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Genomes and GenesSpecies | Luoping ZhangSummaryAffiliation: University of California Country: USA Publications
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Publications
The nature of chromosomal aberrations detected in humans exposed to benzeneLuoping Zhang
School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley 94720 7360, USA
Crit Rev Toxicol 32:1-42. 2002..Leukemia cases associated with benzene exposure are, however, more likely to contain clonal chromosome aberrations then those arising de novo in the general population...- Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workersLuoping Zhang
School of Public Health, University of California, Berkeley, California, USA
Environ Mol Mutagen 48:467-74. 2007..However, they do not rule out the possibility that other rearrangements of the MLL gene at chromosome 11q23 may be induced by benzene... - Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workersLuoping Zhang
School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Chem Biol Interact 153:117-22. 2005..We are currently investigating potential mechanisms for this induction of selective aneuploidy... 
Systems biology of human benzene exposureLuoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 184:86-93. 2010....
Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanismsLuoping Zhang
School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720 7356, USA
Mutat Res 681:150-68. 2009..To test these hypotheses, we recommend that future studies apply biomarkers validated for other chemical leukemogens to the study of formaldehyde...- Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzeneLuoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
Carcinogenesis 32:605-12. 2011..Together, these findings confirm that benzene exposure is associated with specific chromosomal aneuploidies in hematopoietic cells, which suggests that such aneuploidies may play roles in benzene-induced leukemogenesis... - Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessmentLuoping Zhang
School of Public Health, University of California, Berkeley, California 94720 7356, USA
Environ Mol Mutagen 51:181-91. 2010.... - Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cellsLuoping Zhang
School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
Cancer Epidemiol Biomarkers Prev 19:80-8. 2010.... - Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workersYu Sheng Lin
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
Environ Health Perspect 115:28-34. 2007..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts... - Human benzene metabolism following occupational and environmental exposuresStephen M Rappaport
School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 184:189-95. 2010..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway... - Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzeneZhiying Ji
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
Environ Mol Mutagen 53:218-26. 2012..The findings suggest that benzene exposure induces aneuploidies in both blood cells and sperm within the same individuals, but selectively affects chromosome 21 in blood lymphocytes and the sex chromosomes in sperm... - Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese menFrancesco Marchetti
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Environ Health Perspect 120:229-34. 2012..We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy... - Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platformsCliona M McHale
School of Public Health, University of California, Berkeley, CA 94720, USA
Genomics 93:343-9. 2009..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified... - Protein adducts as biomarkers of human benzene metabolismStephen M Rappaport
School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
Chem Biol Interact 153:103-9. 2005..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene... - Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolismSungkyoon Kim
School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
Carcinogenesis 27:772-81. 2006..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures... - Toxicogenomic profiling of chemically exposed humans in risk assessmentCliona M McHale
School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
Mutat Res 705:172-83. 2010.... - Global gene expression profiling of a population exposed to a range of benzene levelsCliona M McHale
School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
Environ Health Perspect 119:628-34. 2011..Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers... - Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjectsCliona M McHale
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Toxicology 229:101-13. 2007..Further examination of the role of these genes in dioxin induced-toxicity is warranted... - Use of 'Omic' technologies to study humans exposed to benzeneMartyn T Smith
School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Chem Biol Interact 153:123-7. 2005..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene... - Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workersMatthew S Forrest
School of Public Health, University of California, Berkeley, California 94720-7360, USA
Environ Health Perspect 113:801-7. 2005..Thus, microarray analysis along with real-time PCR confirmation reveals that altered expressions of CXCL16, ZNF331, JUN, and PF4 are potential biomarkers of benzene exposure... - Molecular biomarkers for the study of childhood leukemiaMartyn T Smith
Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Toxicol Appl Pharmacol 206:237-45. 2005..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia... - The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cellsZhiying Ji
Department of Environmental Health Sciences, University of California, Berkeley, 94720, USA
Mutagenesis 24:367-72. 2009.... - The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitroAndrew J Olaharski
Molecular Epidemiology and Toxicology Laboratory, School of Public Health, University of California, Berkeley, California 94720-7360, USA
Toxicol Sci 93:341-7. 2006..We conclude that TSA is both a clastogen and aneugen in the TK6 cell line and propose that the observed cytostatic and apoptotic properties of TSA may partially be due to this genotoxicity... - An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesisXuefeng Ren
Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
Environ Health Perspect 119:11-9. 2011..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure... - Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinoneXuefeng Ren
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720, USA
Toxicol Sci 107:367-75. 2009..Our data suggests that WRN plays an important role in the surveillance of and protection against DNA damage induced by HQ. This provides mechanistic support for the link between WRN and benzene-induced hematotoxicity... - Evidence that humans metabolize benzene via two pathwaysStephen M Rappaport
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
Environ Health Perspect 117:946-52. 2009..This led us to speculate that an unidentified metabolic pathway was mainly responsible for benzene metabolism at ambient levels... - Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriolLuoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720, USA
Environ Mol Mutagen 45:388-96. 2005..These data support the notion that benzene metabolites affect the ploidy status of specific chromosomes more than others and may initiate or promote leukemia induction through these specific effects... - Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cellsXuefeng Ren
Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
PLoS ONE 6:e14546. 2011..The aim of the present study was to examine the effects of silencing WRN in p53 deficient HL60 and p53 wild-type TK6 hematopoietic cells, in order to further the understanding of WRN-associated tumorigenesis... - Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidyCaihong Xing
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
Environ Health Perspect 118:833-9. 2010..Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Occupational Safety and Health Administration... - Genome-wide functional profiling reveals genes required for tolerance to benzene metabolites in yeastMatthew North
Department of Nutritional Science and Toxicology, University of California, Berkeley, California, United States of America
PLoS ONE 6:e24205. 2011..Many of the yeast genes identified have human orthologs that may modulate human benzene toxicity in a similar manner and could play a role in benzene exposure-related disease... - Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in CaliforniaMelinda C Aldrich
University of California Berkeley, 2150 Shattuck Avenue, Suite 500, Berkeley, CA 94720 7380, USA
Cancer Epidemiol Biomarkers Prev 15:578-81. 2006..The mechanistic basis for this 2-fold variation in frequency of TEL-AML1 may be due to ethnic-specific risk factors or genetics and should be explored further... - Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrationsSungkyoon Kim
School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
Pharmacogenet Genomics 17:789-801. 2007.... - Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypesLuoping Zhang
School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720-7360, USA
Mutat Res 558:63-74. 2004..Together, these studies suggest that low levels of occupational BD exposure do not pose a significant risk of genetic damage... - Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemiaGhislaine Scelo
School of Public Health, University of California Berkeley, Berkeley, California 94704 7380, USA
Environ Health Perspect 117:133-9. 2009..Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia... - Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinoneNoe Galvan
Molecular Epidemiology and Toxicology Laboratory, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
Mutat Res 649:54-61. 2008..Further studies in bone marrow-derived stem or progenitor cells are required to confirm our findings in HeLa cells and expand our ability to extrapolate the results to benzene toxicity in humans... - Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposureWilliam Jaime Jo
Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA
Toxicol Appl Pharmacol 241:294-302. 2009..Based on these findings, we propose a novel role for the MYST1 gene in human sensitivity to arsenic... - Non-linear production of benzene oxide-albumin adducts with human exposure to benzeneStephen M Rappaport
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
J Chromatogr B Analyt Technol Biomed Life Sci 778:367-74. 2002..To our knowledge, this is the first study to investigate the linearity of human metabolism of a carcinogen based upon protein adducts... - Using bioinformatic approaches to identify pathways targeted by human leukemogensReuben Thomas
Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA
Int J Environ Res Public Health 9:2479-503. 2012..However, using two-class random forests to estimate leukemogen and non-leukemogen patterns, we estimated a 76% chance of distinguishing a random leukemogen/non-leukemogen pair from each other... - Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessmentCliona M McHale
Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Carcinogenesis 33:240-52. 2012..These approaches will inform our understanding of the mechanisms of benzene toxicity and identify additional biomarkers of exposure, early effect and susceptibility useful for risk assessment... - Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH)Patricia A Escobar
Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, California 94720, USA
Mutagenesis 22:321-7. 2007..Comet-FISH also appears to be a useful approach for detecting and comparing damage to specific chromosome regions of significance in leukaemogenesis... - Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenicChristine M Hegedus
School of Public Health, University of California, Berkeley, California 94720 7356, USA
Toxicol Sci 106:74-82. 2008..Further studies are warranted to investigate the role of HBD-1 in As-related toxicity... - Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph ConsortiumChristine F Skibola
237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
Am J Epidemiol 171:267-76. 2010..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology... - Reproductive and developmental toxicity of formaldehyde: a systematic reviewAnh Duong
School of Public Health, University of California, Berkeley, CA 94720, USA
Mutat Res 728:118-38. 2011..Together with mechanistic and animal studies, this will allow us to better understand the systemic effect of formaldehyde exposure... - Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidateMichele Fromowitz
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
Environ Mol Mutagen 53:488-91. 2012..In vitro assays, such as the in vitro micronucleus assay, will be essential as international chemical policy is increasingly utilizing green chemistry principles that require more toxicological testing... - Benzene, the exposome and future investigations of leukemia etiologyMartyn T Smith
Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 192:155-9. 2011..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology... - Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicityXuefeng Ren
Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
Environ Health Perspect 119:771-7. 2011..We found that yeast deletion mutants lacking MTQ2 were highly resistant to iAs exposure. The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase... - Formaldehyde and leukemia: an updated meta-analysis and evaluation of biasErika Schwilk
Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA
J Occup Environ Med 52:878-86. 2010..Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia... - Formaldehyde in China: production, consumption, exposure levels, and health effectsXiaojiang Tang
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
Environ Int 35:1210-24. 2009..The lack of quality epidemiological studies and basic data on exposed populations emphasizes the need for more extensive studies on formaldehyde and its related health effects in China... - The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell linesXuefeng Ren
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Arch Toxicol 87:189-96. 2013..Future studies are needed to delineate the role of this pathway in mitigating FA-induced toxicity, particularly in hematopoietic stem cells, the target cells in leukemia... - Predicted toxicity of the biofuel candidate 2,5-dimethylfuran in environmental and biological systemsJimmy Phuong
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Environ Mol Mutagen 53:478-87. 2012..Although inadequate for a stand-alone risk assessment, our data suggest that DMF combustion intermediates pose a much broader range of hazards than DMF itself, and that both should be further investigated... - Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in CaliforniaCliona M McHale
School of Public Health, University of California, Berkeley 94720-7360, USA
Genes Chromosomes Cancer 37:36-43. 2003..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X... - Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeastWilliam J Jo
Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California 94720, USA
Toxicol Sci 111:424-36. 2009..Many of the identified yeast genes have orthologs in humans that could potentially modulate arsenic toxicity in a similar manner as their yeast counterparts... - The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylasesAndrew J Olaharski
School of Public Health, University of California Berkeley, Berkeley, California, USA
PLoS Genet 1:e77. 2005..These findings demonstrate that humans are potentially exposed to epigenetic toxicants that inhibit sirtuin deacetylases... - Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
Nat Genet 41:873-5. 2009..7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1)... - Paternal smoking and risk of childhood acute lymphoblastic leukemia: systematic review and meta-analysisRuiling Liu
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
J Oncol 2011:854584. 2011..Future epidemiologic studies should assess paternal smoking during well-defined exposure windows and should include biomarkers to assess smoking exposure and toxicological mechanisms... - Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patchesRoel Vermeulen
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
J Environ Monit 8:1143-8. 2006..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory... - Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposureMin Shen
Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
Environ Mol Mutagen 49:453-7. 2008..Benzene exposure may induce mtDNA amplification, possibly in response to oxidative stress caused by benzene. The finding needs to be replicated by other studies... - Residue levels of HCHs, DDTs and PCBs in shellfish from coastal areas of east Xiamen Island and Minjiang Estuary, ChinaWeiqi Chen
Key Laboratory for Marine Environmental Science of MOE, Environmental Science Research Center, Xiamen University, China
Mar Pollut Bull 45:385-90. 2002..The residue levels and compositions of HCHs, DDTs and PCBs are discussed... - Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in ChinaRoel Vermeulen
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
Ann Occup Hyg 48:105-16. 2004..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects... - Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemiaShichun Zheng
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
Cancer Res 64:2000-6. 2004..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL... - Hematotoxicity in workers exposed to low levels of benzeneQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI, National Institutes of Health (NIH, Department of Health and Human Services (DHHS, Bethesda, MD 20892, USA
Science 306:1774-6. 2004..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations... - Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzeneQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
Chem Biol Interact 153:111-5. 2005..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function... - Persistent organochlorine pollutants in surface sediments and economic shellfish of Minjiang Estuary-Mazu and Xiamen-Jinmen sea areasWeiqi Chen
State Key Laboratory of Marine Environmental Science (Xiamen University, Environmental Science Research Center, Xiamen University, Xiamen, 361005, P.R. China
J Environ Sci Health A Tox Hazard Subst Environ Eng 40:1895-903. 2005..The concentration distributions, compositions, and residue levels of these OCs are extensively discussed and evaluated... - Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomicsRoel Vermeulen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA
Proc Natl Acad Sci U S A 102:17041-6. 2005.... - Modeling human metabolism of benzene following occupational and environmental exposuresSungkyoon Kim
School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers... - Environmental risk assessment of pesticides on aquatic life in Xiamen, ChinaDavide Calamari
Department of Structural and Functional Biology, University of Insubria, Via J H Dunant, 21100 Varese, Italy
Toxicol Lett 128:45-53. 2002..This study could represent a cost-effective method that may be used before engaging in expensive monitoring programs for pesticide use in developing countries, where analytical facilities are lacking... - In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemiaJoseph L Wiemels
Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
Blood 99:3801-5. 2002.... - Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicityMin Shen
Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 27:2083-9. 2006..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity... - Validation of an agricultural non-point source (AGNPS) pollution model for a catchment in the Jiulong River watershed, ChinaJianchang Liu
State Key Laboratory of Urban and Regional Ecology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
J Environ Sci (China) 20:599-606. 2008..Erosivity and other parameters had little influence on the hydrological and quality outputs... - Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16)Cliona M McHale
Blood 101:4640-1. 2003 - Heavy metal contamination in western Xiamen Bay sediments and its vicinity, ChinaLuoping Zhang
State Key Laboratory of Marine Environmental Science, Environmental Science Research Center, Xiamen University, Xiamen, Fujian 361005, PR China
Mar Pollut Bull 54:974-82. 2007..This study shows that using the sediment quality standard criteria only to assess sediments cannot properly reflect sediment contamination. A multiple approaches should be applied for the sediment quality assessment... - Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populationsQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Immunogenetics 59:839-52. 2007..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted... - Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzeneQing Lan
Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Cancer Res 65:9574-81. 2005..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
Research Grants
- Biomarkers of Formaldehyde Exposure and ToxicityLuoping Zhang; Fiscal Year: 2009..The data produced from these studies will be useful to public health agencies in their evaluation of the leukemia risk presented by formaldehyde. ..
- Biomarkers of Formaldehyde Exposure and ToxicityLuoping Zhang; Fiscal Year: 2010..The data produced from these studies will be useful to public health agencies in their evaluation of the leukemia risk presented by formaldehyde. ..