C S Zent
Affiliation: University of Arkansas for Medical Sciences
- Chronic lymphocytic leukemia incidence is substantially higher than estimated from tumor registry dataC S Zent
Division of Hematology Oncology, Departments of Medicine and Pathology, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Cancer 92:1325-30. 2001..Tumor registry data may underestimate the incidence of CLL substantially because CLL can be diagnosed by flow cytometric analysis of peripheral blood cells, and the majority of patients do not require treatment at the time of diagnosis...
- The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotypeClive S Zent
Division of Hematology Oncology, Central Arkansas Healthcare System and University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
Leuk Res 27:765-74. 2003..CLL and MM differentially expressed 18% of 130 apoptosis related genes, suggesting differences in mechanisms of cell survival...
- Localized herpes simplex lymphadenitis mimicking large-cell (Richter's) transformation of chronic lymphocytic leukemia/small lymphocytic lymphomaL Joseph
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Am J Hematol 68:287-91. 2001..The diagnosis of herpes simplex lymphadenitis in patients with CLL/SLL is especially important because, unlike large cell transformation, the infection usually responds well to treatment...
- Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemiaShanique Palmer
Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Br J Haematol 141:607-14. 2008..These characteristics can be modified and continued evaluation of immunomodulatory drugs, vaccination strategies and cellular therapies to delay/prevent disease progression are warranted...
- MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or= 5 x 10(9) L(-1) but a B-cell lymphocyte count <5 x 10(9) L(-1)?Tait D Shanafelt
Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States
Leuk Res 32:1458-61. 2008..In contrast, CD38 predicted TTT (p=0.02) regardless of the proposed new classification. Molecular characteristics of the leukemic clone are a better predictor of progression than an arbitrary ALC or B lymphocyte count threshold...
- Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemiaRebekah L Browning
Ohio State University, Columbus, OH, United States
Leuk Res 31:1737-40. 2007..199) were noted with lower TCL-1 expression. These data suggest TCL-1 expression may help predict treatment outcome in CLL patients following chemoimmunotherapy, and examination in larger studies is warranted...
- Chronic B-cell lymphoproliferative disorders: how many diseases?Clive S Zent
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Leuk Lymphoma 47:2006-7. 2006
- Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemiaNeil E Kay
Mayo Clinic, Stabile 628, 200 First St SW, Rochester, MN 55905, and The Ohio State University, Columbus, USA
Blood 109:405-11. 2007....
- Indolent systemic mastocytosis as the cause of a long history of unexplained hypotensive episodesElizabeth H Nora
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
South Med J 99:876-9. 2006..Key features in his history and physical examination prompted the conclusive testing. The most telling features were hypotension, tachycardia, and the rash (urticaria pigmentosa)...
- Update on monoclonal antibody therapy in chronic lymphocytic leukemiaClive S Zent
Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA
Clin Adv Hematol Oncol 2:107-13. 2004..This review provides historical context and detailed analysis of current developments, as well as an outline for future prospects and expectations in this exciting new arena of therapeutics...
- Clinical significance of monoclonal B cells in cerebrospinal fluidGrzegorz S Nowakowski
Division of Hematology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Cytometry B Clin Cytom 63:23-7. 2005..Although flow cytometry is increasingly used to detect a monoclonal B-cell population in the CSF, the significance of this finding in the absence of morphologically identifiable malignant cells is unknown...
- Early treatment of high-risk chronic lymphocytic leukemia with alemtuzumab and rituximabClive S Zent
Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA
Cancer 113:2110-8. 2008..In this phase 2 study, the authors tested the safety and efficacy of early treatment for patients with high-risk CLL using alemtuzumab and rituximab...