RONG ZHAI

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
    R Grace Zhai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 4:e416. 2006
  2. pmc NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
    R Grace Zhai
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Nature 452:887-91. 2008
  3. doi request reprint Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme
    Rong Grace Zhai
    Department of Molecular and Cellular Pharmacology, Neuroscience Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Mol Life Sci 66:2805-18. 2009
  4. doi request reprint BMAA neurotoxicity in Drosophila
    Xianchong Zhou
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Amyotroph Lateral Scler 10:61-6. 2009
  5. pmc Activity-independent prespecification of synaptic partners in the visual map of Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Biol 16:1835-43. 2006
  6. ncbi request reprint Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
  7. ncbi request reprint Hauling t-SNAREs on the microtubule highway
    R Grace Zhai
    Nat Cell Biol 6:918-9. 2004
  8. ncbi request reprint Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating
    Patrik Verstreken
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 40:733-48. 2003
  9. pmc Mapping Drosophila mutations with molecularly defined P element insertions
    R Grace Zhai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:10860-5. 2003
  10. ncbi request reprint Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles
    Mika Shapira
    Rappaport Institute and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Haifa, Israel
    Neuron 38:237-52. 2003

Research Grants

  1. Mechanisms of Neuronal Maintenance and Protection.
    Rong Grace Zhai; Fiscal Year: 2010

Collaborators

  • W G Bradley
  • Spyridon Papapetropoulos
  • Yi Zhou
  • U Tepass
  • Menico Rizzi
  • P Robin Hiesinger
  • Sunil Q Mehta
  • Patrik Verstreken
  • Yu Cao
  • Karen L Schulze
  • Hugo J Bellen
  • Xianchong Zhou
  • Tong Wey Koh
  • Mika Shapira
  • Wilfredo Escala
  • Karl Friedrich Fischbach
  • Thomas R Clandinin
  • Ian A Meinertzhagen
  • Slobodan Beronja
  • Michael C Crair
  • Noam E Ziv
  • Thomas Dresbach
  • Eckart D Gundelfinger
  • Tal Bresler
  • Craig C Garner
  • Viviana I Torres
  • Jack Roos

Detail Information

Publications10

  1. pmc Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
    R Grace Zhai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 4:e416. 2006
    ..Our data indicate an NAD-independent requirement of NMNAT for maintaining neuronal integrity that can be exploited to protect neurons from neuronal activity-induced degeneration by overexpression of the protein...
  2. pmc NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
    R Grace Zhai
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Nature 452:887-91. 2008
    ..Our studies provide an entry point for understanding how normal neurons maintain activity, and offer clues for the common mechanisms underlying different neurodegenerative conditions...
  3. doi request reprint Nicotinamide/nicotinic acid mononucleotide adenylyltransferase, new insights into an ancient enzyme
    Rong Grace Zhai
    Department of Molecular and Cellular Pharmacology, Neuroscience Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Mol Life Sci 66:2805-18. 2009
    ..The resultant wealth of biochemical data has built a robust framework upon which design of NMNAT activators, inhibitors or enzyme variants of potential medical interest can be based...
  4. doi request reprint BMAA neurotoxicity in Drosophila
    Xianchong Zhou
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Amyotroph Lateral Scler 10:61-6. 2009
    ..We found that dietary intake of BMAA reduced the lifespan as well as the neurological functions of flies. Furthermore, we have developed an HPLC method to reliably detect both free and protein-bound BMAA in fly tissue extracts...
  5. pmc Activity-independent prespecification of synaptic partners in the visual map of Drosophila
    P Robin Hiesinger
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Biol 16:1835-43. 2006
    ..Our data suggest cell-autonomous control of synapse numbers as part of a developmental program of activity-independent steps that lead to a "hard-wired" visual map in the fly brain...
  6. ncbi request reprint Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
    ..The data also show that functions of other exocyst components persist in the absence of sec15, suggesting that different exocyst components have separable functions...
  7. ncbi request reprint Hauling t-SNAREs on the microtubule highway
    R Grace Zhai
    Nat Cell Biol 6:918-9. 2004
  8. ncbi request reprint Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating
    Patrik Verstreken
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 40:733-48. 2003
    ..Our data also provide further evidence that kiss-and-run is able to maintain neurotransmitter release when synapses are not extensively challenged...
  9. pmc Mapping Drosophila mutations with molecularly defined P element insertions
    R Grace Zhai
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:10860-5. 2003
    ..Our data show that this mapping approach is inexpensive, efficient, and precise, and that it significantly broadens the application of P elements in Drosophila...
  10. ncbi request reprint Unitary assembly of presynaptic active zones from Piccolo-Bassoon transport vesicles
    Mika Shapira
    Rappaport Institute and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Haifa, Israel
    Neuron 38:237-52. 2003
    ..These findings suggest that AZs are assembled from unitary amounts of AZ material carried on PTVs...

Research Grants2

  1. Mechanisms of Neuronal Maintenance and Protection.
    Rong Grace Zhai; Fiscal Year: 2010
    ....