Research Topics
Genomes and Genes | Li ZhangSummaryAffiliation: University of Colorado Denver Country: USA Publications
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Detail Information
Publications
Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD miceLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
Diabetes Metab Res Rev 27:784-9. 2011..Our hypothesis is that immunization with an insulin B:12-22 peptide linked to I-Ag7 in register 3 (I-Ag7-B:RE#3 complex) can induce specific antibodies to the complex, block pathogenic TCRs, and thus prevent diabetes...- Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chainsLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 33:42-9. 2009.... 
Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23Li Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 34:478-84. 2010..This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity...- Conserved T cell receptor alpha-chain induces insulin autoantibodiesMasakazu Kobayashi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 105:10090-4. 2008..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor... - Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationAaron W Michels
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Immunol 187:5921-30. 2011..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications... - Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signalingBrian B Graham
Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
Am J Pathol 177:1549-61. 2010..Our data indicate that experimental schistosomiasis causes PH and potentially relies on up-regulated IL-13 signaling... - Prediction and prevention of Type 1 diabetes mellitusLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
J Diabetes 3:48-57. 2011..We can also prevent T1DM in animal models, but the final goal is the prevention of T1DM in humans. Multiple clinical trials are underway investigating methods to prevent β-cell destruction... - Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouseTakahiro Nakayama
Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
Am J Physiol Renal Physiol 296:F317-27. 2009..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease... - Insulin as an autoantigen in NOD/human diabetesLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
Curr Opin Immunol 20:111-8. 2008....