Lee A Zella

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:435-9. 2007
  2. pmc Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor
    J Wesley Pike
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:389-95. 2007
  3. ncbi request reprint 1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription
    Jackie A Fretz
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:2215-30. 2006
  4. pmc Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Mol Cell Biol 26:6469-86. 2006
  5. pmc The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes
    Lee A Zella
    Department of Biochemistry, University of Wisconsin at Madison, Madison, Wisconsin 53706, USA
    Endocrinology 150:3448-56. 2009
  6. pmc Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:430-4. 2007
  7. pmc Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 24:128-47. 2010
  8. pmc 1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site
    Jackie A Fretz
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:440-5. 2007
  9. pmc Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Endocrinology 149:3656-67. 2008
  10. ncbi request reprint Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo
    Mark B Meyer
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:22344-52. 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Enhancers located in the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:435-9. 2007
    ..Thus, each of these sites appears likely to contribute to VDR autoregulation. Our studies using ChIP/chip analysis coupled to more traditional approaches define a direct mechanism whereby the VDR gene is upregulated by 1,25(OH)(2)D(3)...
  2. pmc Perspectives on mechanisms of gene regulation by 1,25-dihydroxyvitamin D3 and its receptor
    J Wesley Pike
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:389-95. 2007
    ..Our studies suggest that vitamin D enhancers regulate the expression of key target genes by facilitating the recruitment of both the basal transcriptional machinery as well as the protein complexes necessary for altered gene expression...
  3. ncbi request reprint 1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription
    Jackie A Fretz
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:2215-30. 2006
    ..Our studies show that 1,25-(OH)2D3 can enhance the expression of a critical component of the Wnt signaling pathway that is known to impact osteogenesis...
  4. pmc Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Mol Cell Biol 26:6469-86. 2006
    ..Our studies demonstrate that regulation of RankL gene expression by 1,25(OH)(2)D(3) is complex and mediated by at least five distal regions, one of which contains a specific element capable of mediating direct transcriptional activation...
  5. pmc The enhanced hypercalcemic response to 20-epi-1,25-dihydroxyvitamin D3 results from a selective and prolonged induction of intestinal calcium-regulating genes
    Lee A Zella
    Department of Biochemistry, University of Wisconsin at Madison, Madison, Wisconsin 53706, USA
    Endocrinology 150:3448-56. 2009
    ..This action is likely due to a decrease in the rate of intestinal-specific degradation of the ligand rather than to an increase in the functional stability of the vitamin D receptor...
  6. pmc Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:430-4. 2007
    ..We propose that the RANKL gene is regulated via multiple enhancers that while located at significant distances from the TSS, likely form a chromatin hub centered on the RankL promoter...
  7. pmc Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 24:128-47. 2010
    ..Finally, 1,25(OH)(2)D(3) also induced accumulation of VDR and up-regulated H4 acetylation at conserved regions in the human VDR gene. These data provide important new insights into VDR gene regulation in bone cells...
  8. pmc 1,25-Dihydroxyvitamin D3 induces expression of the Wnt signaling co-regulator LRP5 via regulatory elements located significantly downstream of the gene's transcriptional start site
    Jackie A Fretz
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    J Steroid Biochem Mol Biol 103:440-5. 2007
    ..Our studies show that 1,25(OH)(2)D(3) can enhance the expression of a critical component of the Wnt signaling pathway which is known to impact osteogenesis...
  9. pmc Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Endocrinology 149:3656-67. 2008
    ....
  10. ncbi request reprint Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo
    Mark B Meyer
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 282:22344-52. 2007
    ..These studies provide the first evidence for 1,25(OH)(2)D(3)-induced VDR interaction at key target genes in vivo, revealing the consequences of that interaction on the Cyp24a1 and Trpv6 genes...
  11. ncbi request reprint Molecular actions of 1,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis
    J Wesley Pike
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin, USA
    J Bone Miner Res 22:V16-9. 2007
    ..Our studies identified key regulatory regions within the TRPV6 and RANKL genes that are essential for their individual expression in the intestine and bone, respectively...
  12. ncbi request reprint Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Mol Endocrinol 20:1231-47. 2006
    ..The location of these regulatory regions and their apparent distances from the TSS are consistent with new findings suggesting the emerging relevance of distant enhancers...
  13. pmc The vitamin D receptor interacts preferentially with DRIP205-like LxxLL motifs
    Lee A Zella
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Arch Biochem Biophys 460:206-12. 2007
    ..These studies suggest that the LxxLL motif can interact directly with the VDR and that this interaction is regulated by chemically diverse vitamin D ligands...
  14. pmc Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass
    Carlo Galli
    Center for Osteoporosis and Metabolic Bone Disease, University of Arkansas for Medical Sciences, 4301 West Markham Street, MS 587, Little Rock, Arkansas 72205, USA
    Endocrinology 149:146-53. 2008
    ..These findings demonstrate that hormonal control of RANKL expression via the DCR is a critical determinant of the rate of bone remodeling...