KENNETH S contact ZARET

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?
    Kenneth S Zaret
    Epigenetics Program, Institute of Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Electronic address
    Dev Cell 29:132-4. 2014
  2. pmc Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
    Palle Serup
    Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK 2820, Denmark
    Dis Model Mech 5:956-66. 2012
  3. pmc Pioneer transcription factors: establishing competence for gene expression
    Kenneth S Zaret
    Epigenetics Program, Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Genes Dev 25:2227-41. 2011
  4. doi Nuclear mobility and mitotic chromosome binding: similarities between pioneer transcription factor FoxA and linker histone H1
    K S Zaret
    Epigenetics Program and Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Cold Spring Harb Symp Quant Biol 75:219-26. 2010

Collaborators

  • Jason S Carroll
  • Palle Serup
  • Angela Hines
  • Robert Lin
  • Ewa Wandzioch
  • Carsten Gustavsen
  • Janny M L Peterslund
  • Anne Grapin-Botton
  • Christine Bruun
  • Mark A Magnuson
  • Leah A Potter
  • Ashley Davis
  • Raymond J Macdonald
  • Tino Klein
  • Nina Engberg
  • Dorthe R Petersen
  • Nandita Mullapudi

Detail Information

Publications4

  1. pmc Genome reactivation after the silence in mitosis: recapitulating mechanisms of development?
    Kenneth S Zaret
    Epigenetics Program, Institute of Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Smilow Center for Translational Research, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA Electronic address
    Dev Cell 29:132-4. 2014
    ..Thus, features of postmitotic gene reactivation can provide insights into mechanisms of developmental cell fate establishment. ..
  2. pmc Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice
    Palle Serup
    Hagedorn Research Institute, Department of Developmental Biology, Niels Steensens Vej 6, DK 2820, Denmark
    Dis Model Mech 5:956-66. 2012
    ....
  3. pmc Pioneer transcription factors: establishing competence for gene expression
    Kenneth S Zaret
    Epigenetics Program, Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Genes Dev 25:2227-41. 2011
    ..Passive and active roles for the pioneer factor FoxA occur in embryonic development, steroid hormone induction, and human cancers. Herein we review the field and describe how pioneer factors may enable cellular reprogramming...
  4. doi Nuclear mobility and mitotic chromosome binding: similarities between pioneer transcription factor FoxA and linker histone H1
    K S Zaret
    Epigenetics Program and Institute for Regenerative Medicine, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Cold Spring Harb Symp Quant Biol 75:219-26. 2010
    ..The results indicate that the "pioneer" features of FoxA factors involve various chromatin-binding parameters seen in linker histones and that distinguish the factors with respect to their regulatory and mechanistic functions...

Research Grants17

  1. HIGHER ORDER PROTEIN-DNA COMPLEXES IN GENE REGULATION
    Kenneth Zaret; Fiscal Year: 1999
    ..3) To selectively perturb the nucleosome reorganizing properties of HNF3 and assess the functional consequences in endogenous cell chromatin. ..
  2. Novel Epigenetic Marks in Mitosis
    Kenneth Zaret; Fiscal Year: 2009
    ..We will investigate whether FoxA or PARP occupancy, or polyADP ribosylation may induce special structural configurations at epigenetic marks in mitotic chromatin. ..
  3. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2005
    ..abstract_text> ..
  4. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2005
    ..Understanding how multipotent cells are specified to different tissue types is fundamental to organogenesis, tissue regeneration, and stem cell biology, and therefore human health and disease. ..
  5. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2004
    ..abstract_text> ..
  6. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2004
    ..Understanding how multipotent cells are specified to different tissue types is fundamental to organogenesis, tissue regeneration, and stem cell biology, and therefore human health and disease. ..
  7. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2003
    ..Understanding how multipotent cells are specified to different tissue types is fundamental to organogenesis, tissue regeneration, and stem cell biology, and therefore human health and disease. ..
  8. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2003
    ..abstract_text> ..
  9. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2002
    ..abstract_text> ..
  10. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2002
    ..Understanding how multipotent cells are specified to different tissue types is fundamental to organogenesis, tissue regeneration, and stem cell biology, and therefore human health and disease. ..
  11. HIGHER ORDER PROTEIN-DNA COMPLEXES IN GENE REGULATION
    Kenneth Zaret; Fiscal Year: 2001
    ..3) To selectively perturb the nucleosome reorganizing properties of HNF3 and assess the functional consequences in endogenous cell chromatin. ..
  12. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2001
    ..The principles revealed by this proposal should be fundamental to the control of many other cell types and for understanding the proper growth and development of humans. ..
  13. HIGHER ORDER PROTEIN-DNA COMPLEXES IN GENE REGULATION
    Kenneth Zaret; Fiscal Year: 2000
    ..3) To selectively perturb the nucleosome reorganizing properties of HNF3 and assess the functional consequences in endogenous cell chromatin. ..
  14. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 2000
    ..The principles revealed by this proposal should be fundamental to the control of many other cell types and for understanding the proper growth and development of humans. ..
  15. TRANS-ACTING FACTORS CAUSING CELL SPECIFIC GENE CONTROL
    Kenneth Zaret; Fiscal Year: 1999
    ..The principles revealed by this proposal should be fundamental to the control of many other cell types and for understanding the proper growth and development of humans. ..
  16. Novel Epigenetic Marks in Mitosis
    KENNETH S contact ZARET; Fiscal Year: 2010
    ..We will investigate whether FoxA or PARP occupancy, or polyADP ribosylation may induce special structural configurations at epigenetic marks in mitotic chromatin. ..