Han Ting Zhang

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi request reprint Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 27:587-95. 2002
  2. ncbi request reprint Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function
    Yu Zhao
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Pharmacol Exp Ther 307:246-53. 2003
  3. ncbi request reprint Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus
    Han Ting Zhang
    Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 29:1432-9. 2004
  4. ncbi request reprint Antagonism of the antidepressant-like effects of clenbuterol by central administration of beta-adrenergic antagonists in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 170:102-7. 2003
  5. ncbi request reprint Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats
    Han Ting Zhang
    Department of Pharmacology, The University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 182:104-15. 2005
  6. ncbi request reprint Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram
    Yu Zhao
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    J Pharmacol Exp Ther 305:565-72. 2003
  7. ncbi request reprint Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 179:613-9. 2005
  8. ncbi request reprint Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
    JAMES M O'DONNELL
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Trends Pharmacol Sci 25:158-63. 2004
  9. ncbi request reprint Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats
    Han Ting Zhang
    Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Psychopharmacology (Berl) 186:209-17. 2006
  10. pmc Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)
    Han Ting Zhang
    Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Neuropsychopharmacology 33:1611-23. 2008

Detail Information

Publications11

  1. ncbi request reprint Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 27:587-95. 2002
    ....
  2. ncbi request reprint Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function
    Yu Zhao
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Pharmacol Exp Ther 307:246-53. 2003
    ..Collectively, these results suggest that antidepressants, although acting through different pathways, may eventually lead to the regulation of components of the cAMP signal transduction system...
  3. ncbi request reprint Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus
    Han Ting Zhang
    Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 29:1432-9. 2004
    ..PDE4 is likely to be an important link between the cAMP/PKA and MEK/ERK signaling pathways in the mediation of memory...
  4. ncbi request reprint Antagonism of the antidepressant-like effects of clenbuterol by central administration of beta-adrenergic antagonists in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 170:102-7. 2003
    ..At present, it is not known what brain sites are involved in mediating such effects, although some recent evidence suggests the importance of the dorsal hippocampus...
  5. ncbi request reprint Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats
    Han Ting Zhang
    Department of Pharmacology, The University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 182:104-15. 2005
    ..However, it is not known if PDE4 is associated with beta adrenergic receptors in the mediation of antidepressant-like effects...
  6. ncbi request reprint Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram
    Yu Zhao
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    J Pharmacol Exp Ther 305:565-72. 2003
    ..The results indicated that [(3)H]piclamilast is a useful tool to directly study inhibitor interaction with the HARBS and the LARBS in rat brain...
  7. ncbi request reprint Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 179:613-9. 2005
    ..Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4) enhances memory in rodents. MEM1018 and MEM1091 are newly developed PDE4 inhibitors that had not been evaluated as yet for their effects on working and reference memory...
  8. ncbi request reprint Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
    JAMES M O'DONNELL
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Trends Pharmacol Sci 25:158-63. 2004
  9. ncbi request reprint Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats
    Han Ting Zhang
    Departments of Behavioral Medicine and Psychiatry and Neurobiology and Anatomy, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Psychopharmacology (Berl) 186:209-17. 2006
    ..Phosphodiesterase-4 (PDE4) has two conformation states based on rolipram binding, the high-affinity rolipram binding state (HARBS) and the low-affinity rolipram binding state (LARBS); their functions remain to be fully explained...
  10. pmc Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)
    Han Ting Zhang
    Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
    Neuropsychopharmacology 33:1611-23. 2008
    ..Taken together, these results suggest that the PDE4B subfamily is involved in signaling pathways that contribute to anxiogenic-like effects on behavior...
  11. doi request reprint Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats
    Gregory W Konat
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSCN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Metab Brain Dis 23:325-33. 2008
    ..Moreover, the results strongly indicate that the damaging effect is mediated by oxidative stress, as memory dysfunction is preventable by the co-administration of NAC...