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104 4283, USA
    Mod Pathol 13:452-8. 2000
    ..Caution should be taken when using MIC2 as a marker for Ewing's sarcoma/ primitive neuroectodermal tumor or lymphoblastic lymphoma on paraffin sections of either soft tissue or bone marrow specimens...
  9. ncbi request reprint Immunoprofile of MITF, tyrosinase, melan-A, and MAGE-1 in HMB45-negative melanomas
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Surg Pathol 26:82-7. 2002
    ..Melanocyte-specific transcription factor is not a useful marker for desmoplastic melanoma...
  10. ncbi request reprint Can Melan-A replace S-100 and HMB-45 in the evaluation of sentinel lymph nodes from patients with malignant melanoma?
    Cynthia Kucher
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Appl Immunohistochem Mol Morphol 14:324-7. 2006
    ..Melan-A, although very specific, cannot replace the use of S-100 and HMB-45 for the detection of metastatic melanoma in SLNs. It can, however, substitute for HMB-45 with equally good results...
  11. ncbi request reprint Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi
    Cynthia Kucher
    Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Dermatopathol 26:452-7. 2004
    ..Therefore, we investigated whether immunohistochemical staining for Melan-A and Ki-67 expression can be used to discriminate these lesions, distinguishing between epithelioid and spindle cell compartments of the lesions...
  12. ncbi request reprint Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Surg Pathol 31:129-40. 2007
    ..Rather, it likely signifies important biologic changes that alter tumor-stromal interactions and contribute to lymphatic spread and tumor progression...
  13. ncbi request reprint Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin
    Haohai Liang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Surg Pathol 31:304-10. 2007
    ..Our results suggest that podoplanin can be a useful tool to distinguish primary skin adnexal carcinomas form adenocarcinomas metastatic to skin with high sensitivity (94.5%) and specificity (97.2%)...
  14. pmc HER-2/neu overexpression as a predictor for the transition from in situ to invasive breast cancer
    Robert E Roses
    Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Cancer Epidemiol Biomarkers Prev 18:1386-9. 2009
    ..01). These data indicate that HER2 overexpression in DCIS lesions predicts the presence of invasive foci in patients with DCIS and suggest that targeting of HER2 in an early disease setting may forestall or prevent disease progression...
  15. ncbi request reprint Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix
    Zoltan Gombos
    Department of Pathology and Laboratory Medicine and Division of Gynecologic Oncology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Clin Cancer Res 11:8364-71. 2005
    ..Lymphatic invasion and nodal metastasis plays a major role in the spread of cervical cancer; however, little is known about the mechanisms whereby tumor cells enter the lymphatic system...
  16. ncbi request reprint Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease
    F Fogt
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Presbyterian Medical Center, Philadelphia, PA 19104, USA
    Int J Mol Med 13:211-4. 2004
    ..With restoration of architectural morphology, the integrity of the lamina propria in regards to the distribution of lymph vessels is restored...
  17. ncbi request reprint Hypoxia in human intraperitoneal and extremity sarcomas
    S M Evans
    From the Schools of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Radiat Oncol Biol Phys 49:587-96. 2001
    ..Using fluorescent immunohistochemical techniques, we provide data on the presence and distribution of EF5 binding, as a surrogate for hypoxia, in human spindle cell tumors...
  18. ncbi request reprint Comparison of p63 and p73 expression in benign and malignant salivary gland lesions
    Raja R Seethala
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Head Neck 27:696-702. 2005
    ..In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors...
  19. ncbi request reprint Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions
    Raja R Seethala
    University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mod Pathol 17:1491-6. 2004
    ..These findings support the notion that giant cells in giant cell lesions are likely derived from adjacent mononuclear cells and Mitf might play a role in the multinucleation process of such cells...
  20. ncbi request reprint Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix
    Kimberly L Dumoff
    Department of Pathology and Laboratory Medicine, Division of Gynecologic Oncology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Mod Pathol 18:97-104. 2005
    ..Further study of the biological function of the M2A antigen may shed some light on the interaction of tumor cells with lymphatics...
  21. doi request reprint Embryonal and alveolar rhabdomyosarcoma of parameningeal sites in adults: a report of 13 cases
    Kathleen T Montone
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Int J Surg Pathol 17:22-30. 2009
    ..Disease can occur in the elderly. Desmin and myogenin can aid in the diagnosis but cytokeratin reactivity can be seen and care must be taken not to diagnose carcinoma...
  22. ncbi request reprint Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion
    Brian J Czerniecki
    Department of Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 67:1842-52. 2007
    ..DC1 vaccination strategies may therefore have potential for both the prevention and the treatment of early breast cancer...
  23. pmc Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis
    Xiaowei Xu
    Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Pathol 39:901-9. 2008
    ..Lymphatic invasion is an underobserved phenomenon in primary melanomas that can be better detected by immunohistochemical staining. The presence of lymphatic invasion may be a clinically useful predictor of regionally metastatic disease...
  24. doi request reprint The presence of micropapillary features and retraction artifact in core needle biopsy material predicts lymph node metastasis in breast carcinoma
    Geza Acs
    Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Am J Surg Pathol 33:202-10. 2009
    ....
  25. ncbi request reprint Corticomedullary mixed tumor of the adrenal gland with concurrent adrenal myelolipoma
    Albert Y Chu
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Arch Pathol Lab Med 127:e329-32. 2003
    ..The diagnosis of adrenal corticomedullary mixed tumor was confirmed by both immunohistochemistry and electron microscopy. To our knowledge, this is the eighth well-documented report of this rare tumor...
  26. doi request reprint Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker?
    Edward B Lee
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19106, USA
    J Neuropathol Exp Neurol 68:482-8. 2009
    ..Our observations may have implications for the classification of these rare sellar neoplasms, all the while acknowledging the morphological diversity of pituicyte-related neoplasms...
  27. pmc Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 162:1789-806. 2003
    ..Hypoxia-inducible Epo signaling may play a significant role in the aggressive behavior and treatment resistance of hypoxic cervical cancers...
  28. ncbi request reprint Role of different immunostaining patterns in HercepTest interpretation and criteria for gene amplification as determined by fluorescence in situ hybridization
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Appl Immunohistochem Mol Morphol 11:222-9. 2003
    ..Our results suggest that a high concordance (95.8%) between HER-Z overexpression and GA can be achieved by using more stringent pattern-modified criteria for judging protein overexpression and combined criteria for GA...
  29. doi request reprint IMP-3 is differentially expressed in normal and neoplastic lymphoid tissue
    Rebecca L King
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    Hum Pathol 40:1699-705. 2009
    ..However, there does appear to be some association with the latter group of lymphomas, which may prove to have diagnostic or therapeutic relevance as the biologic role of IMP-3 is further elucidated...
  30. ncbi request reprint Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Cancer 95:969-81. 2002
    ....
  31. doi request reprint Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors
    Zhanyong Bing
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19094, USA
    Appl Immunohistochem Mol Morphol 16:316-21. 2008
    ..The significance of cytoplasmic expression of WT-1 in GIST and some smooth muscle tumors is unclear and warrant further investigation. The potential roles of WT-1 in the diagnosis and treatment of GIST were discussed...
  32. ncbi request reprint Expression of neurotrophin receptor Trk-C in nevi and melanomas
    Xiaowei Xu
    Hospital of University of Pennsylvania, Philadelphia, PA, USA
    J Cutan Pathol 30:318-22. 2003
    ..In addition, Trk oncogenes have been shown to be rearranged in some non-neuronal neoplasms. Recently, immunoexpression of NT-3 has been shown to be significantly higher in melanomas than in banal nevi on cryostat tissue...
  33. ncbi request reprint D2-40 functions as an effective chondroid marker distinguishing true chondroid tumors from chordoma
    Jason T Huse
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 6th Floor Founders, Philadelphia, PA 19104, USA
    Acta Neuropathol 113:87-94. 2007
    ..We also demonstrate D2-40 immunoreactivity in two cases of chordoid meningioma and, in doing so, tentatively provide a means to distinguish this tumor from chordoma...
  34. ncbi request reprint D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas
    Subhojit Roy
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 6 Founders, Philadelphia, PA, 19104, USA
    Acta Neuropathol 109:497-502. 2005
    ..In summary, the monoclonal antibody D2-40 is a useful marker to distinguish HB from CRCC...
  35. ncbi request reprint WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Int J Gynecol Pathol 23:110-8. 2004
    ..Our results suggest that WT1 expression in epithelial tumors of the female genital tract may be related to cell differentiation and histologic subtypes of carcinomas, rather than to primary site of origin...
  36. ncbi request reprint Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions
    Jasvir S Khurana
    Department of Pathology, Temple University Hospital, Philadelphia, PA 19140, USA
    Arch Pathol Lab Med 128:1267-69. 2004
    ..Skeletal metastases from epithelial tumors may be either bone-forming (blastic) or non-bone-forming (lytic)...
  37. doi request reprint Cutaneous sarcomatoid carcinoma with features of giant cell tumor of soft parts--a case report
    Bo Feng
    Temple University Hospital, Philadelphia, PA 19140, USA
    Am J Dermatopathol 30:395-7. 2008
    ..The epithelial component resembles a skin adnexal tumor, and the sarcomatous component resembles a giant cell tumor of soft parts...
  38. ncbi request reprint Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma
    Albert Y Chu
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Mod Pathol 18:105-10. 2005
    ..We conclude that D2-40 immunoreactivity is sensitive for cells of mesothelial origin, and may be useful in the differential diagnosis of epithelioid malignant mesothelioma vs adenocarcinoma...
  39. ncbi request reprint Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation
    Kimberly L Dumoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Mod Pathol 19:708-16. 2006
    ..Prospective studies involving larger numbers of patients are needed to further evaluate the clinical utility of examination of podoplanin expression in patients with cervix carcinoma...
  40. ncbi request reprint Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications
    G Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Clin Pathol 115:85-98. 2001
    ..In tumors with histologically equivocal features, immunohistochemical detection of E-cadherin expression can be a useful diagnostic tool for the differentiation of ductal and lobular carcinomas of the breast...
  41. ncbi request reprint Downregulation of gelsolin correlates with the progression to breast carcinoma
    J S Winston
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 65:11-21. 2001
    ..06). In summary, the frequency of gelsolin deficiency increases significantly with progression from ADH to DCIS to ICA. Additionally, gelsolin expression may be an independent marker of prognosis...
  42. ncbi request reprint Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications
    P J Zhang
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Arch Pathol Lab Med 123:812-6. 1999
    ..These results suggest a role for villin in the differential diagnosis of neuroendocrine tumors...
  43. pmc Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation
    Peter T Nelson
    Department of Pathology and Laboratory Medicine, the Division of Anatomical Pathology, University of Pennsylvania, Philadelphia 19104 4283, USA
    Am J Pathol 160:1201-6. 2002
    ..These findings indicate that implanted hNT neurons survive for >2 years in the human brain without deleterious effects...
  44. ncbi request reprint C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significance
    Janice V Scobie
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Int J Gynecol Pathol 22:149-55. 2003
    ..Expression of c-kit may be a potentially adverse prognostic feature in endometrial adenocarcinoma. Patients with c-kit-positive advanced endometrial adenocarcinoma might benefit from tyrosine-kinase-inhibitor therapy...
  45. pmc Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation
    S M Kumar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Oncogene 31:4898-911. 2012
    ..The results suggest that CSC phenotype is dynamic and may be acquired through dedifferentiation. Oct4-mediated tumor cell dedifferentiation may have an important role during tumor progression...
  46. ncbi request reprint Diagnostic value of differential expression of CK19, Galectin-3, HBME-1, ERK, RET, and p16 in benign and malignant follicular-derived lesions of the thyroid: an immunohistochemical tissue microarray analysis
    J E Barroeta
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Endocr Pathol 17:225-34. 2006
    ....
  47. ncbi request reprint Induction of antitumor immunity via intratumoral tetra-costimulator protein transfer
    G Zheng
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Cancer Res 61:8127-34. 2001
    ..Hence, combinatorial costimulator transfer, coupled to intratumoral delivery, may have special advantages for the induction of antitumor immunity...
  48. ncbi request reprint Lymphatic vessel density is significantly increased in melanoma
    T A Giorgadze
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Cutan Pathol 31:672-7. 2004
    ....
  49. ncbi request reprint Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation
    Jeffrey D Goldsmith
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19147, USA
    Am J Surg Pathol 26:1627-33. 2002
    ..In addition to its role as a germ cell marker, PLAP may also be used as a myogenic marker in the diagnosis of soft tissue tumors...
  50. pmc Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome
    Sydney M Evans
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6072, USA
    Int J Radiat Oncol Biol Phys 69:1024-31. 2007
    ..EF5, a 2-nitroimidazole hypoxia marker, was used to study the presence, levels, and prognostic significance of hypoxia in primary head and neck squamous cell tumors...
  51. doi request reprint Glomus tumor
    Zoltan Gombos
    Department of Pathology and Laboratory Medicine, Lafayette General Medical Center, Lafayette, LA 70505, USA
    Arch Pathol Lab Med 132:1448-52. 2008
    ..A malignant counterpart of this lesion exists but is extremely rare...
  52. pmc Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hum Pathol 39:1385-95. 2008
    ..Tumor grade appeared to be prognostically important in cardiac sarcoma. Long survival was achieved in patients who survived the initial surgery well...
  53. ncbi request reprint Fibrillin and other matrix proteins in mitral valve prolapse syndrome
    Joseph F Nasuti
    Hospital of University of Pennsylvania, Philadelphia, PA, USA
    Ann Thorac Surg 77:532-6. 2004
    ..The present study examined the distribution of fibrillin and other extracellular matrix proteins in patients with isolated MVPS...
  54. ncbi request reprint Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte?
    Navneet Narula
    Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 79:1333-7; discussion 1337. 2005
    ..Because ischemic damage to myocytes is also known to induce apoptosis, we evaluated the prevalence of apoptosis in MFL cells in nine ischemic cardiomyopathic hearts explanted during transplantation...
  55. ncbi request reprint The role of beta-catenin, TGF beta 3, NGF2, FGF2, IGFR2, and BMP4 in the pathogenesis of mesenteric sclerosis and angiopathy in midgut carcinoids
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Hum Pathol 35:670-4. 2004
    ..The level of NGF-2 expression was significantly lower in group I than in group III, possibly indicating abnormal angiogenesis in the formation of angiopathy...
  56. ncbi request reprint Case report: glomus tumor of the colon
    Madalina Tuluc
    Department of Pathology, Temple University Hospital, Philadelphia, PA 19140, USA
    Ann Clin Lab Sci 35:97-9. 2005
    ..The histology and immunohistochemical profile of the tumor are described and the literature on visceral glomus tumors is reviewed...
  57. ncbi request reprint Extrathoracic solitary fibrous tumor of the pelvic peritoneum with central malignant degeneration on CT and MRI
    Arastoo Vossough
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    J Magn Reson Imaging 22:684-6. 2005
    ....
  58. ncbi request reprint Immunoprofile of endocervical and endometrial stromal cells and its potential application in localization of tumor involvement
    Julieta E Barroeta
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Int J Gynecol Pathol 26:76-82. 2007
    ..The functional status of the endometrium had no effect on the immunoprofile. The pattern of CD34 and CD10 immunostaining in stromal cells might be helpful in determining tumor involvement in uterine and cervical sites...
  59. ncbi request reprint Lymphatic and blood vessel density in the follicular patterned lesions of thyroid
    Tamar A Giorgadze
    Department of Pathology, East Tennessee State University, Johnson City, TN 37604, USA
    Mod Pathol 18:1424-31. 2005
    ..63, 15.04, and 0.11 respectively; P<0.0001). The results of the study show that intratumoral lymphatic vessel density may serve as a useful tool in the differential diagnosis of follicular patterned lesions of thyroid...
  60. pmc Mitotic recombination as evidence of alternative pathogenesis of gastrointestinal stromal tumours in neurofibromatosis type 1
    Douglas R Stewart
    J Med Genet 44:e61. 2007
    ..Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours that commonly harbour oncogenic mutations in KIT or PDGFRA and are thought to arise from the interstitial cells of Cajal (ICC; the pacemaker cells of the gut)...
  61. pmc Cancer/testis (CT) antigens are expressed in fetal ovary
    Peter T Nelson
    Sanders Brown Center on Aging and Dept of Pathology, University of Kentucky, Lexington, KY, USA
    Cancer Immun 7:1. 2007
    ..We conclude that CT antigens are regularly expressed in fetal ovarian germ cells and might play an important role in male and female germ cell biology...
  62. ncbi request reprint Tyrosinase expression in malignant melanoma, desmoplastic melanoma, and peripheral nerve tumors
    Xiaowei Xu
    Arch Pathol Lab Med 127:1083-4; author reply 1084-5. 2003
  63. ncbi request reprint Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation
    Tamar A Giorgadze
    Department of Pathology, East Tennessee State University, Johnson City, Tennessee 19104, USA
    Cancer 108:186-97. 2006
    ....