W Zareba

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Noninvasive risk stratification in postinfarction patients with severe left ventricular dysfunction and methodology of the MADIT II noninvasive electrocardiology substudy
    Wojciech Zareba
    Heart Research Follow Up Program, Cardiology Unit, University of Rochester, NY 14618, USA
    J Electrocardiol 36:101-8. 2003
  2. doi request reprint Long QT syndrome and short QT syndrome
    Wojciech Zareba
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Prog Cardiovasc Dis 51:264-78. 2008
  3. ncbi request reprint Modulating effects of age and gender on the clinical course of long QT syndrome by genotype
    Wojciech Zareba
    Department of Medicine, Heart Research Follow Up Program, Medical Center, University of Rochester School of Medicine, Rochester, NY 14642 8653, USA
    J Am Coll Cardiol 42:103-9. 2003
  4. ncbi request reprint Long QT syndrome in children
    W Zareba
    Department of Medicine, Heart Research, Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Electrocardiol 34:167-71. 2001
  5. pmc Cardiovascular effects of air pollution: what to measure in ECG?
    W Zareba
    Heart Research, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Environ Health Perspect 109:533-8. 2001
  6. ncbi request reprint Increased level of von Willebrand factor is significantly and independently associated with diabetes in postinfarction patients. THROMBO Investigators
    W Zareba
    Department of Medicine, University of Rochester Medical Center, NY 14642, USA
    Thromb Haemost 86:791-9. 2001
  7. ncbi request reprint Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
  8. pmc Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
  9. ncbi request reprint Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry
    E H Locati
    Department of Medicine, University of Rochester, NY, USA
    Circulation 97:2237-44. 1998
  10. doi request reprint Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:395-400. 2009

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Noninvasive risk stratification in postinfarction patients with severe left ventricular dysfunction and methodology of the MADIT II noninvasive electrocardiology substudy
    Wojciech Zareba
    Heart Research Follow Up Program, Cardiology Unit, University of Rochester, NY 14618, USA
    J Electrocardiol 36:101-8. 2003
    ....
  2. doi request reprint Long QT syndrome and short QT syndrome
    Wojciech Zareba
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Prog Cardiovasc Dis 51:264-78. 2008
    ..beta-Blockers remain the therapy of choice for LQTS, but implantation of a cardioverter defibrillator is increasingly used in high-risk patients...
  3. ncbi request reprint Modulating effects of age and gender on the clinical course of long QT syndrome by genotype
    Wojciech Zareba
    Department of Medicine, Heart Research Follow Up Program, Medical Center, University of Rochester School of Medicine, Rochester, NY 14642 8653, USA
    J Am Coll Cardiol 42:103-9. 2003
    ..We aimed to determine whether long QT syndrome (LQTS) genotype has a differential effect on clinical course of disease in male and female children and adults after adjustment for QTc duration...
  4. ncbi request reprint Long QT syndrome in children
    W Zareba
    Department of Medicine, Heart Research, Cardiology Unit, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Electrocardiol 34:167-71. 2001
    ..In conclusion, there is substantial age, gender, and genotype effect on the clinical course of LQTS children indicating the need of adjusting for those factors in clinical practice...
  5. pmc Cardiovascular effects of air pollution: what to measure in ECG?
    W Zareba
    Heart Research, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Environ Health Perspect 109:533-8. 2001
    ....
  6. ncbi request reprint Increased level of von Willebrand factor is significantly and independently associated with diabetes in postinfarction patients. THROMBO Investigators
    W Zareba
    Department of Medicine, University of Rochester Medical Center, NY 14642, USA
    Thromb Haemost 86:791-9. 2001
    ....
  7. ncbi request reprint Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
    ....
  8. pmc Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
    ..We compared the clinical course of Caucasian and Japanese long QT type-1 (LQT1) patients who were matched for mutations in the KCNQ1 gene...
  9. ncbi request reprint Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry
    E H Locati
    Department of Medicine, University of Rochester, NY, USA
    Circulation 97:2237-44. 1998
    ..Our objectives were to evaluate age- and sex-related differences in events among LQTS patients referred to the LQTS International Registry...
  10. doi request reprint Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:395-400. 2009
    ..There are limited data on the effect of the primary types of HF medications, angiotensin converting enzyme inhibitors (ACE-I), and beta-blockers on HF progression in ICD-treated patients...
  11. ncbi request reprint Fractal correlation properties of heart rate dynamics and adverse events in patients with implantable cardioverter-defibrillators
    J S Perkiömäki
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Cardiol 88:17-22. 2001
    ..10 decrease in alpha(1) (p = 0.020). In conclusion, alpha(1) obtained from a 10-minute electrocardiographic recording yields important prognostic information about the risk of AEs in patients with implantable cardioverter-defibrillators...
  12. ncbi request reprint QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Am Coll Cardiol 44:1481-7. 2004
    ....
  13. pmc Physicians' knowledge and attitudes regarding implantable cardioverter-defibrillators
    Saadia Sherazi
    Department of Medicine, Unity Health System, Rochester, NY 14626, USA
    Cardiol J 17:267-73. 2010
    ..Information is limited regarding the knowledge and attitudes of physicians typically involved in the referral of patients for implantable cardioverter-defibrillator (ICD) implantation...
  14. pmc Mutation-specific risk in two genetic forms of type 3 long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:210-3. 2010
    ..The findings highlight the importance of knowing the specific mutation in risk stratification of patients with long QT syndrome type 3...
  15. ncbi request reprint Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats
    Alison Elder
    Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
    Inhal Toxicol 19:1-12. 2007
    ..These findings show that environmental exposure concentrations of mixed traffic-related UFP/gas-phase emissions can affect the autonomic nervous system...
  16. ncbi request reprint Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome
    A J Moss
    Department of Medicine, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Circulation 101:616-23. 2000
    ..beta-blockers are routinely prescribed in congenital long-QT syndrome (LQTS), but the effectiveness and limitations of beta-blockers in this disorder have not been evaluated...
  17. ncbi request reprint Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome
    A J Moss
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York, USA
    Am J Cardiol 84:876-9. 1999
    ..The clinical profile and genotype findings of patients with LQTS who experience cardiac events related to acute auditory stimuli are quite different from those who experience events accompanying swimming activities...
  18. doi request reprint Gender differences and risk of ventricular tachycardia or ventricular fibrillation
    Mark C Haigney
    Division of Cardiology, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Heart Rhythm 6:180-6. 2009
    ..The role of repolarization duration and stability in arrhythmogenesis in men and women with structural heart disease has not been explored...
  19. ncbi request reprint Beat-to-Beat repolarization variability in LQTS patients with the SCN5A sodium channel gene mutation
    J P Couderc
    Department of Medicine University of Rochester Medical Center, New York 14642, USA
    Pacing Clin Electrophysiol 22:1581-92. 1999
    ..Wavelet-detected repolarization variability contributes to phenotypic identification of SCN5A carriers, with more pronounced beat-to-beat variability in repolarization amplitude than in time...
  20. ncbi request reprint Survival benefit with an implanted defibrillator in relation to mortality risk in chronic coronary heart disease
    A J Moss
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 88:516-20. 2001
    ..In patients with chronic coronary heart disease, the magnitude of the survival benefit from the implanted defibrillator is directly related to the severity of cardiac dysfunction and its associated mortality risk...
  21. ncbi request reprint Long QT syndrome and pregnancy
    Rahul Seth
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 49:1092-8. 2007
    ..This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years...
  22. ncbi request reprint Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:181-4. 2007
    ..The aim of this study was to evaluate the risk of ventricular tachyarrhythmias and sudden death by BMI in patients after myocardial infarction with severe left ventricular dysfunction...
  23. ncbi request reprint Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc interval
    Jean Philippe Couderc
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, New York
    Heart Rhythm 3:1460-6. 2006
    ..At least 50% of LQT2 carriers have borderline QTc (0.42-0.47 s), and they present a diagnostic difficulty to clinicians evaluating patients suspected of having long QT syndrome (LQTS)...
  24. pmc Gender-related differences in electrocardiographic parameters and their association with cardiac events in patients after myocardial infarction
    Hanna Mieszczanska
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 101:20-4. 2008
    ..ST-segment elevation in anterior leads is a significant predictor of events in women, whereas ST depression in lateral leads is a significant predictor in men...
  25. doi request reprint Prognostic value of QT/RR slope in predicting mortality in patients with congestive heart failure
    Iwona Cygankiewicz
    Institut Català Ciències Cardiovasculars, Barcelona, Spain and Heart Research Follow up Program, University of Rochester, Rochester New York, USA
    J Cardiovasc Electrophysiol 19:1066-72. 2008
    ..We aimed to evaluate the prognostic value of QT/RR slope in predicting total mortality (TM) and sudden death (SD) in patients with congestive heart failure (CHF)...
  26. ncbi request reprint Novel compound heterozygous mutations in the KCNQ1 gene associated with autosomal recessive long QT syndrome (Jervell and Lange-Nielsen syndrome)
    Li Ning
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 8:246-50. 2003
    ..This study investigated the molecular pathology of a family with clinical evidence of JLNS...
  27. doi request reprint Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
    ..We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients...
  28. ncbi request reprint Heart rate variability in patients with congenital long QT syndrome
    J S Perkiömäki
    Department of Medicine, University of Rochester Medical Center, Box 653, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 6:298-304. 2001
    ..Despite this well-documented adrenergic component, the data about autonomic modulation of the heart rate in LQTS, as described by heart rate variability (HRV) analysis, are very limited...
  29. ncbi request reprint Association between inflammatory markers, hemostatic, and lipid factors in postinfarction patients
    Tareq S Harb
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 91:1120-3. 2003
  30. ncbi request reprint Effectiveness of the implantable cardioverter defibrillator in blacks versus whites (from MADIT-II)
    Gabriel Vorobiof
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:1383-6. 2006
    ..In conclusion, ICD therapy in MADIT-II was associated with a reduction in total mortality, cardiac death, and sudden cardiac death in whites but not in blacks...
  31. ncbi request reprint Temporal complexity of repolarization and mortality in patients with implantable cardioverter defibrillators
    Juha S Perkiomaki
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 26:1931-6. 2003
    ..None of the repolarization variability parameters independently predicted death/appropriate ICD shocks. Increased temporal complexity of repolarization (RTmax-ApEn) independently predicts mortality in ICD patients...
  32. ncbi request reprint Elevated HDL is a risk factor for recurrent coronary events in a subgroup of non-diabetic postinfarction patients with hypercholesterolemia and inflammation
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Atherosclerosis 187:191-7. 2006
    ..023). We conclude that in non-diabetic postinfarction patients, elevated HDL is predictive of risk of recurrent coronary events within a subgroup of patients characterized by simultaneous elevations in serum CRP and total cholesterol...
  33. ncbi request reprint Comparison of prognostic significance of amino-terminal pro-brain natriuretic Peptide versus blood urea nitrogen for predicting events in patients hospitalized for heart failure
    Heather J Shenkman
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 99:1143-5. 2007
    ..BUN outperforms NT-pro-BNP in predicting mortality in patients with advanced HF. If admitting physicians are confident that the diagnosis of HF is correct, then admission NT-pro-BNP adds little to clinical management...
  34. pmc Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Ritesh Dhar
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Heart Rhythm 5:807-13. 2008
    ..There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs)...
  35. ncbi request reprint Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction
    Brian Morray
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 99:1100-5. 2007
    ..15, p = 0.01, respectively). In conclusion, our findings suggest that high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms are independently associated with a significantly earlier occurrence of coronary events...
  36. ncbi request reprint Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome
    Jenny B Hobbs
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    JAMA 296:1249-54. 2006
    ..Risk factors specific for aborted cardiac arrest and sudden cardiac death have not been investigated...
  37. ncbi request reprint Serum glucose and triglyceride determine high-risk subgroups in non-diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Atherosclerosis 183:293-300. 2005
    ..Finding different within-subgroup predictors of risk underscores the notion of context-dependent risk, an observation that may be relevant for determining optimal use of emerging risk factors...
  38. doi request reprint Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  39. ncbi request reprint Congenital long QT syndrome: considerations for primary care physicians
    Ethan Levine
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642 8679, USA
    Cleve Clin J Med 75:591-600. 2008
    ..We can now classify some types of congenital long QT syndrome according to their genetic mutations and their triggers, such as exercise, rest, or startle...
  40. pmc Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome
    Gregory Ouellet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Cardiol 105:87-9. 2010
    ..In conclusion, diabetes and prolonged QTc interval contributed independent mortality risks in adult patients with LQTS, with no interaction between these 2 risk factors...
  41. ncbi request reprint Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial
    Eric J Rashba
    Division of Cardiology, Department of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Room N3W77, Baltimore, MD 21201, USA
    Heart Rhythm 3:281-6. 2006
    ..The recent expansion of indications for prophylactic implantable cardioverter-defibrillator (ICD) placement in subjects with nonischemic dilated cardiomyopathy has raised concerns about the cost-effectiveness of this therapy...
  42. ncbi request reprint Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction
    Tareq S Harb
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 89:216-21. 2002
  43. ncbi request reprint Factors associated with ventricular inducibility in the MADIT-II study population
    Henry W Sesselberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Cardiol 91:1002-4, A7. 2003
  44. ncbi request reprint Clinical implications for affected parents and siblings of probands with long-QT syndrome
    J Kimbrough
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Circulation 104:557-62. 2001
    ..CONCLUSIONS: The severity profile of LQTS in a proband was not found to be useful in identifying the clinical severity of LQTS in affected first-degree relatives of the proband...
  45. ncbi request reprint Identification of sotalol-induced changes in repolarization with T wave area-based repolarization duration parameters
    Jean Philippe Couderc
    Cardiology Unit, Heart Research Follow Up Program, University of Rochester, NY 14642, USA
    J Electrocardiol 36:115-20. 2003
    ..In conclusion, morphological parameters of T wave are able to identify the changes in repolarization interval induced by sotalol. These parameters are more stable and thus more reliable than the traditional QT interval measurements...
  46. doi request reprint Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
    ..However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified...
  47. ncbi request reprint Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacin
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    Drug Saf 31:249-60. 2008
    ....
  48. doi request reprint Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 51:288-96. 2008
    ..The study was designed to develop a simple risk stratification score for primary therapy with an implantable cardioverter-defibrillator (ICD)...
  49. ncbi request reprint Plasminogen activator inhibitor-1 polymorphism (4G/5G) predicts recurrence in nonhyperlipidemic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 28:548-54. 2008
    ..The aim of this study was to assess such risk as a function of 37 atherosclerosis-associated genetic polymorphisms and 17 blood marker variables...
  50. ncbi request reprint Impaired T-amplitude adaptation to heart rate characterizes I(Kr) inhibition in the congenital and acquired forms of the long QT syndrome
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:1299-305. 2007
    ..In the search for alternative markers, we investigated the T-amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol-induced QT prolongation...
  51. ncbi request reprint Repolarization variability in the risk stratification of MADIT II patients
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Europace 9:717-23. 2007
    ..0; 95% CI; 1.2-3.5; P=0.01). On the basis of the comprehensive testing, TWV value >59 microV was found predictive for arrhythmic events in MADIT II population...
  52. pmc Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals
    Ilan Goldenberg
    Cardiology Division of Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:51-9. 2011
    ..This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals...
  53. doi request reprint Heart rate turbulence predicts all-cause mortality and sudden death in congestive heart failure patients
    Iwona Cygankiewicz
    Catalan Institute of Cardiovascular Sciences, Barcelona, Spain University of Rochester, Rochester, New York 14642, USA
    Heart Rhythm 5:1095-1102. 2008
    ..Abnormal heart rate turbulence (HRT) has been documented as a strong predictor of total mortality and sudden death in postinfarction patients, but data in patients with congestive heart failure (CHF) are limited...
  54. doi request reprint Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 13:287-94. 2008
    ..We hypothesized that several genetic atherosclerotic single nucleotide polymorphisms (SNPs) may exert an additive effect on the earlier occurrence of coronary atherothrombotic disease after adjustment for clinical factors...
  55. doi request reprint Investigating the effect of sotalol on the repolarization intervals in healthy young individuals
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester, Rochester, NY, USA
    J Electrocardiol 41:595-602. 2008
    ..In a group of healthy individuals exposed to sotalol, we compared their drug-induced changes to the drug-induced prolongations of the QTc, QTc apex and T-peak to T-end intervals...
  56. doi request reprint Baseline values and sotalol-induced changes of ventricular repolarization duration, heterogeneity, and instability in patients with a history of drug-induced torsades de pointes
    Jean Philippe Couderc
    Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Clin Pharmacol 49:6-16. 2009
    ....
  57. ncbi request reprint History of hypertension and enhanced thrombogenic activity in postinfarction patients
    Yazid Y Fadl
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Box 653, Rochester, NY 14642, USA
    Hypertension 41:943-9. 2003
    ..02, P=0.005) and nonhypertensive (hazard ratio=2.42, P=0.02) patients. Thus, patients after infarction with a history of hypertension have enhanced thrombogenic activity, which predisposes them to recurrent cardiac events...
  58. ncbi request reprint MADIT-II: clinical implications
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Card Electrophysiol Rev 6:463-5. 2002
    ..These preliminary findings raise questions about the clinical usefulness of electrophysiologic testing as a risk stratifier in patients with advanced left ventricular dysfunction...
  59. doi request reprint Bridging a temporary high risk of sudden arrhythmic death. Experience with the wearable cardioverter defibrillator (WCD)
    Helmut U Klein
    University of Rochester Medical Center, Heart Research Follow Up Program, Rochester, New York 14642, USA
    Pacing Clin Electrophysiol 33:353-67. 2010
    ..Additionally, data are reported on the clinical experience with the WCD based on 354 patients from Germany hospitalized between 2000 and 2008 who wore the WCD for a mean of 3 months...
  60. doi request reprint Time dependence of life-threatening ventricular tachyarrhythmias after coronary revascularization in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 7:1421-7. 2010
    ..Coronary revascularization (CR) may confer electrical stability in patients with ischemic cardiomyopathy. However, data regarding the effect of CR on the development of ventricular tachyarrhythmias in this population are limited...
  61. pmc Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
    ..We evaluated the effect of location, coding type, and biophysical function of KCNQ1 mutations on the clinical phenotype of this disorder...
  62. ncbi request reprint Glycoprotein Ibalpha polymorphism T145M, elevated lipoprotein-associated phospholipase A2, and hypertriglyceridemia predict risk for recurrent coronary events in diabetic postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Diabetes 56:1429-35. 2007
    ....
  63. ncbi request reprint QT interval: how to measure it and what is "normal"
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:333-6. 2006
  64. ncbi request reprint Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with atrial fibrillation
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Heart Rhythm 3:631-7. 2006
    ..Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited...
  65. ncbi request reprint NAD(P)H oxidase polymorphism (C242T) and high HDL cholesterol associate with recurrent coronary events in postinfarction patients
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Atherosclerosis 196:461-8. 2008
    ..34-7.35 and 0.0084). We conclude that oxidative stress plays a significant role in establishment of risk for recurrent coronary events in a high-risk subgroup of postinfarction patients defined by inflammation and hypercholesterolemia...
  66. ncbi request reprint Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol
    Arthur J Moss
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:34-43. 2005
    ..30), and prolonged intraventricular conduction (QRS duration>or=130 ms)...
  67. ncbi request reprint Temporal aspects of improved survival with the implanted defibrillator (MADIT-II)
    Arthur J Moss
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 94:312-5. 2004
    ..In the early period, the rate of nonsudden cardiac death was significantly higher in the ICD group than in the conventional therapy group (p = 0.003). Rates of late nonsudden cardiac death were similar in the 2 treatment arms (p = 0.11)...
  68. ncbi request reprint Polymorphism in the angiotensinogen gene, hypertension, and ethnic differences in the risk of recurrent coronary events
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    Hypertension 48:693-9. 2006
    ..The presence of hypertension significantly augments the risk associated with this genetic mutation...
  69. ncbi request reprint Clinical course and implantable cardioverter defibrillator therapy in postinfarction women with severe left ventricular dysfunction
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Cardiovasc Electrophysiol 16:1265-70. 2005
    ..The aim of this study was to evaluate the risk of cardiac events and effects of ICD therapy in women as compared to men enrolled in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II)...
  70. ncbi request reprint Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:67-83. 2005
    ..However, data on the benefit and cost-effectiveness of device therapy in high-risk patients with inherited cardiac disorders are limited...
  71. ncbi request reprint Safety and efficacy of flecainide in subjects with Long QT-3 syndrome (DeltaKPQ mutation): a randomized, double-blind, placebo-controlled clinical trial
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:59-66. 2005
    ..In vitro studies have shown that flecainide provides correction of the impaired inactivation associated with the DeltaKPQ deletion...
  72. ncbi request reprint Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome
    Ilan Goldenberg
    Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:1161-8. 2006
    ....
  73. ncbi request reprint Implantable cardioverter defibrillator therapy in postinfarction patients
    Wojciech Zareba
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Curr Opin Cardiol 19:619-24. 2004
    ..This paper aims to provide an overview of the current state of knowledge regarding ICD therapy in postinfarction patients...
  74. doi request reprint Cardiac-resynchronization therapy for the prevention of heart-failure events
    Arthur J Moss
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    N Engl J Med 361:1329-38. 2009
    ....
  75. ncbi request reprint Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction
    N K Kaba
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    J Thromb Haemost 2:718-25. 2004
    ..The disturbances in hemostasis and the risk of CVD can be ameliorated by lipid-lowering therapy...
  76. ncbi request reprint Relation of the leukocyte count to recurrent cardiac events in stable patients after acute myocardial infarction
    R Hajj-Ali
    North Shore University Hospital, Cardiology Division and the Heart Research Follow-Up Program, Cardiology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Cardiol 88:1221-4. 2001
    ..These findings indicate that the leukocyte count may be another marker of an atherosclerotic inflammatory process that contributes to cardiac events in postinfarction patients...
  77. doi request reprint Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels
    James P Corsetti
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Thromb Haemost 106:1170-8. 2011
    ..Further studies should focus on additional effects of vascular inflammatory processes on anti-atherogenic functionality of HDL particles...
  78. ncbi request reprint The clinical implications of cumulative right ventricular pacing in the multicenter automatic defibrillator trial II
    Jonathan S Steinberg
    Division of Cardiology, St Luke s Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    J Cardiovasc Electrophysiol 16:359-65. 2005
    ..This study was designed to assess whether right ventricular pacing in the implantable cardioverter defibrillator (ICD) arm of the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II was associated with an unfavorable outcome...
  79. ncbi request reprint Sex steroids and heart rate variability in patients after myocardial infarction
    Jerzy Krzysztof Wranicz
    Department of Cardiology, Medical University of Lodz, Lodz, Poland
    Ann Noninvasive Electrocardiol 9:156-61. 2004
    ..The aim of the study was to evaluate the association between sex steroids and heart rate variability (HRV) parameters in postinfarction patients...
  80. ncbi request reprint Analyses of dynamic beat-to-beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of torsades de pointes during QT prolongation caused by sotalol
    Anthony A Fossa
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Ann Noninvasive Electrocardiol 12:338-48. 2007
    ..We examined whether analyses of sequential beat-to-beat QT and TQ interval measures can be used to quantify ECG restitution changes under normal sinus rhythm...
  81. ncbi request reprint Compound heterozygous mutations in KvLQT1 cause Jervell and Lange-Nielsen syndrome
    Zhiqing Wang
    Department of Medicine Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Genet Metab 75:308-16. 2002
    ..Interestingly, mutations resulting in truncation of the protein appear to be benign, with heterozygous carriers being asymptomatic...
  82. ncbi request reprint Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations
    Jesaia Benhorin
    Department of Cardiology, Bikur Cholim Hospital, Jerusalem, Israel
    Ann Noninvasive Electrocardiol 7:40-6. 2002
    ..This study assessed the phenotypic variability of LQTS in carriers with the same and with different mutations in the LQT2 gene...
  83. ncbi request reprint Risk stratification using heart rate turbulence and ventricular arrhythmia in MADIT II: usefulness and limitations of a 10-minute holter recording
    Alexander Berkowitsch
    Cardiology Unit of Kerckhoff Clinic, Bad Nauheim, Germany
    Ann Noninvasive Electrocardiol 9:270-9. 2004
    ....
  84. ncbi request reprint Holter electrocardiogram parameters in risk stratification of arrhythmic events in idiopathic dilated cardiomyopathy: more studies are needed
    Wojciech Zareba
    J Am Coll Cardiol 50:232-3. 2007
  85. ncbi request reprint Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Mutat Res 621:50-60. 2007
    ..These results suggest that traffic-related and combustion-generated particles show stronger adverse health impact with regard to cardiac effects, and that particles from different sources induce an acute phase response in these patients...
  86. ncbi request reprint Preventing tomorrow's sudden cardiac death today: part I: Current data on risk stratification for sudden cardiac death
    Sana M Al-Khatib
    The Duke Clinical Research Institute, Durham, NC 27715, USA
    Am Heart J 153:941-50. 2007
    ..This article summarizes the presentations and discussions that occurred at that meeting...
  87. doi request reprint A quantitative assessment of T-wave morphology in LQT1, LQT2, and healthy individuals based on Holter recording technology
    Martino Vaglio
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 5:11-8. 2008
    ..The clinical course and the precipitating risk factors in the congenital long QT syndrome (LQTS) are genotype specific...
  88. ncbi request reprint Prognostic significance of heart rate variability in dilated cardiomyopathy
    Maciej Karcz
    National Institute of Cardiology, ul Alpejska 42, 04 628 Warsaw, Poland
    Int J Cardiol 87:75-81. 2003
    ..We aimed to determine prognostic significance of heart rate variability (HRV) for predicting cardiac events in DCM patients with markedly depressed left ventricular function...
  89. ncbi request reprint Dynamics of ventricular repolarization in patients with dilated cardiomyopathy versus healthy subjects
    Jose Luis Alonso
    University Hospital of St Pau Cardiology, Barcelona, Spain
    Ann Noninvasive Electrocardiol 10:121-8. 2005
    ..However, there are limited data regarding feasibility of analyzing repolarization parameters and their dynamics in 24-hour Holter ECG recordings...
  90. pmc Risk of death in the long QT syndrome when a sibling has died
    Elizabeth S Kaufman
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA
    Heart Rhythm 5:831-6. 2008
    ..Sudden death of a sibling is thought to be associated with greater risk of death in long QT syndrome (LQTS). However, there is no evidence of such an association...
  91. ncbi request reprint Implantable cardioverter-defibrillator efficacy in patients with heart failure and left ventricular dysfunction (from the MADIT II population)
    Wojciech Zareba
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    Am J Cardiol 95:1487-91. 2005
    ..However, there is no significant difference in the benefit from ICD therapy among the above subgroups of patients in the Multicenter Automatic Defibrillator Implantation Trial...
  92. ncbi request reprint Prognostic significance of heart rate turbulence in patients undergoing coronary artery bypass grafting
    Iwona Cygankiewicz
    Institute of Cardiology, Medical University of Lodz, Lodz, Poland
    Am J Cardiol 91:1471-4, A8. 2003
  93. ncbi request reprint Relation of heart rate turbulence to severity of heart failure
    Iwona Cygankiewicz
    University Hospital St Pau, Barcelona, Spain
    Am J Cardiol 98:1635-40. 2006
    ....
  94. pmc Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study
    William S Beckett
    Department of Envrionmental Medicine, University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Avenue, Box EHSC, Rochester, New York 14642, USA
    Am J Respir Crit Care Med 171:1129-35. 2005
    ..Ultrafine particles (< 0.1 microm diameter) are believed to be more potent than an equal mass of inhaled accumulation mode particles (0.1-1.0 microm diameter)...
  95. ncbi request reprint Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 113:2810-7. 2006
    ..Implantable cardioverter-defibrillator (ICD) therapy may be associated with an increased risk for heart failure (HF). The present study evaluated the frequency, causes, and consequences of HF after ICD implantation...
  96. ncbi request reprint Differences in outcomes between patients treated with single- versus dual-chamber implantable cardioverter defibrillators: a substudy of the Multicenter Automatic Defibrillator Implantation Trial II
    Loren D Berenbom
    Mid America Cardiology and the Department of Internal Medicine, Division of Cardiology, University of Kansas Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Ann Noninvasive Electrocardiol 10:429-35. 2005
    ....
  97. ncbi request reprint Clinical covariates of abnormal heart rate turbulence in coronary patients
    Iwona Cygankiewicz
    Institute of Cardiology, Medical University of Lodz, Poland
    Ann Noninvasive Electrocardiol 8:289-95. 2003
    ..The aim of this study is to evaluate the association between heart rate turbulence (HRT) parameters and clinical characteristics of coronary artery disease (CAD) patients...