Research Topics
| L I ZhangSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Persistent and specific influences of early acoustic environments on primary auditory cortexL I Zhang
Keck Center for Integrative Neurosciences, University of California at San Francisco, San Francisco, California 94143, USA
Nat Neurosci 4:1123-30. 2001..Thus, auditory experiences during early postnatal development are important in shaping the functional development of auditory cortical representations of specific acoustic environments...- Topography and synaptic shaping of direction selectivity in primary auditory cortexLi I Zhang
Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
Nature 424:201-5. 2003..The spectral asymmetry of the synaptic TRFs co-varied with CF, as had direction selectivity and sideband asymmetry, and thus suggested a synaptic mechanism for the shaping of FM direction selectivity and its topographic ordering... 
Disruption of primary auditory cortex by synchronous auditory inputs during a critical periodLi I Zhang
Keck Center of Integrative Neurosciences, University of California, San Francisco, CA 94143 0732, USA
Proc Natl Acad Sci U S A 99:2309-14. 2002..Thus, patterned auditory inputs appear to play a crucial role in shaping neuronal processing/decoding circuits in the primary auditory cortex during a critical period...- Emergence of input specificity of ltp during development of retinotectal connections in vivoH W Tao
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
Neuron 31:569-80. 2001..Thus, input specificity of LTP emerges with neural development and depends on the pattern of synaptic activity... - Electrical activity and development of neural circuitsL I Zhang
Keck Center of Integrative Neuroscience, University of California, San Francisco, California 94143-0732, USA
Nat Neurosci 4:1207-14. 2001..Selective findings discussed here illustrate some of our current understanding of the effects of electrical activity on circuit development and highlight areas that await further study... - Suppression of cortical representation through backward conditioningShaowen Bao
Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 100:1405-8. 2003.... - Tone-evoked excitatory and inhibitory synaptic conductances of primary auditory cortex neuronsAndrew Y Y Tan
Coleman Memorial Laboratory and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
J Neurophysiol 92:630-43. 2004..Our data indicate that the interaction of synaptic excitation and inhibition shapes the time course and frequency tuning of the spike responses of AI neurons... - Specialization of primary auditory cortex processing by sound exposure in the "critical period"Haruka Nakahara
Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:7170-4. 2004..These results show that the temporal order and pace of early, repetitive postnatal auditory inputs strongly affect the emergent and enduring functional organization of A1... - Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuningGuangying K Wu
Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
Neuron 52:705-15. 2006..Thus, cortical intensity tuning is primarily determined by excitatory inputs and shaped by cortical inhibition through a dynamic control of excitatory and inhibitory timing... - Defining cortical frequency tuning with recurrent excitatory circuitryBao Hua Liu
Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033, USA
Nat Neurosci 10:1594-600. 2007..Thus, weakly tuned thalamocortical inputs determine the subthreshold responding range, whereas intracortical inputs largely define the tuning. Such circuits may ensure a faithful conveyance of sensory information... - Lateral sharpening of cortical frequency tuning by approximately balanced inhibitionGuangying K Wu
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, CA 90033, USA
Neuron 58:132-43. 2008.... - Moving visual stimuli rapidly induce direction sensitivity of developing tectal neuronsFlorian Engert
Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 419:470-5. 2002..Thus, developing neural circuits can be modified rapidly and specifically by visual inputs of defined spatiotemporal patterns, in a manner consistent with predictions based on spike-time-dependent synaptic modification... - Heterosynaptic scaling of developing GABAergic synapses: dependence on glutamatergic input and developmental stageYan Liu
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 27:5301-12. 2007..This mechanism may contribute to the formation of functional neural circuits with correlated excitatory and inhibitory inputs...