Research Topics
| Nada ZecevicSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
Research Grants
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Detail Information
Publications
Myelin basic protein immunoreactivity in the human embryonic CNSN Zecevic
Department of Medicine, University of Connecticut Medical Center, Farmington 06030 1305, USA
Brain Res Dev Brain Res 105:97-108. 1998..Thus, besides the well established role in myelination, these proteins might have an additional and still unknown function in development...- Early development and composition of the human primordial plexiform layer: An immunohistochemical studyN Zecevic
University of Connecticut, Farmington, Connecticut 06030 1840, USA
J Comp Neurol 412:241-54. 1999..This study proposes that an initial PPL may be a universal feature of the developing central nervous system... 
Interneurons in the developing human neocortexNada Zecevic
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Dev Neurobiol 71:18-33. 2011..The increased complexity of progenitors is probably evolutionary adaptation necessary for development of the higher brain functions characteristic to humans...- Specific characteristic of radial glia in the human fetal telencephalonNada Zecevic
Department of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06030 3401, USA
Glia 48:27-35. 2004..Thus, the diversification of cells in human VZ and overlying subventricular zone (SVZ) begins earlier and is more pronounced than in rodents... - Contributions of cortical subventricular zone to the development of the human cerebral cortexNada Zecevic
University of Connecticut Health Center, Department of Neuroscience, Farmington, Connecticut 06030 3401, USA
J Comp Neurol 491:109-22. 2005.... - Cortical progenitor cells in the developing human telencephalonBrian Howard
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3401, USA
Glia 53:57-66. 2006..In conclusion, the diversity of cortical progenitors in the human brain may, in part, explain the unique complexity of the human cerebral cortex... - Sequence of oligodendrocyte development in the human fetal telencephalonIgor Jakovcevski
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030-3401, USA
Glia 49:480-91. 2005..Overall, in addition to considerable similarities with rodents, important differences in temporal and spatial distribution and regulatory signals for OL differentiation exist in the human brain... - Enforced Pax6 expression rescues alcohol-induced defects of neuronal differentiation in cultures of human cortical progenitor cellsZhicheng Mo
Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030 3401, USA
Alcohol Clin Exp Res 36:1374-84. 2012..We previously enriched multipotent progenitor cells, radial glia (RG) cells, from human fetal forebrain and demonstrated that they express transcription factor Pax6 that is necessary for their neurogenic fate... - Interaction between microglia and oligodendrocyte cell progenitors involves Golli proteinsRadmila Filipovic
Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030 340, USA
Ann N Y Acad Sci 1048:166-74. 2005..In summary, these results demonstrate that activated microglia are beneficial for proliferation of OPCs and suggest possible involvement of Golli proteins as one of mediators in this process... - Lipopolysaccharide affects Golli expression and promotes proliferation of oligodendrocyte progenitorsRadmila Filipovic
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
Glia 49:457-66. 2005..Taken together, these results demonstrate that microglia and/or microglia secreted factors, are necessary for the LPS-promoted proliferation of OPCs and suggest possible involvement of Golli proteins as one of mediators in this process... 
Neuroprotective role of minocycline in co-cultures of human fetal neurons and microgliaRadmila Filipovic
University of Connecticut Health Center, Department of Neuroscience, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
Exp Neurol 211:41-51. 2008..The ability of minocycline to regulate activation of human fetal microglia might be relevant in therapies used towards treating neonatal CNS infections...- Human fetal radial glia cells generate oligodendrocytes in vitroZhicheng Mo
Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3401, USA
Glia 57:490-8. 2009..In summary, our in vitro experiments revealed that a portion of cortical RG cells isolated from human forebrain at the second trimester of gestation generates OL progenitors and this suggests a role of SHH in this process... - Multiple origins of human neocortical interneurons are supported by distinct expression of transcription factorsIgor Jakovcevski
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
Cereb Cortex 21:1771-82. 2011..These human-specific developmental events may underlie human brain's higher complexity and capacity to process information... - Dorsal radial glial cells have the potential to generate cortical interneurons in human but not in mouse brainXiaojing Yu
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 31:2413-20. 2011..Multiple progenitors and sites of cortical interneuron origin in human might be an evolutionary adaptation underlying brain expansion and the increased complexity of cortical circuitry in humans... - Spontaneous electrical activity in the human fetal cortex in vitroAnna R Moore
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 31:2391-8. 2011..e., throughout the entire lifespan), the spontaneous slow oscillatory pattern (UP and DOWN states) is a fundamental aspect of human cortical physiology... - Electrical excitability of early neurons in the human cerebral cortex during the second trimester of gestationAnna R Moore
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
Cereb Cortex 19:1795-805. 2009..These results yield the first physiological characterization of developing human fetal cortical neurons with preserved morphologies in intact surrounding brain tissue... - Is Pax6 critical for neurogenesis in the human fetal brain?Zhicheng Mo
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
Cereb Cortex 18:1455-65. 2008.... - Olig transcription factors are expressed in oligodendrocyte and neuronal cells in human fetal CNSIgor Jakovcevski
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 25:10064-73. 2005..Thus, Olig1 and Olig2 transcription factors in the human CNS are important not only for differentiation of the OL lineage, but they may also have a role in neural cell specification... - The effect of CXCL1 on human fetal oligodendrocyte progenitor cellsRadmila Filipovic
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3401, USA
Glia 56:1-15. 2008..These results suggest that in the human fetal brain CXCL1 promotes proliferation of early OPC, acting in part through an ERK1/2-dependent pathway and release of IL-6 from astrocytes... - Human cortical neurons originate from radial glia and neuron-restricted progenitorsZhicheng Mo
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
J Neurosci 27:4132-45. 2007.... - Oligodendrocyte development and the onset of myelination in the human fetal brainIgor Jakovcevski
Department of Neuroscience, University of Connecticut Health Center Farmington, CT, USA
Front Neuroanat 3:5. 2009..Those differences may underlie the unique susceptibility of humans to demyelinating diseases, such as MS... - Emerging complexity of layer I in human cerebral cortexSonja Rakic
Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA
Cereb Cortex 13:1072-83. 2003..In addition to the ganglionic eminence, both the expended subventricular zone and subpial granular layer, contribute to the neuronal population of the developing layer I and underlining cortical plate... - Early oligodendrocyte progenitor cells in the human fetal telencephalonSonja Rakic
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
Glia 41:117-27. 2003..These subpopulations may have different origins; one may originate in the cortical SVZ, while others may come from the GE and/or outside the CNS as hematopoietic stem cells... - COUP-TFII Expressing Interneurons in Human Fetal ForebrainGisela Reinchisi
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA
Cereb Cortex 22:2820-30. 2012..The source of these cells seems to be the CGE and, to a smaller extent, the cortical VZ/SVZ...
Research Grants
- Development of the Cerebral Cortex in MammalsNada Zecevic; Fiscal Year: 2007....
- Cajal-Retzius Cells in Developing Cerebral CortexNada Zecevic; Fiscal Year: 2005..In addition, our findings will establish a prerequisite set of baseline data for proper diagnosis and treatment of pediatric disorders of the CNS. ..
- Development of the Cerebral Cortex in MammalsNada Zecevic; Fiscal Year: 2009..abstract_text> ..