Nada Zecevic

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Oligodendrocyte development and the onset of myelination in the human fetal brain
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center Farmington, CT, USA
    Front Neuroanat 3:5. 2009
  2. pmc Interneurons in the developing human neocortex
    Nada Zecevic
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Dev Neurobiol 71:18-33. 2011
  3. ncbi request reprint Myelin basic protein immunoreactivity in the human embryonic CNS
    N Zecevic
    Department of Medicine, University of Connecticut Medical Center, Farmington 06030 1305, USA
    Brain Res Dev Brain Res 105:97-108. 1998
  4. pmc Contributions of cortical subventricular zone to the development of the human cerebral cortex
    Nada Zecevic
    University of Connecticut Health Center, Department of Neuroscience, Farmington, Connecticut 06030 3401, USA
    J Comp Neurol 491:109-22. 2005
  5. ncbi request reprint Specific characteristic of radial glia in the human fetal telencephalon
    Nada Zecevic
    Department of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06030 3401, USA
    Glia 48:27-35. 2004
  6. ncbi request reprint Early development and composition of the human primordial plexiform layer: An immunohistochemical study
    N Zecevic
    University of Connecticut, Farmington, Connecticut 06030 1840, USA
    J Comp Neurol 412:241-54. 1999
  7. ncbi request reprint Cortical progenitor cells in the developing human telencephalon
    Brian Howard
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
    Glia 53:57-66. 2006
  8. ncbi request reprint Sequence of oligodendrocyte development in the human fetal telencephalon
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
    Glia 49:480-91. 2005
  9. pmc Enforced Pax6 expression rescues alcohol-induced defects of neuronal differentiation in cultures of human cortical progenitor cells
    Zhicheng Mo
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030 3401, USA
    Alcohol Clin Exp Res 36:1374-84. 2012
  10. pmc Neurogenic potential of hESC-derived human radial glia is amplified by human fetal cells
    Gisela Reinchisi
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Stem Cell Res 11:587-600. 2013

Research Grants

Collaborators

Detail Information

Publications26

  1. pmc Oligodendrocyte development and the onset of myelination in the human fetal brain
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center Farmington, CT, USA
    Front Neuroanat 3:5. 2009
    ..Those differences may underlie the unique susceptibility of humans to demyelinating diseases, such as MS...
  2. pmc Interneurons in the developing human neocortex
    Nada Zecevic
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Dev Neurobiol 71:18-33. 2011
    ..The increased complexity of progenitors is probably evolutionary adaptation necessary for development of the higher brain functions characteristic to humans...
  3. ncbi request reprint Myelin basic protein immunoreactivity in the human embryonic CNS
    N Zecevic
    Department of Medicine, University of Connecticut Medical Center, Farmington 06030 1305, USA
    Brain Res Dev Brain Res 105:97-108. 1998
    ..Thus, besides the well established role in myelination, these proteins might have an additional and still unknown function in development...
  4. pmc Contributions of cortical subventricular zone to the development of the human cerebral cortex
    Nada Zecevic
    University of Connecticut Health Center, Department of Neuroscience, Farmington, Connecticut 06030 3401, USA
    J Comp Neurol 491:109-22. 2005
    ....
  5. ncbi request reprint Specific characteristic of radial glia in the human fetal telencephalon
    Nada Zecevic
    Department of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06030 3401, USA
    Glia 48:27-35. 2004
    ..Thus, the diversification of cells in human VZ and overlying subventricular zone (SVZ) begins earlier and is more pronounced than in rodents...
  6. ncbi request reprint Early development and composition of the human primordial plexiform layer: An immunohistochemical study
    N Zecevic
    University of Connecticut, Farmington, Connecticut 06030 1840, USA
    J Comp Neurol 412:241-54. 1999
    ..This study proposes that an initial PPL may be a universal feature of the developing central nervous system...
  7. ncbi request reprint Cortical progenitor cells in the developing human telencephalon
    Brian Howard
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
    Glia 53:57-66. 2006
    ..In conclusion, the diversity of cortical progenitors in the human brain may, in part, explain the unique complexity of the human cerebral cortex...
  8. ncbi request reprint Sequence of oligodendrocyte development in the human fetal telencephalon
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
    Glia 49:480-91. 2005
    ..Overall, in addition to considerable similarities with rodents, important differences in temporal and spatial distribution and regulatory signals for OL differentiation exist in the human brain...
  9. pmc Enforced Pax6 expression rescues alcohol-induced defects of neuronal differentiation in cultures of human cortical progenitor cells
    Zhicheng Mo
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030 3401, USA
    Alcohol Clin Exp Res 36:1374-84. 2012
    ..We previously enriched multipotent progenitor cells, radial glia (RG) cells, from human fetal forebrain and demonstrated that they express transcription factor Pax6 that is necessary for their neurogenic fate...
  10. pmc Neurogenic potential of hESC-derived human radial glia is amplified by human fetal cells
    Gisela Reinchisi
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Stem Cell Res 11:587-600. 2013
    ..Unlike fetal RG cells, the hESC-RG cells are readily available and can be standardized, features that have considerable practical advantages in research and clinics...
  11. ncbi request reprint Interaction between microglia and oligodendrocyte cell progenitors involves Golli proteins
    Radmila Filipovic
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030 340, USA
    Ann N Y Acad Sci 1048:166-74. 2005
    ..In summary, these results demonstrate that activated microglia are beneficial for proliferation of OPCs and suggest possible involvement of Golli proteins as one of mediators in this process...
  12. ncbi request reprint Lipopolysaccharide affects Golli expression and promotes proliferation of oligodendrocyte progenitors
    Radmila Filipovic
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
    Glia 49:457-66. 2005
    ..Taken together, these results demonstrate that microglia and/or microglia secreted factors, are necessary for the LPS-promoted proliferation of OPCs and suggest possible involvement of Golli proteins as one of mediators in this process...
  13. pmc Human fetal radial glia cells generate oligodendrocytes in vitro
    Zhicheng Mo
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Glia 57:490-8. 2009
    ..In summary, our in vitro experiments revealed that a portion of cortical RG cells isolated from human forebrain at the second trimester of gestation generates OL progenitors and this suggests a role of SHH in this process...
  14. ncbi request reprint Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia
    Radmila Filipovic
    University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
    Exp Neurol 211:41-51. 2008
    ..The ability of minocycline to regulate activation of human fetal microglia might be relevant in therapies used towards treating neonatal CNS infections...
  15. pmc Multiple origins of human neocortical interneurons are supported by distinct expression of transcription factors
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cereb Cortex 21:1771-82. 2011
    ..These human-specific developmental events may underlie human brain's higher complexity and capacity to process information...
  16. pmc Spontaneous electrical activity in the human fetal cortex in vitro
    Anna R Moore
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 31:2391-8. 2011
    ..e., throughout the entire lifespan), the spontaneous slow oscillatory pattern (UP and DOWN states) is a fundamental aspect of human cortical physiology...
  17. pmc Dorsal radial glial cells have the potential to generate cortical interneurons in human but not in mouse brain
    Xiaojing Yu
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 31:2413-20. 2011
    ..Multiple progenitors and sites of cortical interneuron origin in human might be an evolutionary adaptation underlying brain expansion and the increased complexity of cortical circuitry in humans...
  18. ncbi request reprint Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNS
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 25:10064-73. 2005
    ..Thus, Olig1 and Olig2 transcription factors in the human CNS are important not only for differentiation of the OL lineage, but they may also have a role in neural cell specification...
  19. pmc Is Pax6 critical for neurogenesis in the human fetal brain?
    Zhicheng Mo
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cereb Cortex 18:1455-65. 2008
    ....
  20. pmc Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestation
    Anna R Moore
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cereb Cortex 19:1795-805. 2009
    ..These results yield the first physiological characterization of developing human fetal cortical neurons with preserved morphologies in intact surrounding brain tissue...
  21. ncbi request reprint Human cortical neurons originate from radial glia and neuron-restricted progenitors
    Zhicheng Mo
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 27:4132-45. 2007
    ....
  22. ncbi request reprint The effect of CXCL1 on human fetal oligodendrocyte progenitor cells
    Radmila Filipovic
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
    Glia 56:1-15. 2008
    ..These results suggest that in the human fetal brain CXCL1 promotes proliferation of early OPC, acting in part through an ERK1/2-dependent pathway and release of IL-6 from astrocytes...
  23. ncbi request reprint Early oligodendrocyte progenitor cells in the human fetal telencephalon
    Sonja Rakic
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    Glia 41:117-27. 2003
    ..These subpopulations may have different origins; one may originate in the cortical SVZ, while others may come from the GE and/or outside the CNS as hematopoietic stem cells...
  24. ncbi request reprint Emerging complexity of layer I in human cerebral cortex
    Sonja Rakic
    Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Cereb Cortex 13:1072-83. 2003
    ..In addition to the ganglionic eminence, both the expended subventricular zone and subpial granular layer, contribute to the neuronal population of the developing layer I and underlining cortical plate...
  25. pmc COUP-TFII expressing interneurons in human fetal forebrain
    Gisela Reinchisi
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cereb Cortex 22:2820-30. 2012
    ..The source of these cells seems to be the CGE and, to a smaller extent, the cortical VZ/SVZ...

Research Grants10

  1. Development of the Cerebral Cortex in Mammals
    Nada Zecevic; Fiscal Year: 2007
    ....
  2. Development of the Cerebral Cortex in Mammals
    Nada Zecevic; Fiscal Year: 2009
    ..abstract_text> ..
  3. Development of the Cerebral Cortex in Mammals
    Nada Zecevic; Fiscal Year: 2006
    ....
  4. Cajal-Retzius Cells in Developing Cerebral Cortex
    Nada Zecevic; Fiscal Year: 2005
    ..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..
  5. Cajal-Retzius Cells in Developing Cerebral Cortex
    Nada Zecevic; Fiscal Year: 2004
    ..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..
  6. Cajal-Retzius Cells in Developing Cerebral Cortex
    Nada Zecevic; Fiscal Year: 2003
    ..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..
  7. Cajal-Retzius Cells in Developing Cerebral Cortex
    Nada Zecevic; Fiscal Year: 2002
    ..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..
  8. Cajal-Retzius Cells in Developing Cerebral Cortex
    Nada Zecevic; Fiscal Year: 2001
    ..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..
  9. Cajal-Retzius Cells in Developing Cerebral Cortex
    Nada Zecevic; Fiscal Year: 2001
    ..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..