Wojciech Zareba

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Genotype-specific ECG patterns in long QT syndrome
    Wojciech Zareba
    Department of Medicine, Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Electrocardiol 39:S101-6. 2006
  2. ncbi Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 13:287-94. 2008
  3. ncbi Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
  4. ncbi Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1657-64. 2010
  5. ncbi Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
  6. ncbi Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
  7. ncbi Applicability of a risk score for prediction of the long-term (8-year) benefit of the implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 59:2075-9. 2012
  8. ncbi Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
  9. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
  10. ncbi Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 28:548-54. 2008

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi Genotype-specific ECG patterns in long QT syndrome
    Wojciech Zareba
    Department of Medicine, Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Electrocardiol 39:S101-6. 2006
    ..In conclusion, comprehensive analyses of static and dynamic features of repolarization provide unique opportunity to understand electrophysiology of cardiac repolarization...
  2. ncbi Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 13:287-94. 2008
    ..We hypothesized that several genetic atherosclerotic single nucleotide polymorphisms (SNPs) may exert an additive effect on the earlier occurrence of coronary atherothrombotic disease after adjustment for clinical factors...
  3. ncbi Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
    ..We compared the clinical course of Caucasian and Japanese long QT type-1 (LQT1) patients who were matched for mutations in the KCNQ1 gene...
  4. ncbi Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1657-64. 2010
    ..To investigate the roles of inflammation and a cholesteryl ester transfer protein (CETP) polymorphism potentially related to recent findings demonstrating coronary risk with increasing high-density lipoprotein cholesterol (HDL-C) level...
  5. ncbi Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
    ..However, limited data exist regarding the efficacy and limitations of this form of medical management within high-risk subsets of these populations...
  6. ncbi Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
    ....
  7. ncbi Applicability of a risk score for prediction of the long-term (8-year) benefit of the implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 59:2075-9. 2012
    ..The present study was designed to explore the 8-year survival benefit of a nonresynchronization implantable cardioverter-defibrillator (ICD) according to a simple risk stratification score...
  8. ncbi Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
    ..However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified...
  9. ncbi Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
    ..This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD...
  10. ncbi Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 28:548-54. 2008
    ..The aim of this study was to assess such risk as a function of 37 atherosclerosis-associated genetic polymorphisms and 17 blood marker variables...
  11. ncbi Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circ Cardiovasc Genet 4:491-9. 2011
    ..The present study was designed to assess the clinical course of individuals who are found negative for the LQTS-causing mutation in their families...
  12. ncbi Lp(a) and risk of recurrent cardiac events in obese postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Obesity (Silver Spring) 16:2717-22. 2008
    ..These findings suggest close monitoring and consideration of weight reduction for obese postinfarction patients with elevated Lp(a) levels...
  13. ncbi Mutation-specific risk in two genetic forms of type 3 long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:210-3. 2010
    ..The findings highlight the importance of knowing the specific mutation in risk stratification of patients with long QT syndrome type 3...
  14. ncbi Improved survival associated with prophylactic implantable defibrillators in elderly patients with prior myocardial infarction and depressed ventricular function: a MADIT-II substudy
    David T Huang
    Cardiology Unit, The Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:833-8. 2007
    ..Effective primary prevention of sudden cardiac death with implantable cardioverter defibrillators is well demonstrated in patients with coronary disease and depressed ventricular function...
  15. ncbi Trigger-specific risk factors and response to therapy in long QT syndrome type 2
    James A Kim
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 7:1797-805. 2010
    ..Cardiac events in patients with long QT syndrome type 2 (LQT2) are predominately associated with sudden arousal. However, exercise-induced events also occur in this population...
  16. ncbi Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 113:2810-7. 2006
    ..Implantable cardioverter-defibrillator (ICD) therapy may be associated with an increased risk for heart failure (HF). The present study evaluated the frequency, causes, and consequences of HF after ICD implantation...
  17. ncbi Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:2416-23. 2011
    ..We aimed to evaluate the relationship between echocardiographic response to cardiac resynchronization therapy (CRT) and the risk of subsequent ventricular tachyarrhythmias (VTAs)...
  18. ncbi Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
    Dimitry Migdalovich
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:1537-43. 2011
    ..We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2...
  19. ncbi Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators
    Iwona Cygankiewicz
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 6:468-73. 2009
    ..Data on long-term follow-up and factors influencing mortality in implantable cardioverter-defibrillator (ICD) recipients are limited...
  20. ncbi Long-QT syndrome after age 40
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2192-201. 2008
    ....
  21. ncbi Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:395-400. 2009
    ..There are limited data on the effect of the primary types of HF medications, angiotensin converting enzyme inhibitors (ACE-I), and beta-blockers on HF progression in ICD-treated patients...
  22. ncbi Long QT syndrome and pregnancy
    Rahul Seth
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 49:1092-8. 2007
    ..This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years...
  23. ncbi Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
    ..We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients...
  24. ncbi Modulating effects of age and gender on the clinical course of long QT syndrome by genotype
    Wojciech Zareba
    Department of Medicine, Heart Research Follow Up Program, Medical Center, University of Rochester School of Medicine, Rochester, NY 14642 8653, USA
    J Am Coll Cardiol 42:103-9. 2003
    ..We aimed to determine whether long QT syndrome (LQTS) genotype has a differential effect on clinical course of disease in male and female children and adults after adjustment for QTc duration...
  25. ncbi Physicians' knowledge and attitudes regarding implantable cardioverter-defibrillators
    Saadia Sherazi
    Department of Medicine, Unity Health System, Rochester, NY 14626, USA
    Cardiol J 17:267-73. 2010
    ..Information is limited regarding the knowledge and attitudes of physicians typically involved in the referral of patients for implantable cardioverter-defibrillator (ICD) implantation...
  26. ncbi Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
    ..Our results indicate that genotype and biophysical phenotype analysis may be useful for risk stratification of LQT1 patients and suggest that slow channel activation is associated with an increased risk of cardiac events...
  27. ncbi Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
    ..We evaluated the effect of location, coding type, and biophysical function of KCNQ1 mutations on the clinical phenotype of this disorder...
  28. ncbi Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 8:1207-13. 2011
    ..A prolonged QT interval corrected for heart rate (QTc) is a major risk factor in patients with long QT syndrome (LQTS). However, heart rate-related risk in this genetic disorder differs among genotypes...
  29. ncbi Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact
    James P Daubert
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 51:1357-65. 2008
    ..This study sought to identify the incidence and outcome related to inappropriate implantable cardioverter-defibrillator (ICD) shocks, that is, those for nonventricular arrhythmias...
  30. ncbi Cardiac-resynchronization therapy for the prevention of heart-failure events
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    N Engl J Med 361:1329-38. 2009
    ....
  31. ncbi Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:34-43. 2005
    ..30), and prolonged intraventricular conduction (QRS duration>or=130 ms)...
  32. ncbi Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome
    Jenny B Hobbs
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    JAMA 296:1249-54. 2006
    ..Among patients with recent syncope, beta-blocker treatment was associated with reduced risk...
  33. ncbi Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 96:177-82. 2005
    ....
  34. ncbi Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome
    Ilan Goldenberg
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 9:49-56. 2012
    ..Arrhythmic events in long-QT syndrome type 1 (LQT1) may be associated with exercise, acute arousal, or rest/sleep...
  35. ncbi Effect of cardiac resynchronization therapy on the risk of first and recurrent ventricular tachyarrhythmic events in MADIT-CRT
    Gregory Ouellet
    Cardiology Division, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Am Coll Cardiol 60:1809-16. 2012
    ..This study aimed to evaluate the effect of cardiac resynchronization therapy with a defibrillator (CRT-D) on the risks of first and recurrent ventricular tachyarrhythmic events (VTEs) in the MADIT-CRT...
  36. ncbi Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death
    Larisa G Tereshchenko
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circ Arrhythm Electrophysiol 5:719-27. 2012
    ..The goal of the present study was to determine the predictive value of beat-to-beat QT variability in heart failure patients across the continuum of left ventricular dysfunction...
  37. ncbi T-wave morphology abnormalities in benign, potent, and arrhythmogenic I(kr) inhibition
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 8:1036-43. 2011
    ..There is a consensus on the limited value of the QTc interval prolongation as a surrogate marker of drug cardiotoxicity and as a risk stratifier in inherited long QT syndrome (LQTS) patients...
  38. ncbi Gender differences and risk of ventricular tachycardia or ventricular fibrillation
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Heart Rhythm 6:180-6. 2009
    ..The role of repolarization duration and stability in arrhythmogenesis in men and women with structural heart disease has not been explored...
  39. ncbi Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome
    Wojciech Zareba
    Cardiology Unit of the Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 14:1149-53. 2003
    ..The aim of this study was to determine whether there is an association between the location of mutations in the KCNQ1 gene and cardiac events in LQT1 patients...
  40. ncbi Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome
    Alon Barsheshet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 125:1988-96. 2012
    ..We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location...
  41. ncbi Effect of elapsed time from coronary revascularization to implantation of a cardioverter defibrillator on long-term survival in the MADIT-II trial
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 22:1237-42. 2011
    ..This study was designed to evaluate the effect of elapsed time from CR on long-term mortality and arrhythmic risk among patients who receive an implantable cardioverter defibrillator (ICD)...
  42. ncbi Reduction in inappropriate therapy and mortality through ICD programming
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 0653, USA
    N Engl J Med 367:2275-83. 2012
    ..The implantable cardioverter-defibrillator (ICD) is highly effective in reducing mortality among patients at risk for fatal arrhythmias, but inappropriate ICD activations are frequent, with potential adverse effects...
  43. ncbi Repolarization variability in the risk stratification of MADIT II patients
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Europace 9:717-23. 2007
    ....
  44. ncbi Polymorphism in the cholesteryl ester transfer protein gene and the risk of early onset myocardial infarction among cigarette smokers
    Ilan Goldenberg
    Cardiology Units of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 12:364-74. 2007
    ..We hypothesized that susceptibility to early onset myocardial infarction (MI) among cigarette smokers may be related to the presence of TaqIB polymorphism in the CETP gene...
  45. ncbi Glycoprotein Ibalpha polymorphism T145M, elevated lipoprotein-associated phospholipase A2, and hypertriglyceridemia predict risk for recurrent coronary events in diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Diabetes 56:1429-35. 2007
    ....
  46. ncbi Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 48:1047-52. 2006
    ..We evaluated the incremental prognostic information provided by multiple corrected QT (QTc) measurements on serial electrocardiograms (ECGs) in patients with the inherited long QT syndrome (LQTS)...
  47. ncbi Time-dependent benefit of preventive cardiac resynchronization therapy after myocardial infarction
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1614-21. 2011
    ..The present study was designed to evaluate the relationship between elapsed time from MI and the benefit of preventive CRT-D therapy in patients with ischaemic cardiomyopathy (ICM)...
  48. ncbi Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:212-8. 2011
    ..Limited data regarding the effect of right ventricular pacing (RVP) on long-term survival following implantable cardioverter-defibrillator (ICD) implantation are available...
  49. ncbi Risk of fatal arrhythmic events in long QT syndrome patients after syncope
    Christian Jons
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 55:783-8. 2010
    ..The aim of this study was to identify risk factors for fatal arrhythmias in long QT syndrome (LQTS) patients presenting with syncope...
  50. ncbi High lipoprotein-associated phospholipase A2 is a risk factor for recurrent coronary events in postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Chem 52:1331-8. 2006
    ....
  51. ncbi Improved outcome with preventive cardiac resynchronization therapy in the elderly: a MADIT-CRT substudy
    Justin Penn
    Department of Internal Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 22:892-7. 2011
    ..Elderly patients comprise a large portion of patients with heart failure (HF). Limited data exist on the effectiveness of cardiac resynchronization therapy with defibrillator (CRT-D) in patients with mild HF symptoms in this population...
  52. ncbi Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome
    Gregory Ouellet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Cardiol 105:87-9. 2010
    ..In conclusion, diabetes and prolonged QTc interval contributed independent mortality risks in adult patients with LQTS, with no interaction between these 2 risk factors...
  53. ncbi Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals
    Ilan Goldenberg
    Cardiology Division of Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:51-9. 2011
    ..This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals...
  54. ncbi Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1622-30. 2011
    ..We evaluated the outcome of patients enrolled in MADIT-CRT by ischaemic and non-ischaemic aetiology of cardiomyopathy (ICM and non-ICM, respectively)...
  55. ncbi Congenital long QT syndrome: considerations for primary care physicians
    Ethan Levine
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 8679, USA
    Cleve Clin J Med 75:591-600. 2008
    ..We can now classify some types of congenital long QT syndrome according to their genetic mutations and their triggers, such as exercise, rest, or startle...
  56. ncbi Ventricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: a MADIT-II substudy
    Henry W Sesselberg
    Department of Medicine, Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Heart Rhythm 4:1395-402. 2007
    ..Much of prognostic implications of ventricular arrhythmia storms remain unclear...
  57. ncbi Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease
    Edward Sze
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 13:327-31. 2008
    ....
  58. ncbi Long-term benefit of primary prevention with an implantable cardioverter-defibrillator: an extended 8-year follow-up study of the Multicenter Automatic Defibrillator Implantation Trial II
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 122:1265-71. 2010
    ..5 years. However, currently there are no data on the long-term efficacy of primary defibrillator therapy...
  59. ncbi Relation between renal function and response to cardiac resynchronization therapy in Multicenter Automatic Defibrillator Implantation Trial--Cardiac Resynchronization Therapy (MADIT-CRT)
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 7:1777-82. 2010
    ..Cardiorenal interactions have been shown to affect outcome in heart failure patients but were not related to response to cardiac resynchronization therapy (CRT)...
  60. ncbi Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 51:288-96. 2008
    ..The study was designed to develop a simple risk stratification score for primary therapy with an implantable cardioverter-defibrillator (ICD)...
  61. ncbi Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Ritesh Dhar
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Heart Rhythm 5:807-13. 2008
    ..There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs)...
  62. ncbi Polymorphism in the angiotensinogen gene, hypertension, and ethnic differences in the risk of recurrent coronary events
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    Hypertension 48:693-9. 2006
    ..The presence of hypertension significantly augments the risk associated with this genetic mutation...
  63. ncbi Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval
    Jean-Philippe Couderc
    Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York
    Heart Rhythm 3:1460-6. 2006
    ..CONCLUSION: Abnormal T-wave morphology is a phenotypic expression of LQT2, and its quantification could be used to identify patients with suspected LQTS who do not have overt QTc prolongation (QTc >470)...
  64. ncbi Relations among renal function, risk of sudden cardiac death, and benefit of the implanted cardiac defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:485-90. 2006
    ..Defibrillator therapy was associated with a significant survival benefit among the study patients with mild to moderate or no renal disease, but no benefit was shown among patients with more advanced renal dysfunction...
  65. ncbi Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats
    Alison Elder
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Inhal Toxicol 19:1-12. 2007
    ..These findings show that environmental exposure concentrations of mixed traffic-related UFP/gas-phase emissions can affect the autonomic nervous system...
  66. ncbi Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT)
    Wojciech Zareba
    Cardiology Division, University of Rochester, Rochester, NY, USA
    Circulation 123:1061-72. 2011
    ....
  67. ncbi Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:181-4. 2007
    ..The aim of this study was to evaluate the risk of ventricular tachyarrhythmias and sudden death by BMI in patients after myocardial infarction with severe left ventricular dysfunction...
  68. ncbi Gender-related differences in electrocardiographic parameters and their association with cardiac events in patients after myocardial infarction
    Hanna Mieszczanska
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 101:20-4. 2008
    ..ST-segment elevation in anterior leads is a significant predictor of events in women, whereas ST depression in lateral leads is a significant predictor in men...
  69. ncbi QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Am Coll Cardiol 44:1481-7. 2004
    ....
  70. ncbi Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  71. ncbi Risk factors for recurrent heart failure events in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Edward Sze
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 21:1217-23. 2010
    ..Risk Factors for Recurrent Heart Failure...
  72. ncbi Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with atrial fibrillation
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Heart Rhythm 3:631-7. 2006
    ..Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited...
  73. ncbi Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome)
    Li Ning
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 8:246-50. 2003
    ..This study investigated the molecular pathology of a family with clinical evidence of JLNS...
  74. ncbi Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Atherosclerosis 187:191-7. 2006
    ..023). We conclude that in non-diabetic postinfarction patients, elevated HDL is predictive of risk of recurrent coronary events within a subgroup of patients characterized by simultaneous elevations in serum CRP and total cholesterol...
  75. ncbi Effectiveness of the implantable cardioverter defibrillator in blacks versus whites (from MADIT-II)
    Gabriel Vorobiof
    Heart Research Follow-up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:1383-6. 2006
    ..In conclusion, ICD therapy in MADIT-II was associated with a reduction in total mortality, cardiac death, and sudden cardiac death in whites but not in blacks...
  76. ncbi Comparison of prognostic significance of amino-terminal pro-brain natriuretic Peptide versus blood urea nitrogen for predicting events in patients hospitalized for heart failure
    Heather J Shenkman
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 99:1143-5. 2007
    ..BUN outperforms NT-pro-BNP in predicting mortality in patients with advanced HF. If admitting physicians are confident that the diagnosis of HF is correct, then admission NT-pro-BNP adds little to clinical management...
  77. ncbi Association between inflammatory markers, hemostatic, and lipid factors in postinfarction patients
    Tareq S Harb
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 91:1120-3. 2003
  78. ncbi Temporal complexity of repolarization and mortality in patients with implantable cardioverter defibrillators
    Juha S Perkiomaki
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 26:1931-6. 2003
    ..None of the repolarization variability parameters independently predicted death/appropriate ICD shocks. Increased temporal complexity of repolarization (RTmax-ApEn) independently predicts mortality in ICD patients...
  79. ncbi Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction
    Brian Morray
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 99:1100-5. 2007
    ..15, p = 0.01, respectively). In conclusion, our findings suggest that high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms are independently associated with a significantly earlier occurrence of coronary events...
  80. ncbi Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial
    Eric J Rashba
    Division of Cardiology, Department of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Room N3W77, Baltimore, MD 21201, USA
    Heart Rhythm 3:281-6. 2006
    ..The recent expansion of indications for prophylactic implantable cardioverter-defibrillator (ICD) placement in subjects with nonischemic dilated cardiomyopathy has raised concerns about the cost-effectiveness of this therapy...
  81. ncbi Serum glucose and triglyceride determine high-risk subgroups in non-diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Atherosclerosis 183:293-300. 2005
    ..Finding different within-subgroup predictors of risk underscores the notion of context-dependent risk, an observation that may be relevant for determining optimal use of emerging risk factors...
  82. ncbi Factors associated with ventricular inducibility in the MADIT-II study population
    Henry W Sesselberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Cardiol 91:1002-4, A7. 2003
  83. ncbi Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction
    Tareq S Harb
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 89:216-21. 2002
  84. ncbi Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 105:794-9. 2002
    ..We investigated the clinical features and prognostic implications of mutations involving pore and nonpore regions of the HERG channel in the LQT2 form of this disorder...
  85. ncbi Relation of body mass index to sudden cardiac death and the benefit of implantable cardioverter-defibrillator in patients with left ventricular dysfunction after healing of myocardial infarction
    Bonnie Choy
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:581-6. 2010
    ..In conclusion, our findings suggest an independent inverse association between BMI values and risk of all-cause mortality and SCD in patients after myocardial infarction with left ventricular dysfunction enrolled in the MADIT-II trial...
  86. ncbi Sudden cardiac death without structural heart disease: update on the long QT and Brugada syndromes
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Curr Cardiol Rep 7:349-56. 2005
    ..In patients identified as high risk for arrhythmic mortality, the implantable cardioverter defibrillator is the most effective treatment and has been shown to provide near-complete protection during long-term follow-up...
  87. ncbi Antipsychotic drugs and QT interval prolongation
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Psychiatr Q 74:291-306. 2003
    ..41 sec), borderline QTc (QTC = 0.42-0.44 sec), and prolonged QTc (0.45 sec) is being proposed to improve the safety of administering antipsychotic drugs and to decrease the risk of drug-related sudden death in psychiatric patients...
  88. ncbi Temporal aspects of improved survival with the implanted defibrillator (MADIT-II)
    Arthur J Moss
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 94:312-5. 2004
    ..In the early period, the rate of nonsudden cardiac death was significantly higher in the ICD group than in the conventional therapy group (p = 0.003). Rates of late nonsudden cardiac death were similar in the 2 treatment arms (p = 0.11)...
  89. ncbi Time dependence of life-threatening ventricular tachyarrhythmias after coronary revascularization in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 7:1421-7. 2010
    ..Coronary revascularization (CR) may confer electrical stability in patients with ischemic cardiomyopathy. However, data regarding the effect of CR on the development of ventricular tachyarrhythmias in this population are limited...
  90. ncbi Implantable cardioverter defibrillator therapy in postinfarction patients
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Cardiol 19:619-24. 2004
    ..This paper aims to provide an overview of the current state of knowledge regarding ICD therapy in postinfarction patients...
  91. ncbi Role of implantable cardioverter defibrillator therapy in patients with long QT syndrome
    James P Daubert
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am Heart J 153:53-8. 2007
    ..1980;303:322-4) as a treatment to prevent sudden cardiac death. Consequently, implanted cardioverter-defibrillator therapy deserves serious consideration as an important therapy for LQTS...
  92. ncbi Prognostic significance of fragmented QRS complex for predicting the risk of recurrent cardiac events in patients with Q-wave myocardial infarction
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 100:583-6. 2007
    ..However, among patients with resolved Q waves, fragmented QRS was associated with increased risk of cardiac events. Fragmented QRS complex should not be neglected in patients with transient Q waves after myocardial infarction...
  93. ncbi Investigating the effect of sotalol on the repolarization intervals in healthy young individuals
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester, Rochester, NY, USA
    J Electrocardiol 41:595-602. 2008
    ..In a group of healthy individuals exposed to sotalol, we compared their drug-induced changes to the drug-induced prolongations of the QTc, QTc apex and T-peak to T-end intervals...
  94. ncbi Baseline values and sotalol-induced changes of ventricular repolarization duration, heterogeneity, and instability in patients with a history of drug-induced torsades de pointes
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Clin Pharmacol 49:6-16. 2009
    ....
  95. ncbi QT interval: how to measure it and what is "normal"
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:333-6. 2006
  96. ncbi Clinical course and implantable cardioverter defibrillator therapy in postinfarction women with severe left ventricular dysfunction
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Cardiovasc Electrophysiol 16:1265-70. 2005
    ..The aim of this study was to evaluate the risk of cardiac events and effects of ICD therapy in women as compared to men enrolled in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II)...
  97. ncbi Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:67-83. 2005
    ..However, data on the benefit and cost-effectiveness of device therapy in high-risk patients with inherited cardiac disorders are limited...
  98. ncbi Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter defibrillator (WCD)
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:353-67. 2010
    ..Additionally, data are reported on the clinical experience with the WCD based on 354 patients from Germany hospitalized between 2000 and 2008 who wore the WCD for a mean of 3 months...
  99. ncbi Clinical covariates of abnormal heart rate turbulence in coronary patients
    Iwona Cygankiewicz
    Institute of Cardiology, Medical University of Lodz, Poland
    Ann Noninvasive Electrocardiol 8:289-95. 2003
    ..Advanced age, prior myocardial infarction and left ventricular dysfunction are key factors influencing values of HRT parameters...
  100. ncbi Analyses of dynamic beat-to-beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of torsades de pointes during QT prolongation caused by sotalol
    Anthony A Fossa
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Ann Noninvasive Electrocardiol 12:338-48. 2007
    ..We examined whether analyses of sequential beat-to-beat QT and TQ interval measures can be used to quantify ECG restitution changes under normal sinus rhythm...
  101. ncbi Impaired T-amplitude adaptation to heart rate characterizes I(Kr) inhibition in the congenital and acquired forms of the long QT syndrome
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:1299-305. 2007
    ..In the search for alternative markers, we investigated the T-amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol-induced QT prolongation...