Jinbin Zhai

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1
    Jinbin Zhai
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, 6100, USA
    Hum Mol Genet 16:3103-16. 2007
  2. ncbi request reprint 3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells
    Hong Lin
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2716-26. 2004
  3. ncbi request reprint RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration
    Hong Lin
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Hum Mol Genet 14:3643-59. 2005
  4. ncbi request reprint Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein
    Junhua Wu
    Department of Pathology and Laboratory Medicine, 609C Stellar Chance Laboratories, University of Pennsylvania Medical School, Philadelphia, PA 19104 6100, USA
    Brain Res Mol Brain Res 117:27-38. 2003
  5. ncbi request reprint HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS
    Jinbin Zhai
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 14:2629-40. 2005
  6. ncbi request reprint Direct interaction of focal adhesion kinase with p190RhoGEF
    Jinbin Zhai
    Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 278:24865-73. 2003
  7. ncbi request reprint Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons
    Hong Lin
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 6100, USA
    J Neuropathol Exp Neurol 62:936-50. 2003
  8. ncbi request reprint Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA
    Weiwen Ge
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 277:42701-5. 2002
  9. pmc The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease
    Jinbin Zhai
    Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 20:4116-31. 2011
  10. ncbi request reprint Aldolases a and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA
    Rafaela Canete-Soler
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19103, USA
    J Neurosci 25:4353-64. 2005

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1
    Jinbin Zhai
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, 6100, USA
    Hum Mol Genet 16:3103-16. 2007
    ..Together, our data support the view that disruption of NF network with aggregation of NFL is a common triggering event of motor neuron degeneration in CMT2E and CMT2F disease...
  2. ncbi request reprint 3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells
    Hong Lin
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:2716-26. 2004
    ....
  3. ncbi request reprint RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration
    Hong Lin
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Hum Mol Genet 14:3643-59. 2005
    ..Together, the findings indicate that p190RhoGEF is involved in aggregation of NF-L protein and support a working hypothesis that aggregation of p190RhoGEF and NF-L is an upstream event triggering neurotoxicity in motor neuron disease...
  4. ncbi request reprint Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein
    Junhua Wu
    Department of Pathology and Laboratory Medicine, 609C Stellar Chance Laboratories, University of Pennsylvania Medical School, Philadelphia, PA 19104 6100, USA
    Brain Res Mol Brain Res 117:27-38. 2003
    ..Taken together, our findings support a model whereby multiple interactions of p190RhoGEF confer homeostatic properties to differentiated neurons and may link neuronal homeostasis to the regulation of NF-L expression...
  5. ncbi request reprint HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS
    Jinbin Zhai
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 14:2629-40. 2005
    ..Taken together, our findings demonstrate that interaction of HoxB2 with mutant SOD1 occurs in motor neurons of G93A mutant SOD1 transgenic mice and suggest that this interaction may modulate the neurotoxicity of mutant SOD1...
  6. ncbi request reprint Direct interaction of focal adhesion kinase with p190RhoGEF
    Jinbin Zhai
    Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 278:24865-73. 2003
    ....
  7. ncbi request reprint Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons
    Hong Lin
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 6100, USA
    J Neuropathol Exp Neurol 62:936-50. 2003
    ....
  8. ncbi request reprint Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA
    Weiwen Ge
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 6100, USA
    J Biol Chem 277:42701-5. 2002
    ..Moreover, we identify a novel binding site in BC1 to account for its interaction with p190RhoGEF. The findings suggest a novel role of BC1 in differentiated neurons involving RNA-protein interactions of p190RhoGEF...
  9. pmc The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease
    Jinbin Zhai
    Division of Neurology, Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 20:4116-31. 2011
    ..These results suggest that manipulation of BDNF/TrkB signaling might have therapeutic efficacy in motor neuron diseases...
  10. ncbi request reprint Aldolases a and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light-neurofilament mRNA
    Rafaela Canete-Soler
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19103, USA
    J Neurosci 25:4353-64. 2005
    ..Interactions of aldolases A and C in NF-L expression may be linked to regulatory pathways that maintain the highly asymmetrical form and function of large neurons...
  11. ncbi request reprint Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice
    Zhenying Nie
    Division of Neuropathology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 6100, USA
    J Neurosci 22:7662-70. 2002
    ..Our results suggest that neuropathic effects of overexpressing NF-L can occur at the level of transgene RNA and are mediated by sequences in the NF-L 3' UTR...
  12. pmc PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
    Yangmi Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 180:187-203. 2008
    ..These studies elucidate a compensatory function for Pyk2 upon FAK loss and identify the FAK-p190RhoGEF complex as an important integrin-proximal regulator of FA formation during FN-stimulated cell motility...