Research Topics
| Li ZhangSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Detail Information
Publications
Insulin as an autoantigen in NOD/human diabetesLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, Building M20, 1775 N Ursula St, P O Box 6511, Aurora, CO 80045 6511, USA
Curr Opin Immunol 20:111-8. 2008....
Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chainsLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 33:42-9. 2009....
Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...- Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23Li Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Autoimmun 34:478-84. 2010..This study reveals a novel specificity for gammadelta TCRs, and raises the possibility that gammadelta T cells become involved in islet-specific autoimmunity... - Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationAaron W Michels
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
J Immunol 187:5921-30. 2011..These studies present a novel method for identifying small molecules capable of both stimulating and inhibiting T cell responses, with potentially therapeutic applications... - Conserved T cell receptor alpha-chain induces insulin autoantibodiesMasakazu Kobayashi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 105:10090-4. 2008..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor... - Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD miceLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
Diabetes Metab Res Rev 27:784-9. 2011..Our hypothesis is that immunization with an insulin B:12-22 peptide linked to I-Ag7 in register 3 (I-Ag7-B:RE#3 complex) can induce specific antibodies to the complex, block pathogenic TCRs, and thus prevent diabetes... - Prediction and prevention of Type 1 diabetes mellitusLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado 80045, USA
J Diabetes 3:48-57. 2011..We can also prevent T1DM in animal models, but the final goal is the prevention of T1DM in humans. Multiple clinical trials are underway investigating methods to prevent β-cell destruction... - Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouseTakahiro Nakayama
Division of Nephrology, Univ of Colorado Denver, P O Box C281, Aurora, CO 80045, USA
Am J Physiol Renal Physiol 296:F317-27. 2009..A lack of eNOS accelerates both glomerular and tubulointerstitial injury with a loss of glomerular capillaries and peritubular capillaries. Impaired endothelial function is likely a direct risk factor for renal disease... - A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1Li Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140 Building M20, 1775 N Ursula Street, Aurora, CO 80045 6511, USA
Clin Immunol 125:131-7. 2007..This simple high throughput competitive europium time resolved fluorescence assay had a sensitivity of > or =86% or greater and a specificity of >99.5%... - A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse autoimmune cardiomyopathyZhao Hui Wang
Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Chin Med J (Engl) 120:1319-25. 2007..In this study we aimed to focus on the molecular mechanism of T cells in the autoimmune cardiomyopathy mouse model by detecting the expression of the two T cell signaling molecules... - Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapyJiang Li
State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
PLoS ONE 2:e1122. 2007..Thus, EBV-specific rejection responses appear to be functionally inactivated at the tumor site in NPC... - Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitateYing Sun
Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China
Endocrinology 149:662-71. 2008..Our findings have potential clinical implications for the use of PPARalpha agonists in the treatment of type 2 diabetes... - KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activityJin Xu
Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada
Am J Physiol Endocrinol Metab 294:E326-35. 2008..2(-/-) mice are STZ resistant because of a decrease in STZ transport by GLUT2 in pancreatic beta-cells and 2) the decreased transport is due to a downregulation of GLUT2 activity involving an effect at the COOH terminus... - Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosusLi Zhang
Division of Rheumatology, Northwestern University Feinberg School of Medicine, 240 East Huron Street, Chicago, IL 60611, USA
Arthritis Rheum 56:4132-41. 2007.... - Speciosaperoxide, a new triterpene acid, and other terpenoids from Chaenomeles speciosaYa Ling Song
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, China
J Asian Nat Prod Res 10:217-22. 2008..Besides compound 1, compounds 2, 8-10 were obtained from this genus for the first time. None of these compounds exhibited inhibitory activity against T-and B-lymphocyte proliferation... - Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeysJanice D Wagner
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Metabolism 57:S24-31. 2008..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects... - T-cell responses to survivin in cancer patients undergoing radiation therapyDorthe Schaue
Department of Radiation Oncology, University of California at Los Angeles, Los Angeles, California 90095 1714, USA
Clin Cancer Res 14:4883-90. 2008..The goal of this study was to determine if radiation therapy (RT) of human cancer enhances or diminishes tumor-specific T-cell reactivity. This is important if immunotherapy is to be harnessed to improve the outcome of cancer radiotherapy... - Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes developmentMegan S Ford
Toronto General Research Institute, University Health Network and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Eur J Immunol 37:2234-41. 2007..Furthermore, transferring gp33-activated DN T cells inhibited the development of autoimmune diabetes, suggesting that DN T cells may provide a novel therapy for T cell-mediated autoimmune diseases... - CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiationDriss Ehirchiou
Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Exp Med 204:1519-24. 2007..Together, we conclude that CD11b facilitates oral tolerance by suppressing Th17 immune differentiation... - Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassayJian Li
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Bioorg Med Chem 14:2209-24. 2006..5-6.2 microM. Pharmacological assay indicated that these four compounds demonstrated somewhat inhibition activities against the proliferation of spleen cells... - A nonredundant role for the adapter protein Shc in thymic T cell developmentLi Zhang
Beirne B Carter Center for Immunology Research and Department of Microbiology University of Virginia, Charlottesville, VA 22908, USA
Nat Immunol 3:749-55. 2002..Thus, both Shc expression and its tyrosine phosphorylation play an essential and nonredundant role in thymic T cell development... - Ly-6A is critical for the function of double negative regulatory T cellsZhu-Xu Zhang
Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, Toronto, Canada
Eur J Immunol 32:1584-92. 2002..Taken together, our data indicate that Ly-6A plays a crucial role in DN T cell-mediated regulation in vitro and in vivo, perhaps by enhancing DN-CD8+ T cell signaling... - The nature and mechanisms of DN regulatory T-cell mediated suppressionKevin J Young
Departments of Laboratory Medicine and Pathobiology, CCRW 2-809, Toronto General Research Institute, University of Toronto, 101 College Street, Toronto, Ontario, Canada M5G 2C4
Hum Immunol 63:926-34. 2002..Together, these data extend our previous findings, and expand the conditions in which DN T cells can potentially be used to specifically suppress allogeneic immune responses... - ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissueTakashi Miki
Department of Cellular and Molecular Medicine, Graduate School of Medicine, Research Center for Pathogenic Fungi and Microbial Toxicoses, and Gene Research Center, Chiba University, Chiba 260 8670, Japan
Am J Physiol Endocrinol Metab 283:E1178-84. 2002..2(-/-) and WT mice, suggesting that the increase in glucose uptake in Kir6.2(-/-) adipocytes is mediated by altered extracellular hormonal or neuronal signals altered by disruption of the K(ATP) channels... - Role of Shc in T-cell development and functionLi Zhang
Department of Microbiology and the Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA
Immunol Rev 191:183-95. 2003..A better molecular understanding of Shc function in the future could provide insights into how multiple adapters coordinate the various outcomes downstream of the TCR... - Soluble fibrinogen-like protein 2/fibroleukin exhibits immunosuppressive properties: suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cellsCamie W Y Chan
Multi Organ Transplant Program, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada
J Immunol 170:4036-44. 2003..These data provide the first evidence to demonstrate that (s)fgl2 exerts immunosuppressive effects on T cell proliferation and DC maturation... - Antitumor activity mediated by double-negative T cellsKevin J Young
Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, 621 University Avenue, Toronto, Ontario M5G 2C4, Canada
Cancer Res 63:8014-21. 2003..Furthermore, DN T cells can suppress lymphoma cells in vivo and in vitro, suggesting that DN T cells could be used as a novel strategy for the treatment of lymphoma... - A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerizationDarren J Moore
Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurochem 87:1558-67. 2003..These properties of the L166P mutation may contribute to the loss of normal DJ-1 function and are likely to be the underlying cause of early onset PD in affected members of the Italian kindred... - Human lupus T cells resist inactivation and escape death by upregulating COX-2Luting Xu
Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave. Chicago, Illinois 60611, USA
Nat Med 10:411-5. 2004..These findings could be useful in the design of lupus therapies... - Effects of hormone therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeysMelanie K Shadoan
Department of Pathology, Comparative Medicine Clinical Research Center, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Steroids 69:313-8. 2004..14). These deficiencies in skeletal muscle insulin signaling likely contribute to the unfavorable changes in whole body insulin sensitivity associated with CEE + MPA treatment... - Rosiglitazone treatment improves insulin regulation and dyslipidemia in type 2 diabetic cynomolgus monkeysMelaney K Gee
Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Metabolism 53:1121-5. 2004..Body weights remained steady in both groups during the study. These results suggest overall improvement in insulin regulation and lipid profiles during treatment with rosiglitazone... - Transient pancytopenia preceding T lineage acute lymphoblastic leukemiaHui Zhao
Department of Thrombosis and Hemostasis, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China
Acta Haematol 112:167-9. 2004..The patient achieved a transient complete remission after initial therapy, but relapsed within a few months and died of leukemic encephalopathy. To the best of our knowledge, this is the first report of T lineage pre-ALL... - T-helper cell intrinsic defects in lupus that break peripheral tolerance to nuclear autoantigensSyamal K Datta
Department of Medicine, Feinberg School of Medicine, Northwestern University, 240 East Huron St, Chicago, IL 60611, USA
J Mol Med (Berl) 83:267-78. 2005..Hence COX-2 inhibitors may work independently of their ability to block the enzymatic function of COX-2, and structural peculiarities of these select inhibitors may lead to better drug discovery and design... - Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-miceNan Ma
Cardiac Surgery, University of Rostock, Rostock, Germany
Cardiovasc Res 66:45-54. 2005..Cord blood cells may hence be useful for cell therapy of ischemic heart disease... - Selective depletion of glycyrrhizin from Si-Ni-San, a traditional Chinese prescription, blocks its effect on contact sensitivity in mice and recovers adhesion and metalloproteinases production of T lymphocytesLi Zhang
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Han Kou Road, Nanjing 210093, China
Int Immunopharmacol 5:1193-204. 2005..The present study also provides a new approach to recognize and validate an active constituent in traditional prescription through a selective depletion... - Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cellsWenhao Chen
Department of Laboratory Medicine and Pathobiology, Multi Organ Transplantation Program, Toronto General Research Institute, University Health Network, Ontario, Canada
J Immunol 175:3409-16. 2005..These data provide direct evidence that DLI can activate recipient DN Treg cells, which can induce donor-specific long-term cardiac xenograft survival by suppressing the proliferation and function of donor-specific CD4+ T cells in vivo... - [Study on the active protein fractions from scorpii tegument]Li Wu
Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
Zhongguo Zhong Yao Za Zhi 30:1083-6. 2005..CONCLUSION: Protein from scorpii tegument could modulate the immune system, which may offer a new way for people to find protein drugs... - Analysis of T-cell repertoire and mixed chimaerism in a patient with aplastic anaemia after allogeneic bone marrow transplantationYutaka Tsutsumi
Department ofHaematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Br J Haematol 118:136-9. 2002..Therefore, some immune responses induced by the recipient CD8-positive T cells had an important role in pancytopenia in AA patients after allo-BMT...