Li Zhang

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. doi request reprint Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:784-9. 2011
  2. doi request reprint Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
  3. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
  4. pmc Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes
    Li Zhang
    Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045
    Proc Natl Acad Sci U S A 111:2656-61. 2014
  5. pmc Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 34:478-84. 2010
  6. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
  7. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
  8. pmc Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling
    Brian B Graham
    Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
    Am J Pathol 177:1549-61. 2010
  9. doi request reprint Prediction and prevention of Type 1 diabetes mellitus
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Diabetes 3:48-57. 2011
  10. pmc Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009

Collaborators

Detail Information

Publications11

  1. doi request reprint Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:784-9. 2011
    ..Our hypothesis is that immunization with an insulin B:12-22 peptide linked to I-Ag7 in register 3 (I-Ag7-B:RE#3 complex) can induce specific antibodies to the complex, block pathogenic TCRs, and thus prevent diabetes...
  2. doi request reprint Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
    ....
  3. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
    ..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
  4. pmc Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes
    Li Zhang
    Barbara Davis Center for Diabetes, University of Colorado, Aurora, CO 80045
    Proc Natl Acad Sci U S A 111:2656-61. 2014
    ....
  5. pmc Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 34:478-84. 2010
    ..This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity...
  6. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
    ..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications...
  7. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
    ..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor...
  8. pmc Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling
    Brian B Graham
    Program in Translational Lung Research, Pulmonary and Critical Care Medicine, University of Colorado, Denver, Colorado, USA
    Am J Pathol 177:1549-61. 2010
    ..Our data indicate that experimental schistosomiasis causes PH and potentially relies on up-regulated IL-13 signaling...
  9. doi request reprint Prediction and prevention of Type 1 diabetes mellitus
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Diabetes 3:48-57. 2011
    ..We can also prevent T1DM in animal models, but the final goal is the prevention of T1DM in humans. Multiple clinical trials are underway investigating methods to prevent β-cell destruction...
  10. pmc Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009
    ..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease...
  11. pmc Insulin as an autoantigen in NOD/human diabetes
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
    Curr Opin Immunol 20:111-8. 2008
    ....