Herbert J Zeh

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Outcomes after robot-assisted pancreaticoduodenectomy for periampullary lesions
    Herbert J Zeh
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 19:864-70. 2012
  2. doi request reprint A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer
    Herbert J Zeh
    Department of Surgery, University of Pittsburgh School of Medicine, PA 15232, USA
    Ann Surg Oncol 16:385-94. 2009
  3. ncbi request reprint Robotic-assisted major pancreatic resection
    H J Zeh
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Suite 417, UPMC Cancer Pavilion, 5150 Center Avenue, Pittsburgh, PA 15232, USA
    Adv Surg 45:323-40. 2011
  4. ncbi request reprint High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy
    Xiang Da Eric Dong
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh, PA 15232, USA
    J Immunother 30:596-606. 2007
  5. ncbi request reprint Phase II study of induction fixed-dose rate gemcitabine and bevacizumab followed by 30 Gy radiotherapy as preoperative treatment for potentially resectable pancreatic adenocarcinoma
    George van Buren
    Division of Surgical Oncology, UPMC Pancreatic Cancer Center, Pittsburgh, PA, USA
    Ann Surg Oncol 20:3787-93. 2013
  6. ncbi request reprint Extensive cytoreductive surgery for appendiceal carcinomatosis: morbidity, mortality, and survival
    Patrick L Wagner
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Surg Oncol 20:1056-62. 2013
  7. doi request reprint Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique
    Mustapha Daouadi
    Division of GI Surgical Oncology, General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Ann Surg 257:128-32. 2013
  8. doi request reprint Metabolic regulation by HMGB1-mediated autophagy and mitophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:1256-8. 2011
  9. pmc Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
    Rui Kang
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    Gastroenterology 146:1097-107. 2014
  10. ncbi request reprint Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts
    Marina N Nikiforova
    Department of Pathology, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Mod Pathol 26:1478-87. 2013

Detail Information

Publications83

  1. doi request reprint Outcomes after robot-assisted pancreaticoduodenectomy for periampullary lesions
    Herbert J Zeh
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 19:864-70. 2012
    ..The goal of this study was to assess the oncologic and safety outcomes after a robot-assisted approach to pancreaticoduodenectomy...
  2. doi request reprint A phase I study of hyperthermic isolated hepatic perfusion with oxaliplatin in the treatment of unresectable liver metastases from colorectal cancer
    Herbert J Zeh
    Department of Surgery, University of Pittsburgh School of Medicine, PA 15232, USA
    Ann Surg Oncol 16:385-94. 2009
    ..The ability to obtain complete vascular isolation with open IHP was confirmed. The response rate in this small phase I study was encouraging...
  3. ncbi request reprint Robotic-assisted major pancreatic resection
    H J Zeh
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Suite 417, UPMC Cancer Pavilion, 5150 Center Avenue, Pittsburgh, PA 15232, USA
    Adv Surg 45:323-40. 2011
    ..Technological innovations and increased surgeon familiarity with this approach will improve, likely leading to greater adoption and acceptance...
  4. ncbi request reprint High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy
    Xiang Da Eric Dong
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh, PA 15232, USA
    J Immunother 30:596-606. 2007
    ....
  5. ncbi request reprint Phase II study of induction fixed-dose rate gemcitabine and bevacizumab followed by 30 Gy radiotherapy as preoperative treatment for potentially resectable pancreatic adenocarcinoma
    George van Buren
    Division of Surgical Oncology, UPMC Pancreatic Cancer Center, Pittsburgh, PA, USA
    Ann Surg Oncol 20:3787-93. 2013
    ....
  6. ncbi request reprint Extensive cytoreductive surgery for appendiceal carcinomatosis: morbidity, mortality, and survival
    Patrick L Wagner
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Surg Oncol 20:1056-62. 2013
    ..Some patients require multivisceral resection because of the volume of disease. It is unclear whether extent of CRS impacts survival in appendiceal carcinomatosis...
  7. doi request reprint Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique
    Mustapha Daouadi
    Division of GI Surgical Oncology, General Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
    Ann Surg 257:128-32. 2013
    ..We hypothesized that robot-assisted distal pancreatectomy (RADP) was superior to LDP as a result of improved surgical manipulation and visualization, potentially expanding the indications for minimally invasive pancreatectomy...
  8. doi request reprint Metabolic regulation by HMGB1-mediated autophagy and mitophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:1256-8. 2011
    ..These findings reveal a novel pathway coupling autophagy and cellular energy metabolism...
  9. pmc Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice
    Rui Kang
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania Electronic address
    Gastroenterology 146:1097-107. 2014
    ..Little is known about its intracellular roles in response to tissue injury or during subsequent local and systemic inflammatory responses. We investigated the function of Hmgb1 in mice after induction of acute pancreatitis...
  10. ncbi request reprint Integration of KRAS testing in the diagnosis of pancreatic cystic lesions: a clinical experience of 618 pancreatic cysts
    Marina N Nikiforova
    Department of Pathology, The University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Mod Pathol 26:1478-87. 2013
    ..Future molecular studies and the combination of other fluid markers are required to improve the detection and classification of pancreatic mucinous neoplasms by endoscopic ultrasound fine-needle aspiration. ..
  11. pmc Significance of serum tumor marker levels in peritoneal carcinomatosis of appendiceal origin
    Patrick L Wagner
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Surg Oncol 20:506-14. 2013
    ....
  12. doi request reprint Robotic-assisted major pancreatic resection and reconstruction
    Amer H Zureikat
    Division of Surgical Oncology, University of Pittsburgh Medical Center Pancreatic Cancer Center, 3550 Terrace St, Pittsburgh, PA 15261, USA
    Arch Surg 146:256-61. 2011
    ..Robotic-assisted pancreatic resection and reconstruction are safe and can reproduce perioperative results seen in open surgery...
  13. pmc HMGB1 in cancer: good, bad, or both?
    Rui Kang
    Department of Surgery, University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 19:4046-57. 2013
    ..Here, we review the current knowledge of both HMGB1's oncogenic and tumor-suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer...
  14. ncbi request reprint Outcome analysis of a decade-long experience of isolated hepatic perfusion for unresectable liver metastases at a single institution
    Deepa Magge
    Division of Surgical Oncology, Koch Regional Perfusion Center and Department of Psychiatry, University of Pittsburgh Medical Center Biostatistics Facility, University of Pittsburgh Cancer Institute, PA
    Ann Surg 259:953-9. 2014
    ..To evaluate outcomes of isolated hepatic perfusion (IHP) on isolated liver metastases (LMs)...
  15. pmc Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer
    Brian A Boone
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Surg Oncol 108:236-41. 2013
    ..Trials examining FOLFIRINOX in metastatic pancreatic cancer demonstrate higher response rates compared to gemcitabine-based regimens. There is currently limited experience with neoadjuvant FOLFIRINOX in pancreatic cancer...
  16. ncbi request reprint Aggressive locoregional management of recurrent peritoneal sarcomatosis
    Joel M Baumgartner
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Surg Oncol 107:329-34. 2013
    ..We sought to determine perioperative and oncologic outcomes after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) for recurrent sarcomatosis...
  17. pmc The receptor for advanced glycation end products promotes pancreatic carcinogenesis and accumulation of myeloid-derived suppressor cells
    Philip J Vernon
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    J Immunol 190:1372-9. 2013
    ..KCR mice also maintained a significantly less suppressive milieu evidenced by marked decreases in CCL22 in relation to CXCL10 and diminished serum levels of IL-6...
  18. pmc The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 109:7031-6. 2012
    ..Our results suggest a critical role for RAGE expression in the earliest stages of pancreatic carcinogenesis, potentially acting as the "autophagic switch," regulating mitochondrial STAT3 signaling...
  19. pmc The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2175-84. 2011
    ..Taken together, these results suggest that RAGE is an important regulator of oxidative injury...
  20. pmc Endogenous HMGB1 regulates autophagy
    Daolin Tang
    Damage Associated Molecular Pattern Molecule Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Cell Biol 190:881-92. 2010
    ..Thus, endogenous HMGB1 is a critical pro-autophagic protein that enhances cell survival and limits programmed apoptotic cell death...
  21. ncbi request reprint 250 robotic pancreatic resections: safety and feasibility
    Amer H Zureikat
    Division of GI Surgical Oncology, General Surgery Epidemiology, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA Institute for Hepatobiliary and Pancreatic Surgery, Department of Surgery BIDMC, Boston, MA
    Ann Surg 258:554-9; discussion 559-62. 2013
    ..We applied this technology to a variety of pancreatic resections to assess the safety, feasibility, versatility, and reliability of this technology...
  22. doi request reprint Comparative effectiveness of minimally invasive and open distal pancreatectomy for ductal adenocarcinoma
    Deepa Magge
    Department of Surgery, University of PittsburghMedical Center, Pittsburgh, Pennsylvania, USA
    JAMA Surg 148:525-31. 2013
    ..Multicenter studies indicate that outcomes of open (ODP) and minimally invasive distal pancreatectomy (MIDP) are equivalent for benign lesions. However, data for pancreatic carcinoma are limited...
  23. doi request reprint Signet ring cell colorectal carcinoma: a distinct subset of mucin-poor microsatellite-stable signet ring cell carcinoma associated with dismal prognosis
    Douglas J Hartman
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 37:969-77. 2013
    ..Further, our results confirm that MSI does not affect survival in colorectal signet ring cell carcinomas...
  24. pmc High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    Daolin Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2185-95. 2011
    ..Autophagy, the process by which cells break down spent biochemical and damaged components, plays an important role in cell survival following stress. High mobility group box 1 (HMGB1) regulates autophagy in response to oxidative stress...
  25. doi request reprint Multivisceral resection does not affect morbidity and survival after cytoreductive surgery and chemoperfusion for carcinomatosis from colorectal cancer
    Jan Franko
    Division of Surgical Oncology, University of Pittsburgh Medical Center, 5150 Centre Ave, Rm 414, Pittsburgh, PA 15232, USA
    Ann Surg Oncol 15:3065-72. 2008
    ..This procedure commonly involves multivisceral resection (MVR) with potentially high morbidity. We analyzed the effect of MVR on the outcome after CS-HIPEC...
  26. ncbi request reprint Impact of aggressive histology and location of primary tumor on the efficacy of surgical therapy for peritoneal carcinomatosis of colorectal origin
    Joshua Winer
    Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 21:1456-62. 2014
    ..Signet ring histology demonstrates aggressive behavior with poor survival. We sought to determine whether CRS/HIPEC increases survival in this subset of patients...
  27. ncbi request reprint The histopathology of PRSS1 hereditary pancreatitis
    Aatur D Singhi
    Departments of Pathology Surgery Medicine Pediatrics, University of Pittsburgh Medical Center UPMC, Pittsburgh, PA
    Am J Surg Pathol 38:346-53. 2014
    ..In summary, PRSS1 hereditary pancreatitis is characterized by progressive lipomatous atrophy of the pancreas. ..
  28. doi request reprint Robotic-assisted minimally invasive central pancreatectomy: technique and outcomes
    Gerard J Abood
    Division of Surgical Oncology, Department of Surgery, Loyola University Medical Center, Maywood, IL 60153, USA
    J Gastrointest Surg 17:1002-8. 2013
    ..We analyzed outcomes after robot-assisted central pancreatectomy (RACP) to reexamine the risk-benefit profile in the era of minimally invasive surgery...
  29. ncbi request reprint High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists
    Petar J Popovic
    Division of Surgical Oncology, Department of Surgery and Molecular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15232, USA
    J Immunol 177:8701-7. 2006
    ..Our observations suggest that HMGB1 may play a critical role in regulating the immune response during chronic inflammation and tissue damage through modulation of PDC function...
  30. pmc Direct molecular interactions between HMGB1 and TP53 in colorectal cancer
    Kristen M Livesey
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Autophagy 8:846-8. 2012
    ..Thus, HMGB1 and TP53 are critical in the cross-regulation of apoptosis and autophagy and central to colon cancer biology...
  31. doi request reprint Distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic adenocarcinoma following neoadjuvant therapy
    Joel M Baumgartner
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA 15232, USA
    J Gastrointest Surg 16:1152-9. 2012
    ..We hypothesized that patients with stage III tumors invading the celiac trunk, who are free of distant disease following neoadjuvant therapy, may derive prolonged survival benefit from aggressive surgical resection...
  32. doi request reprint The redox protein HMGB1 regulates cell death and survival in cancer treatment
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1181-3. 2010
    ..This suggests a new function for HMGB1 within the tumor microenvironment, regulating cell death and survival and suggests that it plays an important functional role in cross-regulating apoptosis and autophagy...
  33. doi request reprint Ethyl pyruvate administration inhibits hepatic tumor growth
    Xiaoyan Liang
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Leukoc Biol 86:599-607. 2009
    ..EP administration may have a therapeutic role in the treatment of cancer in conjunction with other therapeutic agents...
  34. ncbi request reprint The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity
    Michael T Lotze
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Immunol Rev 220:60-81. 2007
    ....
  35. doi request reprint Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis
    Jan Franko
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15232, USA
    Cancer 116:3756-62. 2010
    ..Because of a recent substantial improvement in chemotherapy, the authors analyzed treatment options of colorectal carcinomatosis in the current era...
  36. doi request reprint Phase II study of gemcitabine and erlotinib as adjuvant therapy for patients with resected pancreatic cancer
    Philip Q Bao
    Department of Surgery, Stony Brook University Hospital, Stony Brook, NY, USA
    Ann Surg Oncol 18:1122-9. 2011
    ..This study was designed to evaluate the efficacy of gemcitabine and erlotinib as adjuvant therapy, and to explore potential biomarkers associated with response...
  37. ncbi request reprint Malignant peritoneal mesothelioma: prognostic factors and oncologic outcome analysis
    Deepa Magge
    Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 21:1159-65. 2014
    ..We assessed the efficacy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) in MPM...
  38. ncbi request reprint Aggressive locoregional surgical therapy for gastric peritoneal carcinomatosis
    Deepa Magge
    Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 21:1448-55. 2014
    ..Limited published data demonstrate improved outcomes after aggressive locoregional therapies. We assessed the efficacy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) in GPC...
  39. pmc Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression
    Xiaoyan Liang
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA
    Cancer Res 72:2791-801. 2012
    ..Taken together, our findings provide a novel clinical strategy to enhance the efficacy of HDIL-2 immunotherapy for patients with cancer...
  40. pmc NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells
    Ravikumar Muthuswamy
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Cancer Res 72:3735-43. 2012
    ..Together, our findings suggest the feasibility of exploiting NF-κB hyperactivation in the tumor microenvironment to selectively enhance T(eff) entry into colon tumors...
  41. ncbi request reprint RAGE regulates autophagy and apoptosis following oxidative injury
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 7:442-4. 2011
    ..These findings provide insight into how crosstalk between apoptosis and autophagy is mediated via ROS signaling with a process involving RAGE...
  42. pmc High-mobility group box 1 is essential for mitochondrial quality control
    Daolin Tang
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Cell Metab 13:701-11. 2011
    ..Our findings reveal an essential role for HMGB1 in autophagic surveillance with important effects on mitochondrial quality control...
  43. pmc Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer
    Siuwah Tang
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreas 42:740-59. 2013
    ..These miRNAs are involved in DNA repair, cell cycle, and cell invasion and also play important roles in promoting metastases...
  44. ncbi request reprint Chronic anti-inflammatory drug therapy inhibits gel-forming mucin production in a murine xenograft model of human pseudomyxoma peritonei
    Haroon Asif Choudry
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Surg Oncol 19:1402-9. 2012
    ..We hypothesized that anti-inflammatory drugs targeting inflammation-associated pathways may reduce mucin production and subsequent disease morbidity in PMP...
  45. pmc AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 8:989-91. 2012
    ..Thus, AGER is an important inflammatory mediator that modulates crosstalk between prosurvival pathways, IL6-pSTAT3 and autophagy, in PDA tumor cells, and contributes to early PanIN formation...
  46. doi request reprint The current state of robotic-assisted pancreatic surgery
    Josh Winer
    Division of GI Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center, 5150 Center Avenue, Pittsburgh, PA 15213, USA
    Nat Rev Gastroenterol Hepatol 9:468-76. 2012
    ....
  47. pmc High-mobility group box 1 and cancer
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    Biochim Biophys Acta 1799:131-40. 2010
    ..Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1...
  48. doi request reprint Pancreatic lymphoepithelial cysts express CEA and can contain mucous cells: potential pitfalls in the preoperative diagnosis
    Jay S Raval
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Mod Pathol 23:1467-76. 2010
    ....
  49. pmc High-mobility group box 1, oxidative stress, and disease
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Antioxid Redox Signal 14:1315-35. 2011
    ....
  50. doi request reprint Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma
    Jan Franko
    UPMC Pancreatic Cancer Center, Division of Surgical Oncology, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Gastrointest Surg 12:1664-72; discussion 1672-3. 2008
    ..We hypothesized that genetic analysis of resected cancers would correlate with tumor biology and postoperative survival...
  51. ncbi request reprint HMGB1 as an autophagy sensor in oxidative stress
    Rui Kang
    DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:904-6. 2011
    ..These findings provide insight into how HMGB1, a damage associated molecular pattern (DAMP), triggers autophagy as defense mechanism under conditions of cellular stress...
  52. doi request reprint Technical aspects of robotic-assisted pancreaticoduodenectomy (RAPD)
    Kevin Tri Nguyen
    UPMC Pancreatic Cancer Center, Division of Surgical Oncology, University of Pittsburgh, 5150 Center Avenue, Room 417, Pittsburgh, PA 15232, USA
    J Gastrointest Surg 15:870-5. 2011
    ..We present here the technical aspects of the University of Pittsburgh robotic-assisted pancreaticoduodenctomy...
  53. ncbi request reprint Cytolytic cells induce HMGB1 release from melanoma cell lines
    Norimasa Ito
    Department of Surgery, University of Pittsburgh School of Medicine, Hillman Cancer Center, 5117 Centre Avenue, Room G 21, Pittsburgh, PA 15213, USA
    J Leukoc Biol 81:75-83. 2007
    ..Specifically, HMGB1 may promote healing or immune reactivity, depending on the nature of the local inflammatory response and the presence (or absence) of immune effectors...
  54. pmc p53/HMGB1 complexes regulate autophagy and apoptosis
    Kristen M Livesey
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 72:1996-2005. 2012
    ..These insights provide a novel link between HMGB1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of cell stress, providing insights into their reciprocal roles in carcinogenesis...
  55. ncbi request reprint HMGB1: a novel Beclin 1-binding protein active in autophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 6:1209-11. 2010
    ..Taken together, these findings indicate that endogenous HMGB1 functions as an autophagy effector by regulation of autophagosome formation...
  56. ncbi request reprint Masquerader: high mobility group box-1 and cancer
    Jessica E Ellerman
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 13:2836-48. 2007
    ..This review focuses on current knowledge and speculation on the role of HMGB1 in the development of cancer, metastasis, and potential targets for therapy...
  57. pmc RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
    Louis J Sparvero
    Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, Pittsburgh, USA
    J Transl Med 7:17. 2009
    ..Understanding the molecular structure and function of it and its ligands in the setting of inflammation is critically important in understanding the role of this receptor in tumor biology...
  58. doi request reprint Mucin as a therapeutic target in pseudomyxoma peritonei
    Haroon A Choudry
    Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA
    J Surg Oncol 106:911-7. 2012
    ..signaling pathways lead to a putative goblet cell-lineage differentiation or mucin overexpression?; are targeted therapies against known transcriptional pathways for mucin production a novel therapeutic strategy in this malignancy?..
  59. doi request reprint Adjuvant stereotactic body radiotherapy for resected pancreatic adenocarcinoma with close or positive margins
    Jean Claude M Rwigema
    Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Gastrointest Cancer 43:70-6. 2012
    ..The aim of this study was to evaluate the role of stereotactic body radiotherapy (SBRT) as adjuvant therapy for resected pancreatic adenocarcinoma with close or positive margins...
  60. ncbi request reprint Pancreaticoduodenectomy in the presence of superior mesenteric venous obstruction
    Leonidas G Koniaris
    Department of Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Gastrointest Surg 9:915-21. 2005
    ..Further studies and more long-term follow-up at high-volume centers are required, however, to better determine the indications and potential benefit of such an undertaking...
  61. ncbi request reprint Autophagy inhibition in combination cancer treatment
    Kristen M Livesey
    University of Pittsburgh, G 27A Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Investig Drugs 10:1269-79. 2009
    ..Screening for new agents is ongoing, which, coupled with conventional chemotherapeutic compounds, may usher in a new generation of autophagy-inhibiting agents...
  62. pmc Dendritic cells in cancer immunotherapy: vaccines or autologous transplants?
    Pawel Kalinski
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213 1863, USA
    Immunol Res 50:235-47. 2011
    ....
  63. pmc In vitro circuit stability of 5-fluorouracil and oxaliplatin in support of hyperthermic isolated hepatic perfusion
    Heidi Colville
    Shadyside Hospital Perfusion Services, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Extra Corpor Technol 42:75-9. 2010
    ..Oxaliplatin and 5-FU are sufficiently stable in the circuit for the 1-hour perfusion in ongoing and planned clinical trials...
  64. doi request reprint Pathologic response with neoadjuvant chemotherapy and stereotactic body radiotherapy for borderline resectable and locally-advanced pancreatic cancer
    Malolan S Rajagopalan
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Radiat Oncol 8:254. 2013
    ..In this series, we report the pathologic outcomes in the subset of patients who underwent surgery after neoadjuvant SBRT...
  65. ncbi request reprint Abdominal compartment syndrome is an early, lethal complication of acute pancreatitis
    Brian Boone
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am Surg 79:601-7. 2013
    ..Prompt recognition and decompressive laparotomy may rescue some of these patients and does not mandate future débridement...
  66. pmc PAMPs and DAMPs: signal 0s that spur autophagy and immunity
    Daolin Tang
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Immunol Rev 249:158-75. 2012
    ..Here, we review recent advances in our understanding of autophagic molecular mechanisms and functions in emergent immunity...
  67. ncbi request reprint Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms
    Frances Austin
    Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 19:1386-93. 2012
    ..We assessed postoperative and oncologic outcomes after aggressive surgical management by experienced surgeons...
  68. doi request reprint EUS-guided fiducial placement for stereotactic body radiotherapy in locally advanced and recurrent pancreatic cancer
    Michael K Sanders
    Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastrointest Endosc 71:1178-84. 2010
    ..Traditionally, fiducials have been placed either intraoperatively or percutaneously. Recently, EUS-guided fiducial placement has been reported, but the safety and feasibility of this approach is not well defined...
  69. ncbi request reprint Aggressive surgical management of peritoneal carcinomatosis with low mortality in a high-volume tertiary cancer center
    Niraj J Gusani
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Ann Surg Oncol 15:754-63. 2008
    ..We report our experience performing CS-HIPEC in a high-volume regional perfusion program designed to limit morbidity and mortality...
  70. ncbi request reprint Early detection and staging of adenocarcinoma of the pancreas
    Sam Pappas
    Division of Surgical Oncology, University of Pittsburgh, Suite 417 UPMC Cancer Pavilion 5150 Center Avenue, Pittsburgh, PA 15213, USA
    Gastroenterol Clin North Am 36:413-29, x. 2007
    ..This article provides a review of current methods and results for the early detection and staging of pancreatic cancer, and discusses some potential areas for future development...
  71. pmc DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death
    Qiuhong Zhang
    Department of Surgery, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 9:451-8. 2013
    ..Since both autophagy and DAMPs are important for pathogenesis of human disease, it is crucial to understand how they interplay to sustain homeostasis in stressful or dangerous environments...
  72. pmc Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells
    Sebnem Unlu
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e38899. 2012
    ..Our findings demonstrate that a specific microRNA expression signature is associated with the inflammatory response to damaged/injured cells and carries implications for many acute and chronic inflammatory disorders...
  73. doi request reprint Serum immunoglobulin G fraction 4 levels in pancreatic cancer: elevations not associated with autoimmune pancreatitis
    Amit Raina
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Pathol Lab Med 132:48-53. 2008
    ..A previous Japanese study reported that serum IgG4 greater than 135 mg/dL was 97% specific and 95% sensitive in predicting autoimmune pancreatitis...
  74. doi request reprint Array comparative genomic hybridization analysis of solid pseudopapillary neoplasms of the pancreas
    Chad R Rund
    Department of Pathology, Presbyterian Shadyside Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Mod Pathol 21:559-64. 2008
    ..Additional study and longer follow-up are needed to determine if these genetic abnormalities could help predict clinical behavior in these neoplasms...
  75. ncbi request reprint Natural killer-dendritic cell cross-talk in cancer immunotherapy
    Pawel Kalinski
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Expert Opin Biol Ther 5:1303-15. 2005
    ..Stage I/II clinical trials that are being implemented at present should allow evaluation of the immunological and clinical efficacy of combined NK-DC therapy of melanoma and other cancers...
  76. ncbi request reprint The enhanced tumor selectivity of an oncolytic vaccinia lacking the host range and antiapoptosis genes SPI-1 and SPI-2
    Z Sheng Guo
    Division of Surgical Oncology, University of Pittsburgh Cancer Institute, PA 15232, USA
    Cancer Res 65:9991-8. 2005
    ..Given its enhanced tumor selectivity, improved safety profile, and substantial oncolytic effects following systemic delivery in murine models, it should also serve as a useful vector for tumor-directed gene therapy...
  77. ncbi request reprint Arginine and immunity
    Petar J Popovic
    Department of Surgery, University of Pittsburgh Medical School, Pittsburgh, PA 15213, USA
    J Nutr 137:1681S-1686S. 2007
    ..Not surprisingly, T-cell abnormalities, including decreased proliferation and loss of the zeta-chain, are observed in cancer and after trauma...
  78. doi request reprint Apoptosis to autophagy switch triggered by the MHC class III-encoded receptor for advanced glycation endproducts (RAGE)
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 7:91-3. 2011
    ..These findings provide insight into how autophagy- and apoptosis-crossregulatory molecules interact in response to cellular stress including tumor therapy...
  79. ncbi request reprint Addicted to death: invasive cancer and the immune response to unscheduled cell death
    Herbert J Zeh
    University of Pittsburgh School of Medicine Institute, Room 411, 300 Technology Drive, Pittsburgh, PA 15219, USA
    J Immunother 28:1-9. 2005
    ..quot; This new understanding could inform and drive the development of more effective biologic therapies for patients with cancer...
  80. ncbi request reprint Development of a replication-selective, oncolytic poxvirus for the treatment of human cancers
    Herbert J Zeh
    Division of Surgical Oncology, University of Pittsburgh, University of Pittsburgh Cancer Institute, PB02 Cancer Pavilion, Pittsburgh, Pennsylvania 15232, USA
    Cancer Gene Ther 9:1001-12. 2002
    ..Plans are now underway for clinical trials...
  81. pmc Simultaneous pancreatectomy and liver transplantation: a single-institution experience
    Rajeev Dhupar
    Department of Surgery, University of Pittsburgh Medical Center Pittsburgh, PA, USA
    HPB (Oxford) 11:242-6. 2009
    ..This series provides evidence that combined pancreatic resection and LT can be a strategy in both radical resections and cases with ESLD that would otherwise preclude operative intervention...
  82. pmc Serum biomarker panels for the detection of pancreatic cancer
    Randall E Brand
    Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 17:805-16. 2011
    ..Serum-biomarker based screening for pancreatic cancer could greatly improve survival in appropriately targeted high-risk populations...
  83. ncbi request reprint One hundred laparoscopic adrenalectomies: a single surgeon's experience
    Herbert J Zeh
    University of Pittsburgh, Kaufmann Medical Building, Pittsburgh, Pennsylvania, USA
    Ann Surg Oncol 10:1012-7. 2003
    ..We report a single surgeon's experience with 100 consecutive laparoscopic adrenalectomies...