Hua Zhang

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives
    Hua Zhang
    University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nanomedicine (Lond) 3:83-91. 2008
  2. doi request reprint Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells
    Hua Zhang
    University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Breast Cancer Res Treat 114:277-85. 2009
  3. doi request reprint Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor
    Xianke Zeng
    Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Breast Cancer Res Treat 133:117-26. 2012
  4. pmc Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo
    Xianke Zeng
    Department of Pharmacology and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 15:2840-9. 2009
  5. ncbi request reprint Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    Hua Zhang
    University of Minnesota Cancer Center, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Res 67:391-7. 2007
  6. ncbi request reprint Is the type I insulin-like growth factor receptor a therapeutic target in endometrial cancer?
    Hua Zhang
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 12:6323-5. 2006
  7. pmc Exogenous near-infrared fluorophores and their applications in cancer diagnosis: biological and clinical perspectives
    Hua Zhang
    Department of Medicine, Masonic Cancer Center, MMC 806, 420 Delaware St SE, Minneapolis, MN, 55455, USA
    Expert Opin Med Diagn 5:241-51. 2011
  8. ncbi request reprint The therapeutic potential of agents targeting the type I insulin-like growth factor receptor
    Hua Zhang
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Expert Opin Investig Drugs 13:1569-77. 2004
  9. ncbi request reprint Study on the drug release property of cholesteryl end-functionalized poly(epsilon-caprolactone) microspheres
    Lan Yu
    Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People s Republic of China
    J Biomed Mater Res B Appl Biomater 77:39-46. 2006
  10. ncbi request reprint Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold
    Linette M Demers
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    J Am Chem Soc 124:11248-9. 2002

Collaborators

Detail Information

Publications18

  1. doi request reprint Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives
    Hua Zhang
    University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nanomedicine (Lond) 3:83-91. 2008
    ....
  2. doi request reprint Detection and downregulation of type I IGF receptor expression by antibody-conjugated quantum dots in breast cancer cells
    Hua Zhang
    University of Minnesota Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Breast Cancer Res Treat 114:277-85. 2009
    ..In addition, the inhibitory effect of AVE-1642 Qdots to cell proliferation implies that it may serve as a traceable therapeutic agent...
  3. doi request reprint Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor
    Xianke Zeng
    Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Breast Cancer Res Treat 133:117-26. 2012
    ..Long-term disruption of IGF1R/InsR may not be necessary when combined with cytotoxic chemotherapy...
  4. pmc Sequencing of type I insulin-like growth factor receptor inhibition affects chemotherapy response in vitro and in vivo
    Xianke Zeng
    Department of Pharmacology and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 15:2840-9. 2009
    ..The aim of this study was to determine the optimal sequence of combining anti-type I insulin-like growth factor receptor (IGF1R) antibodies with chemotherapeutic drugs in cancer cells in vitro and in vivo...
  5. ncbi request reprint Down-regulation of type I insulin-like growth factor receptor increases sensitivity of breast cancer cells to insulin
    Hua Zhang
    University of Minnesota Cancer Center, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Res 67:391-7. 2007
    ..Because IR also activates signaling pathways similar to IGF1R in breast cancer cells, agents targeting both receptors may be necessary to disrupt the malignant phenotype regulated by this growth factor system...
  6. ncbi request reprint Is the type I insulin-like growth factor receptor a therapeutic target in endometrial cancer?
    Hua Zhang
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 12:6323-5. 2006
  7. pmc Exogenous near-infrared fluorophores and their applications in cancer diagnosis: biological and clinical perspectives
    Hua Zhang
    Department of Medicine, Masonic Cancer Center, MMC 806, 420 Delaware St SE, Minneapolis, MN, 55455, USA
    Expert Opin Med Diagn 5:241-51. 2011
    ..The authors also anticipate that NIRF imaging research will lead to the development of flurophores with 'high brightness' that will overcome the limited penetration of this modality and be better suited for non invasive tumor targeting...
  8. ncbi request reprint The therapeutic potential of agents targeting the type I insulin-like growth factor receptor
    Hua Zhang
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Expert Opin Investig Drugs 13:1569-77. 2004
    ..As these strategies move forward to clinical trial, several important considerations need to be incorporated into the clinical trial design...
  9. ncbi request reprint Study on the drug release property of cholesteryl end-functionalized poly(epsilon-caprolactone) microspheres
    Lan Yu
    Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People s Republic of China
    J Biomed Mater Res B Appl Biomater 77:39-46. 2006
    ....
  10. ncbi request reprint Thermal desorption behavior and binding properties of DNA bases and nucleosides on gold
    Linette M Demers
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    J Am Chem Soc 124:11248-9. 2002
    ..Similar trends in desorption energies, shifted to lower desorption energy by more than 10 kJ/mol, are observed for deoxynucleoside layers on gold thin films...
  11. pmc Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
    Claude Sportes
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Exp Med 205:1701-14. 2008
    ....
  12. ncbi request reprint [The characteristics of enhanced gadolinium DTPA brain magnetic resonance images in 298 multiple sclerosis patients]
    Hua Zhang
    Department of Neurology, Beijing Hospital, the Ministry of Health, Beijing 100730, China
    Zhonghua Nei Ke Za Zhi 42:490-1. 2003
    ..To investigate the characteristics of enhanced brain magnetic resonance imaging (MRI) with gadolinium-DTPA (GD) in patients with multiple sclerosis (MS)...
  13. pmc Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model
    Hua Zhang
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Biomaterials 29:1976-88. 2008
    ..The rapid and efficient targeting of these particles can be exploited in drug and gene delivery systems and with dynamic positron emission tomography provides a model system to optimize targeting of engineered particles...
  14. pmc A stimulus-responsive contrast agent for ultrasound molecular imaging
    Mark A Borden
    Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    Biomaterials 29:597-606. 2008
    ..These results show, for the first time, the molecular mechanism for reduced immunogenicity for the buried-ligand architecture and feasibility of targeting with this motif using a physiological ligand-receptor pair...
  15. ncbi request reprint Enhanced intracellular delivery and improved antitumor efficacy of doxorubicin by sterically stabilized liposomes modified with a synthetic RGD mimetic
    Xiao Bing Xiong
    School of Pharmaceutical Sciences, Peking University, Beijing, 100083, PR China
    J Control Release 107:262-75. 2005
    ..These results suggest that RGDm-modified SSL may be a promising intracellular targeting carrier for efficient delivery of chemotherapeutic agents into tumor cells...
  16. ncbi request reprint New bisbenzylisoquinoline alkaloids from Cocculus laurifolius
    Hua Zhang
    State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, P R China
    Nat Prod Res 20:553-7. 2006
    ..These alkaloids were characterized mainly by spectroscopic methods...
  17. ncbi request reprint [Preparation of doxorubicin-loaded stealth liposomes modified with RGD mimetic and cellular association in vitro]
    Xiao Bing Xiong
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 40:1085-90. 2005
    ....
  18. ncbi request reprint An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon
    Hua Zhang
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri Kansas City, 5100 Rockhill Road, Kansas City, MO 64110 2499, USA
    Int J Pharm 239:197-205. 2002
    ..Degradation of the chitosan-TPP hydrogel beads in the presence of rat cecal and colonic enzymes indicates the potential of this multiparticulate system to serve as a carrier to deliver macromolecules specifically to the colon...