Affiliation: University of Nevada
Zhang C, Leng F, Saxena L, Hoang N, Yu J, Alejo S, et al
. Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. J Biol Chem. 2019;294:476-489 pubmed publisher
..Our studies provide novel insights into the mechanism by which the methylation-dependent degradation of SOX2 protein is controlled by the L3MBTL3-CRL4DCAF5 ubiquitin ligase complex. ..
Leng F, Saxena L, Hoang N, Zhang C, Lee L, Li W, et al
. Proliferating cell nuclear antigen interacts with the CRL4 ubiquitin ligase subunit CDT2 in DNA synthesis-induced degradation of CDT1. J Biol Chem. 2018;293:18879-18889 pubmed publisher
Wang Q, Yu M, Ma Y, Zhang X, Zhang H, Li S, et al
. PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes. Lab Invest. 2018;98:1627-1641 pubmed publisher
Leng F, Yu J, Zhang C, Alejo S, Hoang N, Sun H, et al
. Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4DCAF5 ubiquitin ligase. Nat Commun. 2018;9:1641 pubmed publisher
..Our studies elucidate for the first time a novel mechanism by which the stability of many methylated non-histone proteins are regulated. ..
Hoang N, Zhang X, Zhang C, Vo V, Leng F, Saxena L, et al
. New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. Bioorg Med Chem. 2018;26:1523-1537 pubmed publisher
..Our studies strongly indicate that CBB3001 is a specific LSD1 inhibitor that selectively inhibits teratocarcinoma and embryonic carcinoma cells that express SOX2 and OCT4. ..
Zhang C, Hoang N, Leng F, Saxena L, Lee L, Alejo S, et al
. LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2. J Biol Chem. 2018;293:3663-3674 pubmed publisher
..In conclusion, our findings reveal an important mechanism by which the stability of the pluripotency-controlling stem-cell protein SOX2 is dynamically regulated by the activities of SET7, LSD1, and PHF20L1 in pluripotent stem cells. ..
Lu F, Wu X, Yin F, Chia Fang Lee C, Yu M, Mihaylov I, et al
. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open. 2016;5:1449-1460 pubmed publisher
..Our studies indicate that the MLL complexes and H3K4 methylation are required for DNA replication but not for DNA damage repair. ..
Chen F, Zhang C, Wu H, Ma Y, Luo X, Gong X, et al
. The E3 ubiquitin ligase SCFFBXL14 complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis. J Biol Chem. 2017;292:20100-20112 pubmed publisher
..Our results suggest that SCFFBXL14 promotes neuronal differentiation by targeting HES1 for ubiquitin-dependent proteolysis and that the C-terminal WRPW motif in HES1 is required for this process. ..