Jing Zhang

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Proteomics of human neurodegenerative diseases
    Jing Zhang
    Department of Pathology, University of Washington, Harborview Medical Centre, Seattle, Washington 98104, USA
    J Neuropathol Exp Neurol 67:923-32. 2008
  2. doi request reprint Identification of glycoproteins in human cerebrospinal fluid
    Hye Jin Hwang
    Department of Pathology, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA, USA
    Methods Mol Biol 566:263-76. 2009
  3. pmc Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Ave, Seattle, WA, 98104, USA
    Acta Neuropathol 126:671-82. 2013
  4. pmc Premotor biomarkers for Parkinson's disease - a promising direction of research
    Brian R Haas
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA, 98104, USA
    Transl Neurodegener 1:11. 2012
  5. ncbi request reprint Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseases
    Jing Zhang
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Alzheimers Dis 8:377-86. 2005
  6. ncbi request reprint Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
  7. doi request reprint Proteomics of human cerebrospinal fluid - the good, the bad, and the ugly
    Jing Zhang
    Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Proteomics Clin Appl 1:805-19. 2007
  8. ncbi request reprint Proteomic approach to studying Parkinson's disease
    Jing Zhang
    University of Washington and Institute for Systems Biology, Seattle, WA
    Mol Neurobiol 29:271-88. 2004
  9. ncbi request reprint Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction
    Jing Zhang
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurochem 84:336-46. 2003
  10. pmc Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
    Ann Neurol 69:570-80. 2011

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. pmc Proteomics of human neurodegenerative diseases
    Jing Zhang
    Department of Pathology, University of Washington, Harborview Medical Centre, Seattle, Washington 98104, USA
    J Neuropathol Exp Neurol 67:923-32. 2008
    ..Here, we review the fundamentals of commonly used proteomic approaches and the outcomes of these investigations with autopsy and cerebrospinal fluid samples from patients with neurodegenerative diseases...
  2. doi request reprint Identification of glycoproteins in human cerebrospinal fluid
    Hye Jin Hwang
    Department of Pathology, Harborview Medical Center, University of Washington School of Medicine, Seattle, WA, USA
    Methods Mol Biol 566:263-76. 2009
    ..This review centers on the technical details involved in various steps in sample preparation as well as proteomic analysis of CSF glycoproteins...
  3. pmc Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Ave, Seattle, WA, 98104, USA
    Acta Neuropathol 126:671-82. 2013
    ....
  4. pmc Premotor biomarkers for Parkinson's disease - a promising direction of research
    Brian R Haas
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA, 98104, USA
    Transl Neurodegener 1:11. 2012
    ..The current review highlights recent advances and underscores areas of potential advancement...
  5. ncbi request reprint Proteomic biomarker discovery in cerebrospinal fluid for neurodegenerative diseases
    Jing Zhang
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Alzheimers Dis 8:377-86. 2005
    ..Great attention has been directed to practical considerations and limitations of several major aspects of proteomic analysis of human CSF...
  6. ncbi request reprint Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
    ..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
  7. doi request reprint Proteomics of human cerebrospinal fluid - the good, the bad, and the ugly
    Jing Zhang
    Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Proteomics Clin Appl 1:805-19. 2007
    ..The potential future directions of CSF proteomics are also discussed with this analysis...
  8. ncbi request reprint Proteomic approach to studying Parkinson's disease
    Jing Zhang
    University of Washington and Institute for Systems Biology, Seattle, WA
    Mol Neurobiol 29:271-88. 2004
    ..This review summarizes the current related research fields and proposes a proteomic approach to investigate the mechanisms that may dictate alpha-synuclein aggregation, Lewy body formation, and neurodegeneration...
  9. ncbi request reprint Manganese ethylene-bis-dithiocarbamate and selective dopaminergic neurodegeneration in rat: a link through mitochondrial dysfunction
    Jing Zhang
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurochem 84:336-46. 2003
    ....
  10. pmc Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
    Ann Neurol 69:570-80. 2011
    ..We and others have demonstrated that a decrease in DJ-1 and/or α-synuclein in the cerebrospinal fluid (CSF) is a potential index for Parkinson disease diagnosis, but not for PD severity...
  11. ncbi request reprint Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 5:1193-204. 2006
    ..Manipulations of mortalin level in dopaminergic neurons resulted in significant changes in sensitivity to PD phenotypes via pathways involving mitochondrial and proteasomal function as well as oxidative stress...
  12. ncbi request reprint Analysis of alpha-synuclein-associated proteins by quantitative proteomics
    Yong Zhou
    Department of Pathology and Medicinal Chemistry, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Biol Chem 279:39155-64. 2004
    ..Furthermore, the protection afforded by hsp70 transfection appeared to be related to suppression of rotenone-induced oxidative stress as well as mitochondrial and proteasomal dysfunction...
  13. pmc Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    BMC Neurosci 8:67. 2007
    ..A comprehensive analysis of the mitochondrial protein expression profile affected by rotenone can provide important insight into the role of mitochondrial dysfunction in PD...
  14. pmc DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease
    Zhen Hong
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Brain 133:713-26. 2010
    ..We have demonstrated that total DJ-1 and alpha-synuclein in human cerebrospinal fluid are helpful diagnostic markers for Parkinson's disease, if variables such as blood contamination and age are taken into consideration...
  15. pmc Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurosci Lett 480:78-82. 2010
    ..In conclusion, unlike in cerebrospinal fluid, total DJ-1 or alpha-synuclein in plasma alone is not useful as biomarkers for Parkinson's disease diagnosis or progression/severity...
  16. ncbi request reprint Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease
    Randall L Woltjer
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
    FASEB J 19:1923-5. 2005
    ..These results are consistent with the amyloid hypothesis of AD and extend it to include widespread protein insolubility, not exclusively Abeta insolubility, early in AD pathogenesis even before the onset of clinical dementia...
  17. pmc Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial
    Angela J Hanson
    Geriatric Research, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington, USA
    JAMA Neurol 70:972-80. 2013
    ..Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. However, not much is known about the lipid states of these proteins in human cerebrospinal fluid...
  18. doi request reprint Mortalin: a protein associated with progression of Parkinson disease?
    Min Shi
    Department of Pathology, University of Washington, School of Medicine, Seattle, Washington, USA
    J Neuropathol Exp Neurol 67:117-24. 2008
    ..Of those, mortalin, a mitochondrial protein, was decreased in the advanced PD cases and was further validated to be decreased using independent techniques. These results suggest a role for mortalin in PD progression...
  19. ncbi request reprint Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Alzheimers Dis 7:125-33; discussion 173-80. 2005
    ....
  20. pmc DJ-1 isoforms in whole blood as potential biomarkers of Parkinson disease
    Xiangmin Lin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Sci Rep 2:954. 2012
    ....
  21. pmc Salivary tau species are potential biomarkers of Alzheimer's disease
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Alzheimers Dis 27:299-305. 2011
    ..These results suggest that salivary tau species could be ideal biomarkers for AD diagnosis, especially at early stages of the disease or even screening asymptomatic subjects, allowing for a much larger therapeutic window for AD patients...
  22. pmc Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy
    Yu Wang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Pathol 178:1509-16. 2011
    ..Both C3 and FH correlated with the severity of impairment in AD as indicated using Mini-Mental State Examination scores...
  23. ncbi request reprint Characterization of proteome of human cerebrospinal fluid
    Jing Xu
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Int Rev Neurobiol 73:29-98. 2006
  24. pmc CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment
    Thomas J Montine
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mov Disord 25:2682-5. 2010
    ..01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of Aβ(42) may be a common feature of PD-CIND and PD-D...
  25. ncbi request reprint Oligomeric alpha-synuclein inhibits tubulin polymerization
    Leo Chen
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Biochem Biophys Res Commun 356:548-53. 2007
    ..Finally, we demonstrated that neurotoxicity induced by oligomeric alpha-synuclein was largely prevented by overexpressing the neuroprotective protein, DJ-1...
  26. ncbi request reprint Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
    Qin Wang
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, Washington 98105, USA
    FASEB J 19:869-71. 2005
    ....
  27. pmc A role for a novel protein, nucleolin, in Parkinson's disease
    W Michael Caudle
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, United States
    Neurosci Lett 459:11-5. 2009
    ..Interestingly, nucleolin expression did not influence mitochondrial complex I activity, suggesting a selective specificity for oxidative stress and proteasomal pathways...
  28. pmc Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    J Neuroinflammation 4:2. 2007
    ..It has been demonstrated that aggregated alpha-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated alpha-synuclein activates microglia are not understood fully...
  29. ncbi request reprint A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Proteomics 7:469-73. 2007
    ..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date...
  30. ncbi request reprint Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease
    Jinghua Jin
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Res Mol Brain Res 134:119-38. 2005
    ..In addition, DJ-1 was present in the halo but not in the core of classical LBs in patients with PD. Our findings suggested that DJ-1 might play an important role in mitochondrial dysfunction, as well as LB formation in PD...
  31. pmc Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Pathol 175:54-65. 2009
    ..These results have, for the first time, suggested that the levels of glutathione S-transferase Pi may play an important role in modulating the progression of PD...
  32. ncbi request reprint Proteomic analysis of microglial contribution to mouse strain-dependent dopaminergic neurotoxicity
    Patrick McLaughlin
    Department of Pathology, University of Washington School of Medicine, Seattle, 98104, USA
    Glia 53:567-82. 2006
    ..SWR/J microglia with semiquantitative Western blot. Further analysis of our proteomic discovery data will likely reveal numerous novel proteins involved in inflammation-mediated neurotoxicity in PD...
  33. doi request reprint Quantitative characterization of glycoproteins in neurodegenerative disorders using iTRAQ
    Min Shi
    Department of Pathology, University of Washington School of Medicine, HMC, Seattle, WA, USA
    Methods Mol Biol 951:279-96. 2013
    ....
  34. pmc Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy
    Wan Yang
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, Seattle, WA 98104, USA
    Am J Pathol 171:993-1002. 2007
    ..These results show that frontal and temporal cortex in PDC is distinguished from AD and PSP by its accumulation of abnormal SNCA and suggest that PDC be considered a synucleinopathy as well as a tauopathy...
  35. pmc CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Am J Clin Pathol 129:526-9. 2008
    ..This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD...
  36. pmc Glycoproteomics in neurodegenerative diseases
    Hyejin Hwang
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Mass Spectrom Rev 29:79-125. 2010
    ....
  37. ncbi request reprint Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
    ..Further investigation of these novel candidates is also necessary to ensure that the potential proteins in cortical LBs are not identified incorrectly because of incomplete current human protein database...
  38. ncbi request reprint Proteomics identification of proteins in human cortex using multidimensional separations and MALDI tandem mass spectrometer
    Sheng Pan
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:1818-23. 2007
    ..Finally 140 proteins found in the cortical proteome were present in the proteome of cerebrospinal fluid, providing tissue-specific candidates for biomarker discovery in body fluid...
  39. ncbi request reprint Identification of glycoproteins in human cerebrospinal fluid with a complementary proteomic approach
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    J Proteome Res 5:2769-79. 2006
    ..This investigation, for the first time, not only categorized many glycoproteins in human CSF but also expanded the existing overall CSF protein database...
  40. ncbi request reprint Identification of novel proteins associated with both alpha-synuclein and DJ-1
    Jinghua Jin
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 6:845-59. 2007
    ..Further characterization of these docking proteins will likely shed more light on the mechanisms by which DJ-1 modulates the function of alpha-synuclein, and vice versa, in the setting of PD...
  41. pmc Mass spectrometry based targeted protein quantification: methods and applications
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 8:787-97. 2009
    ..This report reviews recently developed platform technologies for emerging applications of clinical proteomics and biomarker development...
  42. ncbi request reprint Identification of proteins involved in microglial endocytosis of alpha-synuclein
    Jun Liu
    Departments of Pathology and Materials Science and Engineering, University of Washington School of Medicine, Seattle, Washington 98104, USA
    J Proteome Res 6:3614-27. 2007
    ....
  43. pmc Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion
    Robert C Rostomily
    Department of Neurological Surgery, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
    J Proteome Res 9:2610-8. 2010
    ..Future analysis of larger patient samples are warranted to further refine biomarker panels to predict biological behavior and assist in the identification of deleted gene products that define the 1p/19q phenotype...
  44. pmc Biomarker discovery in neurodegenerative diseases: a proteomic approach
    Min Shi
    Department of Pathology, University of Washington School of Medicine, HMC Box 359635, 325 9th Avenue, Seattle, WA 98104, USA
    Neurobiol Dis 35:157-64. 2009
    ....
  45. pmc Cerebrospinal fluid biomarkers and cognitive performance in non-demented patients with Parkinson's disease
    James B Leverenz
    Mental Illness Research, Education, and Clinical Center of Veterans Administration, Seattle, WA, USA
    Parkinsonism Relat Disord 17:61-4. 2011
    ....
  46. pmc Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Harborview Medical Center, Seattle, Washington 98104, USA
    NeuroRx 3:336-43. 2006
    ..As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases...
  47. pmc Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts
    Isaiah Gregory Schauer
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Neoplasia 15:409-20. 2013
    ..These findings implicate CAFs as an important target for blocking inflammation in the tumor microenvironment and reducing tumor growth...
  48. pmc DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Neurobiol Aging 33:836.e5-7. 2012
    ....
  49. pmc Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism
    Elizabeth A Stoll
    Neurobiology and Behavior Program, University of Washington, Seattle, Washington 98109, USA
    J Biol Chem 286:38592-601. 2011
    ..These results demonstrate that aging NPCs display an altered metabolic phenotype, characterized by a coordinated shift in protein expression, subcellular structure, and metabolic physiology...
  50. pmc Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease
    W Michael Caudle
    University of Washington, Seattle, WA, USA
    Expert Rev Neurother 10:925-42. 2010
    ..It is hoped that further integration of these techniques will yield a more comprehensive understanding of Parkinson's disease etiology and the biological pathways that mediate neurodegeneration...
  51. doi request reprint Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:720-30. 2008
    ....
  52. ncbi request reprint Isofurans, but not F2-isoprostanes, are increased in the substantia nigra of patients with Parkinson's disease and with dementia with Lewy body disease
    Joshua P Fessel
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Neurochem 85:645-50. 2003
    ....
  53. ncbi request reprint Microglial activation induced by neurodegeneration: a proteomic analysis
    Yong Zhou
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Mol Cell Proteomics 4:1471-9. 2005
    ..The search revealed numerous novel proteins that are potentially important in neurodegeneration-mediated microglial activation, a process believed to be critical in Parkinson disease progression...
  54. ncbi request reprint Isoprostanes and related products of lipid peroxidation in neurodegenerative diseases
    Kathleen S Montine
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359791, 325 9th Ave, Seattle, WA 98104, USA
    Chem Phys Lipids 128:117-24. 2004
    ..These results indicate that brain lipid peroxidation is a potential therapeutic target early in the course of AD and HD, that CSF IsoPs may aid in the assessment of anti-oxidant experimental therapeutics and laboratory diagnosis of AD...
  55. pmc Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
    Jennifer L Bayer-Carter
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 68:743-52. 2011
    ....
  56. doi request reprint Applying bioinformatics to proteomics: is machine learning the answer to biomarker discovery for PD and MSA?
    HAYLEY A MATTISON
    Department of Pathology, University of Washington, Seattle, Washington 98104, USA
    Mov Disord 27:1595-7. 2012
    ....
  57. pmc Suppressed pro-inflammatory response of microglia in CX3CR1 knockout mice
    HAYLEY A MATTISON
    Department of Pathology, Box 359635, 325 9th Ave University of Washington, Seattle, WA 98104, USA
    J Neuroimmunol 257:110-5. 2013
    ....
  58. pmc Sex-determining region Y-box 2 expression predicts poor prognosis in human ovarian carcinoma
    Jing Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 43:1405-12. 2012
    ..035; log-rank test). Our results showed that sex-determining region Y-box 2 expression may be a potential marker related to tumor recurrence, as implicated by its role in cancer stem cells...
  59. pmc Phosphorylated α-synuclein in Parkinson's disease
    Yu Wang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Sci Transl Med 4:121ra20. 2012
    ....
  60. pmc Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative disease
    W Michael Caudle
    Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA
    Proteomics Clin Appl 2:1484-97. 2008
    ....
  61. doi request reprint Identification of proteins in human substantia nigra
    Efstathia Kitsou
    Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA
    Proteomics Clin Appl 2:776-82. 2008
    ..Further characterization of the SNpc proteome will significantly facilitate our understanding of the function and expression of proteins involved in PD, as well as provide potential proteins that may be utilized as biomarkers...
  62. ncbi request reprint Biomarkers for Alzheimer's disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2499, USA
    Expert Rev Neurother 7:1021-8. 2007
    ..The next 5 years will see standardization of more established approaches, and the combination of different modalities into the most effective means for assessing different stages of AD...
  63. pmc Biomarkers for cognitive impairment in Parkinson disease
    Min Shi
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    Brain Pathol 20:660-71. 2010
    ..The current findings and perspectives of applying these strategies and techniques are reviewed in this article, together with potential areas of advancement...
  64. ncbi request reprint Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    Guangyu Gu
    Division of Neuropathology, Department of Pathology, University of Washington School of Medicine, Box 359660, Harborview Medical Center, Seattle, WA 98104, USA
    Biochem Biophys Res Commun 308:197-205. 2003
    ..None of these six genes are encoded by mitochondrial DNA. The potential significance of these gene alterations in the context of Parkinson's disease is discussed...
  65. pmc Mucinous adenocarcinoma developed from human fallopian tube epithelial cells through defined genetic modifications
    Weiwei Shan
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Cell Cycle 11:2107-13. 2012
    ..Thus, we provide the first experimental evidence that fimbrial epithelial cells of the fallopian tube could be a potential source of ovarian mucinous adenocarcinoma...
  66. pmc SNCA variant associated with Parkinson disease and plasma alpha-synuclein level
    Ignacio F Mata
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Mailstop S 182, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 67:1350-6. 2010
    ..A functional repeat polymorphism in the SNCA promoter (REP1) conveys susceptibility for Parkinson disease (PD). There is also increasing evidence that single-nucleotide polymorphisms (SNPs) elsewhere in the gene are associated with PD risk...
  67. ncbi request reprint Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders
    Guangyu Gu
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    J Neuropathol Exp Neurol 61:634-9. 2002
    ..These data suggest that accumulation of total mtDNA deletions/rearrangements is a relatively specific characteristic of PD and may be one of the contributing factors leading to mitochondrial dysfunction and neurodegeneration in PD...
  68. ncbi request reprint Catalysis of catechol oxidation by metal-dithiocarbamate complexes in pesticides
    Vanessa A Fitsanakis
    Departments of Pathology and Pharmacology and Centers for Molecular Toxicology and Molecular Neurosciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Free Radic Biol Med 33:1714-23. 2002
    ..Our results point to the potential for manganese- and zinc-containing EBDC pesticides to promote oxidative stress in catecholaminergic regions of the brain...
  69. pmc CD133 expression associated with poor prognosis in ovarian cancer
    Jing Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 25:456-64. 2012
    ..024). Our results thus show that CD133 expression is a predictor of poor clinical outcome for patients with ovarian cancer, supporting the proposed link between CD133 and cancer stem cells...
  70. pmc Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease
    Jake G Hoekstra
    Department of Pathology, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Alzheimers Res Ther 3:21. 2011
    ..Recent discoveries pertaining to mitochondrial dynamics reveal that regulation of mitochondrial fission and fusion may play a key role in the pathogenesis of these diseases and consequently could be novel future therapeutic targets...
  71. pmc UniPep--a database for human N-linked glycosites: a resource for biomarker discovery
    Hui Zhang
    Institute for Systems Biology, Seattle, WA 98103, USA
    Genome Biol 7:R73. 2006
    ..Here, we describe UniPep http://www.unipep.org--a database of human N-linked glycosites--as a resource for biomarker discovery...
  72. ncbi request reprint Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders
    Fadi Abdi
    Applied Biosystems, Framingham, MA, USA
    J Alzheimers Dis 9:293-348. 2006
    ....
  73. ncbi request reprint Proteomic discovery of CSF biomarkers for Alzheimer's disease
    Jing Zhang
    Ann Neurol 61:497; author reply 497-8. 2007
  74. ncbi request reprint Aquaporin 4 regulates the effects of ovarian hormones on monoamine neurotransmission
    Xiu Lan Sun
    Laboratory of Reproductive Medicine and Neuropharmacology, Department of Anatomy, Histology and Pharmacology, Nanjing Medical University, Nanjing, Jiangsu 210029, PR China
    Biochem Biophys Res Commun 353:457-62. 2007
    ..These findings reveal for the first time that AQP4 regulates not only water and ion homeostasis but also the functions of ovarian hormone and neurotransmitter...
  75. ncbi request reprint Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  76. pmc Knockout of the neural and heart expressed gene HF-1b results in apical deficits of ventricular structure and activation
    Kenneth W Hewett
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, United States
    Cardiovasc Res 67:548-60. 2005
    ..This abnormality in myocardial Cx40 led us to address whether 4-week-old HF-1b knockout postnates display other disruptions to ventricular structure and function...
  77. ncbi request reprint Exploring candidate genes for human brain diseases from a brain-specific gene network
    Bing Liu
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China
    Biochem Biophys Res Commun 349:1308-14. 2006
    ..And the higher score a gene has, the more likely this gene is a disease-related one. The results suggest that the proposed method is effective, convenient, and applicable in the future genetic studies...
  78. ncbi request reprint Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans
    Rudy J Castellani
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Neurosci Lett 319:25-8. 2002
    ..These findings not only support prior studies indicating that lipid peroxidation is increased in patients with PD and DLBD but that oxidative damage may play a critical role in Lewy body formation...
  79. ncbi request reprint Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007
    ..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
  80. ncbi request reprint The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation
    Chun Shui Pan
    Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing 100034, China
    Peptides 28:900-9. 2007
    ....
  81. doi request reprint Predominant release of lysosomal enzymes by newborn rat microglia after LPS treatment revealed by proteomic studies
    Jun Liu
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiatong University School of Medicine, Shanghai, China
    J Proteome Res 7:2033-49. 2008
    ....
  82. ncbi request reprint Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase
    Ye Xiong
    Institute of Environmental Health Sciences, Wayne State University, Detroit, Michigan 48201, USA
    J Neurochem 95:732-44. 2005
    ..In conclusion, our results imply that mitochondrial dysfunction induced by superoxide anion radical contributes to lesion formation in mouse brain following physical trauma...
  83. doi request reprint Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
    Xiaochun Chen
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, China
    Brain Res 1200:99-106. 2008
    ..The present study suggests that Ca(2+), calpain, and p25 in CDK5 pathway may play important roles in Abeta(25-35)-induced tau hyperphosphorylation...
  84. pmc Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo
    Jing Zhang
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 102:14605-10. 2005
    ..Taken together, our data identify K-ras as the major regulator for cytokine-dependent Akt activation, which is important for erythroid differentiation in vivo...
  85. ncbi request reprint [Impacts of AOC by O3/TiO2 catalytic oxidation in drinking water]
    Tao Liang
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
    Huan Jing Ke Xue 28:2004-8. 2007
    ..In the processes, AOC-NOX consisting of carboxyl acid mostly increased rapidly, resulting in increase of the proportion of AOC-NOX in AOC over 90% and the majority of AOC turned from AOC-P17 to AOC-NOX...
  86. ncbi request reprint [Difference analysis on proteome of Helicobacter pylori in patients with peptic ulcer, gastritis, and gastric cancer]
    Jing Zhang
    Department of Gastroenterology, Third Hospital, Peking University, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 86:2690-4. 2006
    ..To identify the different proteins of Helicobacter pylori (H. pylori) in gastric cancer, peptic ulcer, and gastritis initially...
  87. doi request reprint Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia
    Xiao Dong Pan
    Department of Neurology, Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, 29 Xinquan Road, Fuzhou, Fujian 350001, People s Republic of China
    Biochem Pharmacol 76:362-72. 2008
    ..Therefore, it is potentially a highly effective therapeutic agent in treating neuroninflammatory diseases...
  88. ncbi request reprint [Studies on the antioxidative activity of polysaccharides from radix Saposhnikoviae]
    Ze Qing Zhang
    Department of Food Engineering, Shanxi Normal University, Xi an 710062, China
    Zhong Yao Cai 31:268-72. 2008
    ..To research the antioxidant activity of polysaccharides from Saposhnikovia divaricata (Turez.) Schischk...
  89. pmc Fragile X-related proteins regulate mammalian circadian behavioral rhythms
    Jing Zhang
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Am J Hum Genet 83:43-52. 2008
    ....
  90. ncbi request reprint Ginsenoside Rg1 delays tert-butyl hydroperoxide-induced premature senescence in human WI-38 diploid fibroblast cells
    Xiaochun Chen
    Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, PR China
    J Gerontol A Biol Sci Med Sci 63:253-64. 2008
    ..These data indicate that ginsenoside Rg1 has an anti-aging effect on t-BHP-induced premature senescence in WI-38 cells. This effect may be mediated by regulating cell cycle proteins and enhancing mitochondrial functioning...
  91. ncbi request reprint UV Raman spectroscopic study on TiO2. I. Phase transformation at the surface and in the bulk
    Jing Zhang
    State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, P O Box 110, Dalian 116023, China
    J Phys Chem B 110:927-35. 2006
    ....
  92. ncbi request reprint [Influence of nanosized TiO2 catalyzed ozonation on the ammonia concentration in Songhua River water]
    Sheng Jun Wang
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
    Huan Jing Ke Xue 28:2520-5. 2007
    ..While the increase of temperature yielded an increase of ammonia removal efficiency when using TiO2/zeolite as the catalyst...
  93. ncbi request reprint Effect of relaxin on myocardial ischemia injury induced by isoproterenol
    Jing Zhang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Peptides 26:1632-9. 2005
    ....
  94. ncbi request reprint SHIP2 controls PtdIns(3,4,5)P(3) levels and PKB activity in response to oxidative stress
    Jing Zhang
    Institut de Recherche Interdisciplinaire IRIBHM, Universite Libre de Bruxelles, Campus Erasme, 808 Route de Lennik, 1070 Brussels, Belgium
    Cell Signal 19:2194-200. 2007
    ..We conclude that SHIP2 lipid phosphatase activity plays an important role in the metabolism PtdIns(3,4,5)P(3) which is demonstrated in oxygen stressed cells...
  95. ncbi request reprint Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall
    Mingyi Wang
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224 6825, USA
    Arterioscler Thromb Vasc Biol 26:1503-9. 2006
    ..To study matrix metalloproteinase 2 (MMP-2) effects on transforming growth factor-beta1 (TGF-beta1) activation status and downstream signaling during arterial aging...
  96. pmc Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways
    Wei Tong
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Blood 105:4604-12. 2005
    ..Hence, Lnk, through its SH2 domain, negatively modulates EpoR signaling by attenuating JAK2 activation, and regulates Epo-mediated erythropoiesis...
  97. doi request reprint Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity
    Andis Klegeris
    Unit of Biology and Physical Geography, Barber School of Arts and Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    Glia 56:675-85. 2008
    ..We found both to be partially protective in a concentration-dependent manner. Inhibition of PEP may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases...
  98. ncbi request reprint [Degradation of trace nitrobenzene by nanosized TiO2 catalyzed ozonation]
    Yi Xin Yang
    School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China
    Huan Jing Ke Xue 27:2028-34. 2006
    ..It was also observed that both ozonation and catalytic ozonation were significantly influenced by tert-butyl alcohol, which testified that nanosized TiO2 catalyzed ozonation of nitrobenzene follows a radicaltype mechanism...
  99. ncbi request reprint Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice
    Jing Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurosci Res 84:587-95. 2006
    ..Our findings indicate that hBMSCs improve functional recovery and may provide a potential therapy aimed at axonal protection in EAE mice, in which NGF may play a vital role...
  100. pmc Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats
    Mingyi Wang
    Laboratory of Cardiovascular Sciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, 3 B 03, Baltimore, MD 21224 6825, USA
    Am J Pathol 167:1429-42. 2005
    ..Thus, Ang II-induced effects on MMP2, transforming growth factor-beta1, collagen, and VSMCs are central to the arterial remodeling that accompanies advancing age...
  101. pmc Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency
    Jing Zhang
    Division of Hematology, Washington University, St Louis, MO, USA
    Blood 111:4973-8. 2008
    ..The studies in mice suggest that human PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype...

Research Grants18

  1. DITHIOCARBAMATE PESTICIDES IN PARKINSON'S DISEASE
    Jing Zhang; Fiscal Year: 2003
    ..The new information will shed more light on the mechanisms by which pesticides interact with aging and genetic vulnerability thereby contributing to development and progression of PD. ..
  2. Biomarkers for Parkinson's Disease (PD) and PD Dementia
    Jing Zhang; Fiscal Year: 2007
    ..abstract_text> ..
  3. Biomarkers for Preclinical Parkinson's disease
    Jing Zhang; Fiscal Year: 2010
    ..This proposal, if successful, can significantly increase the therapeutic window for Parkinson's patients. ..
  4. Microglial Phox Activity In Parkinson's Disease
    Jing Zhang; Fiscal Year: 2010
    ..Elucidation of the mechanisms involved in this interplay may yield new therapies for the devastating disease. ..
  5. Detecting Biomarkers in Plasma for Diagnosing Neurodegenerative Diseases
    Jing Zhang; Fiscal Year: 2007
    ....
  6. Proteomic Studies in Parkinson's Disease
    Jing Zhang; Fiscal Year: 2007
    ....
  7. Post-translational Modifications of Proteins in Parkinson?s disease
    Jing Zhang; Fiscal Year: 2010
    ..Identification of these makers can increase therapeutic window for Parkinson's patients at risk for developing dementia that is associated with mortality, caregiver burden and risk for nursing home admission. ..