Hong Zhang

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
    Wen Chang Li
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P R China
    Clin Cancer Res 12:7140-8. 2006
  2. doi request reprint Suppression of human tumor cell proliferation by Smurf2-induced senescence
    Hong Zhang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 215:613-20. 2008
  3. pmc Regulation of senescence in cancer and aging
    Yahui Kong
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, S7 125, Worcester, MA 01655, USA
    J Aging Res 2011:963172. 2011
  4. pmc Oxidative stress, mitochondrial dysfunction, and aging
    Hang Cui
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Signal Transduct 2012:646354. 2012
  5. ncbi request reprint Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging
    Hong Zhang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 210:567-74. 2007
  6. pmc Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1
    Charusheila Ramkumar
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nat Commun 4:2598. 2013
  7. pmc Notch3 functions as a tumor suppressor by controlling cellular senescence
    Hang Cui
    Departments of Cell and Developmental Biology and Information Service Research Computing Group, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cancer Res 73:3451-9. 2013
  8. pmc Smurf2 regulates the senescence response and suppresses tumorigenesis in mice
    Charusheila Ramkumar
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 72:2714-9. 2012
  9. pmc Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence
    Yahui Kong
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Aging Cell 10:1038-46. 2011
  10. doi request reprint Serial transplantation of bone marrow to test self-renewal capacity of hematopoietic stem cells in vivo
    Charusheila Ramkumar
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 976:17-24. 2013

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
    Wen Chang Li
    Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P R China
    Clin Cancer Res 12:7140-8. 2006
    ..We intended to study the role of signal transducer and activator of transcription 3 (STAT3) aberrant signaling in HCC malignancy, and the therapeutic potential of inhibition of STAT3 expression for HCC...
  2. doi request reprint Suppression of human tumor cell proliferation by Smurf2-induced senescence
    Hong Zhang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 215:613-20. 2008
    ..Our results, which reveal a previously unsuspected tumor suppression function for Smurf2-induced senescence, suggest that modulation of Smurf2 action may be a useful strategy for inhibition of cancer cell growth...
  3. pmc Regulation of senescence in cancer and aging
    Yahui Kong
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, S7 125, Worcester, MA 01655, USA
    J Aging Res 2011:963172. 2011
    ..In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed...
  4. pmc Oxidative stress, mitochondrial dysfunction, and aging
    Hang Cui
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Signal Transduct 2012:646354. 2012
    ..In this paper, we will present the current understanding of the interplay between ROS and mitochondria and will discuss their potential impact on aging and age-related diseases...
  5. ncbi request reprint Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging
    Hong Zhang
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 210:567-74. 2007
    ....
  6. pmc Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1
    Charusheila Ramkumar
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nat Commun 4:2598. 2013
    ..The Smurf2-YY1-c-Myc regulatory axis represents a novel pathway perturbed in DLBCL that suppresses B-cell proliferation and lymphomagenesis, suggesting pharmaceutical targeting of Smurf2 as a new therapeutic paradigm for DLBCL. ..
  7. pmc Notch3 functions as a tumor suppressor by controlling cellular senescence
    Hang Cui
    Departments of Cell and Developmental Biology and Information Service Research Computing Group, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cancer Res 73:3451-9. 2013
    ..Restoration of Notch3 expression in human tumor cells resulted in inhibition of cell proliferation and activation of senescence. Collectively, our results reveal a novel function of Notch3 in senescence regulation and tumor suppression...
  8. pmc Smurf2 regulates the senescence response and suppresses tumorigenesis in mice
    Charusheila Ramkumar
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 72:2714-9. 2012
    ..Taken together, our findings offer the genetic evidence of an important tumor suppressor function for Smurf2...
  9. pmc Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence
    Yahui Kong
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Aging Cell 10:1038-46. 2011
    ..Furthermore, we found that Id1 is the mediator through which Smurf2 regulates p16 expression, providing a mechanistic link between Smurf2 and p16 expression during senescence...
  10. doi request reprint Serial transplantation of bone marrow to test self-renewal capacity of hematopoietic stem cells in vivo
    Charusheila Ramkumar
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 976:17-24. 2013
    ..In this chapter, we describe a bone marrow serial transplantation protocol designed to test the self-renewal capacity of HSCs in vivo...
  11. ncbi request reprint Smurf2 regulates hematopoietic stem cell self-renewal and aging
    Charusheila Ramkumar
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Aging Cell 13:478-86. 2014
    ..As we found that the expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC self-renewal and aging...
  12. ncbi request reprint Oxidative stress, mitochondrial dysfunction and the mitochondria theory of aging
    Yahui Kong
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Mass, USA
    Interdiscip Top Gerontol 39:86-107. 2014
    ..This chapter outlines the interplay between oxidative stress and mitochondrial dysfunction, and discusses their impact on senescence, cell death, stem cell function, age-associated diseases and longevity...
  13. ncbi request reprint Ultraviolet A and B differently induce intracellular protein expression in human skin melanocytes--a speculation of separate pathways in initiation of melanoma
    Hong Zhang
    Department of Dermatology, Institute of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
    Carcinogenesis 24:1929-34. 2003
    ..UVA and UVB may induce initiation of melanoma via separate intracellular pathways...
  14. pmc Smurf2 up-regulation activates telomere-dependent senescence
    Hong Zhang
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genes Dev 18:3028-40. 2004
    ..Smurf2 is the first gene found to be both up-regulated by telomere attrition and sufficient to induce senescence...
  15. pmc Apoptosis of human pancreatic cancer cells induced by Triptolide
    Guo Xiong Zhou
    Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
    World J Gastroenterol 14:1504-9. 2008
    ..To investigate apoptosis in human pancreatic cancer cells induced by Triptolide (TL), and the relationship between this apoptosis and expression of caspase-3' bcl-2 and bax...
  16. pmc Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
    Hong Zhang
    Departments of Genetics and Medicine, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Proc Natl Acad Sci U S A 100:3251-6. 2003
    ..e., quiescence), supports the view that replicative senescence is associated with alteration of chromatin structure...
  17. ncbi request reprint Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
    Hong Zhang
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Oncogene 23:6193-8. 2004
    ....
  18. ncbi request reprint Preparation and biological evaluation of 2-amino-6-[18F]fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-[18F]FPCV) as a novel PET probe for imaging HSV1-tk reporter gene expression
    Hancheng Cai
    Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    Nucl Med Biol 34:717-25. 2007
    ....
  19. ncbi request reprint The C. elegans CBFbeta homolog, BRO-1, regulates the proliferation, differentiation and specification of the stem cell-like seam cell lineages
    Dan Xia
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, PR China
    Dev Biol 309:259-72. 2007
    ..Our studies indicate that the transcriptional repression activity of the RNT-1/BRO-1 complex regulates the G1 to S cell cycle progression during seam cell division...
  20. ncbi request reprint Differences in age-related bone mass of proximal femur between Chinese women and different ethnic women in the United States
    Yan Li Hou
    Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, 86 Renmin Zhong Rd, Changsha, Hunan, 410011, PR China
    J Bone Miner Metab 25:243-52. 2007
    ..At the femoral neck, the vBMD of Chinese women is similar to that of non-Hispanic white women...
  21. ncbi request reprint Who will care for our parents? Changing boundaries of family and public roles in providing care for the aged in urban China
    Hong Zhang
    Department of East Asian Studies, Colby College, Waterville, ME 04901 8844, USA
    Care Manag J 8:39-46. 2007
    ..More specifically, it describes and discusses three new eldercare patterns: at-home eldercare (jujia yanglao), community-based eldercare (shequ yanglao), and institutional care (yanglao jigou yanglao)...
  22. ncbi request reprint Relationships of tumor inflammatory infiltration and necrosis with microsatellite instability in colorectal cancers
    Jing Fang Gao
    Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoping, S 581 85 Linkoping, Sweden
    World J Gastroenterol 11:2179-83. 2005
    ..Our aims were to investigate the associations of inflammatory infiltration and tumor necrosis (TN) with microsatellite status and clinicopathological factors in colorectal cancer patients in whom MSI was not related to survival...
  23. ncbi request reprint Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells
    Andis Klegeris
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
    FASEB J 20:2000-8. 2006
    ..5 microM respectively. We hypothesize that the neuroinflammation stimulated by release of an excess of normal alpha-synuclein or by release of its mutated forms can be involved in the pathobiology of PD...
  24. ncbi request reprint A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination
    Jianhong Ma
    Enzymology and Mechanistic Pharmacology, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA
    Biochemistry 45:9238-45. 2006
    ..This second mdm2-p53 interaction site represents an alternative target for small molecule modulators of the mdm2-p53 pathway...
  25. ncbi request reprint Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae
    Hong Zhang
    Z BioMed Inc, 15725 Crabbs Branch Way, Rockville, MD 20855, USA
    Microbes Infect 8:2172-85. 2006
    ..The advantage of this novel approach is that the detection of pathogens is based on the differences in host gene expression profiles in response to different pathogens instead of detecting pathogens directly...
  26. pmc Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity
    Jeremy R Graff
    Lilly Research Labs, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Clin Invest 117:2638-48. 2007
    ..These data have prompted eIF4E-specific ASO clinical trials for the treatment of human cancers...
  27. ncbi request reprint TIMP-3 gene transfection suppresses invasive and metastatic capacity of human hepatocarcinoma cell line HCC-7721
    Hong Zhang
    Department of General Surgery, Second Hospital of Jilin University, Changchun 130041, China
    Hepatobiliary Pancreat Dis Int 6:487-91. 2007
    ..There are currently four known TIMP family members-TIMP-1, 2, 3, 4. We determined whether increasing levels of TIMP-3 expression could suppress the malignant phenotype of human hepatocarcinoma cell line HCC-7721...
  28. ncbi request reprint AngRem104, an angiotensin II-induced novel upregulated gene in human mesangial cells, is potentially involved in the regulation of fibronectin expression
    Xiubin Liang
    Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    J Am Soc Nephrol 14:1443-51. 2003
    ..It is concluded that AngRem104 is a novel human gene potentially involved in the regulation of FN induced by AngII in human MC. These findings may provide new insights into mechanisms of glomerular sclerosis associated with AngII...
  29. doi request reprint Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity
    Nilantha Sirisoma
    EpiCept Corporation, 6650 Nancy Ridge Drive, San Diego, California 92121, USA
    J Med Chem 51:4771-9. 2008
    ....
  30. doi request reprint Screening potential antitumor agents from natural plant extracts by G-quadruplex recognition and NMR methods
    Qiuju Zhou
    Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
    Angew Chem Int Ed Engl 47:5590-2. 2008
  31. pmc Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice
    Joel N H Stern
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:5172-6. 2008
    ..e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression...
  32. doi request reprint Apoptosis of murine melanoma cells induced by heavy-ion radiation combined with Tp53 gene transfer
    Xin Duan
    Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu Province, China
    Int J Radiat Biol 84:211-7. 2008
    ..To investigate the effect of exogenous wild type p53 (Tp53) on murine melanoma B16 cell apoptosis induced by carbon-ion beam (C-beam) irradiation...
  33. doi request reprint Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice
    Hong Zhang
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    Phytomedicine 15:587-94. 2008
    ..This may do so by relatively increasing the levels of NE, DA in the hippocampus and by decreasing the activity of AChE in the cortex...
  34. doi request reprint Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions
    William Kemnitzer
    EpiCept Corporation, San Diego, CA 92121, USA
    J Med Chem 51:417-23. 2008
    ..Compound 2d was identified as a highly potent apoptosis inducer with an EC50 value of 2 nM and a highly potent inhibitor of cell growth with a GI50 value of 0.3 nM in T47D cells...
  35. pmc Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    Su Young Kim
    Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Clin Exp Metastasis 25:201-11. 2008
    ..Our findings show that inhibition of the CXCR4/CXCL12 pathway decreases metastatic disease in two murine tumor models and expands on previous reports to describe potential mechanisms of action...
  36. ncbi request reprint Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells
    Yanbo Fan
    Institute of Cardiovascular Science and Key Laboratory of Molecular Cardiovascular Science, Peking University Health Science Center, Beijing 100083, China
    Arterioscler Thromb Vasc Biol 28:315-21. 2008
    ..The role of peroxisome proliferator-activated receptor-delta (PPAR-delta) in endothelial activation remains poorly understood. In this study, we investigated the anti-inflammatory effect of PPAR-delta and the mechanism involved...
  37. ncbi request reprint Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells
    Hong Zhang
    Department of Ophthalmology, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang Province, China
    Exp Eye Res 85:825-35. 2007
    ..The application of As(2)O(3) to cells within the capsular bag for a 2min window using the Perfect Capsule system predicts putative therapeutic benefit in vivo...
  38. ncbi request reprint Comparison of clonogenic assay with premature chromosome condensation assay in prediction of human cell radiosensitivity
    Zhuan Zi Wang
    Graduate School of Chinese Academy of Sciences, Beijing, China
    World J Gastroenterol 12:2601-5. 2006
    ..To determine whether the number of non-rejoining G2-chromatid breaks can predict the radiosensitivity of human cell lines...
  39. ncbi request reprint AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment
    Jinhua Luo
    Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA
    Plant J 46:649-57. 2006
    ..These data suggest that the E3 ubiquitin ligase AtCHIP may function upstream of PP2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark...
  40. ncbi request reprint Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development
    Erich Koller
    Department of Functional Genomics, Isis Pharmaceuticals, Carlsbad, California 92008, USA
    Cancer Res 66:2059-66. 2006
    ..These data show, for the first time, the utility of a 2'MOE ASO library for high-throughput cell culture-based functional assays and suggest that an Eg5 ASO also has potential in a therapeutic strategy...
  41. ncbi request reprint Oncological diagnosis using (11)C-choline-positron emission tomography in comparison with 2-deoxy-2-[(18)F] fluoro-D-glucose-positron emission tomography
    Mei Tian
    Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan
    Mol Imaging Biol 6:172-9. 2004
    ..To assess and compare the usefulness of (11)C-Choline-positron emission tomography (PET) with that of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG)-PET for the differentiation between benign and malignant in various tumors...
  42. ncbi request reprint Spam1 (PH-20) expression in the extratesticular duct and accessory organs of the mouse: a possible role in sperm fluid reabsorption
    Hong Zhang
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19711, USA
    Biol Reprod 71:1101-7. 2004
    ..In the efferent ducts, where Spam1 is enriched in the apical (but not basolateral) membrane of nonciliated cells, it is likely to play a role in sperm concentration, which is the established function of that organ...
  43. ncbi request reprint Targeting multiple signal transduction pathways through inhibition of Hsp90
    Hong Zhang
    Department of Biology, Conforma Therapeutics Corporation, 9393 Towne Centre Dr, 92121, San Diego, CA 92121, USA
    J Mol Med (Berl) 82:488-99. 2004
    ..Thus these small molecule inhibitors have proved not only to be of great value in identifying new Hsp90 client proteins and in understanding the biology of Hsp90 but are also promising therapeutics in a variety of tumors...
  44. ncbi request reprint Deletion in p16INK4a and loss of p16 expression in human skin primary and metastatic melanoma cells
    Hong Zhang
    Division of Dermatology, Clinical Research Center, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
    Int J Oncol 24:331-5. 2004
    ..Deletions of p16INK4a gene was uncommon and loss of p16 protein expression was common event in melanoma, especially in the later stages of melanoma...
  45. ncbi request reprint [Antisense DNMT1 gene fragment in the sensitivity change of SMMC-7721 cells to tumor necrosis factor related apoptosis inducing ligand and its mechanism]
    Xiao An Li
    Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    Zhonghua Zhong Liu Za Zhi 25:538-41. 2003
    ..To observe the sensitivity change of SMMC-7721 cells transfected with antisense DNMT1 gene fragment to tumor necrosis factor related apoptosis inducing ligand (TRAIL) and its mechanism...
  46. ncbi request reprint Isolation of DNA-free RNA, DNA, and proteins by cesium trifluoroacetate centrifugation
    Hong Zhang
    Nuvelo Inc, 675 Almanor Ave, Sunnyvale, CA 94085, USA
    Biochem Biophys Res Commun 312:131-7. 2003
    ..Hence, the RNA is recovered with minimum manipulations. The one-step separation of cellular macromolecule classes free of each other in small amount of starting materials provides a major advantage over other methods currently in use...
  47. ncbi request reprint [Influence of tumor cells on endothelial cells in vitro]
    Yu qin Liu
    Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
    Zhonghua Bing Li Xue Za Zhi 32:360-3. 2003
    ..To observe in vitro changes of endothelial cells after confrontation with tumor cells...
  48. ncbi request reprint Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells
    Hong Zhang
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Exp Cell Res 289:352-8. 2003
    ..In total, these results suggest that IRS-1 may be targeted for degradation by calpain during apoptosis...
  49. ncbi request reprint Clinicopathological significance of Nup88 expression in patients with colorectal cancer
    Anna Emterling
    Department of Oncology, Institute of Biomedicine and Surgery, Linkoping University, Linkoping, Sweden
    Oncology 64:361-9. 2003
    ..Our aims were to analyze Nup88 expression in normal mucosa, primary tumors and metastases from colorectal cancer patients and further to identify relationships of Nup88 expression with clinicopathological and other factors...
  50. ncbi request reprint Socioeconomic factors in cancer in Sweden
    Kari Hemminki
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Int J Cancer 105:692-700. 2003
    ..The overall population-attributable fraction for selected sites was 16.7% for men and 10.9% for women and it was highest, over 50%, for lung cancer in both genders...
  51. ncbi request reprint Screening and identification of the up-regulated genes in human mesangial cells exposed to angiotensin II
    Xiubin Liang
    Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing, China
    Hypertens Res 26:225-35. 2003
    ..These findings may lead to new insights into the mechanisms of glomerular sclerosis associated with Ang II...
  52. ncbi request reprint [Clinical application of Lishengsu for treatment of leukopenia induced by chemotherapy]
    Ning Xi Jiang
    General Hospital of Lanzhou Military Area of PLA, Lanzhou 730050, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 11:96-8. 2003
    ..4% (325/327), the side effects were quite slight. It is concluded that Lishengsu is efficient and safe for patients with leukopenia, and can be used as an adjuvant drug for treatment of leukopenia after chemotherapy...
  53. ncbi request reprint Sex hormones and their receptors in patients with age-related cataract
    Xiao Hong Zhang
    Research Laboratory, International Implant Training Center, Tianjin Medical University, Tianjin, China
    J Cataract Refract Surg 29:71-7. 2003
    ..To determine the sex hormone levels in the serum and aqueous humor in patients with age-related cataract and the corresponding hormone receptors in cataract lens epithelial cells (LECs)...
  54. ncbi request reprint Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis
    Rachel E Palmer
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Cancer Cell 2:497-505. 2002
    ..BAIAP3 therefore encodes a transcriptional target of an oncogenic fusion protein that implicates the regulated exocytotic pathway in cancer cell proliferation...
  55. ncbi request reprint The transformed phenotype
    Henry Hoff
    Lankenau Institute for Medical Research, Wynnewood, PA, USA
    Methods Mol Biol 285:95-104. 2004
  56. ncbi request reprint Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity
    Shailaja Kasibhatla
    Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA
    Mol Cancer Ther 3:1365-74. 2004
    ....
  57. ncbi request reprint Effect of exogenous wild-type p53 on melanoma cell death pathways induced by irradiation at different linear energy transfer
    Feng Ling Min
    Institute of Modern Physics, Chinese Academy of Science, Lanzhou, Gansu Province 730000, People s Republic of China
    In Vitro Cell Dev Biol Anim 41:284-8. 2005
    ..Our observation in the study offers the potential application of high-LET radiation combined with p53 in the management of human patients with melanoma...
  58. ncbi request reprint NestinnegCD24low/- population from fetal Nestin-EGFP transgenic mice enriches the pancreatic endocrine progenitor cells
    Xiaojing Wang
    PKU BLARC Mouse Genomics Center, Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    Pancreas 31:385-91. 2005
    ..To identify whether Nestin-positve cells or Nestin-negative cells in pancreas enrich potential pancreatic stem/progenitor cells...
  59. ncbi request reprint Fabrication of three-dimensional porous scaffolds of complicated shape for tissue engineering. I. Compression molding based on flexible-rigid combined mold
    Linbo Wu
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, China
    Tissue Eng 11:1105-14. 2005
    ..Good viability of cells seeded in the porous scaffolds was confirmed. This novel fabrication method is promising in tissue engineering because of its ability to produce precise and complexly (anatomically) shaped porous scaffolds...
  60. ncbi request reprint Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions
    William Kemnitzer
    Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 15:4745-51. 2005
    ....
  61. pmc Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas
    Charles A Fox
    Digestive Health Center of Excellence, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, USA
    Neoplasia 7:407-16. 2005
    ..These potential biomarkers, as well as the relative expression of genes from BE1 versus those from BE2, may be validated in the future to aid in risk stratification and guide treatment protocols in patients with BE and associated AC...
  62. ncbi request reprint Current status of tumor radiogenic therapy
    Feng Ling Min
    Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, Gansu Province, China
    World J Gastroenterol 11:3014-9. 2005
    ....
  63. ncbi request reprint Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo
    Xiaoying Yin
    Department of Otolaryngology Head and Neck Surgery and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina and Conforma Therapeutics, San Diego, California, USA
    Clin Cancer Res 11:3889-96. 2005
    ..These results suggest that this novel ansamycin-based Hsp90 inhibitor affects multiple pathways involved in tumor development and progression and may represent a new strategy for the treatment of HNSCC patients...
  64. ncbi request reprint Survivin protein in UVB induced apoptosis of melanoma cells and in melanoma progression
    Hong Zhang
    Clinical Research Centre, Division of Dermatology, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
    Oncol Rep 13:1121-6. 2005
    ..However, the normal tissues were not expressed in the survivin protein. Survivin plays an important role in UVB-induced apoptosis. Overexpression of survivin might be a biomarker for early diagnosis for melanoma...
  65. ncbi request reprint Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK
    Hong Zhang
    Department of Research and University Women s Hospital Basel, CH 4031 Basel, Switzerland
    Int J Oncol 26:1575-80. 2005
    ..These results may indicate the usefulness of staurosporine or its analogs for the development of a future medical treatment of granulosa tumors...
  66. ncbi request reprint Noggin and bFGF cooperate to maintain the pluripotency of human embryonic stem cells in the absence of feeder layers
    Guangwen Wang
    Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China
    Biochem Biophys Res Commun 330:934-42. 2005
    ..Our data provide new insight into the mechanism how hES cell self-renewal is regulated. The newly developed feeder-free culture system will provide a more reliable alternative for future therapeutic applications of hES cells...
  67. ncbi request reprint Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells
    Mark Stearns
    Department of Pathology, Drexel University School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer Res 65:2085-8. 2005
    ....
  68. ncbi request reprint Effect of mitomycin C and vinblastine on FDG uptake of human nonsmall-cell lung cancer xenografts in nude mice
    Mei Tian
    Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan
    Cancer Biother Radiopharm 19:601-5. 2004
    ..001), as early as day 1. These observations suggest that FDG-PET may be useful for noninvasively monitoring the effects of cancer chemotherapy...
  69. ncbi request reprint Expression profiles of Id1 and p16 proteins in all-trans-retinoic acid-induced apoptosis and cell cycle re-distribution in melanoma
    Hong Zhang
    Division of Dermatology, Clinical Research Centre, Department of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
    Cancer Lett 217:33-41. 2005
    ..These expression profiles of Id1 and p16 proteins may provide molecular evidence for better chemotherapy primarily for early stages of melanoma...
  70. ncbi request reprint Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group
    William Kemnitzer
    Maxim Pharmaceuticals, Inc, 6650 Nancy Ridge Drive, San Diego, California 92121, USA
    J Med Chem 47:6299-310. 2004
    ....
  71. ncbi request reprint Expression of p16, p27, p53, p73 and Nup88 proteins in matched primary and metastatic melanoma cells
    Hong Zhang
    Department of Dermatology, Clinical Research Center, Institute of Biomedicine and Surgery, Linkoping University, SE 581 85 Linkoping, Sweden
    Int J Oncol 21:43-8. 2002
    ..These data suggest that a reduced expression of p16 and p27 and an enhanced expression of p73 and Nup88 might play an important role in the progression of melanoma from primary tumor to metastasis...