Research Topics
| H ZhaiSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Reactions of non-immunologic contact urticaria on scalp, face, and backHongbo Zhai
Department of Dermatology, University of California, San Francisco, California 94143 0989, USA
Skin Res Technol 18:436-41. 2012..This study compared the reactivity of scalp, face, and back to nonimmunologic contact urticants (NICU) to ascertain relative responsiveness...- Allergic contact dermatitis: effect of ageHongbo Zhai
Department of Dermatology, School of Medicine, University of California San Francisco, CA, USA
Cutan Ocul Toxicol 31:20-5. 2012.... - Determination of the antioxidative capacity of an antioxidant complex and idebenone: an in vitro rapid and sensitive methodHongbo Zhai
Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143 0989, USA
J Cosmet Dermatol 7:96-100. 2008.... - Skin decontamination of glyphosate from human skin in vitroH Zhai
Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, 90 Medical Center Way, San Francisco, CA 94143 0989, USA
Food Chem Toxicol 46:2258-60. 2008..This in vitro model is not only economic and rapid, but also provides quantitative data that may aid screening for optimal decontaminants... 
Tape-stripping method in man: comparison of evaporimetric methodsHongbo Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143 0989, USA
Skin Res Technol 13:207-10. 2007..This study compares the sensitivity and correlation of open and closed chamber devices in a tape-stripping human model. The amount of tape removed SC was also quantified with a protein assay method...- Protection from irritantsHongbo Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143 0989, USA
Curr Probl Dermatol 34:47-57. 2007..Additionally, careful selection of appropriate skin protection products in the specific situations/environments is suggested... - In vitro model for decontamination of human skin: formaldehydeH Zhai
Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, 90 Medical Center Way, San Francisco, CA 94143 0989, USA
Food Chem Toxicol 45:618-21. 2007..However, results from this model need validation in vivo. The model may provide a facile and robust method of accelerating knowledge of decontamination mechanism and lead to enhanced efficacy... - Evaluating skin-protective materials against contact irritants and allergens. An in vivo screening human modelH Zhai
Department of Dermatology, University of California, School of Medicine 94143 0989, USA
Contact Dermatitis 38:155-8. 1998..01) decreasing Rhus allergic contact dermatitis. This model, provides an easy approach to screening protectants. Its clinical significance requires comparison with an open rather than an occluded challenge... - Putative skin-protective formulations in preventing and/or inhibiting experimentally-produced irritant and allergic contact dermatitisH Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco 94143 0989, USA
Contact Dermatitis 41:190-2. 1999..Paraffin wax in cetyl alcohol was quantitatively the most effective formulation. These results suggest that some formulations may provide protective effects against certain, but not all, irritants or allergens... - Evaluation of the antioxidant capacity and preventive effects of a topical emulsion and its vehicle control on the skin response to UV exposureH Zhai
Department of Dermatology, School of Medicine, University of California, San Francisco, 94143, USA
Skin Pharmacol Physiol 18:288-93. 2005..Vitamin E emulsion and its vehicle control proved effective in preventing induction of erythema and reducing inflammatory damage caused by UV exposure. The effect of vitamin E emulsion exceeded that of an 'active control'... - Cutaneous bioassay of salicylic acid as a keratolyticS J Bashir
Department of Dermatology, University of California, 90 Medical Center Way, Surge Building #110, P.O. Box 0989, San Francisco, CA 94143-0989, USA
Int J Pharm 292:187-94. 2005..This indicates that the quest to increase the amount of free, non-dissociated SA is, in fact, counterproductive as the more acidic preparations resulted in skin irritation and barrier disruption... - Human in vivo and in vitro hydroquinone topical bioavailability, metabolism, and dispositionR C Wester
Department of Dermatology, University of California, San Francisco 94143 0989, USA
J Toxicol Environ Health A 54:301-17. 1998..Risk assessment should not only involve the bioavailability of intact topical hydroquinone, but also consider phase I and phase II metabolism in both humans and any animal for which toxicity potential was assessed... - Efficacy of corticosteroids in acute experimental irritant contact dermatitis?C Levin
Department of Dermatology, University of California at San Francisco Medical Center, CA 94143 0989, USA
Skin Res Technol 7:214-8. 2001..However, their clinical efficacy remains sub judice. This study was designed to assess the efficacy of low- and medium-potency corticosteroids on irritant dermatitis... - Skin occlusion and irritant and allergic contact dermatitis: an overviewH Zhai
Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, San Francisco, CA 94143-0989, USA
Contact Dermatitis 44:201-6. 2001..This overview summarizes the adverse effects of occlusion... - Hydrating effects of a corticoid oil formulation and its vehicle on human skinH Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco, Calif. 94143-0989, USA
Skin Pharmacol Appl Skin Physiol 16:367-71. 2003..The results support intuitive dermatologic judgment of advising patients to apply moisturizing medicaments after bathing... - Percutaneous penetration enhancers: an overviewH Y Thong
Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94143 0989, USA
Skin Pharmacol Physiol 20:272-82. 2007.... - A rapid, accurate, and facile method to quantify the antioxidative capacity of topical formulationsHongbo Zhai
Department of Dermatology, University of California San Francisco, CA 94143-0989, USA
Skin Res Technol 9:254-6. 2003..The in vitro data obtained in this study require validation by in vivo studies to properly place them in context to alternate methods... - Long-term repetitive sodium lauryl sulfate-induced irritation of the skin: an in vivo studyNara Branco
Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143-0989, USA
Contact Dermatitis 53:278-84. 2005..Alternative models should be developed to prove or disprove the accommodation hypothesis... - Provocative use test of nickel coins in nickel-sensitized subjects and controlsH Zhai
Department of Dermatology, University of California, School of Medicine, Surge 110, Box 0989, San Francisco, CA 94143-0989, USA
Br J Dermatol 149:311-7. 2003..Limitations of the method and clinical extrapolation are detailed. CONCLUSIONS: Individuals handling these nickel-containing coins daily did not develop ACD, as judged by visual signs or bioengineering parameters... - Effects of skin occlusion on percutaneous absorption: an overviewH Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco, Calif 94143-0989, USA
Skin Pharmacol Appl Skin Physiol 14:1-10. 2001..It often, but not always, increases percutaneous absorption of applied chemicals. This overview focuses on the effect of skin occlusion on percutaneous absorption... - Comparative evaporimetry in manJigna H Shah
Department of Dermatology, University of California, San Francisco, CA 94143-0989, USA
Skin Res Technol 11:205-8. 2005..We suspect that both techniques will continue to be used and that the closed method will find increasing use because of its ease of use... - Clinical microneedle injection of methyl nicotinate: stratum corneum penetrationRaja K Sivamani
Department of Bioengineering, University of California, Berkeley, CA, USA
Skin Res Technol 11:152-6. 2005..The design of the microneedle influences its delivery capabilities, because the pointed microneedles seem to be less susceptible to clogging during the injection... - Tape stripping on a human nail: quantification of removalE Tudela
Department of Dermatology, University of California San Francisco, San Francisco, CA 9143 0989, USA
Skin Res Technol 14:472-7. 2008..Tape stripping is commonly used to investigate the stratum corneum (SC). This study assesses if protein quantitative tape stripping method was suitable for human nails... - Tissue viability imaging: mapping skin erythemaHongbo Zhai
Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
Skin Res Technol 15:14-9. 2009..Before TiVi can be effectively used in studies of diseased or damaged skin, the variability in normal skin red blood cell concentration (RBC(conc)) requires evaluation... - Comparison of tissue viability imaging and colorimetry: skin blanchingHongbo Zhai
Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA
Skin Res Technol 15:20-3. 2009.... - Human scalp irritation compared to that of the arm and backHongbo Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco, CA 94143-0989, USA
Contact Dermatitis 51:196-200. 2004..Thus, these data support the current standard skin-compatibility testing procedure, employing the back for potential irritation testing of hair care products... - Measuring human skin buffering capacity: an in vitro modelHongbo Zhai
Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94143 0989, USA
Skin Res Technol 15:470-5. 2009..It has been thought that skin possesses buffering capacity. This study measured the skin buffering capacity against two model solutions of acid and base at three concentrations with an in vitro system... - Hydration vs. skin permeability to nicotinates in manHongbo Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA
Skin Res Technol 8:13-8. 2002..We believe this is a suitable model for evaluating the quality of diaper product performance, as well as in pharmacologic assays of occlusive therapy... - Occlusion vs. skin barrier functionHongbo Zhai
Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA
Skin Res Technol 8:1-6. 2002..CONCLUSIONS: The effects of occlusion on skin barrier function have been defined with various techniques. Optimal hydrocolloid materials can absorb excess water and reduce the unfavourable effects of occlusion...