Luoping Zhang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The nature of chromosomal aberrations detected in humans exposed to benzene
    Luoping Zhang
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley 94720 7360, USA
    Crit Rev Toxicol 32:1-42. 2002
  2. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
  3. ncbi request reprint Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
  4. ncbi request reprint Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 48:467-74. 2007
  5. pmc Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
  6. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
  7. pmc Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
  8. ncbi request reprint Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
  9. pmc Toxicogenomic profiling of chemically exposed humans in risk assessment
    Cliona M McHale
    School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
    Mutat Res 705:172-83. 2010
  10. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010

Detail Information

Publications76

  1. ncbi request reprint The nature of chromosomal aberrations detected in humans exposed to benzene
    Luoping Zhang
    School of Public Health, Division of Environmental Health Sciences, University of California, Berkeley 94720 7360, USA
    Crit Rev Toxicol 32:1-42. 2002
    ..Leukemia cases associated with benzene exposure are, however, more likely to contain clonal chromosome aberrations then those arising de novo in the general population...
  2. pmc Albumin adducts of electrophilic benzene metabolites in benzene-exposed and control workers
    Yu Sheng Lin
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7431, USA
    Environ Health Perspect 115:28-34. 2007
    ..Metabolism of benzene produces reactive electrophiles, including benzene oxide (BO), 1,4-benzoquinone (1,4-BQ), and 1,2-benzoquinone (1,2-BQ), that are capable of reacting with blood proteins to produce adducts...
  3. ncbi request reprint Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers
    Luoping Zhang
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:117-22. 2005
    ..We are currently investigating potential mechanisms for this induction of selective aneuploidy...
  4. ncbi request reprint Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 48:467-74. 2007
    ..However, they do not rule out the possibility that other rearrangements of the MLL gene at chromosome 11q23 may be induced by benzene...
  5. pmc Human benzene metabolism following occupational and environmental exposures
    Stephen M Rappaport
    School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:189-95. 2010
    ..1 ppm, 20 and 58% at 1 ppm, and 2.7 and 17% at 10 ppm. This indicates that the putative high-affinity enzyme was active primarily below 1 ppm and favored the ring-opening pathway...
  6. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
    ..Together, these findings confirm that benzene exposure is associated with specific chromosomal aneuploidies in hematopoietic cells, which suggests that such aneuploidies may play roles in benzene-induced leukemogenesis...
  7. pmc Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
    ..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified...
  8. ncbi request reprint Use of 'Omic' technologies to study humans exposed to benzene
    Martyn T Smith
    School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
    Chem Biol Interact 153:123-7. 2005
    ..Omic technologies therefore have significant potential in generating novel biomarkers of exposure, susceptibility and response to benzene...
  9. pmc Toxicogenomic profiling of chemically exposed humans in risk assessment
    Cliona M McHale
    School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
    Mutat Res 705:172-83. 2010
    ....
  10. pmc Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells
    Luoping Zhang
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
    Cancer Epidemiol Biomarkers Prev 19:80-8. 2010
    ....
  11. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  12. doi request reprint Global gene expression response of a population exposed to benzene: a pilot study exploring the use of RNA-sequencing technology
    Reuben Thomas
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Environ Mol Mutagen 54:566-73. 2013
    ..Overall, this pilot study shows that RNA-seq can complement the information obtained by microarray in the analysis of changes in transcript expression from chemical exposures...
  13. pmc Global gene expression profiling of a population exposed to a range of benzene levels
    Cliona M McHale
    School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
    Environ Health Perspect 119:628-34. 2011
    ..Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers...
  14. ncbi request reprint Protein adducts as biomarkers of human benzene metabolism
    Stephen M Rappaport
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7431, USA
    Chem Biol Interact 153:103-9. 2005
    ..Thus, the biologically effective dose of BO and 1,4-BQ should be proportionally greater in persons exposed to low rather than high levels of benzene...
  15. ncbi request reprint Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, and National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:772-81. 2006
    ..027 and 15.4 p.p.m. Reductions in metabolite production were most pronounced for CA and PH<1 p.p.m., indicating that metabolism favored production of the toxic metabolites, HQ and MA, at low exposures...
  16. ncbi request reprint Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air concentrations
    Sungkyoon Kim
    School of Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacogenet Genomics 17:789-801. 2007
    ....
  17. pmc Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e14546. 2011
    ..The aim of the present study was to examine the effects of silencing WRN in p53 deficient HL60 and p53 wild-type TK6 hematopoietic cells, in order to further the understanding of WRN-associated tumorigenesis...
  18. pmc The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells
    Zhiying Ji
    Department of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    Mutagenesis 24:367-72. 2009
    ....
  19. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    ..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure...
  20. pmc Evidence that humans metabolize benzene via two pathways
    Stephen M Rappaport
    School of Public Health, University of California at Berkeley, Berkeley, California 94720 7356, USA
    Environ Health Perspect 117:946-52. 2009
    ..This led us to speculate that an unidentified metabolic pathway was mainly responsible for benzene metabolism at ambient levels...
  21. ncbi request reprint Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
    ..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia...
  22. pmc Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720, USA
    Toxicol Sci 107:367-75. 2009
    ..Our data suggests that WRN plays an important role in the surveillance of and protection against DNA damage induced by HQ. This provides mechanistic support for the link between WRN and benzene-induced hematotoxicity...
  23. pmc Single molecule quantitation and sequencing of rare translocations using microfluidic nested digital PCR
    Joe Shuga
    School of Public Health, University of California, Berkeley, CA 94720, USA, Department of Chemistry, University of California, Berkeley, CA 94720, USA, Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA, UC San Francisco UC Berkeley Graduate Program in Bioengineering, University of California, Berkeley, CA 94720, USA, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20852, USA, Guangdong Poison Control Center, Guangzhou 510300, China and Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, NL 3508, The Netherlands
    Nucleic Acids Res 41:e159. 2013
    ..In this manner, we created a quantitative map for this carcinogenic mutation in this healthy population and identified the positions on chromosomes 14 and 18 where the vast majority of these t(14;18) events occur...
  24. doi request reprint The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Arch Toxicol 87:189-96. 2013
    ..Future studies are needed to delineate the role of this pathway in mitigating FA-induced toxicity, particularly in hematopoietic stem cells, the target cells in leukemia...
  25. doi request reprint Comparison of aneuploidies of chromosomes 21, X, and Y in the blood lymphocytes and sperm of workers exposed to benzene
    Zhiying Ji
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Environ Mol Mutagen 53:218-26. 2012
    ..The findings suggest that benzene exposure induces aneuploidies in both blood cells and sperm within the same individuals, but selectively affects chromosome 21 in blood lymphocytes and the sex chromosomes in sperm...
  26. pmc Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone
    Noe Galvan
    Molecular Epidemiology and Toxicology Laboratory, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Mutat Res 649:54-61. 2008
    ..Further studies in bone marrow-derived stem or progenitor cells are required to confirm our findings in HeLa cells and expand our ability to extrapolate the results to benzene toxicity in humans...
  27. ncbi request reprint Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Toxicology 229:101-13. 2007
    ..Further examination of the role of these genes in dioxin induced-toxicity is warranted...
  28. pmc Discovery of novel biomarkers by microarray analysis of peripheral blood mononuclear cell gene expression in benzene-exposed workers
    Matthew S Forrest
    School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Environ Health Perspect 113:801-7. 2005
    ..Thus, microarray analysis along with real-time PCR confirmation reveals that altered expressions of CXCL16, ZNF331, JUN, and PF4 are potential biomarkers of benzene exposure...
  29. pmc Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Carcinogenesis 33:240-52. 2012
    ..These approaches will inform our understanding of the mechanisms of benzene toxicity and identify additional biomarkers of exposure, early effect and susceptibility useful for risk assessment...
  30. pmc Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes
    Luoping Zhang
    School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Mutat Res 558:63-74. 2004
    ..Together, these studies suggest that low levels of occupational BD exposure do not pose a significant risk of genetic damage...
  31. ncbi request reprint Leukaemia-specific chromosome damage detected by comet with fluorescence in situ hybridization (comet-FISH)
    Patricia A Escobar
    Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, California 94720, USA
    Mutagenesis 22:321-7. 2007
    ..Comet-FISH also appears to be a useful approach for detecting and comparing damage to specific chromosome regions of significance in leukaemogenesis...
  32. ncbi request reprint The histone deacetylase inhibitor trichostatin a has genotoxic effects in human lymphoblasts in vitro
    Andrew J Olaharski
    Molecular Epidemiology and Toxicology Laboratory, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Toxicol Sci 93:341-7. 2006
    ..We conclude that TSA is both a clastogen and aneugen in the TK6 cell line and propose that the observed cytostatic and apoptotic properties of TSA may partially be due to this genotoxicity...
  33. pmc Formaldehyde and leukemia: epidemiology, potential mechanisms, and implications for risk assessment
    Luoping Zhang
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Environ Mol Mutagen 51:181-91. 2010
    ....
  34. pmc Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Carcinogenesis 34:799-802. 2013
    ..These results provide further evidence that TCE is immunotoxic at relatively low exposure levels and provide additional biologic plausibility for the reported association of TCE with NHL...
  35. pmc Using bioinformatic approaches to identify pathways targeted by human leukemogens
    Reuben Thomas
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA
    Int J Environ Res Public Health 9:2479-503. 2012
    ..However, using two-class random forests to estimate leukemogen and non-leukemogen patterns, we estimated a 76% chance of distinguishing a random leukemogen/non-leukemogen pair from each other...
  36. pmc Reproductive and developmental toxicity of formaldehyde: a systematic review
    Anh Duong
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Mutat Res 728:118-38. 2011
    ..Together with mechanistic and animal studies, this will allow us to better understand the systemic effect of formaldehyde exposure...
  37. doi request reprint Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms
    Luoping Zhang
    School of Public Health, 50 University Hall, University of California, Berkeley, CA 94720 7356, USA
    Mutat Res 681:150-68. 2009
    ..To test these hypotheses, we recommend that future studies apply biomarkers validated for other chemical leukemogens to the study of formaldehyde...
  38. pmc Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic
    Christine M Hegedus
    School of Public Health, University of California, Berkeley, California 94720 7356, USA
    Toxicol Sci 106:74-82. 2008
    ..Further studies are warranted to investigate the role of HBD-1 in As-related toxicity...
  39. pmc Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
    ..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology...
  40. pmc Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium
    Christine F Skibola
    237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 171:267-76. 2010
    ..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology...
  41. doi request reprint Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke
    Matthew North
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    BMC Cancer 14:6. 2014
    ..Increased Ras signaling is implicated as a causal factor in the increased pre-disposition to leukemia of individuals with mutations in NF1...
  42. pmc Tobacco smoke exposure and the risk of childhood acute lymphoblastic and myeloid leukemias by cytogenetic subtype
    Catherine Metayer
    School of Public Health, University of California, 1995 University Avenue, Suite 460, Berkeley, CA94704 7392, USA
    Cancer Epidemiol Biomarkers Prev 22:1600-11. 2013
    ....
  43. pmc Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia
    Ghislaine Scelo
    School of Public Health, University of California Berkeley, Berkeley, California 94704 7380, USA
    Environ Health Perspect 117:133-9. 2009
    ..Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia...
  44. doi request reprint Formaldehyde in China: production, consumption, exposure levels, and health effects
    Xiaojiang Tang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Int 35:1210-24. 2009
    ..The lack of quality epidemiological studies and basic data on exposed populations emphasizes the need for more extensive studies on formaldehyde and its related health effects in China...
  45. doi request reprint Formaldehyde and leukemia: an updated meta-analysis and evaluation of bias
    Erika Schwilk
    Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA
    J Occup Environ Med 52:878-86. 2010
    ..Formaldehyde exposures are common, and data linking these exposures to leukemia have been mixed and controversial. The objective of this analysis is to review the current epidemiologic literature on formaldehyde and leukemia...
  46. doi request reprint Analysis of the transcriptome in molecular epidemiology studies
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Mol Mutagen 54:500-17. 2013
    ..Analysis of datasets at the pathway level can compensate for some of the limitations of RNA-Seq and, as more datasets become available, will increasingly elucidate the exposure-disease continuum...
  47. doi request reprint Bone marrow genotoxicity of 2,5-dimethylfuran, a green biofuel candidate
    Michele Fromowitz
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Environ Mol Mutagen 53:488-91. 2012
    ..In vitro assays, such as the in vitro micronucleus assay, will be essential as international chemical policy is increasingly utilizing green chemistry principles that require more toxicological testing...
  48. ncbi request reprint Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California
    Melinda C Aldrich
    University of California Berkeley, 2150 Shattuck Avenue, Suite 500, Berkeley, CA 94720 7380, USA
    Cancer Epidemiol Biomarkers Prev 15:578-81. 2006
    ..The mechanistic basis for this 2-fold variation in frequency of TEL-AML1 may be due to ethnic-specific risk factors or genetics and should be explored further...
  49. pmc Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure
    William Jaime Jo
    Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA
    Toxicol Appl Pharmacol 241:294-302. 2009
    ..Based on these findings, we propose a novel role for the MYST1 gene in human sensitivity to arsenic...
  50. doi request reprint Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells
    Zhiying Ji
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Toxicol Lett 224:233-9. 2014
    ..Our findings provide further evidence of the toxicity of FA to hematopoietic stem/progenitor cells and support the biological plausibility of FA-induced leukemogenesis...
  51. doi request reprint Predicted toxicity of the biofuel candidate 2,5-dimethylfuran in environmental and biological systems
    Jimmy Phuong
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Environ Mol Mutagen 53:478-87. 2012
    ..Although inadequate for a stand-alone risk assessment, our data suggest that DMF combustion intermediates pose a much broader range of hazards than DMF itself, and that both should be further investigated...
  52. ncbi request reprint Nonrandom aneuploidy of chromosomes 1, 5, 6, 7, 8, 9, 11, 12, and 21 induced by the benzene metabolites hydroquinone and benzenetriol
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Mol Mutagen 45:388-96. 2005
    ..These data support the notion that benzene metabolites affect the ploidy status of specific chromosomes more than others and may initiate or promote leukemia induction through these specific effects...
  53. pmc Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity
    Xuefeng Ren
    Genes and Environment Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:771-7. 2011
    ..We found that yeast deletion mutants lacking MTQ2 were highly resistant to iAs exposure. The human ortholog of the yeast MTQ2 is N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), encoding a putative methyltransferase...
  54. ncbi request reprint Non-linear production of benzene oxide-albumin adducts with human exposure to benzene
    Stephen M Rappaport
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 778:367-74. 2002
    ..To our knowledge, this is the first study to investigate the linearity of human metabolism of a carcinogen based upon protein adducts...
  55. ncbi request reprint Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
    Cliona M McHale
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Genes Chromosomes Cancer 37:36-43. 2003
    ..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X...
  56. pmc Paternal smoking and risk of childhood acute lymphoblastic leukemia: systematic review and meta-analysis
    Ruiling Liu
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    J Oncol 2011:854584. 2011
    ..Future epidemiologic studies should assess paternal smoking during well-defined exposure windows and should include biomarkers to assess smoking exposure and toxicological mechanisms...
  57. pmc The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases
    Andrew J Olaharski
    School of Public Health, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 1:e77. 2005
    ..These findings demonstrate that humans are potentially exposed to epigenetic toxicants that inhibit sirtuin deacetylases...
  58. pmc Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma
    Christine F Skibola
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
    Nat Genet 41:873-5. 2009
    ..7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1)...
  59. pmc Association between mitochondrial DNA copy number, blood cell counts, and occupational benzene exposure
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, Maryland 20892 7240, USA
    Environ Mol Mutagen 49:453-7. 2008
    ..Benzene exposure may induce mtDNA amplification, possibly in response to oxidative stress caused by benzene. The finding needs to be replicated by other studies...
  60. ncbi request reprint Residue levels of HCHs, DDTs and PCBs in shellfish from coastal areas of east Xiamen Island and Minjiang Estuary, China
    Weiqi Chen
    Key Laboratory for Marine Environmental Science of MOE, Environmental Science Research Center, Xiamen University, China
    Mar Pollut Bull 45:385-90. 2002
    ..The residue levels and compositions of HCHs, DDTs and PCBs are discussed...
  61. ncbi request reprint Detailed exposure assessment for a molecular epidemiology study of benzene in two shoe factories in China
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Ann Occup Hyg 48:105-16. 2004
    ..Our goal was to identify workers with a broad range of benzene exposures, for an epidemiologic study relating exposure to early biologic effects...
  62. pmc Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 102:17041-6. 2005
    ....
  63. ncbi request reprint Modeling human metabolism of benzene following occupational and environmental exposures
    Sungkyoon Kim
    School of Public Health, University of North Carolina, CB 7431, Chapel Hill, NC 27599
    Cancer Epidemiol Biomarkers Prev 15:2246-52. 2006
    ..Our results also suggest that GLM + NS models are ideal for evaluating nonlinear relationships between environmental exposures and levels of human biomarkers...
  64. ncbi request reprint Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia
    Shichun Zheng
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 94143 0560, USA
    Cancer Res 64:2000-6. 2004
    ..These results suggest that hypermethylation of the promoter region CpG island of the FHIT gene is a common event and may play an important role in the etiology and pathophysiology of specific cytogenetic subtypes of childhood ALL...
  65. pmc Hematotoxicity in workers exposed to low levels of benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Science 306:1774-6. 2004
    ..Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations...
  66. ncbi request reprint Persistent organochlorine pollutants in surface sediments and economic shellfish of Minjiang Estuary-Mazu and Xiamen-Jinmen sea areas
    Weiqi Chen
    State Key Laboratory of Marine Environmental Science Xiamen University, Environmental Science Research Center, Xiamen University, Xiamen, 361005, P R China
    J Environ Sci Health A Tox Hazard Subst Environ Eng 40:1895-903. 2005
    ..The concentration distributions, compositions, and residue levels of these OCs are extensively discussed and evaluated...
  67. ncbi request reprint Lymphocyte toxicity and T cell receptor excision circles in workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 8109, Bethesda, MD 20892 7240, USA
    Chem Biol Interact 153:111-5. 2005
    ..Although our study does not rule out counterbalancing alterations of TREC levels in specific T cell subsets, benzene's lymphotoxicity does not appear to be mediated through diminished thymus function...
  68. ncbi request reprint Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches
    Roel Vermeulen
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
    J Environ Monit 8:1143-8. 2006
    ..The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory...
  69. ncbi request reprint Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity
    Min Shen
    Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 27:2083-9. 2006
    ..The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity...
  70. ncbi request reprint Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16)
    Cliona M McHale
    Blood 101:4640-1. 2003
  71. ncbi request reprint Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Immunogenetics 59:839-52. 2007
    ..25). These results suggest that there is substantial genetic diversity in immune genes and exploration of SNP associations with immune-related diseases that vary in incidence across these two populations may be warranted...
  72. ncbi request reprint Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene
    Qing Lan
    Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
    Cancer Res 65:9574-81. 2005
    ..041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity...
  73. ncbi request reprint In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia
    Joseph L Wiemels
    Laboratory for Molecular Epidemiology, Department of Epidemiology and Biostatistics, University of California San Francisco 94143 0560, USA
    Blood 99:3801-5. 2002
    ....
  74. ncbi request reprint Environmental risk assessment of pesticides on aquatic life in Xiamen, China
    Davide Calamari
    Department of Structural and Functional Biology, University of Insubria, Via J H Dunant, 21100 Varese, Italy
    Toxicol Lett 128:45-53. 2002
    ..This study could represent a cost-effective method that may be used before engaging in expensive monitoring programs for pesticide use in developing countries, where analytical facilities are lacking...
  75. ncbi request reprint Validation of an agricultural non-point source (AGNPS) pollution model for a catchment in the Jiulong River watershed, China
    Jianchang Liu
    State Key Laboratory of Urban and Regional Ecology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Environ Sci (China) 20:599-606. 2008
    ..Erosivity and other parameters had little influence on the hydrological and quality outputs...
  76. ncbi request reprint Heavy metal contamination in western Xiamen Bay sediments and its vicinity, China
    Luoping Zhang
    State Key Laboratory of Marine Environmental Science, Environmental Science Research Center, Xiamen University, Xiamen, Fujian 361005, PR China
    Mar Pollut Bull 54:974-82. 2007
    ..This study shows that using the sediment quality standard criteria only to assess sediments cannot properly reflect sediment contamination. A multiple approaches should be applied for the sediment quality assessment...