Li Zhang

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Insulin as an autoantigen in NOD/human diabetes
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
    Curr Opin Immunol 20:111-8. 2008
  2. doi request reprint Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
  3. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
  4. pmc Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 34:478-84. 2010
  5. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
  6. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
  7. doi request reprint Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:784-9. 2011
  8. doi request reprint Prediction and prevention of Type 1 diabetes mellitus
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Diabetes 3:48-57. 2011
  9. doi request reprint Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009
  10. pmc A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
    Clin Immunol 125:131-7. 2007

Collaborators

Detail Information

Publications39

  1. pmc Insulin as an autoantigen in NOD/human diabetes
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
    Curr Opin Immunol 20:111-8. 2008
    ....
  2. doi request reprint Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 33:42-9. 2009
    ....
  3. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
    ..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
  4. pmc Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Autoimmun 34:478-84. 2010
    ..This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity...
  5. pmc Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation
    Aaron W Michels
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 187:5921-30. 2011
    ..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications...
  6. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
    ..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor...
  7. doi request reprint Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:784-9. 2011
    ..Our hypothesis is that immunization with an insulin B:12-22 peptide linked to I-Ag7 in register 3 (I-Ag7-B:RE#3 complex) can induce specific antibodies to the complex, block pathogenic TCRs, and thus prevent diabetes...
  8. doi request reprint Prediction and prevention of Type 1 diabetes mellitus
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Diabetes 3:48-57. 2011
    ..We can also prevent T1DM in animal models, but the final goal is the prevention of T1DM in humans. Multiple clinical trials are underway investigating methods to prevent β-cell destruction...
  9. doi request reprint Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse
    Takahiro Nakayama
    Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
    Am J Physiol Renal Physiol 296:F317-27. 2009
    ..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease...
  10. pmc A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
    Clin Immunol 125:131-7. 2007
    ..This simple high throughput competitive europium time resolved fluorescence assay had a sensitivity of > or =86% or greater and a specificity of >99.5%...
  11. ncbi request reprint A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathy
    Zhao Hui Wang
    Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Chin Med J (Engl) 120:1319-25. 2007
    ..In this study we aimed to focus on the molecular mechanism of T cells in the autoimmune cardiomyopathy mouse model by detecting the expression of the two T cell signaling molecules...
  12. pmc Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy
    Jiang Li
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 2:e1122. 2007
    ..Thus, EBV-specific rejection responses appear to be functionally inactivated at the tumor site in NPC...
  13. ncbi request reprint Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate
    Ying Sun
    Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China
    Endocrinology 149:662-71. 2008
    ..Our findings have potential clinical implications for the use of PPARalpha agonists in the treatment of type 2 diabetes...
  14. ncbi request reprint KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity
    Jin Xu
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
    Am J Physiol Endocrinol Metab 294:E326-35. 2008
    ..2(-/-) mice are STZ resistant because of a decrease in STZ transport by GLUT2 in pancreatic beta-cells and 2) the decreased transport is due to a downregulation of GLUT2 activity involving an effect at the COOH terminus...
  15. ncbi request reprint Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus
    Li Zhang
    Division of Rheumatology, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Chicago, IL 60611, USA
    Arthritis Rheum 56:4132-41. 2007
    ....
  16. doi request reprint Speciosaperoxide, a new triterpene acid, and other terpenoids from Chaenomeles speciosa
    Ya Ling Song
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, China
    J Asian Nat Prod Res 10:217-22. 2008
    ..Besides compound 1, compounds 2, 8-10 were obtained from this genus for the first time. None of these compounds exhibited inhibitory activity against T-and B-lymphocyte proliferation...
  17. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
    ..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects...
  18. pmc T-cell responses to survivin in cancer patients undergoing radiation therapy
    Dorthe Schaue
    Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, California 90095 1714, USA
    Clin Cancer Res 14:4883-90. 2008
    ..The goal of this study was to determine if radiation therapy (RT) of human cancer enhances or diminishes tumor-specific T-cell reactivity. This is important if immunotherapy is to be harnessed to improve the outcome of cancer radiotherapy...
  19. ncbi request reprint Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development
    Megan S Ford
    Toronto General Research Institute, University Health Network and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Eur J Immunol 37:2234-41. 2007
    ..Furthermore, transferring gp33-activated DN T cells inhibited the development of autoimmune diabetes, suggesting that DN T cells may provide a novel therapy for T cell-mediated autoimmune diseases...
  20. pmc CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
    Driss Ehirchiou
    Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 204:1519-24. 2007
    ..Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation...
  21. ncbi request reprint Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay
    Jian Li
    Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Bioorg Med Chem 14:2209-24. 2006
    ..5-6.2 microM. Pharmacological assay indicated that these four compounds demonstrated somewhat inhibition activities against the proliferation of spleen cells...
  22. ncbi request reprint A nonredundant role for the adapter protein Shc in thymic T cell development
    Li Zhang
    Beirne B Carter Center for Immunology Research and Department of Microbiology University of Virginia, Charlottesville, VA 22908, USA
    Nat Immunol 3:749-55. 2002
    ..Thus, both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development...
  23. ncbi request reprint Ly-6A is critical for the function of double negative regulatory T cells
    Zhu Xu Zhang
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, Toronto, Canada
    Eur J Immunol 32:1584-92. 2002
    ..Taken together, our data indicate that Ly-6A plays a crucial role in DN T cell-mediated regulation in vitro and in vivo, perhaps by enhancing DN-CD8+ T cell signaling...
  24. ncbi request reprint The nature and mechanisms of DN regulatory T-cell mediated suppression
    Kevin J Young
    Departments of Laboratory Medicine and Pathobiology, CCRW 2 809, Toronto General Research Institute, University of Toronto, 101 College Street, Toronto, Ontario, Canada M5G 2C4
    Hum Immunol 63:926-34. 2002
    ..Together, these data extend our previous findings, and expand the conditions in which DN T cells can potentially be used to specifically suppress allogeneic immune responses...
  25. ncbi request reprint ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue
    Takashi Miki
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Research Center for Pathogenic Fungi and Microbial Toxicoses, and Gene Research Center, Chiba University, Chiba 260 8670, Japan
    Am J Physiol Endocrinol Metab 283:E1178-84. 2002
    ..2(-/-) and WT mice, suggesting that the increase in glucose uptake in Kir6.2(-/-) adipocytes is mediated by altered extracellular hormonal or neuronal signals altered by disruption of the K(ATP) channels...
  26. ncbi request reprint Role of Shc in T-cell development and function
    Li Zhang
    Department of Microbiology and the Beirne B Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
    Immunol Rev 191:183-95. 2003
    ..A better molecular understanding of Shc function in the future could provide insights into how multiple adapters coordinate the various outcomes downstream of the TCR...
  27. ncbi request reprint Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells
    Camie W Y Chan
    Multi Organ Transplant Program, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
    J Immunol 170:4036-44. 2003
    ..These data provide the first evidence to demonstrate that (s)fgl2 exerts immunosuppressive effects on T cell proliferation and DC maturation...
  28. ncbi request reprint Antitumor activity mediated by double-negative T cells
    Kevin J Young
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, 621 University Avenue, Toronto, Ontario M5G 2C4, Canada
    Cancer Res 63:8014-21. 2003
    ..Furthermore, DN T cells can suppress lymphoma cells in vivo and in vitro, suggesting that DN T cells could be used as a novel strategy for the treatment of lymphoma...
  29. ncbi request reprint A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization
    Darren J Moore
    Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurochem 87:1558-67. 2003
    ..These properties of the L166P mutation may contribute to the loss of normal DJ-1 function and are likely to be the underlying cause of early onset PD in affected members of the Italian kindred...
  30. ncbi request reprint Human lupus T cells resist inactivation and escape death by upregulating COX-2
    Luting Xu
    Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave Chicago, Illinois 60611, USA
    Nat Med 10:411-5. 2004
    ..These findings could be useful in the design of lupus therapies...
  31. ncbi request reprint Effects of hormone therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeys
    Melanie K Shadoan
    Department of Pathology, Comparative Medicine Clinical Research Center, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Steroids 69:313-8. 2004
    ..14). These deficiencies in skeletal muscle insulin signaling likely contribute to the unfavorable changes in whole body insulin sensitivity associated with CEE + MPA treatment...
  32. ncbi request reprint Rosiglitazone treatment improves insulin regulation and dyslipidemia in type 2 diabetic cynomolgus monkeys
    Melaney K Gee
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Metabolism 53:1121-5. 2004
    ..Body weights remained steady in both groups during the study. These results suggest overall improvement in insulin regulation and lipid profiles during treatment with rosiglitazone...
  33. ncbi request reprint Transient pancytopenia preceding T lineage acute lymphoblastic leukemia
    Hui Zhao
    Department of Thrombosis and Hemostasis, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China
    Acta Haematol 112:167-9. 2004
    ..The patient achieved a transient complete remission after initial therapy, but relapsed within a few months and died of leukemic encephalopathy. To the best of our knowledge, this is the first report of T lineage pre-ALL...
  34. ncbi request reprint T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigens
    Syamal K Datta
    Department of Medicine, Feinberg School of Medicine, Northwestern University, 240 East Huron St, Chicago, IL 60611, USA
    J Mol Med (Berl) 83:267-78. 2005
    ..Hence COX-2 inhibitors may work independently of their ability to block the enzymatic function of COX-2, and structural peculiarities of these select inhibitors may lead to better drug discovery and design...
  35. ncbi request reprint Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice
    Nan Ma
    Cardiac Surgery, University of Rostock, Rostock, Germany
    Cardiovasc Res 66:45-54. 2005
    ..We tested the hypothesis that intravenously administered human umbilical cord blood (hUCB) cells contribute to repair processes following myocardial infarction...
  36. ncbi request reprint Selective depletion of glycyrrhizin from Si-Ni-San, a traditional Chinese prescription, blocks its effect on contact sensitivity in mice and recovers adhesion and metalloproteinases production of T lymphocytes
    Li Zhang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
    Int Immunopharmacol 5:1193-204. 2005
    ..The present study also provides a new approach to recognize and validate an active constituent in traditional prescription through a selective depletion...
  37. ncbi request reprint Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells
    Wenhao Chen
    Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, Ontario, Canada
    J Immunol 175:3409-16. 2005
    ..These data provide direct evidence that DLI can activate recipient DN Treg cells, which can induce donor-specific long-term cardiac xenograft survival by suppressing the proliferation and function of donor-specific CD4+ T cells in vivo...
  38. ncbi request reprint [Study on the active protein fractions from scorpii tegument]
    Li Wu
    Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
    Zhongguo Zhong Yao Za Zhi 30:1083-6. 2005
    ..Extracting the total protein from scorpii tegument, investigating its effect on immune system by transformation of T/B cell...
  39. ncbi request reprint Analysis of T-cell repertoire and mixed chimaerism in a patient with aplastic anaemia after allogeneic bone marrow transplantation
    Yutaka Tsutsumi
    Department ofHaematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Br J Haematol 118:136-9. 2002
    ..Therefore, some immune responses induced by the recipient CD8-positive T cells had an important role in pancytopenia in AA patients after allo-BMT...