Research Topics
Genomes and Genes | Jianzhi ZhangSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Genetic redundancies and their evolutionary maintenanceJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Adv Exp Med Biol 751:279-300. 2012..The studies summarized here illustrate the utility of systems analysis for understanding evolutionary phenomena and the importance of evolutionary thinking in uncovering the functions and origins of systemic properties...
Gene losses during human originsXiaoxia Wang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA
PLoS Biol 4:e52. 2006....
RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placentaJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 30:1169-75. 2002..The rapid evolution, species-limited deactivation and tissue-specific expression of RNase 8 suggest a unique physiological function and reiterates the evolutionary plasticity of the RNase A superfamily...- Evolution of the human ASPM gene, a major determinant of brain sizeJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 165:2063-70. 2003.... 
Frequent false detection of positive selection by the likelihood method with branch-site modelsJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, USA
Mol Biol Evol 21:1332-9. 2004....- Testing the chromosomal speciation hypothesis for humans and chimpanzeesJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genome Res 14:845-51. 2004.... - Evolution of DMY, a newly emergent male sex-determination gene of medaka fishJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 166:1887-95. 2004.... - Rapid evolution of primate antiviral enzyme APOBEC3GJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor 48109, USA
Hum Mol Genet 13:1785-91. 2004..The identification of pervasive positive selection for charge-altering amino acid substitutions supports the hypothesis of electrostatic interactions between APOBEC3G and vif or its functional equivalents... - Significant impact of protein dispensability on the instantaneous rate of protein evolutionJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 22:1147-55. 2005..A comparison of the fitness contributions of orthologous genes in yeast and nematode supports this conclusion... - Paleomolecular biology unravels the evolutionary mystery of vertebrate UV visionJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:8045-7. 2003 - Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primatesJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:8337-41. 2003.... - Parallel functional changes in the digestive RNases of ruminants and colobines by divergent amino acid substitutionsJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 20:1310-7. 2003.... - Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primatesJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:5486-91. 2002.... - The drifting human genomeJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 104:20147-8. 2007 - Disulfide-bond reshuffling in the evolution of an ape placental ribonucleaseJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 24:505-12. 2007..Our results provide the foundation for detailed analysis toward understanding the impact of disulfide-bond reshuffling on the structure, function, and evolution of proteins in general and human RNase 8 in particular... - Accelerated protein evolution and origins of human-specific features: Foxp2 as an exampleJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 162:1825-35. 2002..Taken together, our results suggest an important role that FOXP2 may have played in the origin of human speech and demonstrate a strategy for identifying candidate genes underlying the emergences of human-specific features... - Human RNase 7: a new cationic ribonuclease of the RNase A superfamilyJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Nucleic Acids Res 31:602-7. 2003.... - Parallel adaptive origins of digestive RNases in Asian and African leaf monkeysJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, Michigan 48109, USA
Nat Genet 38:819-23. 2006..These results demonstrate that despite the overall stochasticity, even molecular evolution has a certain degree of repeatability and predictability under the pressures of natural selection... - Pseudogenization of the tumor-growth promoter angiogenin in a leaf-eating monkeyJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Sciences Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Gene 308:95-101. 2003..Our findings also provide a strong case for the importance of evolutionary analysis in biomedical studies of gene functions... - On the evolution of codon volatilityJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 169:495-501. 2005..These and other considerations suggest that codon volatility has only limited utility for detecting positive selection at the DNA sequence level... - Rapid evolution of primate ESX1, an X-linked placenta- and testis-expressed homeobox geneXiaoxia Wang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Hum Mol Genet 16:2053-60. 2007..These and other results suggest that even the fundamental process of spermatogenesis has been targeted by positive selection in primate and human evolution and that mouse may not be a suitable model for studying human reproduction... - Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammalsWendy E Grus
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 102:5767-72. 2005..In sum, our results demonstrate tremendous diversity and rapid evolution of mammalian V1R gene inventories and caution the generalization of VNO biology from rodents to all mammals... - Ancient expansion of the ribonuclease A superfamily revealed by genomic analysis of placental and marsupial mammalsSoochin Cho
Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Gene 373:116-25. 2006.... - Why is the correlation between gene importance and gene evolutionary rate so weak?Zhi Wang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 5:e1000329. 2009.... - Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolutionXionglei He
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 169:1157-64. 2005..Our results demonstrate that enormous numbers of new functions have originated via gene duplication... - Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networksXionglei He
Department of Ecology and Evolutionary Biology, Ann Arbor, Michigan, USA
Nat Genet 42:272-6. 2010..We offer mechanistic explanations of these findings and experimentally validate them for 61 S. cerevisiae gene pairs... - Rapid turnover and species-specificity of vomeronasal pheromone receptor genes in mice and ratsWendy E Grus
Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Gene 340:303-12. 2004..Our results show that the evolution of the V1r repertoire is characterized by exceptionally fast gene turnover via gains and losses of individual genes, suggesting rapid and substantial changes in pheromone communication between species... - Genetic evidence for the coexistence of pheromone perception and full trichromatic vision in howler monkeysDavid M Webb
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 21:697-704. 2004..We suggest that the ecological differences between OW and NW primates, particularly in habitat selection, may have also affected the evolution of pheromone perception... - Higher duplicability of less important genes in yeast genomesXionglei He
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, USA
Mol Biol Evol 23:144-51. 2006.... - Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesisWendy E Grus
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 25:1593-601. 2008.... - Zebrafish ribonucleases are bactericidal: implications for the origin of the vertebrate RNase A superfamilySoochin Cho
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 24:1259-68. 2007..These results, together with the presence of antibacterial and/or antiviral activities in multiple distantly related mammalian RNases, strongly suggest that the superfamily started as a host-defense mechanism in vertebrate evolution... - Sex-specific splicing of the honeybee doublesex gene reveals 300 million years of evolution at the bottom of the insect sex-determination pathwaySoochin Cho
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 177:1733-41. 2007..Thus, it is likely that the dsx splicing activator system in flies, where the male form is the default, arose during early dipteran evolution... - Null mutations in human and mouse orthologs frequently result in different phenotypesBen Yang Liao
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 105:6987-92. 2008.... - Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodentsKimberly D Dyer
Eosinophil Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Evol 59:657-65. 2004..66. These data suggest that the ancestral rodent RNase 6 was subject to accelerated evolution, resulting in the conserved modern gene, which most likely plays an important role in mouse physiology... - Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in miceOndrej Podlaha
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, USA
Mol Biol Evol 21:2202-9. 2004..Our results illustrate the potential of using evolutionary analysis to identify such pseudogenes from genome sequences... - Adaptive evolution of a duplicated pancreatic ribonuclease gene in a leaf-eating monkeyJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 30:411-5. 2002..Our findings demonstrate the contribution of gene duplication to organismal adaptation and show the power of combining sequence analysis and functional assays in delineating the molecular basis of adaptive evolution... - Evolution of the complementary sex-determination gene of honey bees: balancing selection and trans-species polymorphismsSoochin Cho
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genome Res 16:1366-75. 2006..Our results provide a definitive demonstration of balancing selection acting at the honey bee csd gene, offer insights into the molecular determinants of csd allelic specificities, and help avoid homozygosity in bee breeding... - Gene dosage and gene duplicabilityWenfeng Qian
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 179:2319-24. 2008..On the basis of these and other results, we conclude that selection for higher gene dosage does not play a major role in driving the fixation of duplication genes... - Coexpression of linked genes in Mammalian genomes is generally disadvantageousBen Yang Liao
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 25:1555-65. 2008.... - Positive selection for elevated gene expression noise in yeastZhihua Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Mol Syst Biol 5:299. 2009.... - Positive selection for indel substitutions in the rodent sperm protein catsper1Ondrej Podlaha
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 22:1845-52. 2005..Our findings provide a necessary foundation for future experimental investigations of Catsper1's function in sperm physiology and role in sperm competition using rodent models... - Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to landPeng Shi
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genome Res 17:166-74. 2007..Taken together, our results demonstrate the exceptional evolutionary fluidity of vomeronasal receptors, making them excellent targets for studying the molecular basis of physiological and behavioral diversity and adaptation... - The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary historiesSoochin Cho
Department of Ecology and Evolutionary Biology, University of Michigan, 3003 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Genomics 85:208-20. 2005..Consistent with this hypothesis, all members of the superfamily exhibit high rates of amino acid substitution as is commonly observed in immunity genes... - Accuracy and application of the motif expression decomposition method in dissecting transcriptional regulationZhihua Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor MI 48109, USA
Nucleic Acids Res 36:3185-93. 2008..As an example, MED results are used to demonstrate that motifs generally have higher binding strengths when appearing in multiple copies than appearing in one copy per promoter... - Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebratesWendy E Grus
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 26:407-19. 2009..These findings are important for understanding the evolution of vertebrate sensory systems and illustrate the utility of the genome sequences of early diverging vertebrates for uncovering the evolution of vertebrate-specific traits... - Measuring the evolutionary rate of protein-protein interactionWenfeng Qian
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 108:8725-30. 2011..The extremely slow evolution of protein molecular function may account for the remarkable conservation of life at molecular and cellular levels and allow for studying the mechanistic basis of human disease in much simpler organisms... - Remarkable expansions of an X-linked reproductive homeobox gene cluster in rodent evolutionXiaoxia Wang
Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Genomics 88:34-43. 2006.... - Positive selection on protein-length in the evolution of a primate sperm ion channelOndrej Podlaha
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:12241-6. 2003..This finding suggests that the selection detected may be related to the regulation of the CATSPER1 channel, which can affect sperm motility, an important determinant in sperm competition... - Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genesXiaoxia Wang
Department of Ecology and Evolutionary Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109, USA
Hum Mol Genet 13:2671-8. 2004.... - The microevolution of V1r vomeronasal receptor genes in miceSeong Hwan Park
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA
Genome Biol Evol 3:401-12. 2011..These findings have broad implications for understanding the driving forces of rapid gene turnovers that are often observed in the evolution of large gene families... - Maintenance of duplicate genes and their functional redundancy by reduced expressionWenfeng Qian
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Trends Genet 26:425-30. 2010..Whereas the majority of the expression reductions are likely to be neutral, some are apparently beneficial to rebalancing gene dosage after duplication... - Diversifying selection of the tumor-growth promoter angiogenin in primate evolutionJianzhi Zhang
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Rm 11 N 104, 9000 Rockville Pike, Bethesda, MD 20892, USA
Mol Biol Evol 19:438-45. 2002.... - Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genesPeng Shi
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 23:292-300. 2006..Thus, functional divergence and specialization of taste receptors generally occurred via adaptive evolution... - More genes underwent positive selection in chimpanzee evolution than in human evolutionMargaret A Bakewell
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 104:7489-94. 2007.... - Toward a molecular understanding of pleiotropyXionglei He
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 173:1885-91. 2006..We also provide genomewide evidence that the evolutionary conservation of genes and gene sequences positively correlates with the level of gene pleiotropy... - Low rates of expression profile divergence in highly expressed genes and tissue-specific genes during mammalian evolutionBen-Yang Liao
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 23:1119-28. 2006..Thus, different forces and selective constraints must underlie the evolution of gene sequence and that of gene expression... - Why do hubs tend to be essential in protein networks?Xionglei He
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA
PLoS Genet 2:e88. 2006..These and other findings provide new perspectives on the biological relevance of network structure and robustness... - Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteinsBen-Yang Liao
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 23:2072-80. 2006..Our results suggest a considerable variation in rate determinants between unicellular organisms such as the yeast and multicellular organisms such as mammals... - High expression hampers horizontal gene transferChungoo Park
Department of Ecology and Evolutionary Biology, University of Michigan, MI, USA
Genome Biol Evol 4:523-32. 2012..They also suggest that most successful HGTs are initially slightly deleterious, fixed because of their negligibly low costs rather than high benefits to the recipient... - Gene complexity and gene duplicabilityXionglei He
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor 48109, USA
Curr Biol 15:1016-21. 2005..Thus, gene duplication increases both gene number and gene complexity, two important factors in the origin of genomic and organismal complexity... - Did brain-specific genes evolve faster in humans than in chimpanzees?Peng Shi
Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Trends Genet 22:608-13. 2006..Our results suggest that the unique features of the human brain did not arise by a large number of adaptive amino acid changes in many proteins... - Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular levelJianzhi Zhang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, USA
Mol Biol Evol 22:2472-9. 2005..Bayes empirical Bayes identification of amino acid sites under positive selection along the foreground branches was found to be reliable, but lacked power... - Evolutionary conservation of expression profiles between human and mouse orthologous genesBen-Yang Liao
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 23:530-40. 2006..These results highlight the importance of proper consideration of various estimation errors in comparing the microarray data between species... - Genome-wide evolutionary conservation of N-glycosylation sitesChungoo Park
Department of Ecology and Evolutionary Biology, University of Michigan, USA
Mol Biol Evol 28:2351-7. 2011..Because the majority of N-glycosylation occurs at solvent accessible sites, our results show an overall functional importance for N-glycosylation... - Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon?Xionglei He
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 172:1363-7. 2006..There is little evidence supporting widespread functional compensation of divergently expressed duplicate genes by transcriptional reprogramming... - Mouse duplicate genes are as essential as singletonsBen Yang Liao
Department of Ecology and Evolutionary Biology, University of Michigan, 1075 Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA
Trends Genet 23:378-81. 2007..This suggests that mammalian duplicates rarely compensate for each other, and that the absence of phenotypes in mice deficient for a duplicate gene should not be automatically attributed to paralogous compensation... - Rapid evolution of mammalian X-linked testis-expressed homeobox genesXiaoxia Wang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
Genetics 167:879-88. 2004.... - Why are some human disease-associated mutations fixed in mice?Lizhi Gao
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Trends Genet 19:678-81. 2003 - Origin and evolution of the vertebrate vomeronasal system viewed through system-specific genesWendy E Grus
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109, USA
Bioessays 28:709-18. 2006..We propose that a VNS precursor exists in teleosts and that its evolutionary origin predated the separation between teleosts and tetrapods... - In search of the biological significance of modular structures in protein networksZhi Wang
Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Comput Biol 3:e107. 2007..Taken together, our results suggest the intriguing possibility that the structural modules in the PPI network originated as an evolutionary byproduct without biological significance... - Erratic evolution of SRY in higher primatesXiaoxia Wang
Mol Biol Evol 19:582-4. 2002 - Largest vertebrate vomeronasal type 1 receptor gene repertoire in the semiaquatic platypusWendy E Grus
Mol Biol Evol 24:2153-7. 2007..Our results challenge the view that olfaction is unimportant to aquatic mammals and call for further study into the role of vomeronasal reception in platypus physiology and behavior... - Adaptive diversification of bitter taste receptor genes in Mammalian evolutionPeng Shi
Laboratory of Molecular Evolution and Genome Diversity, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Mol Biol Evol 20:805-14. 2003.... - Composition and evolution of the V2r vomeronasal receptor gene repertoire in mice and ratsHui Yang
Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Genomics 86:306-15. 2005..The identification of the entire V2r repertoire opens the door to genomic-level studies of the structure, function, and evolution of this diverse group of sensory receptors... - Accelerated evolution and loss of a domain of the sperm-egg-binding protein SED1 in ancestral primatesOndrej Podlaha
Mol Biol Evol 23:1828-31. 2006..These results reveal a different evolutionary pattern of SED1 from that of many other sperm-egg-binding proteins, which often show diversifying selection occurring in multiple lineages...
Research Grants
- RNases for understanding the origin of new gene functionJianzhi Zhang; Fiscal Year: 2003....
- Evolution of vertebrate sensory genesJianzhi Zhang; Fiscal Year: 2010..These studies will also help understand human smell and taste variations and disorders. ..
- Functional genomic approaches to duplicate gene evolutionJianzhi Zhang; Fiscal Year: 2010..A clear understanding of these relationships helps clarify the exact molecular basis of human diseases, a necessary step in the treatment and prevention of these diseases. ..
- Evolution of vertebrate sensory genesJianzhi Zhang; Fiscal Year: 2009..These studies will also help understand human smell and taste variations and disorders. ..
- Evolution of vertebrate sensory genesJianzhi Zhang; Fiscal Year: 2007..These studies will also help understand human smell and taste variations and disorders. ..
- RNases for understanding the origin of new gene functionJianzhi Zhang; Fiscal Year: 2007..abstract_text> ..
- RNases for understanding the origin of new gene functionJianzhi Zhang; Fiscal Year: 2006..abstract_text> ..
- Functional genomic approaches to duplicate gene evolutionJianzhi Zhang; Fiscal Year: 2010..A clear understanding of these relationships helps clarify the exact molecular basis of human diseases, a necessary step in the treatment and prevention of these diseases. ..