Nasser Zawia

Summary

Affiliation: University of Rhode Island
Country: USA

Publications

  1. ncbi request reprint Transcriptional involvement in neurotoxicity
    Nasser H Zawia
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Toxicol Appl Pharmacol 190:177-88. 2003
  2. ncbi request reprint Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain
    Celeste M Bolin
    Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana, USA
    FASEB J 20:788-90. 2006
  3. ncbi request reprint Environmental risk factors and the developmental basis for Alzheimer's disease
    Nasser H Zawia
    Neurotoxicology and Epigenomics Lab, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston 02881, USA
    Rev Neurosci 16:325-37. 2005
  4. ncbi request reprint The environment, epigenetics and amyloidogenesis
    Jinfang Wu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    J Mol Neurosci 34:1-7. 2008
  5. ncbi request reprint Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm
    Syed Waseem Bihaqi
    Department of Biomedical and Pharmaceutical Sciences, Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 9:574-88. 2012
  6. ncbi request reprint Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro
    Syed Waseem Bihaqi
    Department of Biomedical and Pharmaceutical Sciences, Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 9:555-62. 2012
  7. ncbi request reprint The ability of tolfenamic acid to penetrate the brain: a model for testing the brain disposition of candidate Alzheimer's drugs using multiple platforms
    Gehad M Subaiea
    Neurodegeneration Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 8:860-7. 2011
  8. pmc Epigenetics, oxidative stress, and Alzheimer disease
    Nasser H Zawia
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Free Radic Biol Med 46:1241-9. 2009
  9. ncbi request reprint Disruption of the zinc finger domain: a common target that underlies many of the effects of lead
    N H Zawia
    Department of Biomedical Sciences, University of Rhode Island, Kingston 02881, USA
    Neurotoxicology 21:1069-80. 2000
  10. ncbi request reprint Lead-induced developmental perturbations in hippocampal Sp1 DNA-binding are prevented by zinc supplementation: in vivo evidence for Pb and Zn competition
    Md Riyaz Basha
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Int J Dev Neurosci 21:1-12. 2003

Research Grants

Collaborators

  • Axel Schumacher
  • Debomoy Lahiri
  • Deborah A Rice
  • Gaylia Jean Harry
  • Hui Cai
  • Remi Dosunmu
  • Md Riyaz Basha
  • Syed Waseem Bihaqi
  • Bryan Maloney
  • Jinfang Wu
  • Brian Brock
  • Saleh A Bakheet
  • Wei Wei
  • Gehad M Subaiea
  • L I Adwan
  • Daniel J Abrams
  • Riyaz Basha
  • Fernando Cardozo-Pelaez
  • Celeste M Bolin
  • Yuan Wen Ge
  • Hasan K Siddiqi
  • M Riyaz Basha
  • M Abdelrahim
  • R Basha
  • David A Serra
  • Maged Alwan
  • Bothaina H Alansi
  • G M Subaiea
  • Kevin S Choo
  • Amy Anderson
  • Christopher A McPherson
  • Jean Harry
  • David P Cox
  • Karen E Stevens
  • Lijun Zheng
  • Demao Chen
  • Katie DiPalma
  • Thomas J Anchordoquy
  • Jun J Yang
  • Prasada Rao S Kodavanti
  • Nykeba S Braddy
  • David Cox
  • Omar K Siddiqi
  • Koyel Ghosal
  • Hilal A Lashuel
  • Manjari Murali
  • Nathalie Benitez
  • Michelle Brydie
  • M Razmiafshari

Detail Information

Publications20

  1. ncbi request reprint Transcriptional involvement in neurotoxicity
    Nasser H Zawia
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Toxicol Appl Pharmacol 190:177-88. 2003
    ..Disturbances in the regulation of gene expression associated with the neurotoxic response are also presented. Specific focus and detail is presented on the effects of heavy metals on the integrity and function of zinc finger proteins...
  2. ncbi request reprint Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain
    Celeste M Bolin
    Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana, USA
    FASEB J 20:788-90. 2006
    ..These data suggest that oxidative damage and neurodegeneration in the aging brain could be impacted by the developmental disturbances...
  3. ncbi request reprint Environmental risk factors and the developmental basis for Alzheimer's disease
    Nasser H Zawia
    Neurotoxicology and Epigenomics Lab, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston 02881, USA
    Rev Neurosci 16:325-37. 2005
    ..In this review, we present evidence for the developmental basis of neurodegeneration and discuss mechanisms that may explain how perturbations during development can have long-term or delayed consequences in the aging brain...
  4. ncbi request reprint The environment, epigenetics and amyloidogenesis
    Jinfang Wu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    J Mol Neurosci 34:1-7. 2008
    ....
  5. ncbi request reprint Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm
    Syed Waseem Bihaqi
    Department of Biomedical and Pharmaceutical Sciences, Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 9:574-88. 2012
    ..In the present review we present the evidence that support the role of epigenetics in the development of AD and explore the potential pathways and mechanisms that may be involved...
  6. ncbi request reprint Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro
    Syed Waseem Bihaqi
    Department of Biomedical and Pharmaceutical Sciences, Interdisciplinary Neuroscience Program, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 9:555-62. 2012
    ..RT-PCR analysis of Dnmt1, Dnmt3a and MeCP2 indicated a significant down-regulation of the mRNA levels. These data suggest that Pb interferes with DNA methylating capacity in these cells, thus altering the expression of AD-related genes...
  7. ncbi request reprint The ability of tolfenamic acid to penetrate the brain: a model for testing the brain disposition of candidate Alzheimer's drugs using multiple platforms
    Gehad M Subaiea
    Neurodegeneration Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 8:860-7. 2011
    ..The present study provides the first evidence of the ability of tolfenamic acid to cross the BBB and offers a comparative analysis of approaches used to predict the ability of compounds to penetrate into the brain...
  8. pmc Epigenetics, oxidative stress, and Alzheimer disease
    Nasser H Zawia
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Free Radic Biol Med 46:1241-9. 2009
    ..Although the conditions leading to early life hypo- or hypermethylation of specific genes are not known, these changes can have an impact on gene expression and imprint susceptibility to oxidative DNA damage in the aged brain...
  9. ncbi request reprint Disruption of the zinc finger domain: a common target that underlies many of the effects of lead
    N H Zawia
    Department of Biomedical Sciences, University of Rhode Island, Kingston 02881, USA
    Neurotoxicology 21:1069-80. 2000
    ..Thus by specifically targeting zinc finger proteins (ZFP), Pb is able to produce multiple responses through its action on a common site that is present in enzymes, channels and receptors...
  10. ncbi request reprint Lead-induced developmental perturbations in hippocampal Sp1 DNA-binding are prevented by zinc supplementation: in vivo evidence for Pb and Zn competition
    Md Riyaz Basha
    Department of Biomedical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Int J Dev Neurosci 21:1-12. 2003
    ..These data suggest that Pb and Zn can compete both in vivo and in vitro at the zinc finger domain of Sp1 with a consequential effect on Sp1 DNA-binding, subsequent gene expression and brain development...
  11. ncbi request reprint Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway
    L I Adwan
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Curr Alzheimer Res 8:385-92. 2011
    ....
  12. ncbi request reprint Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation
    Md Riyaz Basha
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    FASEB J 19:2083-4. 2005
    ..The aforementioned results provide further evidence for the developmental basis of amyloidogenesis and late-life disturbances in AD-associated proteins by environmental agents...
  13. ncbi request reprint Environmental and dietary risk factors in Alzheimer's disease
    Remi Dosunmu
    University of Rhode Island, Department of Biomedical and Pharmaceutical Sciences, Kingston, RI 02881, USA
    Expert Rev Neurother 7:887-900. 2007
    ..The evidence examined in this review provides a brief overview of the current literature on selected, significant risk factors in promoting amyloid-beta accumulation and aggregation, thus contributing to neurodegeneration...
  14. ncbi request reprint How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD
    Debomoy K Lahiri
    Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Alzheimer Res 4:219-28. 2007
    ..The LEARn model may explain the etiology of AD and other neuropsychiatric and developmental disorders...
  15. pmc Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD
    Jinfang Wu
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Neurosci 28:3-9. 2008
    ..These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD...
  16. ncbi request reprint The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain
    M Riyaz Basha
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Neurosci 25:823-9. 2005
    ..These data suggested that environmental influences occurring during brain development predetermined the expression and regulation of APP later in life, potentially altering the course of amyloidogenesis...
  17. ncbi request reprint Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis
    Brian Brock
    Neurotoxicology and Epigenomics Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    J Alzheimers Dis 13:71-80. 2008
    ..These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene...
  18. pmc An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients
    Daniel J Abrams
    Department of Psychiatry, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, United States
    Schizophr Res 100:86-96. 2008
    ....
  19. ncbi request reprint Ontogenetic alterations in prototypical transcription factors in the rat cerebellum and hippocampus following perinatal exposure to a commercial PCB mixture
    Md Riyaz Basha
    Department of Biomedical Sciences and Pharmaceutical, University of Rhode Island, RI 02881, USA
    Neurotoxicology 27:118-24. 2006
    ..These distinct changes delineate the involvement of specific transduction-transcription coupling pathways that may mediate PCB-induced perturbations in developmental gene expression...
  20. ncbi request reprint Lead exposure: expression and activity levels of Oct-2 in the developing rat brain
    Saleh A Bakheet
    Neurotoxicology and Epigenomics Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Toxicol Sci 95:436-42. 2007
    ..These findings identify Oct-2 as a potential molecular target for Pb and suggest that Oct-2 may be associated with lead-induced disturbances in gene expression...

Research Grants8

  1. INTERACTION OF LEAD WITH ZINC FINGER PROTEINS
    Nasser Zawia; Fiscal Year: 2002
    ..Understanding the mechanism of lead neurotoxicity with the models and experiments hitherto proposed will shed more light on metal toxicity and broaden our knowledge of the impact of heavy metals in the environment on our health. ..
  2. Fetal Pb-exposure and neurodegeneration in aging brains
    Nasser Zawia; Fiscal Year: 2006
    ..abstract_text> ..
  3. Neonatal exposure & neurodegeneration of the aged brain
    Nasser Zawia; Fiscal Year: 2006
    ..We would like to test this hypothesis by examining the effect of Pb exposure on DNA-methylation and determine whether these actions selectively impact genes rich in GC box elements such as APP and BACE. ..
  4. Occupational exposure and the developmental-basis of AD
    NASSER HUSSEIN ZAWIA; Fiscal Year: 2010
    ..We further would like to examine the mechanisms associated with sensitization of animals to disease by early life exposure and how such processes respond in the event of re-exposure during adulthood. ..
  5. Occupational exposure and the developmental-basis of AD
    NASSER HUSSEIN ZAWIA; Fiscal Year: 2011
    ..We further would like to examine the mechanisms associated with sensitization of animals to disease by early life exposure and how such processes respond in the event of re-exposure during adulthood. ..