Wojciech Zareba

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Genotype-specific ECG patterns in long QT syndrome
    Wojciech Zareba
    Department of Medicine, Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Electrocardiol 39:S101-6. 2006
  2. pmc Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:941-50. 2011
  3. ncbi request reprint Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 13:287-94. 2008
  4. ncbi request reprint Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
  5. pmc Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
  6. pmc Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1657-64. 2010
  7. pmc Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
  8. pmc Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
    Jason Costa
    Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    Heart Rhythm 9:892-8. 2012
  9. doi request reprint Applicability of a risk score for prediction of the long-term (8-year) benefit of the implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 59:2075-9. 2012
  10. ncbi request reprint Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 28:548-54. 2008

Collaborators

Detail Information

Publications136 found, 100 shown here

  1. ncbi request reprint Genotype-specific ECG patterns in long QT syndrome
    Wojciech Zareba
    Department of Medicine, Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Electrocardiol 39:S101-6. 2006
    ..In conclusion, comprehensive analyses of static and dynamic features of repolarization provide unique opportunity to understand electrophysiology of cardiac repolarization...
  2. pmc Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:941-50. 2011
    ..We aimed to identify risk factors for recurrent syncope in children and adolescents with congenital long QT syndrome (LQTS)...
  3. ncbi request reprint Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 13:287-94. 2008
    ..We hypothesized that several genetic atherosclerotic single nucleotide polymorphisms (SNPs) may exert an additive effect on the earlier occurrence of coronary atherothrombotic disease after adjustment for clinical factors...
  4. ncbi request reprint Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
    ....
  5. pmc Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
    ..We compared the clinical course of Caucasian and Japanese long QT type-1 (LQT1) patients who were matched for mutations in the KCNQ1 gene...
  6. pmc Cholesteryl ester transfer protein polymorphism (TaqIB) associates with risk in postinfarction patients with high C-reactive protein and high-density lipoprotein cholesterol levels
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 30:1657-64. 2010
    ..To investigate the roles of inflammation and a cholesteryl ester transfer protein (CETP) polymorphism potentially related to recent findings demonstrating coronary risk with increasing high-density lipoprotein cholesterol (HDL-C) level...
  7. pmc Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
    ..However, limited data exist regarding the efficacy and limitations of this form of medical management within high-risk subsets of these populations...
  8. pmc Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome
    Jason Costa
    Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    Heart Rhythm 9:892-8. 2012
    ..Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events...
  9. doi request reprint Applicability of a risk score for prediction of the long-term (8-year) benefit of the implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 59:2075-9. 2012
    ..The present study was designed to explore the 8-year survival benefit of a nonresynchronization implantable cardioverter-defibrillator (ICD) according to a simple risk stratification score...
  10. ncbi request reprint Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 28:548-54. 2008
    ..The aim of this study was to assess such risk as a function of 37 atherosclerosis-associated genetic polymorphisms and 17 blood marker variables...
  11. pmc Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
    ..However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified...
  12. ncbi request reprint Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 110:3760-5. 2004
    ..This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD...
  13. doi request reprint QRS axis and the benefit of cardiac resynchronization therapy in patients with mildly symptomatic heart failure enrolled in MADIT-CRT
    Andrew Brenyo
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 24:442-8. 2013
    ..The presence of QRS axis deviation may influence response to CRT-D. The objective of this study was to determine whether QRS axis deviation will be associated with differential benefit from CRT-D...
  14. pmc Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations
    Jamie Mullally
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 10:378-82. 2013
    ..Patients with long QT syndrome (LQTS) who harbor multiple mutations (i.e. ≥ 2 mutations in ≥ 1 LQTS-susceptibility gene) may experience increased risk for life-threatening cardiac events...
  15. pmc Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circ Cardiovasc Genet 4:491-9. 2011
    ..The present study was designed to assess the clinical course of individuals who are found negative for the LQTS-causing mutation in their families...
  16. ncbi request reprint Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 113:2810-7. 2006
    ..Implantable cardioverter-defibrillator (ICD) therapy may be associated with an increased risk for heart failure (HF). The present study evaluated the frequency, causes, and consequences of HF after ICD implantation...
  17. doi request reprint Lp(a) and risk of recurrent cardiac events in obese postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Obesity (Silver Spring) 16:2717-22. 2008
    ..These findings suggest close monitoring and consideration of weight reduction for obese postinfarction patients with elevated Lp(a) levels...
  18. pmc Trigger-specific risk factors and response to therapy in long QT syndrome type 2
    James A Kim
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 7:1797-805. 2010
    ..Cardiac events in patients with long QT syndrome type 2 (LQT2) are predominately associated with sudden arousal. However, exercise-induced events also occur in this population...
  19. ncbi request reprint Improved survival associated with prophylactic implantable defibrillators in elderly patients with prior myocardial infarction and depressed ventricular function: a MADIT-II substudy
    David T Huang
    Cardiology Unit, The Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:833-8. 2007
    ..Effective primary prevention of sudden cardiac death with implantable cardioverter defibrillators is well demonstrated in patients with coronary disease and depressed ventricular function...
  20. pmc Mutation-specific risk in two genetic forms of type 3 long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:210-3. 2010
    ..The findings highlight the importance of knowing the specific mutation in risk stratification of patients with long QT syndrome type 3...
  21. doi request reprint Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:2416-23. 2011
    ..We aimed to evaluate the relationship between echocardiographic response to cardiac resynchronization therapy (CRT) and the risk of subsequent ventricular tachyarrhythmias (VTAs)...
  22. pmc Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome
    Dimitry Migdalovich
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:1537-43. 2011
    ..We hypothesized that data regarding the location of the disease-causing mutation in the KCNH2 channel may affect gender-specific risk in LQT2...
  23. pmc Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
    ..We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients...
  24. doi request reprint Long-QT syndrome after age 40
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2192-201. 2008
    ....
  25. doi request reprint Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:395-400. 2009
    ..There are limited data on the effect of the primary types of HF medications, angiotensin converting enzyme inhibitors (ACE-I), and beta-blockers on HF progression in ICD-treated patients...
  26. pmc Physicians' knowledge and attitudes regarding implantable cardioverter-defibrillators
    Saadia Sherazi
    Department of Medicine, Unity Health System, Rochester, NY 14626, USA
    Cardiol J 17:267-73. 2010
    ..Information is limited regarding the knowledge and attitudes of physicians typically involved in the referral of patients for implantable cardioverter-defibrillator (ICD) implantation...
  27. doi request reprint Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators
    Iwona Cygankiewicz
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 6:468-73. 2009
    ..Data on long-term follow-up and factors influencing mortality in implantable cardioverter-defibrillator (ICD) recipients are limited...
  28. pmc Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 8:1207-13. 2011
    ..A prolonged QT interval corrected for heart rate (QTc) is a major risk factor in patients with long QT syndrome (LQTS). However, heart rate-related risk in this genetic disorder differs among genotypes...
  29. doi request reprint Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
    ..Our results indicate that genotype and biophysical phenotype analysis may be useful for risk stratification of LQT1 patients and suggest that slow channel activation is associated with an increased risk of cardiac events...
  30. pmc Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
    ..We evaluated the effect of location, coding type, and biophysical function of KCNQ1 mutations on the clinical phenotype of this disorder...
  31. ncbi request reprint Long QT syndrome and pregnancy
    Rahul Seth
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 49:1092-8. 2007
    ..This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years...
  32. ncbi request reprint Modulating effects of age and gender on the clinical course of long QT syndrome by genotype
    Wojciech Zareba
    Department of Medicine, Heart Research Follow Up Program, Medical Center, University of Rochester School of Medicine, Rochester, NY 14642 8653, USA
    J Am Coll Cardiol 42:103-9. 2003
    ..We aimed to determine whether long QT syndrome (LQTS) genotype has a differential effect on clinical course of disease in male and female children and adults after adjustment for QTc duration...
  33. ncbi request reprint The effect of intermittent atrial tachyarrhythmia on heart failure or death in cardiac resynchronization therapy with defibrillator versus implantable cardioverter-defibrillator patients: a MADIT-CRT substudy (Multicenter Automatic Defibrillator Implantat
    Anne Christine Ruwald
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark Electronic address
    J Am Coll Cardiol 63:1190-7. 2014
    ....
  34. ncbi request reprint A metric for evaluating the cardiac response to resynchronization therapy
    Yidi Ge
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, New York
    Am J Cardiol 113:1371-7. 2014
    ..In conclusion, approximately 90% of CRT-D-treated patients in MADIT-CRT had a significant and meaningful reduction in LVESV, and these LVESV responders had reduced rates of cardiac events during long-term follow-up...
  35. doi request reprint In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models
    Ryan Hoefen
    Division of Cardiology, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Am Coll Cardiol 60:2182-91. 2012
    ..The study was designed to assess the ability of computer-simulated electrocardiography parameters to predict clinical outcomes and to risk-stratify patients with long QT syndrome type 1 (LQT1)...
  36. doi request reprint Effect of defibrillation threshold testing on heart failure hospitalization or death in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT)
    Mehmet K Aktas
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 10:193-9. 2013
    ..Defibrillation threshold (DFT) testing is commonly practiced at the time of implantable cardioverter-defibrillator (ICD) implant. The clinical consequence of ICD shocks delivered during DFT testing is unknown...
  37. doi request reprint Cardiac-resynchronization therapy for the prevention of heart-failure events
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    N Engl J Med 361:1329-38. 2009
    ....
  38. ncbi request reprint Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 96:177-82. 2005
    ....
  39. doi request reprint Inappropriate implantable cardioverter-defibrillator shocks in MADIT II: frequency, mechanisms, predictors, and survival impact
    James P Daubert
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 51:1357-65. 2008
    ..This study sought to identify the incidence and outcome related to inappropriate implantable cardioverter-defibrillator (ICD) shocks, that is, those for nonventricular arrhythmias...
  40. ncbi request reprint Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:34-43. 2005
    ..30), and prolonged intraventricular conduction (QRS duration>or=130 ms)...
  41. doi request reprint Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome
    Andrew Mathias
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 10:720-5. 2013
    ..Individual corrected QT interval (QTc) may vary widely among carriers of the same long QT syndrome (LQTS) mutation. Currently, neither the mechanism nor the implications of this variable penetrance are well understood...
  42. doi request reprint Brain natriuretic peptide and cardiac resynchronization therapy in patients with mildly symptomatic heart failure
    Andrew Brenyo
    Division of Cardiology, and the Department of Biostatistics, University of Rochester Medical Center, Rochester, NY and the Cardiovascular Division, Brigham and Women s Hospital, Boston, MA
    Circ Heart Fail 6:998-1004. 2013
    ..There are limited data on the prognostic implications of brain natriuretic peptide (BNP) assessment in patients with mildly symptomatic heart failure (HF) who receive cardiac resynchronization therapy with a defibrillator (CRT-D)...
  43. doi request reprint Reduction in inappropriate therapy and mortality through ICD programming
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 0653, USA
    N Engl J Med 367:2275-83. 2012
    ..The implantable cardioverter-defibrillator (ICD) is highly effective in reducing mortality among patients at risk for fatal arrhythmias, but inappropriate ICD activations are frequent, with potential adverse effects...
  44. doi request reprint Effect of cardiac resynchronization therapy on the risk of first and recurrent ventricular tachyarrhythmic events in MADIT-CRT
    Gregory Ouellet
    Cardiology Division, Department of Medicine, University of Rochester, Rochester, New York 14642, USA
    J Am Coll Cardiol 60:1809-16. 2012
    ..This study aimed to evaluate the effect of cardiac resynchronization therapy with a defibrillator (CRT-D) on the risks of first and recurrent ventricular tachyarrhythmic events (VTEs) in the MADIT-CRT...
  45. pmc Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death
    Larisa G Tereshchenko
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circ Arrhythm Electrophysiol 5:719-27. 2012
    ..The goal of the present study was to determine the predictive value of beat-to-beat QT variability in heart failure patients across the continuum of left ventricular dysfunction...
  46. doi request reprint Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome
    Ilan Goldenberg
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 9:49-56. 2012
    ..Arrhythmic events in long-QT syndrome type 1 (LQT1) may be associated with exercise, acute arousal, or rest/sleep...
  47. doi request reprint Gender differences and risk of ventricular tachycardia or ventricular fibrillation
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Heart Rhythm 6:180-6. 2009
    ..The role of repolarization duration and stability in arrhythmogenesis in men and women with structural heart disease has not been explored...
  48. ncbi request reprint Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome
    Wojciech Zareba
    Cardiology Unit of the Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 14:1149-53. 2003
    ..The aim of this study was to determine whether there is an association between the location of mutations in the KCNQ1 gene and cardiac events in LQT1 patients...
  49. pmc T-wave morphology abnormalities in benign, potent, and arrhythmogenic I(kr) inhibition
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 8:1036-43. 2011
    ..There is a consensus on the limited value of the QTc interval prolongation as a surrogate marker of drug cardiotoxicity and as a risk stratifier in inherited long QT syndrome (LQTS) patients...
  50. doi request reprint Dyssynchrony and the risk of ventricular arrhythmias
    Valentina Kutyifa
    University of Rochester Medical Center, Rochester, New York, USA
    JACC Cardiovasc Imaging 6:432-44. 2013
    ....
  51. ncbi request reprint Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome
    Jenny B Hobbs
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    JAMA 296:1249-54. 2006
    ..Risk factors specific for aborted cardiac arrest and sudden cardiac death have not been investigated...
  52. doi request reprint QRS fragmentation and the risk of sudden cardiac death in MADIT II
    Andrew Brenyo
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 23:1343-8. 2012
    ..Its prognostic value for sudden cardiac death (SCD) and ventricular arrhythmias in ischemic cardiomyopathy (ICM) remains unknown...
  53. doi request reprint Effect of elapsed time from coronary revascularization to implantation of a cardioverter defibrillator on long-term survival in the MADIT-II trial
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 22:1237-42. 2011
    ..This study was designed to evaluate the effect of elapsed time from CR on long-term mortality and arrhythmic risk among patients who receive an implantable cardioverter defibrillator (ICD)...
  54. pmc Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome
    Alon Barsheshet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Circulation 125:1988-96. 2012
    ..We evaluated a possible association between ion channel response to β-adrenergic stimulation and clinical response to β-blocker therapy according to mutation location...
  55. doi request reprint Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:212-8. 2011
    ..Limited data regarding the effect of right ventricular pacing (RVP) on long-term survival following implantable cardioverter-defibrillator (ICD) implantation are available...
  56. doi request reprint Time-dependent benefit of preventive cardiac resynchronization therapy after myocardial infarction
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1614-21. 2011
    ..The present study was designed to evaluate the relationship between elapsed time from MI and the benefit of preventive CRT-D therapy in patients with ischaemic cardiomyopathy (ICM)...
  57. ncbi request reprint Glycoprotein Ibalpha polymorphism T145M, elevated lipoprotein-associated phospholipase A2, and hypertriglyceridemia predict risk for recurrent coronary events in diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Diabetes 56:1429-35. 2007
    ....
  58. ncbi request reprint Polymorphism in the cholesteryl ester transfer protein gene and the risk of early onset myocardial infarction among cigarette smokers
    Ilan Goldenberg
    Cardiology Units of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 12:364-74. 2007
    ..We hypothesized that susceptibility to early onset myocardial infarction (MI) among cigarette smokers may be related to the presence of TaqIB polymorphism in the CETP gene...
  59. doi request reprint Risk of fatal arrhythmic events in long QT syndrome patients after syncope
    Christian Jons
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 55:783-8. 2010
    ..The aim of this study was to identify risk factors for fatal arrhythmias in long QT syndrome (LQTS) patients presenting with syncope...
  60. ncbi request reprint Repolarization variability in the risk stratification of MADIT II patients
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Europace 9:717-23. 2007
    ..0; 95% CI; 1.2-3.5; P=0.01). On the basis of the comprehensive testing, TWV value >59 microV was found predictive for arrhythmic events in MADIT II population...
  61. ncbi request reprint High lipoprotein-associated phospholipase A2 is a risk factor for recurrent coronary events in postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Clin Chem 52:1331-8. 2006
    ....
  62. ncbi request reprint Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 48:1047-52. 2006
    ..We evaluated the incremental prognostic information provided by multiple corrected QT (QTc) measurements on serial electrocardiograms (ECGs) in patients with the inherited long QT syndrome (LQTS)...
  63. doi request reprint Clinical significance of ventricular tachyarrhythmias in patients treated with CRT-D
    Valentina Kutyifa
    University of Rochester Medical Center, Rochester, New York 14642, USA roehester edu
    Heart Rhythm 10:943-50. 2013
    ..Data on the outcome of cardiac resynchronization therapy with defibrillator (CRT-D) in patients developing ventricular arrhythmias are limited...
  64. ncbi request reprint Improved outcome with preventive cardiac resynchronization therapy in the elderly: a MADIT-CRT substudy
    Justin Penn
    Department of Internal Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 22:892-7. 2011
    ..Elderly patients comprise a large portion of patients with heart failure (HF). Limited data exist on the effectiveness of cardiac resynchronization therapy with defibrillator (CRT-D) in patients with mild HF symptoms in this population...
  65. ncbi request reprint Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats
    Alison Elder
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Inhal Toxicol 19:1-12. 2007
    ..These findings show that environmental exposure concentrations of mixed traffic-related UFP/gas-phase emissions can affect the autonomic nervous system...
  66. doi request reprint Long-term benefit of primary prevention with an implantable cardioverter-defibrillator: an extended 8-year follow-up study of the Multicenter Automatic Defibrillator Implantation Trial II
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 122:1265-71. 2010
    ..5 years. However, currently there are no data on the long-term efficacy of primary defibrillator therapy...
  67. ncbi request reprint Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval
    Jean Philippe Couderc
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, New York
    Heart Rhythm 3:1460-6. 2006
    ..At least 50% of LQT2 carriers have borderline QTc (0.42-0.47 s), and they present a diagnostic difficulty to clinicians evaluating patients suspected of having long QT syndrome (LQTS)...
  68. pmc Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Ritesh Dhar
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Heart Rhythm 5:807-13. 2008
    ..There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs)...
  69. ncbi request reprint Congenital long QT syndrome: considerations for primary care physicians
    Ethan Levine
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 8679, USA
    Cleve Clin J Med 75:591-600. 2008
    ..We can now classify some types of congenital long QT syndrome according to their genetic mutations and their triggers, such as exercise, rest, or startle...
  70. doi request reprint Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 51:288-96. 2008
    ..The study was designed to develop a simple risk stratification score for primary therapy with an implantable cardioverter-defibrillator (ICD)...
  71. doi request reprint Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1622-30. 2011
    ..We evaluated the outcome of patients enrolled in MADIT-CRT by ischaemic and non-ischaemic aetiology of cardiomyopathy (ICM and non-ICM, respectively)...
  72. pmc Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals
    Ilan Goldenberg
    Cardiology Division of Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:51-9. 2011
    ..This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals...
  73. pmc Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome
    Gregory Ouellet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Cardiol 105:87-9. 2010
    ..In conclusion, diabetes and prolonged QTc interval contributed independent mortality risks in adult patients with LQTS, with no interaction between these 2 risk factors...
  74. pmc Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease
    Edward Sze
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 13:327-31. 2008
    ....
  75. ncbi request reprint Ventricular arrhythmia storms in postinfarction patients with implantable defibrillators for primary prevention indications: a MADIT-II substudy
    Henry W Sesselberg
    Department of Medicine, Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Heart Rhythm 4:1395-402. 2007
    ..Much of prognostic implications of ventricular arrhythmia storms remain unclear...
  76. doi request reprint Relation between renal function and response to cardiac resynchronization therapy in Multicenter Automatic Defibrillator Implantation Trial--Cardiac Resynchronization Therapy (MADIT-CRT)
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 7:1777-82. 2010
    ..Cardiorenal interactions have been shown to affect outcome in heart failure patients but were not related to response to cardiac resynchronization therapy (CRT)...
  77. ncbi request reprint Polymorphism in the angiotensinogen gene, hypertension, and ethnic differences in the risk of recurrent coronary events
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    Hypertension 48:693-9. 2006
    ..The presence of hypertension significantly augments the risk associated with this genetic mutation...
  78. ncbi request reprint Relations among renal function, risk of sudden cardiac death, and benefit of the implanted cardiac defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:485-90. 2006
    ..Defibrillator therapy was associated with a significant survival benefit among the study patients with mild to moderate or no renal disease, but no benefit was shown among patients with more advanced renal dysfunction...
  79. pmc Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  80. ncbi request reprint Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with atrial fibrillation
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Heart Rhythm 3:631-7. 2006
    ..Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited...
  81. doi request reprint Risk factors for recurrent heart failure events in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Edward Sze
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 21:1217-23. 2010
    ..Risk Factors for Recurrent Heart Failure...
  82. ncbi request reprint Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:181-4. 2007
    ..The aim of this study was to evaluate the risk of ventricular tachyarrhythmias and sudden death by BMI in patients after myocardial infarction with severe left ventricular dysfunction...
  83. doi request reprint Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT)
    Wojciech Zareba
    Cardiology Division, University of Rochester, Rochester, NY, USA
    Circulation 123:1061-72. 2011
    ....
  84. ncbi request reprint QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Am Coll Cardiol 44:1481-7. 2004
    ....
  85. pmc Gender-related differences in electrocardiographic parameters and their association with cardiac events in patients after myocardial infarction
    Hanna Mieszczanska
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 101:20-4. 2008
    ..ST-segment elevation in anterior leads is a significant predictor of events in women, whereas ST depression in lateral leads is a significant predictor in men...
  86. ncbi request reprint Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome)
    Li Ning
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 8:246-50. 2003
    ..This study investigated the molecular pathology of a family with clinical evidence of JLNS...
  87. ncbi request reprint Association between inflammatory markers, hemostatic, and lipid factors in postinfarction patients
    Tareq S Harb
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 91:1120-3. 2003
  88. ncbi request reprint Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Atherosclerosis 187:191-7. 2006
    ..023). We conclude that in non-diabetic postinfarction patients, elevated HDL is predictive of risk of recurrent coronary events within a subgroup of patients characterized by simultaneous elevations in serum CRP and total cholesterol...
  89. ncbi request reprint Temporal complexity of repolarization and mortality in patients with implantable cardioverter defibrillators
    Juha S Perkiomaki
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 26:1931-6. 2003
    ..None of the repolarization variability parameters independently predicted death/appropriate ICD shocks. Increased temporal complexity of repolarization (RTmax-ApEn) independently predicts mortality in ICD patients...
  90. ncbi request reprint Comparison of prognostic significance of amino-terminal pro-brain natriuretic Peptide versus blood urea nitrogen for predicting events in patients hospitalized for heart failure
    Heather J Shenkman
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 99:1143-5. 2007
    ..BUN outperforms NT-pro-BNP in predicting mortality in patients with advanced HF. If admitting physicians are confident that the diagnosis of HF is correct, then admission NT-pro-BNP adds little to clinical management...
  91. ncbi request reprint Effectiveness of the implantable cardioverter defibrillator in blacks versus whites (from MADIT-II)
    Gabriel Vorobiof
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:1383-6. 2006
    ..In conclusion, ICD therapy in MADIT-II was associated with a reduction in total mortality, cardiac death, and sudden cardiac death in whites but not in blacks...
  92. ncbi request reprint Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction
    Brian Morray
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 99:1100-5. 2007
    ..15, p = 0.01, respectively). In conclusion, our findings suggest that high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms are independently associated with a significantly earlier occurrence of coronary events...
  93. ncbi request reprint Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial
    Eric J Rashba
    Division of Cardiology, Department of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Room N3W77, Baltimore, MD 21201, USA
    Heart Rhythm 3:281-6. 2006
    ..The recent expansion of indications for prophylactic implantable cardioverter-defibrillator (ICD) placement in subjects with nonischemic dilated cardiomyopathy has raised concerns about the cost-effectiveness of this therapy...
  94. ncbi request reprint Factors associated with ventricular inducibility in the MADIT-II study population
    Henry W Sesselberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Cardiol 91:1002-4, A7. 2003
  95. ncbi request reprint Serum glucose and triglyceride determine high-risk subgroups in non-diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Atherosclerosis 183:293-300. 2005
    ..Finding different within-subgroup predictors of risk underscores the notion of context-dependent risk, an observation that may be relevant for determining optimal use of emerging risk factors...
  96. ncbi request reprint Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction
    Tareq S Harb
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 89:216-21. 2002
  97. ncbi request reprint Sudden cardiac death without structural heart disease: update on the long QT and Brugada syndromes
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Curr Cardiol Rep 7:349-56. 2005
    ..In patients identified as high risk for arrhythmic mortality, the implantable cardioverter defibrillator is the most effective treatment and has been shown to provide near-complete protection during long-term follow-up...
  98. ncbi request reprint Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:67-83. 2005
    ..However, data on the benefit and cost-effectiveness of device therapy in high-risk patients with inherited cardiac disorders are limited...
  99. ncbi request reprint Temporal aspects of improved survival with the implanted defibrillator (MADIT-II)
    Arthur J Moss
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 94:312-5. 2004
    ..In the early period, the rate of nonsudden cardiac death was significantly higher in the ICD group than in the conventional therapy group (p = 0.003). Rates of late nonsudden cardiac death were similar in the 2 treatment arms (p = 0.11)...
  100. ncbi request reprint Antipsychotic drugs and QT interval prolongation
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Psychiatr Q 74:291-306. 2003
    ..41 sec), borderline QTc (QTC = 0.42-0.44 sec), and prolonged QTc (0.45 sec) is being proposed to improve the safety of administering antipsychotic drugs and to decrease the risk of drug-related sudden death in psychiatric patients...
  101. ncbi request reprint Implantable cardioverter defibrillator therapy in postinfarction patients
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Cardiol 19:619-24. 2004
    ..This paper aims to provide an overview of the current state of knowledge regarding ICD therapy in postinfarction patients...