Affiliation: University of Southern California
- Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseasesChris Zarow
Department of Neurology, University of Southern California, Los Angeles, CA, USA
Arch Neurol 60:337-41. 2003..Alzheimer disease (AD) and Parkinson disease (PD) are associated with neuronal degeneration in major subcortical nuclei, but few studies have examined the neuronal degeneration in these nuclei concurrently...
- A standardized method for brain-cutting suitable for both stereology and MRI-brain co-registrationC Zarow
Department of Neurology, Rancho Los Amigos National Rehabilitation Center, University of Southern California, Downey, CA 90242, USA
J Neurosci Methods 139:209-15. 2004..For design-based stereology, the volume of interest (VOI) is defined using reproducible anatomical boundaries. This method is suitable for stereologic measures of structures ranging from defined nuclei to whole brain...
- Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issuesChris Zarow
University of Southern California, Rancho Los Amigos National Rehabilitation Center, 7601 E Imperial Highway, Medical Science Building, Room 26, Downey, CA 90242, USA
Curr Neurol Neurosci Rep 8:363-70. 2008..Little is known about the prevention and treatment of late-life HS, although circumstantial evidence suggests the importance of identifying and treating vascular risk factors...
- Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementiaChris Zarow
University of Southern California, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
Ann Neurol 57:896-903. 2005..Reductions in magnetic resonance imaging-derived hippocampal volume reflect loss, rather than shrinkage, of CA1 neurons...
- Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular diseaseBruce R Reed
University of California, Davis, CA, USA
Brain 130:731-9. 2007....
- Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysisScott A Lyness
Department of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
Neurobiol Aging 24:1-23. 2003..Symptomatic drug treatment for AD might be beneficially directed toward ameliorating multiple neurotransmitter deficiencies, particularly cholinergic and noradrenergic...
- Cognitive impact of subcortical vascular and Alzheimer's disease pathologyHelena C Chui
Department of Neurology, University of Southern California, Los Angeles, USA
Ann Neurol 60:677-87. 2006..To assess the interactions among three types of pathology (ie, cerebrovascular disease, hippocampal sclerosis [HS], and Alzheimer's disease [AD]), cognitive status, and apolipoprotein E genotype...
- Histological, immunocytochemical, and morphometrical analyses of pancreatic islets in the BSB mouse model of obesityBernard G Slavin
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Anat Rec (Hoboken) 293:108-16. 2010..The correlation between this descriptive information and physiological data might lend insights to the cause of obesity-related diabetes...
- Neuropathological basis of magnetic resonance images in aging and dementiaWilliam J Jagust
School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720 3190, USA
Ann Neurol 63:72-80. 2008..Magnetic resonance (MR) imaging is used widely for assessment of patients with cognitive impairment, but the pathological correlates are unclear, especially when multiple pathologies are present...
- Clinical and neuropsychological features in autopsy-defined vascular dementiaBruce R Reed
Alzheimer s Disease Center, University of California, Davis 94553, USA
Clin Neuropsychol 18:63-74. 2004..A illustrative case example is included. We conclude that the profile of cognitive impairment in IVD is highly variable, but that in clinical settings neuropsychological readings may contribute to the differential diagnosis of dementia...