Jun Ming Zhang

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Cytokines, inflammation, and pain
    Jun Ming Zhang
    Department of Anesthesiology, University of Cincinnati, Cincinnati, Ohio, 45267 0531, USA
    Int Anesthesiol Clin 45:27-37. 2007
  2. pmc NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons
    Rui Hua Yang
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0531, USA
    Mol Pain 5:26. 2009
  3. ncbi request reprint Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain
    Jun Ming Zhang
    Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Sheng Li Xue Bao 60:617-27. 2008
  4. pmc Neuropathic pain: early spontaneous afferent activity is the trigger
    Wenrui Xie
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Pain 116:243-56. 2005
  5. ncbi request reprint Thermosensitivity of large primary sensory neurons
    Huiqing Li
    Department of Anesthesiology, Slot 515, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Brain Res 926:18-26. 2002
  6. pmc Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block
    Wenrui Xie
    Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670531, Cincinnati, OH 45267 0531, USA
    J Neurophysiol 97:492-502. 2007
  7. ncbi request reprint A comparison of chronic pain behavior following local application of tumor necrosis factor alpha to the normal and mechanically compressed lumbar ganglia in the rat
    Yuko Homma
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72211, USA
    Pain 95:239-46. 2002
  8. pmc Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia
    Wenrui Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pain 154:1170-80. 2013
  9. ncbi request reprint Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia
    Baogang Liu
    Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 88:1393-9. 2002
  10. pmc Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro
    Fei Dong
    Department of Anesthesiology, Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Anesthesiology 117:1102-12. 2012

Research Grants

  1. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2000
  2. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2010
  3. NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAIN
    Jun Ming Zhang; Fiscal Year: 2010
  4. NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAIN
    Jun Ming Zhang; Fiscal Year: 2009
  5. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2007
  6. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2006
  7. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2005
  8. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2004
  9. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2003
  10. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2002

Detail Information

Publications26

  1. pmc Cytokines, inflammation, and pain
    Jun Ming Zhang
    Department of Anesthesiology, University of Cincinnati, Cincinnati, Ohio, 45267 0531, USA
    Int Anesthesiol Clin 45:27-37. 2007
  2. pmc NF-kappaB mediated enhancement of potassium currents by the chemokine CXCL1/growth related oncogene in small diameter rat sensory neurons
    Rui Hua Yang
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0531, USA
    Mol Pain 5:26. 2009
    ..Fluorescently labeled isolectin B4 (IB4) was used to classify cells as IB4-positive or IB4-negative...
  3. ncbi request reprint Recent evidence for activity-dependent initiation of sympathetic sprouting and neuropathic pain
    Jun Ming Zhang
    Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Sheng Li Xue Bao 60:617-27. 2008
    ..An improved understanding of the causes of spontaneous activity and the origins of neuropathic pain should facilitate the development of novel strategies for effective treatment of pathological pain...
  4. pmc Neuropathic pain: early spontaneous afferent activity is the trigger
    Wenrui Xie
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Pain 116:243-56. 2005
    ..Our results suggest that effective pre-emptive analgesia can be achieved only when nerve block is administered early after injury and lasts several days...
  5. ncbi request reprint Thermosensitivity of large primary sensory neurons
    Huiqing Li
    Department of Anesthesiology, Slot 515, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Brain Res 926:18-26. 2002
    ..It also suggests that maintenance of a stable temperature is critical for reliable characterization of spontaneous activity of sensory neurons...
  6. pmc Sympathetic sprouting near sensory neurons after nerve injury occurs preferentially on spontaneously active cells and is reduced by early nerve block
    Wenrui Xie
    Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670531, Cincinnati, OH 45267 0531, USA
    J Neurophysiol 97:492-502. 2007
    ....
  7. ncbi request reprint A comparison of chronic pain behavior following local application of tumor necrosis factor alpha to the normal and mechanically compressed lumbar ganglia in the rat
    Yuko Homma
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72211, USA
    Pain 95:239-46. 2002
    ..Results also suggest that endogenous TNF-alpha contributes to the early development of mechanical allodynia in rats with chronic DRG compression...
  8. pmc Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia
    Wenrui Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pain 154:1170-80. 2013
    ..However, the results suggest that NaV1.6 may be a useful therapeutic target for chronic pain and that some pain conditions may be mediated primarily by myelinated A fiber sensory neurons...
  9. ncbi request reprint Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia
    Baogang Liu
    Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 88:1393-9. 2002
    ..Inflammatory cytokines such as TNF-alpha increased the sensitivity of sensory neurons in normal and CCD rats. The CCD injury itself, on the other hand, increased neuronal responses to inflammatory cytokines...
  10. pmc Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro
    Fei Dong
    Department of Anesthesiology, Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Anesthesiology 117:1102-12. 2012
    ..The mineralocorticoid receptor (MR) plays a proinflammatory role in many nonrenal tissues, but its role in peripheral pain at the DRG level is not well studied...
  11. pmc Increased excitability and spontaneous activity of rat sensory neurons following in vitro stimulation of sympathetic fiber sprouts in the isolated dorsal root ganglion
    Wenrui Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Pain 151:447-59. 2010
    ..The latter treatment, a relatively minimal form of sympathectomy, was also highly effective in reducing mechanical pain ipsilateral to the SNL...
  12. pmc Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse
    Wenrui Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Mol Pain 7:53. 2011
    ..Medium and large diameter lumbar sensory neurons with and without nearby sympathetic fibers were recorded in whole ganglion preparations using microelectrodes...
  13. ncbi request reprint Acute topical application of tumor necrosis factor alpha evokes protein kinase A-dependent responses in rat sensory neurons
    Jun Ming Zhang
    Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 88:1387-92. 2002
    ....
  14. pmc Microarray analysis of rat sensory ganglia after local inflammation implicates novel cytokines in pain
    Judith A Strong
    Department of Anesthesiology, Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e40779. 2012
    ..Cxcl11, Cxcl13, and Cxcl14 were found to be significantly upregulated in all these conditions, while Cxcl9, Cxcl10, and Cxcl16 were upregulated in at least two of these conditions...
  15. ncbi request reprint Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neuropathic pain using lidocaine
    Jun Ming Zhang
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 W Markham St, 515, Little Rock, AR 72205, USA
    Pain 109:143-9. 2004
    ..g. neuroma). This finding provides new insight into the mechanisms underlying sympathetic sprouting and increases our current understanding of the prolonged therapeutic effects of lidocaine on neuropathic pain syndromes...
  16. pmc Knockdown of the sphingosine-1-phosphate receptor S1PR1 reduces pain behaviors induced by local inflammation of the rat sensory ganglion
    Wenrui Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Neurosci Lett 515:61-5. 2012
    ..The results indicate that the S1PR1 receptors in sensory ganglia cells may play an important role in regulating behavioral sensitivity during inflammation...
  17. pmc Preclinical studies of low back pain
    Judith A Strong
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Mol Pain 9:17. 2013
    ..Additional preclinical research is needed to address other possible reasons for limited efficacy of steroids, such as central sensitization or presence of an ongoing inflammatory stimulus in some forms of low back pain...
  18. pmc Local inflammation in rat dorsal root ganglion alters excitability and ion currents in small-diameter sensory neurons
    Jun Gang Wang
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Anesthesiology 107:322-32. 2007
    ..This results in prolonged mechanical pain, local increases in proinflammatory cytokines, increased neuronal hyperexcitability, and abnormal spontaneous activity...
  19. ncbi request reprint Mechanical hyperalgesia in rat models of systemic and local hyperglycemia
    Maxim Dobretsov
    Department of Anesthesiology, Slot 515, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205 7101, USA
    Brain Res 960:174-83. 2003
    ..These data also support the idea of activation of aldose reductase and polyol pathway as an important mechanism of hyperglycemia-induced impairment of nerve function...
  20. pmc Increased function of the TRPV1 channel in small sensory neurons after local inflammation or in vitro exposure to the pro-inflammatory cytokine GRO/KC
    Fei Dong
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0531, USA
    Neurosci Bull 28:155-64. 2012
    ..The aim of this study was to characterize the regulation of the TRPV1 channel by local DRG inflammation and by growth-related oncogene (GRO/KC, systemic name: CXCL1), a cytokine known to be upregulated in inflamed DRGs...
  21. pmc The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons
    Jun Gang Wang
    Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0531, USA
    Mol Pain 4:38. 2008
    ..Neurons and glia express its receptor (CXCR2). CXCL1 has well-known effects on immune cells, but little is known about its direct effects on neurons...
  22. ncbi request reprint Nonopioid analgesics
    Muhammad A Munir
    Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 67031, Cincinnati, OH 45267 0531, USA
    Med Clin North Am 91:97-111. 2007
    ..Their use is frequently overlooked in patients with postoperative and chronic pain. Unless there is a contraindication, the use of an NSAID should be routinely considered to manage acute pain, chronic cancer, and noncancer pain...
  23. pmc Systemic antiinflammatory corticosteroid reduces mechanical pain behavior, sympathetic sprouting, and elevation of proinflammatory cytokines in a rat model of neuropathic pain
    Huiqing Li
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0531, USA
    Anesthesiology 107:469-77. 2007
    ..Chronic pain models are commonly defined as either nerve-injury or inflammation models, but recent work suggests inflammatory processes are important in nerve injury-induced pain...
  24. ncbi request reprint Nonopioid analgesics
    Muhammad A Munir
    Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 67031, Cincinnati, OH 45267 0531, USA
    Anesthesiol Clin 25:761-74, vi. 2007
    ..Clinicians treating pain should be familiar with the actions, adverse effects, and individual agents in the group of nonopioid analgesics...
  25. pmc Peripheral nerve injury sensitizes neonatal dorsal horn neurons to tumor necrosis factor-alpha
    Jie Li
    Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Mol Pain 5:10. 2009
    ..Thus we examined the effects of TNFalpha on synaptic transmission and intrinsic membrane excitability in developing rat SDH neurons in the absence or presence of sciatic nerve damage...
  26. pmc Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling
    W Keith Jones
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, OH 45267 0575, USA
    Circulation 120:S1-9. 2009
    ..We previously described a remote cardioprotective effect of nonischemic surgical trauma (abdominal incision) called remote preconditioning of trauma (RPCT). In the present study, we elucidate mechanisms underlying this phenomenon...

Research Grants14

  1. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2000
    ....
  2. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2010
    ..We propose to continue the study of sympathetic component in neuropathic pain. Using a rat/mouse model, we will determine how abnormal activity, inflammation, ATP release affect sympathetic outgrowth and the neurons that sense pain. ..
  3. NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAIN
    Jun Ming Zhang; Fiscal Year: 2010
    ..We propose to study the newly recognized role of inflammation in chronic pain. Using a rat model, we will determine how inflammation directly affects the neurons that sense pain. ..
  4. NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAIN
    Jun Ming Zhang; Fiscal Year: 2009
    ..We propose to study the newly recognized role of inflammation in chronic pain. Using a rat model, we will determine how inflammation directly affects the neurons that sense pain. ..
  5. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2007
    ..Such therapies could provide more effective non-opioid analgesia to patients with neuropathic pain. ..
  6. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2006
    ..Such therapies could provide more effective non-opioid analgesia to patients with neuropathic pain. ..
  7. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2005
    ..Such therapies could provide more effective non-opioid analgesia to patients with neuropathic pain. ..
  8. STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTING
    Jun Ming Zhang; Fiscal Year: 2004
    ..Such therapies could provide more effective non-opioid analgesia to patients with neuropathic pain. ..
  9. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2003
    ....
  10. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2002
    ....
  11. STUDY OF CHEMOGENIC LOW BACK PAIN
    Jun Ming Zhang; Fiscal Year: 2001
    ....
  12. NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAIN
    Jun Ming Zhang; Fiscal Year: 2011
    ..We propose to study the newly recognized role of inflammation in chronic pain. Using a rat model, we will determine how inflammation directly affects the neurons that sense pain. ..