Kang Zhang

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians
    Pearse A Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 2PD, UK
    J Ophthalmol 2012:483034. 2012
  2. pmc Retinal vein occlusion and macular edema - critical evaluation of the clinical value of ranibizumab
    Pearse A Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
    Clin Ophthalmol 5:771-81. 2011
  3. ncbi request reprint Vascular changes in eyes treated with dexamethasone intravitreal implant for macular edema after retinal vein occlusion
    SriniVas Sadda
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 120:1423-31. 2013
  4. doi request reprint Comparison of manually corrected retinal thickness measurements from multiple spectral-domain optical coherence tomography instruments
    Florian M Heussen
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Br J Ophthalmol 96:380-5. 2012
  5. pmc Risk factors for proliferative diabetic retinopathy in a latino american population
    Muneeswar G Nittala
    Doheny Eye Institute, Los Angeles, California NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology Shiley Eye Center, University of California, San Diego, California Veterans Administration Healthcare System, San Diego, California and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California
    Retina 34:1594-9. 2014
  6. ncbi request reprint Autologous transplantation of retinal pigment epithelium after mechanical debridement of Bruch's membrane
    Stephen J Phillips
    Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Eye Res 26:81-8. 2003
  7. ncbi request reprint Quantitative comparison of optical coherence tomography after pegaptanib or bevacizumab in neovascular age-related macular degeneration
    Sandra Joeres
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Ophthalmology 115:347-354.e2. 2008
  8. ncbi request reprint Structure and function of embryonic rat retinal sheet transplants
    Qing Peng
    Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Curr Eye Res 32:781-9. 2007
  9. pmc BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function
    Magdalene J Seiler
    Ophthalmology USC, Doheny, Los Angeles, CA, USA
    Exp Eye Res 86:92-104. 2008
  10. ncbi request reprint The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits
    Hossein Ameri
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Invest Ophthalmol Vis Sci 48:5708-15. 2007

Collaborators

  • Srinivas R Sadda
  • Magdalene J Seiler
  • Hiroshi Ishikawa
  • Guanting Qiu
  • Eyal Margalit
  • M Sehi
  • N A Rao
  • Joel Schuman
  • Susanne Binder
  • David S Greenfield
  • Neil M Bessler
  • Biju B Thomas
  • D J Pieramici
  • Hossein Ameri
  • Alexander C Walsh
  • Pearse A Keane
  • Sandra Joeres
  • Paul G Updike
  • Florian M Heussen
  • Sandra Liakopoulos
  • Muneeswar G Nittala
  • Tarkan Mumcuoglu
  • Tae Eun Choe
  • Sandeep Msutta
  • Rohit Varma
  • Vikas Chopra
  • Peggy W Romano
  • Allyson T Collins
  • Qing Peng
  • Usha Chakravarthy
  • Ziqiang Wu
  • Rahul N Khurana
  • Eugene de Juan
  • David A DiLoreto
  • Stephen J Phillips
  • Ramsudha Narala
  • Emma C McDonnell
  • Humberto Ruiz-Garcia
  • Yanling Ouyang
  • Gerard Medioni
  • Larry Kagemann
  • David Huang
  • Carolyn D Quinn
  • Kyung Rim Sung
  • Brian Francis
  • Sharel C Ongchin
  • Ou Tan
  • Jacob W Brubaker
  • Gadi Wollstein
  • Farnaz Memarzadeh
  • Sharel Ongchin
  • Kelly A Townsend
  • Robert J Noecker
  • Isaac Cohen
  • Richard A Bilonick
  • Kenneth L Lu
  • Alok Bansal
  • Rick Bilonick
  • Karen T Chang
  • Kevin Kaplowitz
  • Jerry W Tsong
  • Laurie D Labree
  • Matti Vazeen
  • Laurie Dustin
  • Zhenhai Chen
  • Robert B Aramant
  • Alyson Muldrew
  • Tara Barbour
  • Gildo Y Fujii
  • Mark S Humayun
  • Mark S Humayan
  • Mark O M Tso

Detail Information

Publications32

  1. pmc Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians
    Pearse A Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1V 2PD, UK
    J Ophthalmol 2012:483034. 2012
    ..In this review, we provide a guide for clinicians on the development of anti-VEGF therapies for intraocular use...
  2. pmc Retinal vein occlusion and macular edema - critical evaluation of the clinical value of ranibizumab
    Pearse A Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK
    Clin Ophthalmol 5:771-81. 2011
    ..In this review, we provide a critical evaluation of clinical trial data for the safety and efficacy of ranibizumab, and address unresolved issues in the management of this disorder...
  3. ncbi request reprint Vascular changes in eyes treated with dexamethasone intravitreal implant for macular edema after retinal vein occlusion
    SriniVas Sadda
    Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Ophthalmology 120:1423-31. 2013
    ..7 mg in the treatment of macular edema (ME) after branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO)...
  4. doi request reprint Comparison of manually corrected retinal thickness measurements from multiple spectral-domain optical coherence tomography instruments
    Florian M Heussen
    Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, California 90033, USA
    Br J Ophthalmol 96:380-5. 2012
    ..To compare retinal thickness measurements from three different spectral domain optical coherence instruments when manual segmentation is employed to standardise retinal boundary locations...
  5. pmc Risk factors for proliferative diabetic retinopathy in a latino american population
    Muneeswar G Nittala
    Doheny Eye Institute, Los Angeles, California NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology Shiley Eye Center, University of California, San Diego, California Veterans Administration Healthcare System, San Diego, California and Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California
    Retina 34:1594-9. 2014
    ..To assess the personal and demographic risk factors for proliferative diabetic retinopathy in Latino Americans in Los Angeles County...
  6. ncbi request reprint Autologous transplantation of retinal pigment epithelium after mechanical debridement of Bruch's membrane
    Stephen J Phillips
    Wilmer Ophthalmological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Curr Eye Res 26:81-8. 2003
    ..To determine whether transplantation of autologous retinal pigment epithelium (RPE) will prevent atrophy of the choriocapillaris and loss of photoreceptors in an area in which the RPE has been mechanically debrided from Bruch's membrane...
  7. ncbi request reprint Quantitative comparison of optical coherence tomography after pegaptanib or bevacizumab in neovascular age-related macular degeneration
    Sandra Joeres
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Ophthalmology 115:347-354.e2. 2008
    ....
  8. ncbi request reprint Structure and function of embryonic rat retinal sheet transplants
    Qing Peng
    Department of Ophthalmology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People s Republic of China
    Curr Eye Res 32:781-9. 2007
    ..To evaluate retinal sheet transplants in S334ter-line-3 retinal degenerate rats by comparing visual responses recorded electrophysiologically with morphology based on light and electron microscopy...
  9. pmc BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function
    Magdalene J Seiler
    Ophthalmology USC, Doheny, Los Angeles, CA, USA
    Exp Eye Res 86:92-104. 2008
    ..The mechanism of the BDNF effects--either promoting functional integration between the transplant and the host retina and/or synergistic action with other putative humoral factors released by the RPCs--still needs to be elucidated...
  10. ncbi request reprint The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits
    Hossein Ameri
    Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Invest Ophthalmol Vis Sci 48:5708-15. 2007
    ..To evaluate the effects of intravitreous bevacizumab in a rabbit retinal neovascularization model...
  11. pmc Behavioral evaluation of visual function of rats using a visual discrimination apparatus
    Biju B Thomas
    Department of Ophthalmology, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Neurosci Methods 162:84-90. 2007
    ..03, paired t-test). This apparatus could be useful to train rats at a very early age to distinguish between two different visual stimuli and may be effective for visual functional evaluations following therapeutic interventions...
  12. ncbi request reprint Visual functional effects of constant blue light in a retinal degenerate rat model
    Biju B Thomas
    Doheny Retina Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
    Photochem Photobiol 83:759-65. 2007
    ..Histological evaluation showed reduction of the rod population in the central area of the light-damaged retina. Exposure to constant BL considerably reduces the residual visual responses in a rapid degenerating RD rat model...
  13. pmc Quantitative subanalysis of optical coherence tomography after treatment with ranibizumab for neovascular age-related macular degeneration
    Pearse A Keane
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 49:3115-20. 2008
    ..To investigate the effects of ranibizumab on retinal morphology in patients with neovascular age-related macular degeneration (AMD) using optical coherence tomography (OCT) quantitative subanalysis...
  14. pmc Quantitative optical coherence tomography findings in various subtypes of neovascular age-related macular degeneration
    Sandra Liakopoulos
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 49:5048-54. 2008
    ..To compare the volume of various spaces visible on optical coherence tomography (OCT) images in different angiographic lesion subtypes of neovascular age-related macular degeneration (AMD)...
  15. pmc Assessing the relationship between central corneal thickness and retinal nerve fiber layer thickness in healthy subjects
    Tarkan Mumcuoglu
    UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 146:561-6. 2008
    ....
  16. ncbi request reprint Retinal transplants restore visual responses: trans-synaptic tracing from visually responsive sites labels transplant neurons
    Magdalene J Seiler
    Ophthalmology USC, Doheny Eye Institute, 1355 San Pablo Street, DVRC 402, Los Angeles, CA 90033, USA
    Eur J Neurosci 28:208-20. 2008
    ..This study provides anatomical evidence that synaptic connections between fetal retinal transplants and host retinas contribute to the visual responses in the SC...
  17. ncbi request reprint Optokinetic test to evaluate visual acuity of each eye independently
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute DVRC 402, Keck School of Medicine at the University of Southern California, 1355 San Pablo St, Los Angeles, CA 90033, USA
    J Neurosci Methods 138:7-13. 2004
    ..In conclusion, contributions from the fellow eye to the optokinetic tracking response can be limited by this testing modification, which is useful for evaluation of treatment effects to one eye...
  18. ncbi request reprint Superior colliculus responses to light - preserved by transplantation in a slow degeneration rat model
    Biju B Thomas
    Department of Ophthalmology, Doheny Eye Institute, University of Southern California, 1450 San Pablo St, Los Angeles, CA 90033, USA
    Exp Eye Res 79:29-39. 2004
    ....
  19. ncbi request reprint Retinal and optic nerve diseases
    Eyal Margalit
    Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA
    Artif Organs 27:963-74. 2003
    ..Clearly, a sound understanding of retinal and optic nerve disease pathophysiology is critical for designing and choosing the optimal visual prosthetic device...
  20. ncbi request reprint Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) with preserved perfusion
    David A DiLoreto
    Retinal Vascular Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Retina 23:554-7. 2003
  21. pmc 2-D registration and 3-D shape inference of the retinal fundus from fluorescein images
    Tae Eun Choe
    Institute for Robotics and Intelligent Systems, University of Southern California, 3737 Watt Way, Los Angeles, CA 90248, USA
    Med Image Anal 12:174-90. 2008
    ..The mutual information criterion is used to accurately estimate the dense disparity map. Our experimental results validate the proposed method on a set of difficult fluorescein image pairs...
  22. ncbi request reprint Changes in lesion size after submacular surgery for subfoveal choroidal neovascularization in the submacular surgery trials pilot study
    Srinivas R Sadda
    Doheny Retina Institute, Doheny Eye Institute, Los Angeles, California, USA
    Retina 24:888-99. 2004
    ..To compare the size of subfoveal lesions based on photographic documentation before and after submacular surgery of choroidal neovascularization (CNV) lesions...
  23. ncbi request reprint Light response differences in the superior colliculus of albino and pigmented rats
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, DVRC 402, 1355 San Pablo St, Los Angeles, CA 90033, USA
    Neurosci Lett 385:143-7. 2005
    ..This can be attributed to the transmission of rod-driven responses. The differences observed in the light response characteristics of albino rats may be indicative of their visual abnormalities...
  24. ncbi request reprint Quantitative fluorescein angiographic analysis of choroidal neovascular membranes: validation and correlation with visual function
    Usha Chakravarthy
    Doheny Retina Institute Advanced Macular Diagnostics Lab, Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine, at the University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 48:349-54. 2007
    ....
  25. ncbi request reprint Retinal transplantation. A treatment strategy for retinal degenerative diseases
    Biju B Thomas
    Dept Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Adv Exp Med Biol 572:367-76. 2006
    ..Modified functional evaluation techniques permit better understanding of the physiological mechanisms underlying visual improvement in animal models...
  26. ncbi request reprint Error correction and quantitative subanalysis of optical coherence tomography data using computer-assisted grading
    Srinivas R Sadda
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 48:839-48. 2007
    ..To demonstrate feature subanalysis and error correction of optical coherence tomography (OCT) data by using computer-assisted grading...
  27. pmc Automated detection of clinically significant macular edema by grid scanning optical coherence tomography
    Srinivas R Sadda
    Doheny Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Ophthalmology 113:1187.e1-12. 2006
    ..To compare the detection of clinically significant diabetic macular edema (DME) by an optical coherence tomography (OCT) grid scanning protocol and biomicroscopic examination...
  28. ncbi request reprint Errors in retinal thickness measurements obtained by optical coherence tomography
    Srinivas R Sadda
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California 90033, USA
    Ophthalmology 113:285-93. 2006
    ..To report the frequency and severity of optical coherence tomography (OCT) retinal thickness measurement errors and to describe parameters that predict these errors...
  29. ncbi request reprint Retinal transplants evaluated by optical coherence tomography in photoreceptor degenerate rats
    Biju B Thomas
    Department of Ophthalmology, Doheny Retina Institute, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033, USA
    J Neurosci Methods 151:186-93. 2006
    ..OCT is a useful technique for in vivo screening and evaluation of retinal transplants. This technique determines surgical outcomes at a much earlier stage...
  30. ncbi request reprint Reproducibility of quantitative optical coherence tomography subanalysis in neovascular age-related macular degeneration
    Sandra Joeres
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Invest Ophthalmol Vis Sci 48:4300-7. 2007
    ..To determine the intergrader reproducibility for computer-assisted grading of optical coherence tomography (OCT) images in eyes with neovascular age-related macular degeneration (AMD), by using a standardized grading procedure...
  31. ncbi request reprint Rapid recurrence of geographic atrophy after full macular translocation for nonexudative age-related macular degeneration
    Rahul N Khurana
    Doheny Retina Institute, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Ophthalmology 112:1586-91. 2005
    ..To report the recurrence of geographic atrophy (GA) in a patient with nonexudative age-related macular degeneration (AMD) after full macular translocation...
  32. ncbi request reprint Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography
    Ziqiang Wu
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California 90033, USA
    Ophthalmology 114:1505-12. 2007
    ..To identify factors associated with variability in retinal nerve fiber layer (RNFL) thickness measurements obtained by optical coherence tomography (OCT)...

Research Grants3

  1. Objective Diagnosis & Quantification of Retinal Disease
    SriniVas Sadda; Fiscal Year: 2007
    ..This technology will be of great value in future clinical and pre-clinical studies, and in everyday clinical practice. ..
  2. Genetic Susceptibility for Development of Proliferative Diabetic Retinopathy
    SriniVas Sadda; Fiscal Year: 2009
    ..abstract_text> ..
  3. Genetic Susceptibility for Development of Proliferative Diabetic Retinopathy
    Kang Zhang; Fiscal Year: 2010
    ..abstract_text> ..