Affiliation: University of Texas at Dallas
Sohoni S, Ghosh P, Wang T, Kalainayakan S, Vidal C, Dey S, et al
. Elevated heme synthesis and uptake underpin intensified oxidative metabolism and tumorigenic functions in non-small cell lung cancer cells. Cancer Res. 2019;: pubmed publisher
..These data show that elevated heme flux and function underlie enhanced OXPHOS and tumorigenicity of NSCLC cells. Targeting heme flux and function offers a potential strategy for developing therapies for lung cancer. ..
Kalainayakan S, Ghosh P, Dey S, FitzGerald K, Sohoni S, Konduri P, et al
. Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression. Sci Rep. 2019;9:1405 pubmed publisher
..Together, our results strongly suggest that CycT suppress tumor growth in the lung by inhibiting heme metabolism and OXPHOS. Targeting heme metabolism and OXPHOS may be an effective strategy to combat lung cancer. ..
Hooda J, ALAM M, Zhang L. Measurement of Heme Synthesis Levels in Mammalian Cells. J Vis Exp. 2015;:e51579 pubmed publisher
..This method measures the relative levels of heme biosynthesis rather than the total heme content. To demonstrate the use of this technique the levels of heme biosynthesis were measured in several mammalian cell lines. ..
Comer J, Zhang L. Experimental Methods for Studying Cellular Heme Signaling. Cells. 2018;7: pubmed publisher
..This review sums up the latest methods used to study reversible heme binding. Heme-regulated proteins will also be reviewed, as well as a system for imaging the cellular localization of heme. ..
Alam M, Lal S, FitzGerald K, Zhang L. A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors. Clin Transl Med. 2016;5:3 pubmed publisher
..This review therefore attempts to comprehensively consider and summarize the experimental data supporting our latest view of cancer bioenergetics. ..
Alam M, Lal S, FitzGerald K, Zhang L. Correction to: A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors. Clin Transl Med. 2018;7:8 pubmed publisher
Alam M, Sohoni S, Kalainayakan S, Garrossian M, Zhang L. Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells. BMC Cancer. 2016;16:150 pubmed publisher
..Our work provides novel mechanistic insights into the action of Hh inhibitors in cancer cells. ..
Lal S, Alam M, Hooda J, Shah A, Cao T, Xuan Z, et al
. The Swi3 protein plays a unique role in regulating respiration in eukaryotes. Biosci Rep. 2016;36: pubmed publisher
..Together, these experimental and computational data demonstrated that Swi3 and its mammalian homologues are key regulators in regulating respiration. ..