Steven Zeisel

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Common genetic polymorphisms affect the human requirement for the nutrient choline
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB 7461, Chapel Hill, North Carolina 27599, USA
    FASEB J 20:1336-44. 2006
  2. pmc Effects of a high daily dose of soy isoflavones on DNA damage, apoptosis, and estrogenic outcomes in healthy postmenopausal women: a phase I clinical trial
    Elena A Pop
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Menopause 15:684-92. 2008
  3. pmc Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis
    Steven H Zeisel
    University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, NC 28081, USA
    Clin Chem Lab Med 51:467-75. 2013
  4. pmc Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis
    Karen D Corbin
    University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NorthCarolina 28081, USA
    FASEB J 27:1674-89. 2013
  5. pmc Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research
    Steven H Zeisel
    University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA
    JPEN J Parenter Enteral Nutr 37:190-200. 2013
  6. doi request reprint Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism
    Steven H Zeisel
    Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, N C 28081, USA
    Ann Nutr Metab 60:19-25. 2012
  7. pmc Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study
    Aurelian Bidulescu
    Cardiovascular Research Institute and Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Nutr J 8:14. 2009
  8. pmc The betaine content of sweat from adolescent females
    Shona S Craig
    Danisco A S, Elmsford, NY, USA
    J Int Soc Sports Nutr 7:3. 2010
  9. pmc Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study
    Aurelian Bidulescu
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    BMC Cardiovasc Disord 7:20. 2007
  10. pmc Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1237:5-11. 2008

Research Grants

  1. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2007
  2. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2009
  3. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven H Zeisel; Fiscal Year: 2010
  4. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2009
  5. NUTRITION TRAINING GRANT
    Steven Zeisel; Fiscal Year: 2006
  6. NUTRITIONAL BIOCHEMISTRY AND EPIDEMIOLOGY OF CANCER
    Steven Zeisel; Fiscal Year: 2006
  7. Nutrition in Medicine
    Steven Zeisel; Fiscal Year: 2006
  8. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2004
  9. Diethanolamine, brain development and adult memory
    Steven Zeisel; Fiscal Year: 2006
  10. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven H Zeisel; Fiscal Year: 2010

Detail Information

Publications88

  1. pmc Common genetic polymorphisms affect the human requirement for the nutrient choline
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB 7461, Chapel Hill, North Carolina 27599, USA
    FASEB J 20:1336-44. 2006
    ..Identification of common polymorphisms that affect dietary requirements for choline could enable us to identify individuals for whom we need to assure adequate dietary choline intake...
  2. pmc Effects of a high daily dose of soy isoflavones on DNA damage, apoptosis, and estrogenic outcomes in healthy postmenopausal women: a phase I clinical trial
    Elena A Pop
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Menopause 15:684-92. 2008
    ..Principal outcome measures included DNA damage, apoptosis, and changes indicative of estrogenic stimulation...
  3. pmc Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis
    Steven H Zeisel
    University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, NC 28081, USA
    Clin Chem Lab Med 51:467-75. 2013
    ....
  4. pmc Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis
    Karen D Corbin
    University of North Carolina at Chapel Hill Nutrition Research Institute, Kannapolis, NorthCarolina 28081, USA
    FASEB J 27:1674-89. 2013
    ....
  5. pmc Highlights of the 2012 Research Workshop: Using nutrigenomics and metabolomics in clinical nutrition research
    Steven H Zeisel
    University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA
    JPEN J Parenter Enteral Nutr 37:190-200. 2013
    ..The relationships between diet and nutrigenomic-metabolomic profiles, as well as between these profiles and health, are being elucidated, and this will dramatically alter clinical practice in nutrition...
  6. doi request reprint Diet-gene interactions underlie metabolic individuality and influence brain development: implications for clinical practice derived from studies on choline metabolism
    Steven H Zeisel
    Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, N C 28081, USA
    Ann Nutr Metab 60:19-25. 2012
    ..Some of the actions of choline are mediated by epigenetic mechanisms that permit 'retuning' of metabolic pathways during early life...
  7. pmc Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study
    Aurelian Bidulescu
    Cardiovascular Research Institute and Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, USA
    Nutr J 8:14. 2009
    ....
  8. pmc The betaine content of sweat from adolescent females
    Shona S Craig
    Danisco A S, Elmsford, NY, USA
    J Int Soc Sports Nutr 7:3. 2010
    ..This study was developed to establish whether betaine was present in the sweat of females and to determine any correlations with other sweat components...
  9. pmc Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study
    Aurelian Bidulescu
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    BMC Cardiovasc Disord 7:20. 2007
    ..S. nutrient composition database. Our objective was to assess the association of dietary intake of choline and betaine with incident coronary heart disease (CHD), adjusting for dietary intake measurement error...
  10. pmc Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res 1237:5-11. 2008
    ..Some of these increase the risk of choline deficiency many-fold. These variations in choline requirement could have important implications for brain development...
  11. pmc Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 86:542-8. 2007
    ..Investments made today in training programs and in research methods could ensure a new foundation for clinical nutrition in the future...
  12. ncbi request reprint Is there a metabolic basis for dietary supplementation?
    S H Zeisel
    School of Public Health and the School of Medicine, University of North Carolina at Chapel Hill, 27599 7400, USA
    Am J Clin Nutr 72:507S-11S. 2000
    ..An understanding of how the variation in nutrient requirements comes about and of the pharmacologic actions of nutrient supplements can help to identify which individuals are most likely to benefit from dietary supplements...
  13. ncbi request reprint Antioxidants suppress apoptosis
    Steven H Zeisel
    Department of Nutrition, University of North Carolina Chapel Hill, Chapel Hill, NC 27599 7461, USA
    J Nutr 134:3179S-3180S. 2004
  14. pmc The fetal origins of memory: the role of dietary choline in optimal brain development
    Steven H Zeisel
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Pediatr 149:S131-6. 2006
    ..The currently available animal data on choline and hippocampal development are compelling, but studies are needed to determine whether the same is true in humans...
  15. ncbi request reprint Nutritional importance of choline for brain development
    Steven H Zeisel
    Department of Nutrition, School of Public Health, The University of North Carolina, Chapel Hill, NC, USA
    J Am Coll Nutr 23:621S-626S. 2004
    ..We suggest that choline-rich foods are an important component of the diet and that especially during pregnancy it would be prudent to include them as part of a healthy diet...
  16. pmc Choline: critical role during fetal development and dietary requirements in adults
    Steven H Zeisel
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Annu Rev Nutr 26:229-50. 2006
    ..Aside from gender differences, there is significant variation in the dietary requirement for choline that can be explained by very common genetic polymorphisms...
  17. pmc Perinatal choline influences brain structure and function
    Steven H Zeisel
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, 27599 7416, USA
    Nutr Rev 64:197-203. 2006
    ....
  18. ncbi request reprint Betaine supplementation and blood lipids: fact or artifact?
    Steven H Zeisel
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, USA
    Nutr Rev 64:77-9. 2006
    ..However, whether the betaine effect on LDL concentration is a clinically significant problem that should change treatment options or is simply an artifact needs further study...
  19. pmc Is maternal diet supplementation beneficial? Optimal development of infant depends on mother's diet
    Steven H Zeisel
    Nutrition Research Institute, and the Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 89:685S-7S. 2009
    ..The infant is not protected from the inadequate diet of the mother...
  20. pmc Importance of methyl donors during reproduction
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 89:673S-7S. 2009
    ....
  21. ncbi request reprint Choline: needed for normal development of memory
    S H Zeisel
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, 27599 7400, USA
    J Am Coll Nutr 19:528S-531S. 2000
    ..If folate isn't available in the first few weeks of pregnancy, the brain does not form normally. Thus, we suggest that pregnancy is a period when special attention has to be paid to dietary intake...
  22. pmc The supply of choline is important for fetal progenitor cells
    Steven H Zeisel
    Nutrition Research Institute, School of Public Health and School of Medicine, The University of North Carolina at Chapel Hill, Kannapolis, NC 28081, United States
    Semin Cell Dev Biol 22:624-8. 2011
    ..When these women eat diets low in choline, the supply of this nutrient to the fetus is likely to be inadequate, and may perturb progenitor cell proliferation, migration, differentiation and apoptosis...
  23. pmc Nutritional genomics: defining the dietary requirement and effects of choline
    Steven H Zeisel
    Nutrition Research Institute, School of Public Health, The University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA
    J Nutr 141:531-4. 2011
    ....
  24. pmc What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders
    Steven H Zeisel
    Department of Nutrition, UNC Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill, 500 Laureate Way, Room 2218, Kannapolis, NC 28081, USA
    Mol Neurobiol 44:185-91. 2011
    ..Thus, the varied effects of choline could affect the expression of FASD, and studies on choline might shed some light on the underlying molecular mechanisms responsible for FASD...
  25. pmc The nutritional phenotype in the age of metabolomics
    S H Zeisel
    American Society for Nutritional Sciences Long Range Planning Committee, Bethesda, MD 20814 3990, USA
    J Nutr 135:1613-6. 2005
    ..This conceptualization of a nutritional phenotype provides a concrete form and substance to the recognized future of nutritional sciences as a field addressing diet, integrated metabolism, and health...
  26. pmc Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    IUBMB Life 59:380-7. 2007
    ..This results in long term alterations in brain structure and function, specifically memory function...
  27. pmc Choline: an essential nutrient for public health
    Steven H Zeisel
    Department of Nutrition at the Nutrition Research Institute, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nutr Rev 67:615-23. 2009
    ..Given the importance of choline in a wide range of critical functions in the human body, coupled with less-than-optimal intakes among the population, dietary guidance should be developed to encourage the intake of choline-rich foods...
  28. ncbi request reprint Concentrations of choline-containing compounds and betaine in common foods
    Steven H Zeisel
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    J Nutr 133:1302-7. 2003
    ..It may be helpful to also consider choline intake as a confounding factor because folate and choline methyl donation can be interchangeable...
  29. pmc Epigenetic mechanisms for nutrition determinants of later health outcomes
    Steven H Zeisel
    Nutrition Research Institute, The University of North Carolina, Chapel Hill, NC, USA
    Am J Clin Nutr 89:1488S-1493S. 2009
    ..There are interesting examples of the effects of nutrition in early life that result in altered health in adults, and some of these could be the result of altered epigenetic regulation of gene expression...
  30. pmc Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 81:440-4. 2005
    ..A parallel pathway exists for methylation of homocysteine, in which choline, by way of betaine, is the methyl donor...
  31. pmc The association between betaine and choline intakes and the plasma concentrations of homocysteine in women
    Stephanie E Chiuve
    Department of Nutrition, Harvard School of Public Health, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 86:1073-81. 2007
    ..Elevated total homocysteine (tHcy), a risk factor for many chronic diseases, can be remethylated to methionine by folate. Alternatively, tHcy can be metabolized by other 1-carbon nutrients, ie, betaine and its precursor, choline...
  32. ncbi request reprint Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus
    Xiaonan Zhu
    Department of Nutrition, McGavran Greenberg Building, CB 7461, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    Brain Res Dev Brain Res 149:121-9. 2004
    ..This is the first report of altered brain development in Pemt-/- mice...
  33. pmc Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma
    Leslie M Fischer
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA
    Am J Clin Nutr 92:336-46. 2010
    ..Choline is essential for infant nutrition, and breast milk is a rich source of this nutrient. Common single nucleotide polymorphisms (SNPs) change dietary requirements for choline intake...
  34. pmc Maternal dietary choline deficiency alters angiogenesis in fetal mouse hippocampus
    Mihai G Mehedint
    University of North Carolina Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA
    Proc Natl Acad Sci U S A 107:12834-9. 2010
    ..01). We conclude that maternal dietary choline intake alters angiogenesis in the developing fetal hippocampus...
  35. pmc Dietary choline requirements of women: effects of estrogen and genetic variation
    Leslie M Fischer
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Clin Nutr 92:1113-9. 2010
    ..A common genetic polymorphism (rs12325817) in the PEMT gene can also increase this risk...
  36. pmc Sex and menopausal status influence human dietary requirements for the nutrient choline
    Leslie M Fischer
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Am J Clin Nutr 85:1275-85. 2007
    ..A recommended Adequate Intake (AI) exists for choline; however, an Estimated Average Requirement has not been set because of a lack of sufficient human data...
  37. ncbi request reprint Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment
    Marion Couch
    Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, G0412 Neurosciences Hospital, Chapel Hill, NC 27599 7070, USA
    Head Neck 29:401-11. 2007
    ..This article outlines the diagnosis of cancer cachexia, reviews its impact on patient quality of life (QOL) and survival, and updates the reader on potential therapies that may suppress it...
  38. ncbi request reprint Second trimester folate status and preterm birth
    Anna Maria Siega-Riz
    Carolina Population Center, CB 8120 University Square, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516 3997, USA
    Am J Obstet Gynecol 191:1851-7. 2004
    ..The purpose of this study was to show that maternal folate status during pregnancy may be related to preterm birth...
  39. ncbi request reprint Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill 27599 7400, USA
    J Nutr 132:2333S-2335S. 2002
    ....
  40. ncbi request reprint Choline- and betaine-defined diets for use in clinical research and for the management of trimethylaminuria
    Marjorie G Busby
    Health, Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599, USA
    J Am Diet Assoc 104:1836-45. 2004
    ..This article describes applications of this diet for use in clinical research on methyl-group requirements in humans and for use in clinical practice for counseling the client who requires a choline-controlled diet...
  41. doi request reprint Nutrition education in U.S. medical schools: latest update of a national survey
    Kelly M Adams
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Acad Med 85:1537-42. 2010
    ..To quantify the number of required hours of nutrition education at U.S. medical schools and the types of courses in which the instruction was offered, and to compare these results with results from previous surveys...
  42. doi request reprint Nutrition in medicine: nutrition education for medical students and residents
    Kelly M Adams
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    Nutr Clin Pract 25:471-80. 2010
    ..The NIM project is strengthening medical nutrition practice by providing a free, comprehensive, online nutrition curriculum with clinically relevant, evidence-based medical education for undergraduate and postgraduate learners...
  43. ncbi request reprint Adapting the contents of computer-based instruction based on knowledge tests maintains effectiveness of nutrition education
    Martin Kohlmeier
    Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, 27599 7461, USA
    Am J Clin Nutr 77:1025S-1027S. 2003
    ....
  44. pmc Choline deficiency alters global histone methylation and epigenetic marking at the Re1 site of the calbindin 1 gene
    Mihai G Mehedint
    UNC Nutrition Research Institute at Kannapolis, University of North Carolina, 500 Laureate Way, Kannapolis, NC 28081, USA
    FASEB J 24:184-95. 2010
    ..01) in CD. These changes resulted in increased expression of calbindin 1 in CD (260%; P<0.05). Thus, CD modulates histone methylation in NPCs, and this could underlie the observed changes in neurogenesis...
  45. pmc Status of nutrition education in medical schools
    Kelly M Adams
    Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 83:941S-944S. 2006
    ..However, most graduating medical students continue to rate their nutrition preparation as inadequate...
  46. pmc Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
    Martin Kohlmeier
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:16025-30. 2005
    ....
  47. pmc Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, 27599 7461 USA
    FASEB J 20:43-9. 2006
    ..These data suggest that choline deficiency-induced changes in gene methylation could mediate the expression of a cell cycle regulator and thereby alter brain development...
  48. pmc Choline deficiency increases lymphocyte apoptosis and DNA damage in humans
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 84:88-94. 2006
    ..Whereas deficiency of the essential nutrient choline is associated with DNA damage and apoptosis in cell and rodent models, it has not been shown in humans...
  49. pmc Dietary docosahexaenoic acid supplementation modulates hippocampal development in the Pemt-/- mouse
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 285:1008-15. 2010
    ..05). These results suggest that the changes in hippocampal development in the Pemt(-/-) mouse could be mediated by altered DHA incorporation into membrane phospholipids, and that maternal dietary DHA can influence fetal brain development...
  50. pmc Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes
    Craig D Albright
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7461, USA
    Cell Physiol Biochem 15:59-68. 2005
    ....
  51. pmc Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus
    Craig D Albright
    Department of Nutrition, CB 7461, Room 2212 McGavran Greenberg Hall, School of Public Health and School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA
    Brain Res Dev Brain Res 159:149-54. 2005
    ..Changes in the expression of cell migration cues during development could account for some of the lifelong consequences of maternal dietary choline availability for cognitive and memory processes...
  52. pmc Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    Am J Clin Nutr 86:230-9. 2007
    ..The risk of developing such organ dysfunction is increased by the presence of single-nucleotide polymorphisms (SNPs) in genes involved in folate and choline metabolism...
  53. ncbi request reprint Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina Chapel Hill 27599, USA
    J Nutr 134:162-6. 2004
    ..FS mice did not differ significantly from FCT mice in any of these measures. These results suggest that progenitor cells in fetal forebrain are sensitive to maternal dietary folate during late gestation...
  54. pmc Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill, NC 27599 7461, USA
    J Neurochem 89:1252-9. 2004
    ..This may be a mechanism for our previously reported observation that stem cell proliferation in hippocampus neuroepithelium is decreased in choline-deficient rat and mouse fetuses...
  55. pmc Diethanolamine alters proliferation and choline metabolism in mouse neural precursor cells
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7461, USA
    Toxicol Sci 96:321-6. 2007
    ..Our study suggests that prenatal exposure to DEA may have a detrimental effect on brain development...
  56. ncbi request reprint Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, 2212 McGavran Greenberg Hall, Chapel Hill, NC 27599 7461, USA
    Brain Res Mol Brain Res 134:309-22. 2005
    ..These findings support our previous work suggesting that choline deficiency decreases the proliferation of neural precursors and possibly increases premature neuronal differentiation and apoptosis...
  57. pmc Ad libitum choline intake in healthy individuals meets or exceeds the proposed adequate intake level
    Leslie M Fischer
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    J Nutr 135:826-9. 2005
    ..7 mg/(kg . d) in women. Intake of folate, vitamin B-12, and methionine + cysteine, were similar and sufficient in all subjects. The current recommended AI for choline seems to be a good approximation of the actual intake of this nutrient...
  58. pmc Deletion of murine choline dehydrogenase results in diminished sperm motility
    Amy R Johnson
    Department of Nutrition, Nutrition Research Institute, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    FASEB J 24:2752-61. 2010
    ..Mitochondrial changes were also detected in liver, kidney, heart, and testis tissues. We suggest that men who have SNPs in CHDH that decrease the activity of the CHDH enzyme could have decreased sperm motility and fertility...
  59. ncbi request reprint Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry
    Hasan Koc
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599, USA
    Anal Chem 74:4734-40. 2002
    ..The new LC/ESI-IDMS method was validated using the existing published GC/IDMS method...
  60. pmc Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline
    Xiaonan Zhu
    Department of Nutrition, CB 7461, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
    Biochem J 370:987-93. 2003
    ....
  61. ncbi request reprint Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro
    Melanie C Fisher
    Department of Cell Biology and Anatomy, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    FASEB J 16:619-21. 2002
    ..Results suggest that endogenous PtdCho synthesis is important during neurulation and that perturbed choline metabolism contributes to neural tube defects produced by DMAE and ET-18-OCH3...
  62. ncbi request reprint Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus
    Craig D Albright
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Nutr Neurosci 6:129-34. 2003
    ..Thus, alterations in the level of calretinin protein in fetal brain hippocampus could underlie the known, life long effects of maternal dietary choline availability on brain development and behavior...
  63. pmc Dose response effects of dermally applied diethanolamine on neurogenesis in fetal mouse hippocampus and potential exposure of humans
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    Toxicol Sci 107:220-6. 2009
    ..8 mg DEA per gram resulted in detectable plasma concentrations of DEA and dimethyldiethanolamine, but these were far below those concentrations associated with perturbed brain development in the mouse...
  64. ncbi request reprint Deficiency in methionine, tryptophan, isoleucine, or choline induces apoptosis in cultured cells
    Chi Liang E Yen
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill 27599 7400, USA
    J Nutr 132:1840-7. 2002
    ..These observations suggest that deficiency of each studied nutrient activates different pathways for signaling apoptosis that ultimately converge on a common execution pathway...
  65. pmc The evolution of Nutrition in Medicine, a computer-assisted nutrition curriculum
    Karen C Lindell
    Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 83:956S-962S. 2006
    ..These innovative strategies should allow a better fit of NIM within diverse medical school environments and help to promote incorporation of the curriculum into more medical schools...
  66. pmc Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Nutr 140:1162-6. 2010
    ..These results suggest that neural progenitor cells in fetal forebrain are sensitive to maternal dietary folate during late gestation and that choline supplementation can modify some, but not all, of these effects...
  67. pmc Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7461, USA
    J Nutr Biochem 18:380-90. 2007
    ....
  68. pmc Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes
    Mary Resseguie
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    FASEB J 21:2622-32. 2007
    ..This study is the first to explore the underlying mechanism of why dietary requirements for choline vary with estrogen status in humans...
  69. pmc Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    J Nutr 133:3614-8. 2003
    ..We conclude that the dietary availability of choline to the mouse dam influences progenitor cell proliferation and apoptosis in the fetal brain...
  70. ncbi request reprint Mitochondrial and microsomal derived reactive oxygen species mediate apoptosis induced by transforming growth factor-beta1 in immortalized rat hepatocytes
    Craig D Albright
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
    J Cell Biochem 89:254-61. 2003
    ..Since inhibition of either of these two sources of ROS interferes with apoptosis, it is reasonable to conclude that the combined involvement of both pathways is essential for completion of TGFbeta1-induced apoptosis...
  71. ncbi request reprint Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer
    Woytek Miltyk
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill 27599 7400, USA
    Am J Clin Nutr 77:875-82. 2003
    ..Genistein may be useful in the prevention or treatment of prostate cancer; however, it causes genetic damage in cultured human cells...
  72. pmc Diethanolamine alters neurogenesis and induces apoptosis in fetal mouse hippocampus
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599 7461, USA
    FASEB J 20:1635-40. 2006
    ....
  73. ncbi request reprint Elevated serum creatine phosphokinase in choline-deficient humans: mechanistic studies in C2C12 mouse myoblasts
    Kerry Ann da Costa
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Am J Clin Nutr 80:163-70. 2004
    ..Choline is a required nutrient, and humans deprived of choline develop liver damage...
  74. pmc Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study
    Eunyoung Cho
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 83:905-11. 2006
    ..The physiologic relevance of a variation in dietary choline and betaine in the general population and the validity of intake assessed by food-frequency questionnaire (FFQ) have not been evaluated...
  75. pmc Choline metabolism and risk of breast cancer in a population-based study
    Xinran Xu
    Department of Community and Preventive Medicine, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    FASEB J 22:2045-52. 2008
    ..We observed a significant interaction between dietary betaine intake and the PEMT rs7926 polymorphism (P(interaction)=0.04). Our findings suggest that choline metabolism may play an important role in breast cancer etiology...
  76. pmc Homocysteine metabolism in ZDF (type 2) diabetic rats
    Enoka P Wijekoon
    Department of Biochemistry, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Diabetes 54:3245-51. 2005
    ..These results emphasize the importance of betaine metabolism in determining plasma Hcy levels in type 2 diabetes...
  77. ncbi request reprint Is there a new component of the Mediterranean diet that reduces inflammation?
    Steven H Zeisel
    Am J Clin Nutr 87:277-8. 2008
  78. ncbi request reprint Choline, homocysteine, and pregnancy
    Steven H Zeisel
    Am J Clin Nutr 82:719-20. 2005
  79. ncbi request reprint Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice
    Steven M Watkins
    Lipomics Technologies, Incorporated, West Sacramento, CA 95691, USA
    J Nutr 133:3386-91. 2003
    ....
  80. ncbi request reprint Effects of betaine in a murine model of mild cystathionine-beta-synthase deficiency
    Bernd C Schwahn
    Department of Pediatrics, Montreal Children s Hospital, McGill University Health Center, Montrreal, Quebec, Canada
    Metabolism 53:594-9. 2004
    ..Homocysteinemia in mice is sensitive to a disruption of Cbs and to methyl donor intake. Because betaine leads to a greater flux through BHMT and lowers homocysteine, betaine supplementation may be beneficial in mild hyperhomocysteinemia...
  81. pmc Dietary choline and betaine and the risk of distal colorectal adenoma in women
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 99:1224-31. 2007
    ..No epidemiologic study has examined the association of intake of these nutrients and colorectal adenoma risk...
  82. ncbi request reprint Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency
    Bernd C Schwahn
    Department of Pediatrics, McGill University Montreal Children s Hospital, Montreal, Canada
    FASEB J 17:512-4. 2003
    ..Hyperhomocysteinemia, in the range of that associated with folate deficiency or with homozygosity for the 677T MTHFR variant, may be associated with disturbed choline metabolism...
  83. ncbi request reprint Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice
    Xiaonan Zhu
    Department of Nutrition, CB 7461, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Brain Res Mol Brain Res 134:239-55. 2005
    ..These findings are consistent with the biochemical changes that we previous reported in fetal brains from Pemt knockout mice. This is the first report of gene profiling in Pemt(-/-) mouse brain...
  84. ncbi request reprint Adverse event associated with methionine loading test: a case report
    E M Cottington
    Case Western Reserve University, Cleveland, Ohio, USA
    Arterioscler Thromb Vasc Biol 22:1046-50. 2002
    ....
  85. ncbi request reprint Diethanolamine induces hepatic choline deficiency in mice
    Lois D Lehman-McKeeman
    Central Product Safety Division, Miami Valley Laboratories, Procter and Gamble Co, Cincinnati, Ohio 45253, USA
    Toxicol Sci 67:38-45. 2002
    ....
  86. ncbi request reprint The role of dietary supplements during cancer therapy
    Helen A Norman
    American Institute for Cancer Research, Washington, DC, USA
    J Nutr 133:3794S-3799S. 2003
    ..In addition, the AICR Cancer Resource Advisory Council concluded that further scientific research is needed to provide a set of firm guidelines for the use of vitamin and mineral supplements by cancer patients during treatment...
  87. ncbi request reprint Computer-assisted teaching of nutritional anemias and diabetes to first-year medical students
    Maciej S Buchowski
    Center for Nutrition, the Department of Family Medicine and Pediatrics, Meharry Medical College, Nashville, TN 37208 3599, USA
    Am J Clin Nutr 75:154-61. 2002
    ..Seven computer-based Nutrition in Medicine interactive modules for teaching nutrition are available for instruction in medical schools...
  88. pmc GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans
    Susan E Steck
    Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
    J Nutr 137:904-9. 2007
    ..03). These results are in agreement with another feeding study, and lend support to the idea of alternative routes of ITC metabolism...

Research Grants23

  1. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2007
    ..abstract_text> ..
  2. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2009
    ....
  3. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven H Zeisel; Fiscal Year: 2010
    ....
  4. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2009
    ....
  5. NUTRITION TRAINING GRANT
    Steven Zeisel; Fiscal Year: 2006
    ..Graduates of this training program are trained to investigate 1) human nutritional biochemistry, 2) the epidemiologic aspects of nutrition, and 3) promotion of health and prevention of disease at the individual and community level. ..
  6. NUTRITIONAL BIOCHEMISTRY AND EPIDEMIOLOGY OF CANCER
    Steven Zeisel; Fiscal Year: 2006
    ..We are requesting two postdoctoral and six predoctoral trainee positions each year for this purpose. ..
  7. Nutrition in Medicine
    Steven Zeisel; Fiscal Year: 2006
    ..g. lite version, supplement index), and automate aspects of efficacy evaluation. 4) Provide ongoing technical support and materials via the web to maximize and maintain use of the full curriculum. ..
  8. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven Zeisel; Fiscal Year: 2004
    ..Subjects who experience grade 2 toxicity will be immediately switched to the control diet and followed until they return to normal. ..
  9. Diethanolamine, brain development and adult memory
    Steven Zeisel; Fiscal Year: 2006
    ..abstract_text> ..
  10. HUMAN REQUIREMENTS FOR THE NUTRIENT CHOLINE
    Steven H Zeisel; Fiscal Year: 2010
    ....