Research Topics
Genomes and GenesSpecies | Joseph E ZerwekhSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
Nutrition and renal stone disease in spaceJoseph E Zerwekh
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Nutrition 18:857-63. 2002..Success in reducing the risk for stone formation in astronauts would also be of potential major benefit to the estimated 20 million Americans with nephrolithiasis...- Bone disease and hypercalciuria in childrenJoseph E Zerwekh
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
Pediatr Nephrol 25:395-401. 2010..Thus, a better understanding of bone loss in children with IH is warranted... - Biochemical and histological assessment of alkali therapy during high animal protein intake in the ratJoseph E Zerwekh
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Bone 45:1004-9. 2009..In this animal model of high dietary animal protein intake, the major skeletal effect of alkali therapy is to reduce bone resorption, with little or no effect on bone formation... - Blood biomarkers of vitamin D statusJoseph E Zerwekh
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Am J Clin Nutr 87:1087S-91S. 2008.... - Bone disease and idiopathic hypercalciuriaJoseph E Zerwekh
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Semin Nephrol 28:133-42. 2008..Available evidence suggests that potential mechanisms may be dependent in large part to genetic, metabolic, and nutritional causes of hypercalciuria and bone loss in patients with IH... - Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed restJoseph E Zerwekh
Center for Mineral Metabolism and Clinical Research, and the Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Urol 177:2179-84. 2007..This study was performed to evaluate the efficacy of potassium alkali as potassium-magnesium citrate in reducing renal stone risk and bone turnover... - Pathogenesis of hypercalciuric nephrolithiasisJoseph E Zerwekh
Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Endocrinol Metab Clin North Am 31:869-84. 2002..Such studies have disclosed that hypercalciuria is probably polygenic in nature and will require a concerted effort to better understand the defects while attempting to develop gene-specific countermeasures... - The measurement of vitamin D: analytical aspectsJoseph E Zerwekh
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Ann Clin Biochem 41:272-81. 2004..This review will consider when vitamin D measurements should be undertaken and how best to perform such assays... - Intestinal hyperabsorption of calcium and low bone turnover in hypercalciuric postmenopausal osteoporosisClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
Urol Res 36:233-9. 2008.... - Effect of high protein diet on stone-forming propensity and bone loss in ratsJamshid Amanzadeh
Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8885, USA
Kidney Int 64:2142-9. 2003..Hypocitraturia is probably renal in origin. This rat model will be useful in elucidating the mechanisms by which high protein intake increases the risk of nephrolithiasis and bone loss in human beings... - Severely suppressed bone turnover: a potential complication of alendronate therapyClarita V Odvina
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
J Clin Endocrinol Metab 90:1294-301. 2005..Our observations emphasize the need for increased awareness and monitoring for the potential development of excessive suppression of bone turnover during long-term alendronate therapy... - Defining hypercalciuria in nephrolithiasisCharles Y C Pak
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
Kidney Int 80:777-82. 2011..When dietary variables are controlled, the classic definition of hypercalciuria of nephrolithiasis appears valid... - Unusual mid-shaft fractures during long-term bisphosphonate therapyClarita V Odvina
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
Clin Endocrinol (Oxf) 72:161-8. 2010..Although existing evidence supports a good safety profile, there is concern that chronic administration of these agents could result in severe suppression of bone turnover with increased risk of nonvertebral fractures... - Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by ?-CateninWei Wei
Department of Pharmacology, UT Southwestern Medical Center, 6001 Forest Park Road, Room ND8 502B, Dallas, TX 75390 9041
Mol Cell Biol 31:4706-19. 2011..Importantly, these findings suggest that Wnt activation is a more effective treatment for skeletal fragility than previously recognized that confers dual anabolic and anti-catabolic benefits... - Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *Orhan K Oz
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9153, USA
J Bone Miner Res 22:1893-902. 2007..ArKO mice have hypercalciuria and lower levels of calcium transport proteins, whereas levels of the klotho protein are elevated. Thus, estrogen deficiency is sufficient to cause altered renal calcium handling... - Inhibition of osteoclast formation and function by bicarbonate: role of soluble adenylyl cyclaseWeidong Geng
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX 75390 8885, USA
J Cell Physiol 220:332-40. 2009..This HCO(3)(-) effect on BV/TV was blocked by 2-hydroxyestradiol. In summary, sAC mediates the inhibition of osteoclast function by HCO(3)(-), by acting as a HCO(3)(-) sensor... - Variability in urinary oxalate measurements between six international laboratoriesNaim M Maalouf
Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA
Nephrol Dial Transplant 26:3954-9. 2011..Hyperoxaluria is a major risk factor for kidney stone formation. Although urinary oxalate measurement is part of all basic stone risk assessment, there is no standardized method for this measurement... - Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushiteCharles Y C Pak
Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Urol 181:1423-8. 2009..To attempt resolution the supersaturation index according to the Joint Expert Speciation System and the relative saturation ratio according to Equil 2 were compared with the semi-empirically derived concentration-to-product ratio... - Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturityJoseph E Zerwekh
Bone 40:553. 2007 - Effect of subcutaneous leptin replacement therapy on bone metabolism in patients with generalized lipodystrophyVinaya Simha
Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Clin Endocrinol Metab 87:4942-5. 2002..Our preliminary data suggest that sc leptin replacement in hypoleptinemic patients with generalized lipodystrophy has no effect on the mature adult skeleton... - Recovery from skeletal fluorosis (an enigmatic, American case)Etah S Kurland
Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
J Bone Miner Res 22:163-70. 2007..Nearly a decade of detailed follow-up documented considerable correction of the disorder after removal of the putative source of fluoride (toothpaste)...