Chi Zhang

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Sclerostin is a direct target of osteoblast-specific transcription factor osterix
    Fan Yang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 400:684-8. 2010
  2. pmc Osteoblast-specific transcription factor Osterix (Osx) is an upstream regulator of Satb2 during bone formation
    Wanjin Tang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, Texas 75390, USA
    J Biol Chem 286:32995-3002. 2011
  3. pmc Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts
    Wanjin Tang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA
    J Biol Chem 287:1671-8. 2012
  4. pmc 1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway
    Dafu Chen
    Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing 100035, China
    Int J Biol Sci 9:649-55. 2013
  5. pmc HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts
    Dafu Chen
    Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China
    PLoS ONE 8:e65940. 2013
  6. pmc Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e50525. 2012
  7. ncbi Molecular mechanisms of osteoblast-specific transcription factor Osterix effect on bone formation
    Chi Zhang
    University of Texas Southwestern Medical Center, Dallas, TX 75219, USA
    Beijing Da Xue Xue Bao 44:659-65. 2012
  8. doi Lactoferrin activates BMP7 gene expression through the mitogen-activated protein kinase ERK pathway in articular cartilage
    Chi Zhang
    Department of Research, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 431:31-5. 2013
  9. pmc Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis
    Chi Zhang
    Department of Research, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA
    Sci Rep 2:650. 2012
  10. ncbi Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, 2222 Welborn St, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 420:782-6. 2012

Collaborators

Detail Information

Publications17

  1. ncbi Sclerostin is a direct target of osteoblast-specific transcription factor osterix
    Fan Yang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 400:684-8. 2010
    ..Taken together, these findings support our hypothesis that Sost is a direct target of Osx. This provides a new additional mechanism through which Osx inhibits Wnt signaling during bone formation...
  2. pmc Osteoblast-specific transcription factor Osterix (Osx) is an upstream regulator of Satb2 during bone formation
    Wanjin Tang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, Texas 75390, USA
    J Biol Chem 286:32995-3002. 2011
    ..Taken together, our findings indicate that Osx is an upstream regulator of Satb2 during bone formation. This reveals a new additional link of the transcriptional regulation mechanism that Osx controls bone formation...
  3. pmc Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts
    Wanjin Tang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA
    J Biol Chem 287:1671-8. 2012
    ..We provide the first evidence that Osx controlled VEGF expression, suggesting a potential role of Osx in coordinating osteogenesis and angiogenesis...
  4. pmc 1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway
    Dafu Chen
    Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing 100035, China
    Int J Biol Sci 9:649-55. 2013
    ..Since MMP13 plays a major role in cartilage degradation in OA, we speculate that the ability of 1,25-(OH)2D3 to potentiate MMP13 expression might facilitate cartilage erosion at the site of inflammatory arthritis...
  5. pmc HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts
    Dafu Chen
    Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China
    PLoS ONE 8:e65940. 2013
    ..These findings support our hypothesis that HIF-1α activates Sost expression. This study provides a novel molecular mechanism through which HIF-1α inhibits Wnt signaling in osteoblasts...
  6. pmc Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 7:e50525. 2012
    ..Taken together, these data strongly support a direct regulatory role for Osx in MMP13 gene expression in osteoblasts. They further provide new insight into potential mechanisms and pathways that Osx controls bone formation...
  7. ncbi Molecular mechanisms of osteoblast-specific transcription factor Osterix effect on bone formation
    Chi Zhang
    University of Texas Southwestern Medical Center, Dallas, TX 75219, USA
    Beijing Da Xue Xue Bao 44:659-65. 2012
    ..Studies since the Osx discovery have provided convincing evidences to demonstrate that Osx is the master gene that controls osteoblast lineage commitment and the subsequent osteoblast differentiation and proliferation...
  8. doi Lactoferrin activates BMP7 gene expression through the mitogen-activated protein kinase ERK pathway in articular cartilage
    Chi Zhang
    Department of Research, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 431:31-5. 2013
    ..Since BMP7 is important for the maintenance of homeostasis in articular cartilage, we speculate that there is a protective function of LF at the site of joint inflammation...
  9. pmc Regulation of VEGF expression by HIF-1α in the femoral head cartilage following ischemia osteonecrosis
    Chi Zhang
    Department of Research, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA
    Sci Rep 2:650. 2012
    ..Moreover, transfection of siRNA directed against HIF-1α led to inhibition of VEGF expression. Taken together, our data indicated that upregulation of VEGF during hypoxia in chondrocyte is mediated partially through HIF-1α...
  10. ncbi Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center, 2222 Welborn St, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 420:782-6. 2012
    ..Taken together, these findings support our hypothesis that Dkk1 is a direct target of Osx...
  11. pmc Osteoblast-specific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
    PLoS ONE 6:e26504. 2011
    ..They further provide new insight into potential mechanisms and pathways that Osx controls in osteoblasts and during the process of osteoblastic cell differentiation...
  12. doi Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis
    Chi Zhang
    Department of Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA
    Bone 48:507-13. 2011
    ..We speculate that HIF-1α upregulation of Sox9 activity may have a chondroprotective role following femoral head ischemia...
  13. pmc Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx
    Chi Zhang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Department of Orthopedic Surgery, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    J Orthop Surg Res 5:37. 2010
    ..This review is to highlight recent progress in understanding the molecular mechanisms of transcriptional regulation of bone formation by Osx...
  14. pmc Synergistic inhibition of Wnt pathway by HIF-1α and osteoblast-specific transcription factor osterix (Osx) in osteoblasts
    Dafu Chen
    Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing, China
    PLoS ONE 7:e52948. 2012
    ..Our findings indicate that Osx and HIF-1α cooperatively inhibit Wnt pathway. This study revealed additional new information of the cooperation between HIF-1α and Osx in osteoblasts...
  15. doi Osteoblast-specific transcription factor Osterix (Osx) and HIF-1α cooperatively regulate gene expression of vascular endothelial growth factor (VEGF)
    Dafu Chen
    Laboratory of Bone Tissue Engineering, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Beijing 100035, China
    Biochem Biophys Res Commun 424:176-81. 2012
    ..Interestingly, synergistic interplays were observed between Osx and HIF-1α in VEGF promoter activation in transfection assay. Our findings indicate that Osx and HIF-1α cooperatively regulate VEGF expression...
  16. doi Detection of bond formations by DNA-programmed chemical reactions and PCR amplification
    Yizhou Li
    Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 202 Chengfu Rd, Beijing, 100871, China
    Chem Commun (Camb) 48:9513-5. 2012
    ..Products from bond-forming events re-ligate original templates, amplifiable by PCR, therefore distinguishing bond formation from background. This system provides a novel approach for discovering potential new chemical reactions...
  17. doi A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades
    Weiqiang Qiu
    Department of Ophthalmology, Peking University Third Hospital, Beijing, China
    J Cell Physiol 223:819-26. 2010
    ..Bcl-2/Bax ratio was significantly higher with the antagonist, suggested that the glycine site-specific NMDA receptor antagonist protecting RGC death might through inhibition of apoptotic signaling...