Research Topics
| Hong ZhangSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3Wen-Chang Li
Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P.R. China
Clin Cancer Res 12:7140-8. 2006..05). CONCLUSIONS: Constitutively activated STAT3 is essential for the growth, survival, and metastasis of HCC, suggesting that STAT3-targeted therapy may have utility for HCC...
Suppression of human tumor cell proliferation by Smurf2-induced senescenceHong Zhang
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Physiol 215:613-20. 2008..Our results, which reveal a previously unsuspected tumor suppression function for Smurf2-induced senescence, suggest that modulation of Smurf2 action may be a useful strategy for inhibition of cancer cell growth...- Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and agingHong Zhang
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Cell Physiol 210:567-74. 2007.... - Smurf2 regulates the senescence response and suppresses tumorigenesis in miceCharusheila Ramkumar
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Cancer Res 72:2714-9. 2012..Taken together, our findings offer the genetic evidence of an important tumor suppressor function for Smurf2... 
Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescenceYahui Kong
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Aging Cell 10:1038-46. 2011..Furthermore, we found that Id1 is the mediator through which Smurf2 regulates p16 expression, providing a mechanistic link between Smurf2 and p16 expression during senescence...- Serial transplantation of bone marrow to test self-renewal capacity of hematopoietic stem cells in vivoCharusheila Ramkumar
Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA
Methods Mol Biol 976:17-24. 2013..In this chapter, we describe a bone marrow serial transplantation protocol designed to test the self-renewal capacity of HSCs in vivo... - Ultraviolet A and B differently induce intracellular protein expression in human skin melanocytes--a speculation of separate pathways in initiation of melanomaHong Zhang
Department of Dermatology, Institute of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
Carcinogenesis 24:1929-34. 2003..UVA and UVB may induce initiation of melanoma via separate intracellular pathways... - Apoptosis of human pancreatic cancer cells induced by TriptolideGuo Xiong Zhou
Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
World J Gastroenterol 14:1504-9. 2008..To investigate apoptosis in human pancreatic cancer cells induced by Triptolide (TL), and the relationship between this apoptosis and expression of caspase-3' bcl-2 and bax... - Smurf2 up-regulation activates telomere-dependent senescenceHong Zhang
Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
Genes Dev 18:3028-40. 2004..Smurf2 is the first gene found to be both up-regulated by telomere attrition and sufficient to induce senescence... - Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditionsHong Zhang
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA
Oncogene 23:6193-8. 2004.... - Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal lociHong Zhang
Departments of Genetics and Medicine, Stanford University School of Medicine, Stanford, CA 94305-5120, USA
Proc Natl Acad Sci U S A 100:3251-6. 2003..e., quiescence), supports the view that replicative senescence is associated with alteration of chromatin structure... - Who will care for our parents? Changing boundaries of family and public roles in providing care for the aged in urban ChinaHong Zhang
Department of East Asian Studies, Colby College, Waterville, ME 04901 8844, USA
Care Manag J 8:39-46. 2007..More specifically, it describes and discusses three new eldercare patterns: at-home eldercare (jujia yanglao), community-based eldercare (shequ yanglao), and institutional care (yanglao jigou yanglao)... - Preparation and biological evaluation of 2-amino-6-[18F]fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-[18F]FPCV) as a novel PET probe for imaging HSV1-tk reporter gene expressionHancheng Cai
Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Nucl Med Biol 34:717-25. 2007.... - Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cellsAndis Klegeris
Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
FASEB J 20:2000-8. 2006..5 microM respectively. We hypothesize that the neuroinflammation stimulated by release of an excess of normal alpha-synuclein or by release of its mutated forms can be involved in the pathobiology of PD... - A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitinationJianhong Ma
Enzymology and Mechanistic Pharmacology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA
Biochemistry 45:9238-45. 2006..This second mdm2-p53 interaction site represents an alternative target for small molecule modulators of the mdm2-p53 pathway... - Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniaeHong Zhang
Z BioMed Inc, 15725 Crabbs Branch Way, Rockville, MD 20855, USA
Microbes Infect 8:2172-85. 2006..The advantage of this novel approach is that the detection of pathogens is based on the differences in host gene expression profiles in response to different pathogens instead of detecting pathogens directly... - Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivityZhuan Zi Wang
Graduate School of Chinese Academy of Sciences, Beijing, China
World J Gastroenterol 12:2601-5. 2006..To determine whether the number of non-rejoining G2-chromatid breaks can predict the radiosensitivity of human cell lines... - AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatmentJinhua Luo
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
Plant J 46:649-57. 2006..These data suggest that the E3 ubiquitin ligase AtCHIP may function upstream of PP2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark... - Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug developmentErich Koller
Department of Functional Genomics, Isis Pharmaceuticals, Carlsbad, California 92008, USA
Cancer Res 66:2059-66. 2006..These data show, for the first time, the utility of a 2'MOE ASO library for high-throughput cell culture-based functional assays and suggest that an Eg5 ASO also has potential in a therapeutic strategy... - Effect of exogenous wild-type p53 on melanoma cell death pathways induced by irradiation at different linear energy transferFeng-Ling Min
Institute of Modern Physics, Chinese Academy of Science, Lanzhou, Gansu Province 730000, People's Republic of China
In Vitro Cell Dev Biol Anim 41:284-8. 2005..Our observation in the study offers the potential application of high-LET radiation combined with p53 in the management of human patients with melanoma... - Differences in age-related bone mass of proximal femur between Chinese women and different ethnic women in the United StatesYan Li Hou
Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, 86 Renmin Zhong Rd, Changsha, Hunan, 410011, PR China
J Bone Miner Metab 25:243-52. 2007..At the femoral neck, the vBMD of Chinese women is similar to that of non-Hispanic white women... - The C. elegans CBFbeta homolog, BRO-1, regulates the proliferation, differentiation and specification of the stem cell-like seam cell lineagesDan Xia
Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, PR China
Dev Biol 309:259-72. 2007..Our studies indicate that the transcriptional repression activity of the RNT-1/BRO-1 complex regulates the G1 to S cell cycle progression during seam cell division... - Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activityNilantha Sirisoma
EpiCept Corporation, 6650 Nancy Ridge Drive, San Diego, California 92121, USA
J Med Chem 51:4771-9. 2008.... - Screening potential antitumor agents from natural plant extracts by G-quadruplex recognition and NMR methodsQiuju Zhou
Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
Angew Chem Int Ed Engl 47:5590-2. 2008 - Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in miceJoel N H Stern
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 105:5172-6. 2008..e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression... - Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transferXin Duan
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu Province, China
Int J Radiat Biol 84:211-7. 2008..To investigate the effect of exogenous wild type p53 (Tp53) on murine melanoma B16 cell apoptosis induced by carbon-ion beam (C-beam) irradiation... - Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic miceHong Zhang
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
Phytomedicine 15:587-94. 2008..This may do so by relatively increasing the levels of NE, DA in the hippocampus and by decreasing the activity of AChE in the cortex... - Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positionsWilliam Kemnitzer
EpiCept Corporation, San Diego, CA 92121, USA
J Med Chem 51:417-23. 2008..Compound 2d was identified as a highly potent apoptosis inducer with an EC50 value of 2 nM and a highly potent inhibitor of cell growth with a GI50 value of 0.3 nM in T47D cells... - Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastasesSu Young Kim
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Clin Exp Metastasis 25:201-11. 2008..Our findings show that inhibition of the CXCR4/CXCL12 pathway decreases metastatic disease in two murine tumor models and expands on previous reports to describe potential mechanisms of action... - Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cellsYanbo Fan
Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100083, China
Arterioscler Thromb Vasc Biol 28:315-21. 2008..The role of peroxisome proliferator-activated receptor-delta (PPAR-delta) in endothelial activation remains poorly understood. In this study, we investigated the anti-inflammatory effect of PPAR-delta and the mechanism involved... - Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cellsHong Zhang
Department of Ophthalmology, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province, China
Exp Eye Res 85:825-35. 2007..The application of As(2)O(3) to cells within the capsular bag for a 2min window using the Perfect Capsule system predicts putative therapeutic benefit in vivo... - TIMP-3 gene transfection suppresses invasive and metastatic capacity of human hepatocarcinoma cell line HCC-7721Hong Zhang
Department of General Surgery, Second Hospital of Jilin University, Changchun 130041, China
Hepatobiliary Pancreat Dis Int 6:487-91. 2007..There are currently four known TIMP family members-TIMP-1, 2, 3, 4. We determined whether increasing levels of TIMP-3 expression could suppress the malignant phenotype of human hepatocarcinoma cell line HCC-7721... - Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicityJeremy R Graff
Lilly Research Labs, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Clin Invest 117:2638-48. 2007..These data have prompted eIF4E-specific ASO clinical trials for the treatment of human cancers... - NestinnegCD24low/- population from fetal Nestin-EGFP transgenic mice enriches the pancreatic endocrine progenitor cellsXiaojing Wang
PKU-BLARC Mouse Genomics Center, Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
Pancreas 31:385-91. 2005..CONCLUSIONS: Pancreatic endocrine stem/progenitor cells are enriched in the NestinCD24 population of embryonic pancreas... - Fabrication of three-dimensional porous scaffolds of complicated shape for tissue engineering. I. Compression molding based on flexible-rigid combined moldLinbo Wu
Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, China
Tissue Eng 11:1105-14. 2005..Good viability of cells seeded in the porous scaffolds was confirmed. This novel fabrication method is promising in tissue engineering because of its ability to produce precise and complexly (anatomically) shaped porous scaffolds... - Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positionsWilliam Kemnitzer
Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA
Bioorg Med Chem Lett 15:4745-51. 2005.... - Targeting multiple signal transduction pathways through inhibition of Hsp90Hong Zhang
Department of Biology, Conforma Therapeutics Corporation, 9393 Towne Centre Dr, 92121, San Diego, CA 92121, USA
J Mol Med 82:488-99. 2004..Thus these small molecule inhibitors have proved not only to be of great value in identifying new Hsp90 client proteins and in understanding the biology of Hsp90 but are also promising therapeutics in a variety of tumors... - Deletion in p16INK4a and loss of p16 expression in human skin primary and metastatic melanoma cellsHong Zhang
Division of Dermatology, Clinical Research Center, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
Int J Oncol 24:331-5. 2004..Deletions of p16INK4a gene was uncommon and loss of p16 protein expression was common event in melanoma, especially in the later stages of melanoma... - [Antisense DNMT1 gene fragment in the sensitivity change of SMMC-7721 cells to tumor necrosis factor related apoptosis inducing ligand and its mechanism]Xiao-an Li
Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Zhonghua Zhong Liu Za Zhi 25:538-41. 2003..CONCLUSION: The sensitivity of SMMC-7721 cells to TRAIL can be enhanced by the transfection of antisense DNMT1 gene fragment, which may be related to the increase of bax and bad expression... - Isolation of DNA-free RNA, DNA, and proteins by cesium trifluoroacetate centrifugationHong Zhang
Nuvelo Inc, 675 Almanor Ave, Sunnyvale, CA 94085, USA
Biochem Biophys Res Commun 312:131-7. 2003..Hence, the RNA is recovered with minimum manipulations. The one-step separation of cellular macromolecule classes free of each other in small amount of starting materials provides a major advantage over other methods currently in use... - [Influence of tumor cells on endothelial cells in vitro]Yu qin Liu
Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
Zhonghua Bing Li Xue Za Zhi 32:360-3. 2003..To observe in vitro changes of endothelial cells after confrontation with tumor cells... - Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cellsHong Zhang
Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Exp Cell Res 289:352-8. 2003..In total, these results suggest that IRS-1 may be targeted for degradation by calpain during apoptosis... - AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expressionXiubin Liang
Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
J Am Soc Nephrol 14:1443-51. 2003..It is concluded that AngRem104 is a novel human gene potentially involved in the regulation of FN induced by AngII in human MC. These findings may provide new insights into mechanisms of glomerular sclerosis associated with AngII... - Clinicopathological significance of Nup88 expression in patients with colorectal cancerAnna Emterling
Department of Oncology, Institute of Biomedicine and Surgery, , , Sweden
Oncology 64:361-9. 2003..02). CONCLUSIONS: It seems that overexpression of Nup88 was involved in the tumorigenesis and aggressiveness of colorectal cancers, and Nup88 may be used as a prognostic factor in patients with distal tumors... - Socioeconomic factors in cancer in SwedenKari Hemminki
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
Int J Cancer 105:692-700. 2003..The overall population-attributable fraction for selected sites was 16.7% for men and 10.9% for women and it was highest, over 50%, for lung cancer in both genders... - Screening and identification of the up-regulated genes in human mesangial cells exposed to angiotensin IIXiubin Liang
Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
Hypertens Res 26:225-35. 2003..These findings may lead to new insights into the mechanisms of glomerular sclerosis associated with Ang II... - [Clinical application of Lishengsu for treatment of leukopenia induced by chemotherapy]Ning Xi Jiang
General Hospital of Lanzhou Military Area of PLA, Lanzhou 730050, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 11:96-8. 2003..4% (325/327), the side effects were quite slight. It is concluded that Lishengsu is efficient and safe for patients with leukopenia, and can be used as an adjuvant drug for treatment of leukopenia after chemotherapy... - Sex hormones and their receptors in patients with age-related cataractXiao Hong Zhang
Research Laboratory, International Implant Training Center, Tianjin Medical University, Tianjin, China
J Cataract Refract Surg 29:71-7. 2003..To determine the sex hormone levels in the serum and aqueous humor in patients with age-related cataract and the corresponding hormone receptors in cataract lens epithelial cells (LECs)... - Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesisRachel E Palmer
Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
Cancer Cell 2:497-505. 2002..BAIAP3 therefore encodes a transcriptional target of an oncogenic fusion protein that implicates the regulated exocytotic pathway in cancer cell proliferation... - Spam1 (PH-20) expression in the extratesticular duct and accessory organs of the mouse: a possible role in sperm fluid reabsorptionHong Zhang
Department of Biological Sciences, University of Delaware, Newark, Delaware 19711, USA
Biol Reprod 71:1101-7. 2004..In the efferent ducts, where Spam1 is enriched in the apical (but not basolateral) membrane of nonciliated cells, it is likely to play a role in sperm concentration, which is the established function of that organ... - Oncological diagnosis using (11)C-choline-positron emission tomography in comparison with 2-deoxy-2-[(18)F] fluoro-D-glucose-positron emission tomographyMei Tian
Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan
Mol Imaging Biol 6:172-9. 2004..To assess and compare the usefulness of (11)C-Choline-positron emission tomography (PET) with that of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG)-PET for the differentiation between benign and malignant in various tumors... - Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomasCharles A Fox
Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
Neoplasia 7:407-16. 2005..These potential biomarkers, as well as the relative expression of genes from BE1 versus those from BE2, may be validated in the future to aid in risk stratification and guide treatment protocols in patients with BE and associated AC... - Current status of tumor radiogenic therapyFeng Ling Min
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China
World J Gastroenterol 11:3014-9. 2005.... - Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivoXiaoying Yin
Department of Otolaryngology/Head and Neck Surgery and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina and Conforma Therapeutics, San Diego, California, USA
Clin Cancer Res 11:3889-96. 2005..These results suggest that this novel ansamycin-based Hsp90 inhibitor affects multiple pathways involved in tumor development and progression and may represent a new strategy for the treatment of HNSCC patients... - Survivin protein in UVB induced apoptosis of melanoma cells and in melanoma progressionHong Zhang
Clinical Research Centre, Division of Dermatology, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
Oncol Rep 13:1121-6. 2005..However, the normal tissues were not expressed in the survivin protein. Survivin plays an important role in UVB-induced apoptosis. Overexpression of survivin might be a biomarker for early diagnosis for melanoma... - Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPKHong Zhang
Department of Research and University Women's Hospital Basel, CH-4031 Basel, Switzerland
Int J Oncol 26:1575-80. 2005..These results may indicate the usefulness of staurosporine or its analogs for the development of a future medical treatment of granulosa tumors... - Relationships of tumor inflammatory infiltration and necrosis with microsatellite instability in colorectal cancersJing-Fang Gao
Department of Oncology, Institute of Biomedicine and Surgery, , , Sweden
World J Gastroenterol 11:2179-83. 2005..02 for univariate, and P = 0.05 for multivariate analysis). CONCLUSION: The result that high inflammatory infiltration was not related to MSI might help explain the non-association of MSI with survival in colorectal cancer patients... - Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layersGuangwen Wang
Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
Biochem Biophys Res Commun 330:934-42. 2005..Our data provide new insight into the mechanism how hES cell self-renewal is regulated. The newly developed feeder-free culture system will provide a more reliable alternative for future therapeutic applications of hES cells... - Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cellsMark Stearns
Department of Pathology, Drexel University School of Medicine, Philadelphia, Pennsylvania, USA
Cancer Res 65:2085-8. 2005.... - Effect of mitomycin C and vinblastine on FDG uptake of human nonsmall-cell lung cancer xenografts in nude miceMei Tian
Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan
Cancer Biother Radiopharm 19:601-5. 2004..001), as early as day 1. These observations suggest that FDG-PET may be useful for noninvasively monitoring the effects of cancer chemotherapy... - Expression profiles of Id1 and p16 proteins in all-trans-retinoic acid-induced apoptosis and cell cycle re-distribution in melanomaHong Zhang
Division of Dermatology, Clinical Research Centre, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
Cancer Lett 217:33-41. 2005..These expression profiles of Id1 and p16 proteins may provide molecular evidence for better chemotherapy primarily for early stages of melanoma... - Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl groupWilliam Kemnitzer
Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, California 92121, USA
J Med Chem 47:6299-310. 2004.... - Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activityShailaja Kasibhatla
Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA
Mol Cancer Ther 3:1365-74. 2004.... - The transformed phenotypeHenry Hoff
Lankenau Institute for Medical Research, Wynnewood, PA, USA
Methods Mol Biol 285:95-104. 2004 - Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cellsHong Zhang
Department of Dermatology, Clinical Research Center, Institute of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
Int J Oncol 21:43-8. 2002..These data suggest that a reduced expression of p16 and p27 and an enhanced expression of p73 and Nup88 might play an important role in the progression of melanoma from primary tumor to metastasis...
Research Grants
- Genetic pathways of replicative senescence and its function in tumorigenesisHong Zhang; Fiscal Year: 2010....