Research Topics
Genomes and GenesSpecies | Jonathan ZaroffSummaryAffiliation: University of California Country: USA Publications
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Publications
Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined populationRodney A Gabriel
UCSF Department of Anesthesia and Perioperative Care, 1001 Potrero Ave, Room 3C 38, San Francisco, CA 94110, USA
Stroke 41:21-6. 2010....
A risk model derived from the National Registry of Myocardial Infarction 2 database for predicting mortality after coronary artery bypass grafting during acute myocardial infarctionJonathan G Zaroff
Department ofFrom the Department of Medicine Cardiology, University of California San Francisco, San Francisco, California 94117 0124, USA
Am J Cardiol 90:1-4. 2002..Using the described risk score, clinicians can quantify the impact of patient risk factors in making decisions about referral for and timing of CABG...- Echocardiographic evaluation of the potential cardiac donorJonathan Zaroff
Cardiology Division, Department of Medicine, University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA, USA
J Heart Lung Transplant 23:S250-2. 2004 - Adrenoceptor polymorphisms and the risk of cardiac injury and dysfunction after subarachnoid hemorrhageJonathan G Zaroff
Department of Medicine, University of California, San Francisco, USA
Stroke 37:1680-5. 2006..We hypothesized that adrenoceptor polymorphisms resulting in greater catecholamine sensitivity would be associated with an increased risk of cardiac injury... - Temporal changes in left ventricular systolic function in heart donors: results of serial echocardiographyJonathan G Zaroff
Department of Medicine, University of California, San Francisco, California 94143 0124, USA
J Heart Lung Transplant 22:383-8. 2003..The aim of this study was to determine whether intensive donor management results in improved left ventricular systolic function as measured by serial echocardiography... - The impact of left ventricular dysfunction on cardiac donor transplant ratesJonathan G Zaroff
Department of Medicine, University of California, San Francisco California 94143 0124, USA
J Heart Lung Transplant 22:334-7. 2003..The purpose of this study was to quantify the effects of left ventricular (LV) systolic dysfunction on heart donor use... - Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, VaJonathan G Zaroff
UCSF Medical Center, San Francisco, Calif 94143 0124, USA
Circulation 106:836-41. 2002.... - Prospective analysis of prevalence, distribution, and rate of recovery of left ventricular systolic dysfunction in patients with subarachnoid hemorrhageNader Banki
Division of Cardiology, University of California, San Francisco Medical Center, San Francisco, California, USA
J Neurosurg 105:15-20. 2006..CONCLUSIONS: Left ventricular systolic dysfunction occurs frequently after SAH and usually improves over time. The observed segmental patterns of LV dysfunction often do not correlate with coronary artery distributions... - Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformationsLudmila Pawlikowska
Cardiovascular Research Institute, University of California, San Francisco, CA 94110, USA
Stroke 36:2278-80. 2005..We investigated whether polymorphisms in these genes are also associated with sporadic BAVM... - Age and aneurysm position predict patterns of left ventricular dysfunction after subarachnoid hemorrhageKiran Khush
Division of Cardiology, Department of Radiology, University of California-San Francisco Medical Center, 505 Parnassus Avenue, San Francisco, CA 941243, USA
J Am Soc Echocardiogr 18:168-74. 2005..Both patterns of wall-motion abnormalities appear to be transient, reversible phenomena. The AS pattern may represent a unique form of neurally mediated cardiac injury... - Prevalence and implications of diastolic dysfunction after subarachnoid hemorrhageAlexander Kopelnik
Division of Cardiology, University of California San Francisco Medical Center, San Francisco, CA 94143-0124, USA
Neurocrit Care 3:132-8. 2005..CONCLUSION: Diastolic dysfunction is common after SAH. It is associated with history of hypertension and older age and may explain the development of pulmonary edema in many SAH patients... - Predictors of neurocardiogenic injury after subarachnoid hemorrhagePoyee Tung
Division of Cardiology, UCSF Medical Center, USA
Stroke 35:548-51. 2004..This finding supports the hypothesis that cardiac injury after SAH is a neurally mediated process... - Polymorphisms in genes involved in inflammatory and angiogenic pathways and the risk of hemorrhagic presentation of brain arteriovenous malformationsLudmila Pawlikowska
Cardiovascular Research Institute, University of California, San Francisco, Calif 94110, USA
Stroke 35:2294-300. 2004..Identification of genetic polymorphisms associated with ICH would facilitate risk stratification in BAVM patients... - Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAHLandis A Fisher
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 5:180-5. 2006..075). CONCLUSION: In the acute period after SAH, hypernatremia is associated with adverse cardiac outcomes and death. SAH patients with hypernatremia should be monitored for evidence of cardiac dysfunction... - Plasma B-type natriuretic peptide levels are associated with early cardiac dysfunction after subarachnoid hemorrhagePoyee P Tung
Division of Cardiology, University of California, San Francisco, CA, USA
Stroke 36:1567-9. 2005..The aim of this study was to prospectively quantify the relationship between BNP levels and cardiac outcomes after SAH... - Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformationHelen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cerebrovasc Dis 27:176-82. 2009..The aim of this study was to investigate associations between single nucleotide polymorphisms (SNPs) in IL-1beta and intracranial hemorrhage (ICH) in the natural course of brain arteriovenous malformation (BAVM) patients... - Interleukin-6 and atrial fibrillation in patients with coronary artery disease: data from the Heart and Soul StudyGregory M Marcus
Electrophysiology Section, Division of Cardiology, University of California, San Francisco, CA 94143 1354, USA
Am Heart J 155:303-9. 2008..We therefore examined several biomarkers of inflammation and ultimately genotyped IL-6 polymorphisms in patients with AF in a cohort of subjects with known CAD... - Donor cardiac troponin I levels do not predict recipient survival after cardiac transplantationKiran K Khush
Division of Cardiology, Department of Medicine, University of California at San Francisco Medical Center, San Francisco, California, USA
J Heart Lung Transplant 26:1048-53. 2007..This study was performed to determine whether donor cardiac cTnI levels exceeding 1.0 microg/liter are associated with adverse recipient outcomes... - Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilizationAnil Sapru
Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
J Heart Lung Transplant 30:211-7. 2011..We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation... - Tumor necrosis factor-alpha-238G>A promoter polymorphism is associated with increased risk of new hemorrhage in the natural course of patients with brain arteriovenous malformationsAchal S Achrol
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, California, USA
Stroke 37:231-4. 2006.... - Acute neurocardiogenic injury after subarachnoid hemorrhageNader M Banki
Division of Cardiology, Department of Radiology, UCSF Medical Center, San Francisco, California, USA
Circulation 112:3314-9. 2005..These findings may be explained by excessive release of norepinephrine from myocardial sympathetic nerves, which could damage both myocytes and nerve terminals... - Predictors of left ventricular regional wall motion abnormalities after subarachnoid hemorrhageAvinash Kothavale
Division of Cardiology, UCSF Medical Center, San Francisco, CA, USA
Neurocrit Care 4:199-205. 2006..34 per 10 bpm increase, p = 0.024) were predictive of RWMA. CONCLUSIONS: RWMA were frequent after SAH. High-grade SAH, an elevation in cTi levels, a history of prior stimulant drug use, and tachycardia are independent predictors of RWMA... - Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhageNerissa U Ko
Department of Neurology, University of California, San Francisco, USA
Stroke 39:1103-8. 2008..Decreased availability of nitric oxide (NO) may be crucial in its pathogenesis. We hypothesized that endothelial NO synthase (eNOS) polymorphisms may determine susceptibility to vasospasm in SAH patients... - Cardiovascular predictors of in-patient mortality after subarachnoid hemorrhageSirisha Yarlagadda
Department of Medicine, University of California San Francisco, San Francisco, CA 94143-0124, USA
Neurocrit Care 5:102-7. 2006..Though these effects may be explained by a reduction in cerebral perfusion pressure or other mechanisms, further research is required to determine whether or not they are causal in nature... - Association of tumor necrosis factor-alpha-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain arteriovenous malformation treatmentAchal S Achrol
Center for Cerebrovascular Research and Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94110, USA
Neurosurgery 61:731-9; discussion 740. 2007..We hypothesized that the risk of posttreatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes... - Cardiac injury after subarachnoid hemorrhage is independent of the type of aneurysm therapyJacob C Miss
Department of Medicine, University of California, San Francisco, California 94143-0124, USA
Neurosurgery 55:1244-50; discussion 1250-1. 2004..CONCLUSION: Surgical and endovascular aneurysm therapies were associated with similar risks of cardiac injury and dysfunction after SAH. The presence of neurocardiogenic injury should not affect aneurysm treatment decisions... - Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulationWhittemore G Tingley
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:8461-6. 2007..Our stem cell-based screen may provide a means of identifying other genes that control heart rhythm... - Apolipoprotein E epsilon 2 is associated with new hemorrhage risk in brain arteriovenous malformationsLudmila Pawlikowska
The Cardiovascular Research Institute, University of California, San Francisco 94110, USA
Neurosurgery 58:838-43; discussion 838-43. 2006..Identification of genetic variants associated with increased new ICH risk would facilitate risk stratification and guide therapeutic intervention... - Electrocardiographic repolarization abnormalities in subarachnoid hemorrhageClaire E Sommargren
Department of Physiological Nursing, University of California, San Francisco, USA
J Electrocardiol 35:257-62. 2002..Prolonged QTc interval after SAH is significantly related to myocardial injury, but unrelated to mortality, and there is no association between ST-T wave abnormalities and either myocardial injury or mortality... - Independent associations between electrocardiographic abnormalities and outcomes in patients with aneurysmal subarachnoid hemorrhage: findings from the intraoperative hypothermia aneurysm surgery trialLandis A Coghlan
University of California, Los Angeles, California, USA
Stroke 40:412-8. 2009..The aim of this study was to determine whether any specific electrocardiographic abnormalities are independently associated with adverse neurological outcomes... - Neurogenic stunned myocardiumHoang Nguyen
Cardiology Department, Kaiser San Francisco Medical Center, San Francisco, CA 94115, USA
Curr Neurol Neurosci Rep 9:486-91. 2009..These are reversible abnormalities, and although management should include careful cardiac monitoring, treatments should generally focus on the underlying neurologic process to maximize neurologic recovery... - Hormonal resuscitation yields more transplanted hearts, with improved early functionJohn D Rosendale
Research Department, United Network for Organ Sharing, Richmond, VA 23219, USA
Transplantation 75:1336-41. 2003..CONCLUSIONS: This study suggests that 3HR treatment of brain-dead donors results in increased numbers of transplanted hearts, with improved short-term graft function... - Aggressive pharmacologic donor management results in more transplanted organsJohn D Rosendale
Research Department, United Network for Organ Sharing, Richmond, VA 23218, USA
Transplantation 75:482-7. 2003..CONCLUSION: HR stabilizes certain brain-dead donors and is associated with significant increases in organs transplanted per donor... - Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donorBruce R Rosengard
Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
Am J Transplant 2:701-11. 2002
Research Grants
- VENTRICULAR DYSFUNCTION AFTER SUBARACHNOID HEMORRHAGEJonathan Zaroff; Fiscal Year: 2004..abstract_text> ..
- Risk factors for cardiac injury after SAHJonathan Zaroff; Fiscal Year: 2006..5. To test the hypothesis that SAH-induced cardiac dysfunction is associated with decreased systolic blood pressure and increased inpatient mortality. ..