Jianhua Zhang

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditions
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Biochem Biophys Res Commun 297:537-44. 2002
  2. ncbi request reprint Neural system-enriched gene expression: relationship to biological pathways and neurological diseases
    Jianhua Zhang
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati 45267, USA
    Physiol Genomics 18:167-83. 2004
  3. pmc Endonuclease G is required for early embryogenesis and normal apoptosis in mice
    Jianhua Zhang
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 100:15782-7. 2003
  4. ncbi request reprint Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors
    Lu Zhang
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Neurosci 24:3344-54. 2004
  5. ncbi request reprint Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors
    Dongsheng Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Neuropsychopharmacology 30:1443-54. 2005
  6. ncbi request reprint c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons
    Mei Dong
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neurosci Lett 400:177-80. 2006
  7. ncbi request reprint C-fos regulates neuropeptide Y expression in mouse dentate gyrus
    Yongfei Wu
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neurosci Lett 363:6-10. 2004
  8. ncbi request reprint The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion
    Laurel M Pritchard
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 86:718-26. 2007
  9. ncbi request reprint Role of endonuclease G in neuronal excitotoxicity in mice
    Yongfei Wu
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267, USA
    Neurosci Lett 364:203-7. 2004
  10. ncbi request reprint Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes
    Yang Wang
    Division of Nephrology, University of Cincinnati, Albert Sabin Way, Cincinnati, OH 45267 0585, USA
    Nephrol Dial Transplant 23:525-33. 2008

Detail Information

Publications66

  1. ncbi request reprint Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditions
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Biochem Biophys Res Commun 297:537-44. 2002
    ..This study provides valuable information on possible molecular mechanisms of differential apoptotic responses to developmental signals, environmental stimuli, and therapeutic treatments in tissue-specific manner...
  2. ncbi request reprint Neural system-enriched gene expression: relationship to biological pathways and neurological diseases
    Jianhua Zhang
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati 45267, USA
    Physiol Genomics 18:167-83. 2004
    ..Together, our data indicate the power of profiling an individual biologic system in a multisystem context to gain insight into the genomic basis of its structure and function...
  3. pmc Endonuclease G is required for early embryogenesis and normal apoptosis in mice
    Jianhua Zhang
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 100:15782-7. 2003
    ..These findings indicate that EndoG is essential during early embryogenesis and plays a critical role in normal apoptosis and nuclear DNA fragmentation...
  4. ncbi request reprint Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors
    Lu Zhang
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Neurosci 24:3344-54. 2004
    ..These results suggest that the D1 and D3 receptors elicit opposite regulation of target gene expression by regulating ERK activation and c-fos induction after acute and chronic cocaine treatment...
  5. ncbi request reprint Repeated cocaine administration induces gene expression changes through the dopamine D1 receptors
    Dongsheng Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Neuropsychopharmacology 30:1443-54. 2005
    ....
  6. ncbi request reprint c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons
    Mei Dong
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neurosci Lett 400:177-80. 2006
    ..Our findings indicate that c-fos regulates expression of BDNF in distinct neuron populations of the hippocampal formation in vivo...
  7. ncbi request reprint C-fos regulates neuropeptide Y expression in mouse dentate gyrus
    Yongfei Wu
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Neurosci Lett 363:6-10. 2004
    ..As NPY is an important endogenous anti-epileptic agent, our result is consistent with a hypothesis that the neuroprotective function of c-fos is mediated in part by regulation of NPY expression...
  8. ncbi request reprint The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion
    Laurel M Pritchard
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 86:718-26. 2007
    ..In combination, these data add to the behavioral profile of this novel D3 receptor ligand and provide further support for a role for dopamine D3 receptor inhibitory function in the modulation of rodent locomotion...
  9. ncbi request reprint Role of endonuclease G in neuronal excitotoxicity in mice
    Yongfei Wu
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267, USA
    Neurosci Lett 364:203-7. 2004
    ..These results indicate that reduced expression of EndoG in the hippocampi of EndoG+/- mice leads to resistance to excitotoxicity...
  10. ncbi request reprint Venous stenosis in a pig arteriovenous fistula model--anatomy, mechanisms and cellular phenotypes
    Yang Wang
    Division of Nephrology, University of Cincinnati, Albert Sabin Way, Cincinnati, OH 45267 0585, USA
    Nephrol Dial Transplant 23:525-33. 2008
    ..The aim of this study was to develop and validate a pig model of AV fistula stenosis and then use it to dissect out the mechanisms responsible for this lesion...
  11. ncbi request reprint The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression
    Dongsheng Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Neurochem 82:1453-64. 2002
    ..These results suggest that the D1 receptor is a critical mediator for cocaine-induced expression of these genes...
  12. pmc Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Synapse 60:399-405. 2006
    ..0 and 10 mg/kg AMPH doses. These findings provide further support for an inhibitory role for the D3R in AMPH-induced locomotor activity, and demonstrate a more limited role for the D3R in modulating AMPH-induced stereotypy...
  13. ncbi request reprint Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice
    Jill M Slane McQuade
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267, USA
    Neurosci Lett 403:125-30. 2006
    ..These findings suggest that hippocampal c-fos plays a role in gender-dependent response to stress...
  14. pmc Systems biology of the autophagy-lysosomal pathway
    Anil G Jegga
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Autophagy 7:477-89. 2011
    ....
  15. ncbi request reprint Identification of chronic cocaine-induced gene expression through dopamine d1 receptors by using cDNA microarrays
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Ann N Y Acad Sci 965:1-9. 2002
    ..Further studies are in progress to determine the physiological significance of the differential expression of these genes in chronic cocaine-induced behaviors...
  16. ncbi request reprint DNA fragmentation factor 45 knockout mice exhibit longer memory retention in the novel object recognition task compared to wild-type mice
    Jill M Slane McQuade
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    Physiol Behav 76:315-20. 2002
    ..These results suggest that a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory...
  17. ncbi request reprint Generating gene knockout mice for studying mechanisms underlying drug addiction
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Methods Mol Med 79:351-63. 2003
  18. doi request reprint Hemodynamic wall shear stress profiles influence the magnitude and pattern of stenosis in a pig AV fistula
    Mahesh K Krishnamoorthy
    Cincinnati Dialysis Access Research Program, Department of Mechanical, Industrial, and Nuclear Engineering, University of Cincinnati, Cincinnati, Ohio 45267 0585, USA
    Kidney Int 74:1410-9. 2008
    ..These results suggest that fistula failure could be reduced by using computer modeling prior to surgical placement to alter the anatomical and, consequently, the wall shear stress profiles in an arteriovenous fistula...
  19. ncbi request reprint Hippocampal expression of c-fos is not essential for spatial learning
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Synapse 46:91-9. 2002
    ..Our results suggest that hippocampal c-fos expression is not essential for spatial learning...
  20. ncbi request reprint Neointimal hyperplasia in early arteriovenous fistula failure
    Prabir Roy-Chaudhury
    Department of Medicine, Division of Nephrology, Cincinnati Dialysis Access Research Program, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Am J Kidney Dis 50:782-90. 2007
    ..Although inadequate dilatation of the venous segment was believed to have a role in early AVF failure, the exact pathogenesis of early AVF failure is unknown despite the magnitude of the clinical problem...
  21. pmc Cellular phenotypes in human stenotic lesions from haemodialysis vascular access
    Prabir Roy-Chaudhury
    Departments of Medicine, University of Cincinnati, OH, USA
    Nephrol Dial Transplant 24:2786-91. 2009
    ..The aim of the current study was to identify the specific cell types present within stenotic tissue samples from patients with AV fistula and graft failure...
  22. ncbi request reprint Hemodialysis vascular access dysfunction: from pathophysiology to novel therapies
    Prabir Roy-Chaudhury
    University of Cincinatti Medical Center, Ohio 45267, USA
    Blood Purif 21:99-110. 2003
    ..Special emphasis is laid on the fact that PTFE dialysis access grafts could be the ideal clinical model for testing out novel local therapies to block neointimal hyperplasia...
  23. ncbi request reprint Vascular access in hemodialysis: issues, management, and emerging concepts
    Prabir Roy-Chaudhury
    Division of Nephrology and Hypertension, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Cardiol Clin 23:249-73. 2005
    ..The possibility that dialysis access grafts and fistulae could be the ideal clinical model for testing novel local therapies to block neointimal hyperplasia is discussed...
  24. ncbi request reprint Novel therapies for hemodialysis vascular access dysfunction: fact or fiction!
    Prabir Roy-Chaudhury
    University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    Blood Purif 23:29-35. 2005
    ..This is particularly unfortunate, since neointimal hyperplasia in the setting of hemodialysis vascular access fistulae and grafts could be the ideal clinical model to test novel therapeutic interventions for neointimal hyperplasia...
  25. ncbi request reprint 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment
    Laurel M Pritchard
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati, OH, USA
    Neuropsychopharmacology 28:100-7. 2003
    ..Potential implications of these observations are discussed...
  26. ncbi request reprint c-fos regulates neuronal excitability and survival
    Jianhua Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Nat Genet 30:416-20. 2002
    ..Our results suggest that c-fos is a genetic regulator for cellular mechanisms mediating neuronal excitability and survival...
  27. ncbi request reprint Development of a local perivascular paclitaxel delivery system for hemodialysis vascular access dysfunction: polymer preparation and in vitro activity
    Murad Melhem
    Department of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Blood Purif 24:289-98. 2006
    ..We believe that these paclitaxel-loaded polymeric wraps could be ideally suited for perivascular drug delivery in the context of dialysis access grafts and fistulae...
  28. ncbi request reprint Molecular genetic probing of dopamine receptors in drug addiction
    Ming Xu
    University of Cincinnati College of Medicine, Department of Cell Biology, Neurobiology and Anatomy, Cincinnati, OH 45267 0521, USA
    Curr Opin Drug Discov Devel 7:703-8. 2004
    ..These studies will provide new insights for improved therapeutic strategies for the prevention and treatment of drug addiction...
  29. ncbi request reprint Perivascular paclitaxel wraps block arteriovenous graft stenosis in a pig model
    Burnett Kelly
    Department of Surgery, Industrial and Nuclear Engineering, University of Cincinnati, Cincinnati, OH 45267 0585, USA
    Nephrol Dial Transplant 21:2425-31. 2006
    ..The aim of the current study was to evaluate the in vivo use of these perivascular wraps (for both safety and efficacy) at different time points in our pig model of arteriovenous graft stenosis...
  30. ncbi request reprint Expression of the rat CYP2A3 gene in transgenic mice
    Ting Su
    Wadsworth Center, New York State Department of Health and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Drug Metab Dispos 30:548-52. 2002
    ..Furthermore, the levels of CYP2A3 mRNA were very low in all lines examined, suggesting that more distal regulatory regions may be involved in the abundant expression of the CYP2A genes in the olfactory mucosa...
  31. ncbi request reprint The graft response to transplantation: a gene expression profile analysis
    Kenneth Christopher
    Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Genomics 15:52-64. 2003
    ..Post-transplant, a shift was noted in genes classified as defense, communication, and metabolism. Our results identify novel components of the graft response to transplantation injury and rejection...
  32. pmc Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice
    S Barak Caine
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 27:13140-50. 2007
    ..We conclude that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice...
  33. ncbi request reprint Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord
    Wei Zheng
    Division of Molecular Medicine, Harbor UCLA Medical Center, The David Geffen School of Medicine University of California Los Angeles, Torrance, California 90502, USA
    J Biol Chem 278:48321-9. 2003
    ..These findings indicate that the GABA receptor/channel rho 1 subunit plays an important role in modulating spinal cord pain transmission functions in vivo...
  34. pmc Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
    Nadine De Albuquerque
    Toronto General Hospital, 585 University Ave, NCSB 11 1236, Toronto, Ontario M5G 2N2, Canada
    J Virol 80:10382-94. 2006
    ..This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies...
  35. ncbi request reprint Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice
    Yan Zhou
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 61:50-9. 2007
    ....
  36. ncbi request reprint Altered distributions of nucleocytoplasmic transport-related proteins in the spinal cord of a mouse model of amyotrophic lateral sclerosis
    Jianhua Zhang
    Department of Neurology, Kansai Medical University, 10 15, Fumizono cho, Moriguchi, Osaka, 570 8507, Japan
    Acta Neuropathol 112:673-80. 2006
    ..This is the first report investigating nucleocytoplasmic transport in the ALS model mouse, and our present results imply that its dysfunction could be involved in the pathomechanisms underlying ALS...
  37. ncbi request reprint Opposite regulation of cocaine-induced intracellular signaling and gene expression by dopamine D1 and D3 receptors
    Jianhua Zhang
    Department of Anesthesia and Critical Care, The University of Chicago, Chicago, IL 60637, USA
    Ann N Y Acad Sci 1074:1-12. 2006
    ..Lastly, such regulation requires proper ERK activation. These results suggest that D1 and D3 receptors oppositely regulate target gene expression by regulating ERK activation after cocaine administration...
  38. ncbi request reprint c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes
    Jianhua Zhang
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 26:13287-96. 2006
    ..Our findings indicate that c-Fos produced in D1 receptor-expressing neurons integrates mechanisms to facilitate both the acquisition and extinction of cocaine-induced persistent changes...
  39. pmc Kainic acid induces early and transient autophagic stress in mouse hippocampus
    John J Shacka
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, SC 961, 1530 3rd Ave S, Birmingham, AL 35294 0017, USA
    Neurosci Lett 414:57-60. 2007
    ..Together these data indicate the transient induction of autophagic stress by KA which may serve to regulate excitotoxic death in mouse hippocampus...
  40. ncbi request reprint Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicin
    Mei Dong
    Cell Res 17:735-6. 2007
  41. ncbi request reprint Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation
    Hongyuan Jiao
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    J Neurochem 103:840-8. 2007
    ..These results suggest that dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via phosphorylation of NR1...
  42. ncbi request reprint Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways
    Huichao Zou
    The 1st Affiliated Hospital of Harbin Medical University, No 23 Youzheng Street, Nangang District, Harbin, Heilongjiang Province, China
    Brain Res 1185:231-8. 2007
    ..These results suggest that 2-ME enhancement of the sensitivity of glioma cell lines to radiotherapy is mediated by induction of G2/M cell cycle arrest and increased DNA damage via activation of ATM kinases...
  43. pmc Differential activation of c-fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia
    Jayne M Ness
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Neurosci Res 86:1115-24. 2008
    ..The differential expression of c-Fos in HI-resistant hippocampal subpopulations vs. cleaved caspase-3 in dying neurons suggests a neuroprotective role for c-Fos expression in neonatal HI...
  44. ncbi request reprint Rac1 GTPase is activated by hepatitis B virus replication--involvement of HBX
    Tuan Lin Tan
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459 Singapore
    Biochim Biophys Acta 1783:360-74. 2008
    ..HBV may possibly make use of an activated Rac1 signaling pathway for increased replication and resultant metastatic effects...
  45. doi request reprint Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS
    Jianjun Sui
    School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore
    Mol Cell Proteomics 7:1007-18. 2008
    ..Our preliminary results thus provide molecular evidence on the metabolic effect and possible link of calcium-binding proteins with treatment of hypertension associated with atenolol...
  46. pmc Nitric oxide activation of Erk1/2 regulates the stability and translation of mRNA transcripts containing CU-rich elements
    Shuibang Wang
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 34:3044-56. 2006
    ..Over-expression of hnRNP K, like NO*, repressed translation of CURE-containing mRNA. These findings define a sequence-specific mechanism of NO*-triggered gene regulation that stabilizes mRNA, but represses translation...
  47. pmc Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments
    Torstein Tengs
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nucleic Acids Res 32:e121. 2004
    ..Here, we show that the RECORD libraries may be used for digital karyotyping and for pathogen identification by computational subtraction...
  48. pmc Activities of key enzymes in sucrose-to-starch conversion in wheat grains subjected to water deficit during grain filling
    Jianchang Yang
    College of Agriculture, Yangzhou University, Yangzhou, Jiangsu, China 225009
    Plant Physiol 135:1621-9. 2004
    ....
  49. ncbi request reprint Effects of nicotine preexposure on sulpiride-induced dopamine release in the nucleus accumbens
    Shafiqur Rahman
    Smoking and Nicotine Dependence Research, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    Eur J Pharmacol 494:31-4. 2004
    ..The reduction of sulpiride-induced nucleus accumbens dopamine release after nicotine treatment is likely the result of down-regulation of somatodendritic dopamine autoreceptors...
  50. ncbi request reprint Characterization of stem cell factor gene-modified human natural killer cell line, NK-92 cells: implication in NK cell-based adoptive cellular immunotherapy
    Jian Zhang
    School of Life Sciences, University of Science and Technology of China, Hefei City, Anhui 230027, PR China
    Oncol Rep 11:1097-106. 2004
    ..SCF gene-modified NK-92 cells (NK92-SCF cells) are more promising than their parent cells for adoptive cellular immunotherapy...
  51. ncbi request reprint Pharmacological manipulations of the pedunculopontine tegmental nucleus in the rat reduce self-administration of both nicotine and cocaine
    William A Corrigall
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 160:198-205. 2002
    ..The direct action of nicotine in PPTg may be through GABAergic mechanisms that have been shown to influence nicotine self-administration preferentially compared to cocaine...
  52. ncbi request reprint BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time
    Yi Luo
    Amgen Inc, Thousand Oaks, CA, USA
    Neurobiol Dis 14:81-8. 2003
    ..These data provide evidence that neither beta-secretase nor Abeta plays a vital role in mouse physiology and that chronic beta-secretase inhibition could be a useful approach in treating AD...
  53. ncbi request reprint Cardiopulmonary sympathetic and vagal afferents excite C1-C2 propriospinal cells in rats
    Jianhua Zhang
    Department of Physiology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Brain Res 969:53-8. 2003
    ..Results are consistent with the hypothesis that CPSA input can be processed in C1-C2 segments to produce neural modulation in distant spinal segments...
  54. ncbi request reprint Differential effects of urinary bladder distension on high cervical projection neurons in primates
    Margaret J Chandler
    Department of Physiology, BMSB 653, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Brain Res 949:97-104. 2002
    ..Furthermore, results of this study indicated that effects of sensory inputs on spinal neurons might vary depending on axonal projections of the neurons examined...
  55. ncbi request reprint Protease-activated receptor-2 (PAR-2) expression in human fibroblasts is regulated by growth factors and extracellular matrix
    Barry L Gruber
    Department of Medicine, Stony Brook University School of Medicine, Stony Brook, New York, USA
    J Invest Dermatol 123:832-9. 2004
    ..Results indicate that the degree of fibroblast proliferation, attenuated by extracellular matrix and upregulated by growth factors, influences whether fibroblasts express PAR-2 and, thus, would be responsive to protease signaling...
  56. ncbi request reprint Identification of a region in the vitamin D-binding protein that mediates its C5a chemotactic cofactor function
    Jianhua Zhang
    Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794 8691, USA
    J Biol Chem 279:53282-7. 2004
    ....
  57. ncbi request reprint Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion via induction of AP-1
    Tao Rui
    Vascular Cell Biology Laboratory, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 4G5
    Cardiovasc Res 65:719-27. 2005
    ..Since I/R-induced myocardial dysfunction is associated with an acute inflammatory response, we assessed the anti-inflammatory properties of EPO using in vitro and in vivo models of I/R...
  58. pmc Living with genome instability: the adaptation of phytoplasmas to diverse environments of their insect and plant hosts
    Xiaodong Bai
    Department of Entomology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, 44691, USA
    J Bacteriol 188:3682-96. 2006
    ..The AY-WB genome is approximately 154 kb smaller than the OY-M genome, primarily as a result of fewer multicopy sequences, including PMUs. Furthermore, AY-WB lacks genes that are truncated and are part of incomplete pathways in OY-M...
  59. pmc Mitogen-activated protein kinase is involved in abscisic acid-induced antioxidant defense and acts downstream of reactive oxygen species production in leaves of maize plants
    Aying Zhang
    College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, People s Republic of China
    Plant Physiol 141:475-87. 2006
    ..ABA-induced H(2)O(2) production activates MAPK, which in turn induces the expression and the activities of antioxidant enzymes. The activation of MAPK also enhances the H(2)O(2) production, forming a positive feedback loop...
  60. ncbi request reprint Recombinant human prolactin protects against irradiation-induced myelosuppression
    Wei Ci Zhang
    Institute of Immunopharmacology and Immunotherapy, Shandong University, 44 Wenhua West Road, Jinan 250021, China
    Cell Mol Immunol 2:379-85. 2005
    ..It was concluded that rhPRL might act on erythropoiesis and could be a potential candidate for the treatment of irradiation-induced myelosuppresion in clinic...
  61. pmc cGMP-independent nitric oxide signaling and regulation of the cell cycle
    Xiaolin Cui
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    BMC Genomics 6:151. 2005
    ..Bt2cAMP was used to block signaling attributable to NO*-induced decreases in cAMP...
  62. ncbi request reprint Human prolactin improves engraftment and reconstitution of human peripheral blood lymphocytes in SCID mice
    Rui Sun
    School of Pharmacy, Shandong University, Jinan 250012, China
    Cell Mol Immunol 1:129-36. 2004
    ..Thus, rhPRL stimulation promotes reconstitution of human immune system in huPBL-SCID mice...
  63. ncbi request reprint Effects of gene tranfection with CH50 polypeptide on the invasion ability of bladder cancer cell line BIU-87
    Zhuang Wu
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:320-2, 338. 2005
    ..05). It was concluded that CH50 polypeptide was successfully expressed in BIU-87 cells by gene transfection, by which the in vitro invasion ability of BIU-87 was inhibited...
  64. ncbi request reprint Selective interaction of nitric oxide synthase inhibition with phencyclidine: behavioural and NMDA receptor binding studies in the rat
    Daniel Klamer
    Department of Pharmacology, The Sahlgrenska Academy at Goteborg University, Goteborg University, P O Box 431, SE 40530 Goteborg, Sweden
    Behav Brain Res 159:95-103. 2005
    ..These results suggest that the NO-sensitive effects of PCP are not sufficiently explained by its antagonistic effect at the NMDA receptor channel complex...
  65. ncbi request reprint [Genetic polymorphism of two STR loci D2S1399 and D5S2500 in Eastern Chinese Han population]
    Shui xiu Xia
    Department of Forensic Medicine, Medical School of Soochow University, Suzhou 215007, China
    Fa Yi Xue Za Zhi 20:200-1, 204. 2004
    ..To obtain the genetic polymorphism data of two STR loci D2S1399 and D5S2500 in Eastern Chinese Han population...
  66. ncbi request reprint Spinal inhibitory effects of cardiopulmonary afferent inputs in monkeys: neuronal processing in high cervical segments
    Margaret J Chandler
    Department of Physiology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    J Neurophysiol 87:1290-302. 2002
    ..Results of these studies were consistent with the idea that modulation of spinal nociceptive transmission might involve neuronal connections in high cervical segments...